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Volumn 28, Issue 3, 2014, Pages 437-453

Understanding the Biology of Melanoma and Therapeutic Implications

Author keywords

BRAF; Immunotherapy; MITF; NRAS; Targeted therapy

Indexed keywords

CHIR 265; DABRAFENIB; IPILIMUMAB; LGX 818; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; SORAFENIB; UNCLASSIFIED DRUG; VEMURAFENIB; ONCOPROTEIN;

EID: 84901437839     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2014.02.007     Document Type: Review
Times cited : (32)

References (121)
  • 1
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman P.B., Hauschild A., Robert C., et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. NEngl J Med 2011, 364(26):2507-2516.
    • (2011) NEngl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 2
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty K.T., Robert C., Hersey P., et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. NEngl J Med 2012, 367(2):107-114.
    • (2012) NEngl J Med , vol.367 , Issue.2 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 3
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A., Grob J.J., Demidov L.V., et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012, 380(9839):358-365.
    • (2012) Lancet , vol.380 , Issue.9839 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi F.S., O'Day S.J., McDermott D.F., et al. Improved survival with ipilimumab in patients with metastatic melanoma. NEngl J Med 2010, 363(8):711-723.
    • (2010) NEngl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 5
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C., Thomas L., Bondarenko I., et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. NEngl J Med 2011, 364(26):2517-2526.
    • (2011) NEngl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 6
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch C.M., Gershenwald J.E., Soong S.J., et al. Final version of 2009 AJCC melanoma staging and classification. JClin Oncol 2009, 27(36):6199-6206.
    • (2009) JClin Oncol , vol.27 , Issue.36 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 8
    • 84869084595 scopus 로고    scopus 로고
    • An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
    • Mitra D., Luo X., Morgan A., et al. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 2012, 491(7424):449-453.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 449-453
    • Mitra, D.1    Luo, X.2    Morgan, A.3
  • 9
    • 33748920021 scopus 로고    scopus 로고
    • Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    • D'Orazio J.A., Nobuhisa T., Cui R., et al. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 2006, 443(7109):340-344.
    • (2006) Nature , vol.443 , Issue.7109 , pp. 340-344
    • D'Orazio, J.A.1    Nobuhisa, T.2    Cui, R.3
  • 10
    • 33847422145 scopus 로고    scopus 로고
    • Central role of p53 in the suntan response and pathologic hyperpigmentation
    • Cui R., Widlund H.R., Feige E., et al. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 2007, 128(5):853-864.
    • (2007) Cell , vol.128 , Issue.5 , pp. 853-864
    • Cui, R.1    Widlund, H.R.2    Feige, E.3
  • 11
    • 84864258996 scopus 로고    scopus 로고
    • Alandscape of driver mutations in melanoma
    • Hodis E., Watson I.R., Kryukov G.V., et al. Alandscape of driver mutations in melanoma. Cell 2012, 150(2):251-263.
    • (2012) Cell , vol.150 , Issue.2 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 12
    • 0035038927 scopus 로고    scopus 로고
    • Sensorineural deafness and pigmentation genes: melanocytes and the Mitf transcriptional network
    • Price E.R., Fisher D.E. Sensorineural deafness and pigmentation genes: melanocytes and the Mitf transcriptional network. Neuron 2001, 30(1):15-18.
    • (2001) Neuron , vol.30 , Issue.1 , pp. 15-18
    • Price, E.R.1    Fisher, D.E.2
  • 13
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway L.A., Widlund H.R., Rubin M.A., et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005, 436(7047):117-122.
    • (2005) Nature , vol.436 , Issue.7047 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3
  • 14
    • 82555187007 scopus 로고    scopus 로고
    • Anovel recurrent mutation in MITF predisposes to familial and sporadic melanoma
    • Yokoyama S., Woods S.L., Boyle G.M., et al. Anovel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature 2011, 480(7375):99-103.
    • (2011) Nature , vol.480 , Issue.7375 , pp. 99-103
    • Yokoyama, S.1    Woods, S.L.2    Boyle, G.M.3
  • 15
    • 84876436850 scopus 로고    scopus 로고
    • Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
    • Haq R., Shoag J., Andreu-Perez P., et al. Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF. Cancer Cell 2013, 23(3):302-315.
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 302-315
    • Haq, R.1    Shoag, J.2    Andreu-Perez, P.3
  • 16
    • 84875019584 scopus 로고    scopus 로고
    • BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition
    • Haq R., Yokoyama S., Hawryluk E.B., et al. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci USA 2013, 110(11):4321-4326.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.11 , pp. 4321-4326
    • Haq, R.1    Yokoyama, S.2    Hawryluk, E.B.3
  • 17
    • 18444418797 scopus 로고    scopus 로고
    • Bcl2 regulation by the melanocyte master regulator MITF modulates lineage survival and melanoma cell viability
    • McGill G.G., Horstmann M., Widlund H.R., et al. Bcl2 regulation by the melanocyte master regulator MITF modulates lineage survival and melanoma cell viability. Cell 2002, 109(6):707-718.
    • (2002) Cell , vol.109 , Issue.6 , pp. 707-718
    • McGill, G.G.1    Horstmann, M.2    Widlund, H.R.3
  • 18
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath T.J., Price E.R., Takemoto C., et al. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 1998, 391(6664):298-301.
    • (1998) Nature , vol.391 , Issue.6664 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3
  • 19
    • 0034142326 scopus 로고    scopus 로고
    • C-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
    • Wu M., Hemesath T.J., Takemoto C.M., et al. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 2000, 14(3):301-312.
    • (2000) Genes Dev , vol.14 , Issue.3 , pp. 301-312
    • Wu, M.1    Hemesath, T.J.2    Takemoto, C.M.3
  • 20
    • 0348223934 scopus 로고    scopus 로고
    • NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression
    • Omholt K., Platz A., Kanter L., et al. NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res 2003, 9(17):6483-6488.
    • (2003) Clin Cancer Res , vol.9 , Issue.17 , pp. 6483-6488
    • Omholt, K.1    Platz, A.2    Kanter, L.3
  • 21
    • 84877590959 scopus 로고    scopus 로고
    • MAP kinase signaling and inhibition in melanoma
    • Sullivan R.J., Flaherty K. MAP kinase signaling and inhibition in melanoma. Oncogene 2012, 32(19):2373-2379.
    • (2012) Oncogene , vol.32 , Issue.19 , pp. 2373-2379
    • Sullivan, R.J.1    Flaherty, K.2
  • 22
    • 0141815693 scopus 로고    scopus 로고
    • Regulation of Raf through phosphorylation and N terminus-C terminus interaction
    • Chong H., Guan K.L. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. JBiol Chem 2003, 278(38):36269-36276.
    • (2003) JBiol Chem , vol.278 , Issue.38 , pp. 36269-36276
    • Chong, H.1    Guan, K.L.2
  • 23
    • 0027337519 scopus 로고
    • Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase
    • Moodie S.A., Willumsen B.M., Weber M.J., et al. Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 1993, 260(5114):1658-1661.
    • (1993) Science , vol.260 , Issue.5114 , pp. 1658-1661
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3
  • 24
    • 0032555494 scopus 로고    scopus 로고
    • Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity
    • Winkler D.G., Cutler R.E., Drugan J.K., et al. Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity. JBiol Chem 1998, 273(34):21578-21584.
    • (1998) JBiol Chem , vol.273 , Issue.34 , pp. 21578-21584
    • Winkler, D.G.1    Cutler, R.E.2    Drugan, J.K.3
  • 25
    • 29144462587 scopus 로고    scopus 로고
    • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
    • Garnett M.J., Rana S., Paterson H., et al. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 2005, 20(6):963-969.
    • (2005) Mol Cell , vol.20 , Issue.6 , pp. 963-969
    • Garnett, M.J.1    Rana, S.2    Paterson, H.3
  • 26
    • 33747615527 scopus 로고    scopus 로고
    • The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf
    • Terai K., Matsuda M. The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf. EMBO J 2006, 25(15):3556-3564.
    • (2006) EMBO J , vol.25 , Issue.15 , pp. 3556-3564
    • Terai, K.1    Matsuda, M.2
  • 27
    • 79954579925 scopus 로고    scopus 로고
    • Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value
    • Oba J., Nakahara T., Abe T., et al. Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value. JDermatol Sci 2011, 62(2):116-123.
    • (2011) JDermatol Sci , vol.62 , Issue.2 , pp. 116-123
    • Oba, J.1    Nakahara, T.2    Abe, T.3
  • 28
    • 24344487227 scopus 로고    scopus 로고
    • Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas
    • Takata M., Goto Y., Ichii N., et al. Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas. JInvest Dermatol 2005, 125(2):318-322.
    • (2005) JInvest Dermatol , vol.125 , Issue.2 , pp. 318-322
    • Takata, M.1    Goto, Y.2    Ichii, N.3
  • 29
    • 33646907501 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells
    • Calipel A., Mouriaux F., Glotin A.L., et al. Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. JBiol Chem 2006, 281(14):9238-9250.
    • (2006) JBiol Chem , vol.281 , Issue.14 , pp. 9238-9250
    • Calipel, A.1    Mouriaux, F.2    Glotin, A.L.3
  • 30
    • 33847027884 scopus 로고    scopus 로고
    • Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells
    • Bhatt K.V., Hu R., Spofford L.S., et al. Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells. Oncogene 2007, 26(7):1056-1066.
    • (2007) Oncogene , vol.26 , Issue.7 , pp. 1056-1066
    • Bhatt, K.V.1    Hu, R.2    Spofford, L.S.3
  • 31
    • 19644397029 scopus 로고    scopus 로고
    • Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling
    • Bhatt K.V., Spofford L.S., Aram G., et al. Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling. Oncogene 2005, 24(21):3459-3471.
    • (2005) Oncogene , vol.24 , Issue.21 , pp. 3459-3471
    • Bhatt, K.V.1    Spofford, L.S.2    Aram, G.3
  • 32
    • 58149399847 scopus 로고    scopus 로고
    • Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured invitro
    • Eskandarpour M., Huang F., Reeves K.A., et al. Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured invitro. Int J Cancer 2009, 124(1):16-26.
    • (2009) Int J Cancer , vol.124 , Issue.1 , pp. 16-26
    • Eskandarpour, M.1    Huang, F.2    Reeves, K.A.3
  • 33
    • 17644383337 scopus 로고    scopus 로고
    • Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells
    • Eskandarpour M., Kiaii S., Zhu C., et al. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. Int J Cancer 2005, 115(1):65-73.
    • (2005) Int J Cancer , vol.115 , Issue.1 , pp. 65-73
    • Eskandarpour, M.1    Kiaii, S.2    Zhu, C.3
  • 34
    • 34548096400 scopus 로고    scopus 로고
    • Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
    • Wang Y.F., Jiang C.C., Kiejda K.A., et al. Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin Cancer Res 2007, 13(16):4934-4942.
    • (2007) Clin Cancer Res , vol.13 , Issue.16 , pp. 4934-4942
    • Wang, Y.F.1    Jiang, C.C.2    Kiejda, K.A.3
  • 35
    • 33845797913 scopus 로고    scopus 로고
    • Anovel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
    • Verhaegen M., Bauer J.A., Martin de la Vega C., et al. Anovel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res 2006, 66(23):11348-11359.
    • (2006) Cancer Res , vol.66 , Issue.23 , pp. 11348-11359
    • Verhaegen, M.1    Bauer, J.A.2    Martin de la Vega, C.3
  • 36
    • 52049084154 scopus 로고    scopus 로고
    • Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim
    • Sheridan C., Brumatti G., Martin S.J. Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim. JBiol Chem 2008, 283(32):22128-22135.
    • (2008) JBiol Chem , vol.283 , Issue.32 , pp. 22128-22135
    • Sheridan, C.1    Brumatti, G.2    Martin, S.J.3
  • 37
    • 38149102519 scopus 로고    scopus 로고
    • GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines
    • Panka D.J., Cho D.C., Atkins M.B., et al. GSK-3beta inhibition enhances sorafenib-induced apoptosis in melanoma cell lines. JBiol Chem 2008, 283(2):726-732.
    • (2008) JBiol Chem , vol.283 , Issue.2 , pp. 726-732
    • Panka, D.J.1    Cho, D.C.2    Atkins, M.B.3
  • 38
    • 52149107116 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival
    • Cartlidge R.A., Thomas G.R., Cagnol S., et al. Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell Melanoma Res 2008, 21(5):534-544.
    • (2008) Pigment Cell Melanoma Res , vol.21 , Issue.5 , pp. 534-544
    • Cartlidge, R.A.1    Thomas, G.R.2    Cagnol, S.3
  • 39
    • 58149328950 scopus 로고    scopus 로고
    • CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations
    • Smalley K.S., Xiao M., Villanueva J., et al. CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations. Oncogene 2009, 28(1):85-94.
    • (2009) Oncogene , vol.28 , Issue.1 , pp. 85-94
    • Smalley, K.S.1    Xiao, M.2    Villanueva, J.3
  • 40
    • 79951818357 scopus 로고    scopus 로고
    • Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
    • Jiang C.C., Lai F., Tay K.H., et al. Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS. Cell Death Dis 2010, 1:e69.
    • (2010) Cell Death Dis , vol.1
    • Jiang, C.C.1    Lai, F.2    Tay, K.H.3
  • 41
    • 84886425815 scopus 로고    scopus 로고
    • Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma
    • Kwong L.N., Davies M.A. Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma. Clin Cancer Res 2013, 19(19):5310-5319.
    • (2013) Clin Cancer Res , vol.19 , Issue.19 , pp. 5310-5319
    • Kwong, L.N.1    Davies, M.A.2
  • 42
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao H., Zhang X., Fowlkes K., et al. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 2000, 60(7):1800-1804.
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3
  • 43
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
    • Tsao H., Goel V., Wu H., et al. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. JInvest Dermatol 2004, 122(2):337-341.
    • (2004) JInvest Dermatol , vol.122 , Issue.2 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3
  • 44
    • 53849132331 scopus 로고    scopus 로고
    • Anovel AKT3 mutation in melanoma tumours and cell lines
    • Davies M.A., Stemke-Hale K., Tellez C., et al. Anovel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer 2008, 99(8):1265-1268.
    • (2008) Br J Cancer , vol.99 , Issue.8 , pp. 1265-1268
    • Davies, M.A.1    Stemke-Hale, K.2    Tellez, C.3
  • 45
    • 84876037369 scopus 로고    scopus 로고
    • Elucidating distinct roles for NF1 in melanomagenesis
    • Maertens O., Johnson B., Hollstein P., et al. Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov 2013, 3(3):338-349.
    • (2013) Cancer Discov , vol.3 , Issue.3 , pp. 338-349
    • Maertens, O.1    Johnson, B.2    Hollstein, P.3
  • 46
    • 58649110598 scopus 로고    scopus 로고
    • Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    • Zheng B., Jeong J.H., Asara J.M., et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell 2009, 33(2):237-247.
    • (2009) Mol Cell , vol.33 , Issue.2 , pp. 237-247
    • Zheng, B.1    Jeong, J.H.2    Asara, J.M.3
  • 47
    • 84883644630 scopus 로고    scopus 로고
    • TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma
    • 196ra98
    • Corcoran R.B., Rothenberg S.M., Hata A.N., et al. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci Transl Med 2013, 5(196):196ra98.
    • (2013) Sci Transl Med , vol.5 , Issue.196
    • Corcoran, R.B.1    Rothenberg, S.M.2    Hata, A.N.3
  • 48
    • 0036894746 scopus 로고    scopus 로고
    • BRAF and RAS mutations in human lung cancer and melanoma
    • Brose M.S., Volpe P., Feldman M., et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 2002, 62(23):6997-7000.
    • (2002) Cancer Res , vol.62 , Issue.23 , pp. 6997-7000
    • Brose, M.S.1    Volpe, P.2    Feldman, M.3
  • 49
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H., Bignell G.R., Cox C., et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417(6892):949-954.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 50
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn S.J., Milagre C., Whittaker S., et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010, 140(2):209-221.
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3
  • 51
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos P.I., Zhang C., Bollag G., et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464(7287):427-430.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3
  • 52
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long G.V., Menzies A.M., Nagrial A.M., et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. JClin Oncol 2011, 29(10):1239-1246.
    • (2011) JClin Oncol , vol.29 , Issue.10 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3
  • 53
    • 84862584008 scopus 로고    scopus 로고
    • Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    • Menzies A.M., Haydu L.E., Visintin L., et al. Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin Cancer Res 2012, 18(12):3242-3249.
    • (2012) Clin Cancer Res , vol.18 , Issue.12 , pp. 3242-3249
    • Menzies, A.M.1    Haydu, L.E.2    Visintin, L.3
  • 54
    • 84882832283 scopus 로고    scopus 로고
    • Initial results from a phase I, open-label, dose escalation study of the oral BRAF inhibitor LGX818 in patients with BRAF V600 mutant advanced or metastatic melanoma
    • [abstract], Abstract 9028
    • Dummer R., Robert C., Nyakas M., et al. Initial results from a phase I, open-label, dose escalation study of the oral BRAF inhibitor LGX818 in patients with BRAF V600 mutant advanced or metastatic melanoma. JClin Oncol 2013, 31(Suppl). [abstract], Abstract 9028.
    • (2013) JClin Oncol , vol.31 , Issue.SUPPL
    • Dummer, R.1    Robert, C.2    Nyakas, M.3
  • 55
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong L.N., Costello J.C., Liu H., et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med 2012, 18(10):1503-1510.
    • (2012) Nat Med , vol.18 , Issue.10 , pp. 1503-1510
    • Kwong, L.N.1    Costello, J.C.2    Liu, H.3
  • 56
    • 0027102715 scopus 로고
    • C-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas
    • Funasaka Y., Boulton T., Cobb M., et al. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol Biol Cell 1992, 3(2):197-209.
    • (1992) Mol Biol Cell , vol.3 , Issue.2 , pp. 197-209
    • Funasaka, Y.1    Boulton, T.2    Cobb, M.3
  • 57
    • 33645693156 scopus 로고    scopus 로고
    • Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate
    • Wardelmann E., Merkelbach-Bruse S., Pauls K., et al. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res 2006, 12(6):1743-1749.
    • (2006) Clin Cancer Res , vol.12 , Issue.6 , pp. 1743-1749
    • Wardelmann, E.1    Merkelbach-Bruse, S.2    Pauls, K.3
  • 58
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin J.A., Busam K., Pinkel D., et al. Somatic activation of KIT in distinct subtypes of melanoma. JClin Oncol 2006, 24(26):4340-4346.
    • (2006) JClin Oncol , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3
  • 59
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal R.D., Antonescu C.R., Wolchok J.D., et al. KIT as a therapeutic target in metastatic melanoma. JAMA 2011, 305(22):2327-2334.
    • (2011) JAMA , vol.305 , Issue.22 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 60
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
    • Guo J., Si L., Kong Y., et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. JClin Oncol 2011, 29(21):2904-2909.
    • (2011) JClin Oncol , vol.29 , Issue.21 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3
  • 61
    • 84881512367 scopus 로고    scopus 로고
    • Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin
    • Hodi F.S., Corless C.L., Giobbie-Hurder A., et al. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. JClin Oncol 2013, 31(26):3182-3190.
    • (2013) JClin Oncol , vol.31 , Issue.26 , pp. 3182-3190
    • Hodi, F.S.1    Corless, C.L.2    Giobbie-Hurder, A.3
  • 62
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • Van Raamsdonk C.D., Bezrookove V., Green G., et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 2009, 457(7229):599-602.
    • (2009) Nature , vol.457 , Issue.7229 , pp. 599-602
    • Van Raamsdonk, C.D.1    Bezrookove, V.2    Green, G.3
  • 63
  • 64
    • 84908316203 scopus 로고    scopus 로고
    • Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
    • Chen X., Wu Q., Tan L., et al. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene 2013, 10.1038/onc.2013.418.
    • (2013) Oncogene
    • Chen, X.1    Wu, Q.2    Tan, L.3
  • 65
    • 84866079583 scopus 로고    scopus 로고
    • Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-kappaB pathways
    • Wu X., Li J., Zhu M., et al. Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-kappaB pathways. Mol Cancer Ther 2012, 11(9):1905-1914.
    • (2012) Mol Cancer Ther , vol.11 , Issue.9 , pp. 1905-1914
    • Wu, X.1    Li, J.2    Zhu, M.3
  • 66
    • 84859810061 scopus 로고    scopus 로고
    • Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines
    • von Euw E., Atefi M., Attar N., et al. Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines. Mol Cancer 2012, 11:22.
    • (2012) Mol Cancer , vol.11 , pp. 22
    • von Euw, E.1    Atefi, M.2    Attar, N.3
  • 67
    • 84865096605 scopus 로고    scopus 로고
    • Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner
    • Khalili J.S., Yu X., Wang J., et al. Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res 2012, 18(16):4345-4355.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4345-4355
    • Khalili, J.S.1    Yu, X.2    Wang, J.3
  • 68
    • 85047656288 scopus 로고    scopus 로고
    • Selumetinib shows promise in metastatic uveal melanoma
    • Selumetinib shows promise in metastatic uveal melanoma. Cancer Discov 2013, 3(7):OF8.
    • (2013) Cancer Discov , vol.3 , Issue.7
  • 69
    • 85047284709 scopus 로고    scopus 로고
    • Selumetinib increases the efficacy of first-line dacarbazine
    • Selumetinib increases the efficacy of first-line dacarbazine. Cancer Discov 2013, 3(7):OF16.
    • (2013) Cancer Discov , vol.3 , Issue.7
  • 70
    • 84886438147 scopus 로고    scopus 로고
    • The cell cycle regulator CDK4 an emerging therapeutic target in melanoma
    • Sheppard K.E., McArthur G.A. The cell cycle regulator CDK4 an emerging therapeutic target in melanoma. Clin Cancer Res 2013, 19:5320-5328.
    • (2013) Clin Cancer Res , vol.19 , pp. 5320-5328
    • Sheppard, K.E.1    McArthur, G.A.2
  • 71
    • 84886393866 scopus 로고    scopus 로고
    • Clinical significance of genomic alterations of the CDK4-pathway and sensitivity to the CDK4 inhibitor PD 0332991 in melanoma
    • [abstract], Abstract 8520
    • McArthur G.A., Young R.J., Sheppard K.E., et al. Clinical significance of genomic alterations of the CDK4-pathway and sensitivity to the CDK4 inhibitor PD 0332991 in melanoma. JClin Oncol 2012, 30(Suppl). [abstract], Abstract 8520.
    • (2012) JClin Oncol , vol.30 , Issue.SUPPL
    • McArthur, G.A.1    Young, R.J.2    Sheppard, K.E.3
  • 72
    • 0030728259 scopus 로고    scopus 로고
    • CDKN2A/p16 is inactivated in most melanoma cell lines
    • Castellano M., Pollock P.M., Walters M.K., et al. CDKN2A/p16 is inactivated in most melanoma cell lines. Cancer Res 1997, 57(21):4868-4875.
    • (1997) Cancer Res , vol.57 , Issue.21 , pp. 4868-4875
    • Castellano, M.1    Pollock, P.M.2    Walters, M.K.3
  • 73
    • 78149464297 scopus 로고    scopus 로고
    • High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma
    • Jonsson A., Tuominen R., Grafstrom E., et al. High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma. JInvest Dermatol 2010, 130(12):2809-2817.
    • (2010) JInvest Dermatol , vol.130 , Issue.12 , pp. 2809-2817
    • Jonsson, A.1    Tuominen, R.2    Grafstrom, E.3
  • 74
    • 0032217165 scopus 로고    scopus 로고
    • CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds
    • Fargnoli M.C., Chimenti S., Keller G., et al. CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds. JInvest Dermatol 1998, 111(6):1202-1206.
    • (1998) JInvest Dermatol , vol.111 , Issue.6 , pp. 1202-1206
    • Fargnoli, M.C.1    Chimenti, S.2    Keller, G.3
  • 75
    • 0032900535 scopus 로고    scopus 로고
    • Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma
    • Liu L., Dilworth D., Gao L., et al. Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma. Nat Genet 1999, 21(1):128-132.
    • (1999) Nat Genet , vol.21 , Issue.1 , pp. 128-132
    • Liu, L.1    Dilworth, D.2    Gao, L.3
  • 76
    • 0028981664 scopus 로고
    • Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma
    • Liu L., Lassam N.J., Slingerland J.M., et al. Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma. Oncogene 1995, 11(2):405-412.
    • (1995) Oncogene , vol.11 , Issue.2 , pp. 405-412
    • Liu, L.1    Lassam, N.J.2    Slingerland, J.M.3
  • 77
    • 0028998866 scopus 로고
    • Mutations associated with familial melanoma impair p16INK4 function
    • Ranade K., Hussussian C.J., Sikorski R.S., et al. Mutations associated with familial melanoma impair p16INK4 function. Nat Genet 1995, 10(1):114-116.
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 114-116
    • Ranade, K.1    Hussussian, C.J.2    Sikorski, R.S.3
  • 78
    • 84878886596 scopus 로고    scopus 로고
    • Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants
    • Puntervoll H.E., Yang X.R., Vetti H.H., et al. Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. JMed Genet 2013, 50(4):264-270.
    • (2013) JMed Genet , vol.50 , Issue.4 , pp. 264-270
    • Puntervoll, H.E.1    Yang, X.R.2    Vetti, H.H.3
  • 79
    • 0028209220 scopus 로고
    • Absence of p53 gene mutations in cutaneous melanoma
    • Lubbe J., Reichel M., Burg G., et al. Absence of p53 gene mutations in cutaneous melanoma. JInvest Dermatol 1994, 102(5):819-821.
    • (1994) JInvest Dermatol , vol.102 , Issue.5 , pp. 819-821
    • Lubbe, J.1    Reichel, M.2    Burg, G.3
  • 80
    • 33645836292 scopus 로고    scopus 로고
    • Amplification of CDK4 and MDM2 in malignant melanoma
    • Muthusamy V., Hobbs C., Nogueira C., et al. Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosomes Cancer 2006, 45(5):447-454.
    • (2006) Genes Chromosomes Cancer , vol.45 , Issue.5 , pp. 447-454
    • Muthusamy, V.1    Hobbs, C.2    Nogueira, C.3
  • 81
    • 0035887146 scopus 로고    scopus 로고
    • HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma
    • Polsky D., Bastian B.C., Hazan C., et al. HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma. Cancer Res 2001, 61(20):7642-7646.
    • (2001) Cancer Res , vol.61 , Issue.20 , pp. 7642-7646
    • Polsky, D.1    Bastian, B.C.2    Hazan, C.3
  • 82
    • 0032474749 scopus 로고    scopus 로고
    • Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
    • Tsao H., Zhang X., Benoit E., et al. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 1998, 16(26):3397-3402.
    • (1998) Oncogene , vol.16 , Issue.26 , pp. 3397-3402
    • Tsao, H.1    Zhang, X.2    Benoit, E.3
  • 83
    • 84883482902 scopus 로고    scopus 로고
    • Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436)
    • Nathanson K.L., Martin A.M., Wubbenhorst B., et al. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). Clin Cancer Res 2013, 19(17):4868-4878.
    • (2013) Clin Cancer Res , vol.19 , Issue.17 , pp. 4868-4878
    • Nathanson, K.L.1    Martin, A.M.2    Wubbenhorst, B.3
  • 84
    • 84891898344 scopus 로고    scopus 로고
    • Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
    • Shi H., Hugo W., Kong X., et al. Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov 2014, 4(1):80-93.
    • (2014) Cancer Discov , vol.4 , Issue.1 , pp. 80-93
    • Shi, H.1    Hugo, W.2    Kong, X.3
  • 85
    • 51349148948 scopus 로고    scopus 로고
    • PTEN-deficient cancers depend on PIK3CB
    • Wee S., Wiederschain D., Maira S.M., et al. PTEN-deficient cancers depend on PIK3CB. Proc Natl Acad Sci USA 2008, 105(35):13057-13062.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.35 , pp. 13057-13062
    • Wee, S.1    Wiederschain, D.2    Maira, S.M.3
  • 86
    • 84859873585 scopus 로고    scopus 로고
    • RAF265 inhibits the growth of advanced human melanoma tumors
    • Su Y., Vilgelm A.E., Kelley M.C., et al. RAF265 inhibits the growth of advanced human melanoma tumors. Clin Cancer Res 2012, 18(8):2184-2198.
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2184-2198
    • Su, Y.1    Vilgelm, A.E.2    Kelley, M.C.3
  • 87
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm S.M., Adnane L., Newell P., et al. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008, 7(10):3129-3140.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3
  • 88
    • 27244457769 scopus 로고    scopus 로고
    • Raf: a strategic target for therapeutic development against cancer
    • Beeram M., Patnaik A., Rowinsky E.K. Raf: a strategic target for therapeutic development against cancer. JClin Oncol 2005, 23(27):6771-6790.
    • (2005) JClin Oncol , vol.23 , Issue.27 , pp. 6771-6790
    • Beeram, M.1    Patnaik, A.2    Rowinsky, E.K.3
  • 89
    • 70349193673 scopus 로고    scopus 로고
    • Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment
    • Smalley K.S., Flaherty K.T. Development of a novel chemical class of BRAF inhibitors offers new hope for melanoma treatment. Future Oncol 2009, 5(6):775-778.
    • (2009) Future Oncol , vol.5 , Issue.6 , pp. 775-778
    • Smalley, K.S.1    Flaherty, K.T.2
  • 90
    • 33749238553 scopus 로고    scopus 로고
    • Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
    • Wilhelm S., Carter C., Lynch M., et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 2006, 5(10):835-844.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.10 , pp. 835-844
    • Wilhelm, S.1    Carter, C.2    Lynch, M.3
  • 91
    • 79958785634 scopus 로고    scopus 로고
    • Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling
    • Chen J., Shen Q., Labow M., et al. Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer Res 2011, 71(12):4280-4291.
    • (2011) Cancer Res , vol.71 , Issue.12 , pp. 4280-4291
    • Chen, J.1    Shen, Q.2    Labow, M.3
  • 92
    • 73349121946 scopus 로고    scopus 로고
    • Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases
    • Amaravadi R.K., Schuchter L.M., McDermott D.F., et al. Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases. Clin Cancer Res 2009, 15(24):7711-7718.
    • (2009) Clin Cancer Res , vol.15 , Issue.24 , pp. 7711-7718
    • Amaravadi, R.K.1    Schuchter, L.M.2    McDermott, D.F.3
  • 93
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis
    • Eisen T., Ahmad T., Flaherty K.T., et al. Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 2006, 95(5):581-586.
    • (2006) Br J Cancer , vol.95 , Issue.5 , pp. 581-586
    • Eisen, T.1    Ahmad, T.2    Flaherty, K.T.3
  • 94
    • 84873346707 scopus 로고    scopus 로고
    • Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma
    • Flaherty K.T., Lee S.J., Zhao F., et al. Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma. JClin Oncol 2013, 31(3):373-379.
    • (2013) JClin Oncol , vol.31 , Issue.3 , pp. 373-379
    • Flaherty, K.T.1    Lee, S.J.2    Zhao, F.3
  • 95
    • 51049095131 scopus 로고    scopus 로고
    • Aphase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel
    • Flaherty K.T., Schiller J., Schuchter L.M., et al. Aphase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clin Cancer Res 2008, 14(15):4836-4842.
    • (2008) Clin Cancer Res , vol.14 , Issue.15 , pp. 4836-4842
    • Flaherty, K.T.1    Schiller, J.2    Schuchter, L.M.3
  • 96
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A., Agarwala S.S., Trefzer U., et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. JClin Oncol 2009, 27(17):2823-2830.
    • (2009) JClin Oncol , vol.27 , Issue.17 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 97
    • 84857073184 scopus 로고    scopus 로고
    • Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438)
    • Margolin K.A., Moon J., Flaherty L.E., et al. Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438). Clin Cancer Res 2012, 18(4):1129-1137.
    • (2012) Clin Cancer Res , vol.18 , Issue.4 , pp. 1129-1137
    • Margolin, K.A.1    Moon, J.2    Flaherty, L.E.3
  • 98
    • 43749110700 scopus 로고    scopus 로고
    • Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group
    • McDermott D.F., Sosman J.A., Gonzalez R., et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. JClin Oncol 2008, 26(13):2178-2185.
    • (2008) JClin Oncol , vol.26 , Issue.13 , pp. 2178-2185
    • McDermott, D.F.1    Sosman, J.A.2    Gonzalez, R.3
  • 99
    • 80052539696 scopus 로고    scopus 로고
    • Results from the first-in-human (FIH) phase I study of the oral RAF inhibitor RAF265 administered daily to patients with advanced cutaneous melanoma
    • [abstract], Abstract 8508
    • Sharfman W.H., Hodi F.S., Lawrence D.P., et al. Results from the first-in-human (FIH) phase I study of the oral RAF inhibitor RAF265 administered daily to patients with advanced cutaneous melanoma. JClin Oncol 2011, 29(Suppl). [abstract], Abstract 8508.
    • (2011) JClin Oncol , vol.29 , Issue.SUPPL
    • Sharfman, W.H.1    Hodi, F.S.2    Lawrence, D.P.3
  • 100
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • Joseph E.W., Pratilas C.A., Poulikakos P.I., et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc Natl Acad Sci USA 2010, 107(33):14903-14908.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.33 , pp. 14903-14908
    • Joseph, E.W.1    Pratilas, C.A.2    Poulikakos, P.I.3
  • 101
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty K.T., Puzanov I., Kim K.B., et al. Inhibition of mutated, activated BRAF in metastatic melanoma. NEngl J Med 2010, 363(9):809-819.
    • (2010) NEngl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 102
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman J.A., Kim K.B., Schuchter L., et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. NEngl J Med 2012, 366(8):707-714.
    • (2012) NEngl J Med , vol.366 , Issue.8 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 103
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • Ugurel S., Hildenbrand R., Zimpfer A., et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer 2005, 92(8):1398-1405.
    • (2005) Br J Cancer , vol.92 , Issue.8 , pp. 1398-1405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3
  • 104
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy
    • Wyman K., Atkins M.B., Prieto V., et al. Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006, 106(9):2005-2011.
    • (2006) Cancer , vol.106 , Issue.9 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3
  • 105
    • 0014825236 scopus 로고
    • Immunological factors which influence response to immunotherapy in malignant melanoma
    • [discussion: 63-4]
    • Morton D., Eilber F.R., Malmgren R.A., et al. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery 1970, 68(1):158-163. [discussion: 63-4].
    • (1970) Surgery , vol.68 , Issue.1 , pp. 158-163
    • Morton, D.1    Eilber, F.R.2    Malmgren, R.A.3
  • 106
    • 0016176253 scopus 로고
    • BCG immunotherapy of malignant melanoma: summary of a seven-year experience
    • Morton D.L., Eilber F.R., Holmes E.C., et al. BCG immunotherapy of malignant melanoma: summary of a seven-year experience. Ann Surg 1974, 180(4):635-643.
    • (1974) Ann Surg , vol.180 , Issue.4 , pp. 635-643
    • Morton, D.L.1    Eilber, F.R.2    Holmes, E.C.3
  • 107
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993
    • Atkins M.B., Lotze M.T., Dutcher J.P., et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. JClin Oncol 1999, 17(7):2105-2116.
    • (1999) JClin Oncol , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 108
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood J.M., Strawderman M.H., Ernstoff M.S., et al. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. JClin Oncol 1996, 14(1):7-17.
    • (1996) JClin Oncol , vol.14 , Issue.1 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3
  • 109
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update
    • Atkins M.B., Kunkel L., Sznol M., et al. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J Sci Am 2000, 6(Suppl 1):S11-S14.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL 1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3
  • 110
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O., Robert C., Daud A., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. NEngl J Med 2013, 369(2):134-144.
    • (2013) NEngl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 111
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian S.L., Hodi F.S., Brahmer J.R., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. NEngl J Med 2012, 366(26):2443-2454.
    • (2012) NEngl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 112
    • 84886442207 scopus 로고    scopus 로고
    • The intersection of immune-directed and molecularly targeted therapy in advanced melanoma: where we have been, are, and will be
    • Sullivan R.J., Lorusso P.M., Flaherty K.T. The intersection of immune-directed and molecularly targeted therapy in advanced melanoma: where we have been, are, and will be. Clin Cancer Res 2013, 19(19):5283-5291.
    • (2013) Clin Cancer Res , vol.19 , Issue.19 , pp. 5283-5291
    • Sullivan, R.J.1    Lorusso, P.M.2    Flaherty, K.T.3
  • 113
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick D.T., Piris A., Cogdill A.P., et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res 2013, 19(5):1225-1231.
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3
  • 114
    • 84859807701 scopus 로고    scopus 로고
    • BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency
    • Hong D.S., Vence L., Falchook G., et al. BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency. Clin Cancer Res 2012, 18(8):2326-2335.
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2326-2335
    • Hong, D.S.1    Vence, L.2    Falchook, G.3
  • 115
    • 84863393623 scopus 로고    scopus 로고
    • Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    • Wilmott J.S., Long G.V., Howle J.R., et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res 2012, 18(5):1386-1394.
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1386-1394
    • Wilmott, J.S.1    Long, G.V.2    Howle, J.R.3
  • 116
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A., Cogdill A.P., Dang P., et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010, 70(13):5213-5219.
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3
  • 117
    • 78650391890 scopus 로고    scopus 로고
    • The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
    • Comin-Anduix B., Chodon T., Sazegar H., et al. The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations. Clin Cancer Res 2010, 16(24):6040-6048.
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6040-6048
    • Comin-Anduix, B.1    Chodon, T.2    Sazegar, H.3
  • 118
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas A., Hodi F.S., Callahan M., et al. Hepatotoxicity with combination of vemurafenib and ipilimumab. NEngl J Med 2013, 368(14):1365-1366.
    • (2013) NEngl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3
  • 119
    • 84155171313 scopus 로고    scopus 로고
    • Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma
    • Joseph R.W., Sullivan R.J., Harrell R., et al. Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma. JImmunother 2012, 35(1):66-72.
    • (2012) JImmunother , vol.35 , Issue.1 , pp. 66-72
    • Joseph, R.W.1    Sullivan, R.J.2    Harrell, R.3
  • 120
    • 84862494584 scopus 로고    scopus 로고
    • Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab
    • Shahabi V., Whitney G., Hamid O., et al. Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab. Cancer Immunol Immunother 2012, 61(5):733-737.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.5 , pp. 733-737
    • Shahabi, V.1    Whitney, G.2    Hamid, O.3
  • 121
    • 84901388008 scopus 로고    scopus 로고
    • NRAS mutation: a potential biomarker of clinical response to immune-based therapies in metastatic melanoma (MM)
    • [abstract], Abstract 9019
    • Johnson D.B., Lovly C.M., Flavin M., et al. NRAS mutation: a potential biomarker of clinical response to immune-based therapies in metastatic melanoma (MM). JClin Oncol 2013, 31(Suppl). [abstract], Abstract 9019.
    • (2013) JClin Oncol , vol.31 , Issue.SUPPL
    • Johnson, D.B.1    Lovly, C.M.2    Flavin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.