Biological perspectives of delayed fracture healing

Injury

Volumn 45, Issue SUPPL. 2, 2014, Pages

  Hankenson, K D ^a   Zimmerman, G ^b   Marcucio, R ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bone healing; Mediators; Non union; TGFbeta1; Vascularity

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; BIOLOGICAL FACTOR; BIOLOGICAL MARKER; CATHEPSIN K; COLLAGEN TYPE 1; COLONY STIMULATING FACTOR 1; HYPOXIA INDUCIBLE FACTOR; MEDRONIC ACID; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; OXYGEN; SODIUM FLUORIDE F 18; THROMBOSPONDIN 2; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; BETAIG-H3 PROTEIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ARTICLE; BLOOD FLOWMETRY; BONE MINERALIZATION; BONE REMODELING; CELL DIFFERENTIATION; CHONDROGENESIS; ENCHONDRAL OSSIFICATION; FLUORESCENCE IMAGING; FRACTURE HEALING; FRACTURE NONUNION; HUMAN; INFLAMMATION; INFLAMMATORY CELL; INTRAMEMBRANOUS OSSIFICATION; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSSIFICATION; OSTEOLYSIS; OUTCOME ASSESSMENT; PERIOSTEUM; PRIORITY JOURNAL; RELIABILITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION; ANIMAL; BLOOD; FRACTURES, BONE; MOUSE; PHYSIOLOGY; TIME;

ANIMALS; BIOLOGICAL MARKERS; EXTRACELLULAR MATRIX PROTEINS; FRACTURE HEALING; FRACTURES, BONE; FRACTURES, UNUNITED; HUMANS; MICE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84901416360     PISSN: 00201383     EISSN: 18790267     Source Type: Journal    
DOI: 10.1016/j.injury.2014.04.003     Document Type: Article

References (49)

1. T.A. Einhorn The cell and molecular biology of fracture healing Clin Orthop 355 Suppl. 1998 S7 S21
2. C. Colnot, X. Zhang, and M.L. Knothe Tate Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches J Orthop Res 30 12 2012 1869 1878
3. C.S. Bahney, D.P. Hu, A.J. Taylor, F. Ferro, H.M. Britz, and B. Hallgrimsson et al. Stem Cell Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation J Bone Miner Res Nov 2013
4. D.G. Little, M. Ramachandran, and A. Schindeler The anabolic and catabolic responses in bone repair J Bone Joint Surg Br 89 4 2007 425 433 (Pubitemid 46851119)
5. C. Colnot, S. Huang, and J. Helms Analyzing the cellular contribution of bone marrow to fracture healing using bone marrow transplantation in mice Biochem Biophys Res Commun 350 3 2006 557 561 (Pubitemid 44547884)
6. K.A. Alexander, M.K. Chang, E.R. Maylin, T. Kohler, R. Muller, and A.C. Wu et al. Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model J Bone Miner Res 26 7 Jul 2011 1517 1532
7. Z. Xing, C. Lu, D. Hu, Y.Y. Yu, X. Wang, and C. Colnot et al. Multiple roles for CCR2 during fracture healing Dis Model Mech 3 7/8 Jul-Aug 2010 451 458
8. M.I. Dishowitz, J.D. Takacs, A.M. Barr, J.B. Engiles, J. Ahn, and K.D. Hankenson Inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing PLoS ONE 8 7 2013 e68726
9. Z. Xing, C. Lu, D. Hu, T. 3rd Miclau, and R.S. Marcucio Rejuvenation of the inflammatory system stimulates fracture repair in aged mice J Orthop Res 28 8 Aug 2010 1000 1006
10. J.A. Slade Shantz, Y.Y. Yu, W. Andres, T. 3rd Miclau, and R. Marcucio Modulation of Macrophage Activity During Fracture Repair has Differential Effects in Young Adult and Elderly Mice J Orthop Trauma Dec 2013
11. C. Sebastian, M. Espia, M. Serra, A. Celada, and J. Lloberas MacrophAging: a cellular and molecular review Immunobiology 210 2-4 2005 121 126 (Pubitemid 41025152)
12. K. Kumagai, A. Vasanji, J.A. Drazba, R.S. Butler, and G.F. Muschler Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model J Orthop Res 26 2 Feb 2008 165 175 (Pubitemid 351220134)
13. C. Colnot Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration J Bone Miner Res 2008
14. D. Grcevic, S. Pejda, B.G. Matthews, D. Repic, L. Wang, and H. Li et al. In vivo fate mapping identifies mesenchymal progenitor cells Stem Cells 30 2 Feb 2012 187 196
15. C. Lu, T. Miclau, D. Hu, and R.S. Marcucio Ischemia leads to delayed union during fracture healing: a mouse model J Orthop Res 25 1 Jan 2007 51 61 (Pubitemid 46070731)
16. R. Riddle, R. Khatri, E. Schipani, and T. Clemens Role of hypoxia-inducible factor-1α in angiogenic-osteogenic coupling J Mol Med 87 6 2009 583 590
17. K.A. Jacobsen, Z.S. Al-Aql, C. Wan, J.L. Fitch, S.N. Stapleton, and Z.D. Mason et al. Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling J Bone Miner Res 23 5 2008 596 609 (Pubitemid 351575014)
18. C. Merceron, C. Vinatier, S. Portron, M. Masson, Jrm. Amiaud, and L. Guigand et al. Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells Am J Physiol Cell Physiol 298 2 Feb 1 2010 C355 C364
19. R. Amarilio, S.V. Viukov, A. Sharir, I. Eshkar-Oren, R.S. Johnson, and E. Zelzer HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis Dev 134 21 Nov 2007 3917 3928 (Pubitemid 350187350)
20. M. Wagegg, T. Gaber, F.L. Lohanatha, M. Hahne, C. Strehl, and M. Fangradt et al. Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner PLoS ONE 7 9 2012 pe46483
21. G. D'Ippolito, S. Diabira, G.A. Howard, B.A. Roos, and P.C. Schiller Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells Bone 39 3 2006 513 522 (Pubitemid 44149268)
22. Z. Thompson, Z. Thompson, T. Miclau, D. Hu, and J.A. Helms A model for intramembranous ossification during fracture healing J Orthop Res 20 5 Sep 2002 1091 1098
23. C. Lu, N. Saless, D. Hu, X. Wang, Z. Xing, and H. Hou et al. Mechanical stability affects angiogenesis during early fracture healing J Orthop Trauma 25 8 Aug 2011 494 499
24. C. Lu, N. Saless, X. Wang, A. Sinha, S. Decker, and G. Kazakia et al. The role of oxygen during fracture healing Bone 52 1 Jan 2013 220 229
25. D. Burke, M. Dishowitz, M. Sweetwyne, E. Miedel, K.D. Hankenson, and D.J. Kelly The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice J Orthop Res Jun 15 2013
26. C. Wan, S.R. Gilbert, Y. Wang, X. Cao, X. Shen, and G. Ramaswamy et al. Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration Proc Natl Acad Sci USA 105 2 Jan 15 2008 686 691 (Pubitemid 351171769)
27. A.Y. Sheikh, M.D. Rollins, H.W. Hopf, and T.K. Hunt Hyperoxia improves microvascular perfusion in a murine wound model Wound Repair Regen 13 3 May-Jun 2005 303 308 official publication of the Wound Healing Society [and] the European Tissue Repair Society
28. J. Street, M. Bao, L. deGuzman, S. Bunting, F.V. Peale, and N. Jr. Ferrara et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover Proc Natl Acad Sci USA 99 15 Jul 23 2002 9656 9661 (Pubitemid 34831103)
29. D.K. Taylor, J.A. Meganck, S. Terkhorn, R. Rajani, A. Naik, and R.J. O'Keefe et al. Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing J Bone Miner Res 24 6 2009 1043 1054
30. K. Wang, P. Vishwanath, G.S. Eichler, M.O. Al-Sebaei, C.M. Edgar, and T.A. Einhorn et al. Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression Matrix Biol 25 5 2006 271 281
31. T.A. Einhorn, R.J. Majeska, E.B. Rush, P.M. Levine, and M.C. Horowitz The expression of cytokine activity by fracture callus J Bone Miner Res 10 8 1995 1272 1281
32. P. Kobbe, Y. Vodovotz, D.J. Kaczorowski, K.P. Mollen, T.R. Billiar, and H.C. Pape Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture Shock (Augusta, Ga) 30 1 2008 43 47
33. B.M. Ingle, S.M. Hay, H.M. Bottjer, and R. Eastell Changes in bone mass and bone turnover following distal forearm fracture Osteoporos Int 10 5 1999 399 407
34. K. Sarahrudi, A. Thomas, C. Albrecht, and S. Aharinejad Strongly enhanced levels of sclerostin during human fracture healing J Orthopaed Res 30 10 2012 1549 1555
35. K. Sarahrudi, M. Mousavi, A. Thomas, S. Eipeldauer, V. Vécsei, and P. Pietschmann et al. Elevated levels of macrophage colony-stimulating factor in human fracture healing J Orthopaed Res 28 5 2010 671 676
36. G. Zimmermann, U. Muller, and A. Wentzensen The value of laboratory and imaging studies in the evaluation of long-bone non-unions Injury 38 Suppl. 2 May 2007 S33 S37
37. A. Komnenou, M. Karayannopoulou, Z.S. Polizopoulou, T.C. Constantinidis, and A. Dessiris Correlation of serum alkaline phosphatase activity with the healing process of long bone fractures in dogs Vet Clin Pathol 34 1 2005 35 38 (Pubitemid 40462823)
38. K. Sarahrudi, A. Thomas, M. Mousavi, G. Kaiser, J. Kottstorfer, and M. Kecht et al. Elevated transforming growth factor-beta 1 (TGF-Î21) levels in human fracture healing Injury 42 8 2011 833 837
39. K. Sarahrudi, A. Thomas, M. Mousavi, G. Kaiser, J. Kottstorfer, and M. Kecht et al. Elevated transforming growth factor-beta 1 (TGF-beta1) levels in human fracture healing Injury 42 8 2011 833 837
40. G. Zimmermann, P. Henle, M. Küsswetter, A. Moghaddam, A. Wentzensen, and W. Richter et al. TGF-[beta]1 as a marker of delayed fracture healing Bone 36 5 2005 779 785 (Pubitemid 40616012)
41. S. Sprague, and M. Bhandari An economic evaluation of early versus delayed operative treatment in patients with closed tibial shaft fractures Arch Orthop Trauma Surg 122 6 2002 315 323 (Pubitemid 36097230)
42. M. Kamano, S. Narita, Y. Honda, K. Fukushima, and Y. Yamano Contrast enhanced magnetic resonance imaging for femoral neck fracture Clin Orthop Relat Res 350 1998 179 186 (Pubitemid 28228273)
43. J.S. Dawson, A.L. Martel, and T.R. Davis Scaphoid blood flow and acute fracture healing. A dynamic MRI study with enhancement with gadolinium J Bone Joint Surg Br 83 6 2001 809 814 (Pubitemid 32785547)
44. K. Megerle, H. Worg, G. Christopoulos, R. Schmitt, and H. Krimmer Gadolinium-enhanced preoperative MRI scans as a prognostic parameter in scaphoid nonunion J Hand Surg Eur Vol 36 1 2011 23 28
45. Y. Zilberman, I. Kallai, Y. Gafni, G. Pelled, S. Kossodo, and W. Yared et al. Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells J Orthop Res 26 4 2008 522 530
46. B.C. Fleming, H.L. Oksendahl, W.A. Mehan, R. Portnoy, P.D. Fadale, and M.J. Hulstyn et al. Delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) following ACL injury Osteoarthritis Cartilage 18 5 2010 662 667
47. C. Copuroglu, G.M. Calori, and P.V. Giannoudis Fracture non-union: who is at risk? Injury 44 11 2013 1379 1382
48. R. Dimitriou, N. Kanakaris, P.N. Soucacos, and P.V. Giannoudis Genetic predisposition to non-union: evidence today Injury 44 Suppl. 1 2013 S50 S53
49. I. Pountos, T. Georgouli, S. Pneumaticos, and P.V. Giannoudis Fracture non-union: can biomarkers predict outcome? Injury 44 12 2013 1725 1732