Remote ischemic postconditioning protects the heart by upregulating ALDH2 expression levels through the PI3K/Akt signaling pathway

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 536-542

  Yu, Ying ^a   Jia, Xian Jie ^a   Zong, Qiao Feng ^a   Zhang, Guan Jun ^a   Ye, Hong Wei ^a   Hu, Jie ^a   Gao, Qin ^a   Guan, Su Dong ^a  

^a BENGBU MEDICAL COLLEGE   (China)

Author keywords

Akt; ALDH2; Cardioprotection; Ischemia reperfusion; Remote ischemic postconditioning

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; CASPASE 3; CREATINE KINASE; LACTATE DEHYDROGENASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; WORTMANNIN; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, RAT; ANDROSTANE DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; MITOCHONDRIAL PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CORONARY ARTERY OCCLUSION; CREATINE KINASE BLOOD LEVEL; HEART INFARCTION SIZE; HEART PROTECTION; HEART RATE; ISCHEMIC POSTCONDITIONING; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REMOTE ISCHEMIC POSTCONDITIONING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CORONARY BLOOD VESSEL; DRUG EFFECTS; GENETICS; HEART MUSCLE; HEMODYNAMICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ALDEHYDE DEHYDROGENASE; ANDROSTADIENES; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CORONARY VESSELS; CREATINE KINASE; HEMODYNAMICS; IMMUNOSUPPRESSIVE AGENTS; ISCHEMIC POSTCONDITIONING; L-LACTATE DEHYDROGENASE; MALE; MITOCHONDRIAL PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84901397550     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2156     Document Type: Article

References (39)

1. Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 357: 1121-1135, 2007.
2. Murry CE, Jennings RB and Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986. (Pubitemid 17174962)
3. Kharbanda RK, Mortensen UM, White PA, et al: Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 106: 2881-2883, 2002. (Pubitemid 35424735)
4. Zhao ZQ, Corvera JS, Halkos ME, et al: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285: H579-H588, 2003. (Pubitemid 36885888)
5. Kerendi F, Kin H, Halkos ME, Jiang R, Zatta AJ, Zhao ZQ, Guyton RA and Vinten-Johansen J: Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol 100: 404-412, 2005. (Pubitemid 41300495)
6. Gao Q, Hu J, Hu J, Yu Y, Ye H, Li Z and Guan S: Calcium activated potassium channel and protein kinase C participate in the cardiac protection of remote post conditioning. Pak J Pharm Sci 26: 285-290, 2013.
7. Ren C, Yan Z, Wei D, Gao X, Chen X and Zhao H: Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res 1288: 88-94, 2009.
8. Wei M, Xin P, Li S, Tao J, Li Y, Li J, Liu M, Li J, Zhu W and Redington AN: Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circ Res 108: 1220-1225, 2011.
9. Ren J: Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models. Novartis Found Symp 285: 69-79, 198-199, 2007.
10. Li SY and Ren J: Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress. J Mol Cell Cardiol 44: 992-1001, 2008.
11. Hu XY, Fang Q, Wang JS, Xie JQ, Chai BS, Li FQ, Cui X and Yang Y: Over-expression of aldehyde dehydrogenase-2 protects against H2O2-induced oxidative damage and apoptosis in peripheral blood mononuclear cells. Acta Pharmacol Sin 32: 245-252, 2011.
12. Stewart MJ, Malek K and Crabb DW: Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J Investig Med 44: 42-46, 1996. (Pubitemid 126820662)
13. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD and Mochly-Rosen D: Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321: 1493-1495, 2008.
14. Gao Q, Wang HJ, Wang XM, Kang PF, Yu Y, Ye HW, Zhou H and Li ZH: Activation of ALDH2 with ethanol attenuates diabetes induced myocardial injury in rats. Food Chem Toxicol 56: 419-424, 2013.
15. Fang J, Chen L, Wu L and Li W: Intra-cardiac remote ischemic post-conditioning attenuates ischemia-reperfusion injury in rats. Scand Cardiovasc J 43: 386-394, 2009.
16. Hausenloy DJ and Yellon DM: Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. Heart Fail Rev 2: 217-234, 2007. (Pubitemid 350176695)
17. Schwartz LM and Lagranha CJ: Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs. Am J Physiol Heart Circ Physiol 290: H1011-H1018, 2006.
18. Dong XX, Wang YR, Qin S, Liang ZQ, Liu BH, Qin ZH and Wang Y: p53 mediates autophagy activation and mitochondria dysfunction in kainic acid-induced excitotoxicity in primary striatal neurons. Neuroscience 207: 52-64, 2012.
19. Wang YQ, Liu CH, Zhang JQ, Zhu DN and Yu BY: Protective effects and active ingredients of yi-qi-fu-mai sterile powder against myocardial oxidative damage in mice. J Pharmacol Sci 122: 17-27, 2013.
20. Lang XE, Wang X, Zhang KR, Lv JY, Jin JH and Li QS: Isoflurane preconditioning confers cardioprotection by activation of ALDH2. PLoS One 8: e52469, 2013.
21. Contractor H, Støttrup NB, Cunnington C, Manlhiot C, Diesch J, Ormerod JO, Jensen R, Bøtker HE, Redington A, Schmidt MR, Ashrafian H and Kharbanda RK: Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models. Basic Res Cardiol 108: 343, 2013.
22. Li CM, Zhang XH, Ma XJ and Luo M: Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury. Scand Cardiovasc J 40: 312-317, 2006.
23. Andreka G, Vertesaljai M, Szantho G, Font G, Piroth Z, Fontos G, Juhasz ED, Szekely L, Szelid Z, Turner MS, Ashrafian H, Frenneaux MP and Andreka P: Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs. Heart 93: 749-752, 2007. (Pubitemid 46808282)
24. Xin P, Zhu W, Li J, Ma S, Wang L, Liu M, Wei M, Redington AN: Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning. Am J Physiol Heart Circ Physiol 298: H1819-H1831, 2010.
25. Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sørensen HT, Redington AN and Nielsen TT: Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375: 727-734, 2010.
26. Thielmann M, Kottenberg E, Boengler K, Raffelsieper C, Neuhaeuser M, Peters J, Jakob H and Heusch G: Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest. Basic Res Cardiol 105: 657-664, 2010.
27. Loukogeorgakis SP, Williams R, Panagiotidou AT, Kolvekar SK, Donald A, Cole TJ, Yellon DM, Deanfield JE and MacAllister RJ: Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism. Circulation 116: 1386-1395, 2007. (Pubitemid 47417565)
28. Churchill EN, Disatnik MH and Mochly-Rosen D: Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol 46: 278-284, 2009.
29. He L, Liu B, Dai Z, Zhang HF, Zhang YS, Luo XJ, Ma QL and Peng J: Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation. Eur J Pharmacol 678: 32-38, 2012.
30. Wang HJ, Kang PF, Wu WJ, Tang Y, Pan QQ, Ye HW, Tang B, Li ZH and Gao Q: Changes in cardiac mitochondrial aldehyde dehydrogenase 2 activity in relation to oxidative stress and inflammatory injury in diabetic rats. Mol Med Rep 8: 686-690, 2013.
31. Li ZH, Jiang CR, Xia ML, Ye HW, Guan SD and Gao Q: Activation of mitochondrial aldehyde dehydrogenase 2 and inhibition of mitochondrial permeability transition pore involved in cardioprotection of ethanol postconditioning. Zhejiang Da Xue Xue Bao Yi Xue Ban 39: 566-571, 2010 (In Chinese).
32. Xu D, Guthrie JR, Mabry S, Sack TM and Truog WE: Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291: L966-L975, 2006. (Pubitemid 44772059)
33. Wang SP, Wang ZH, Peng DY, Li SM, Wang H and Wang XH: Therapeutic effect of mesenchymal stem cells in rats with intracerebral hemorrhage: reduced apoptosis and enhanced neuroprotection. Mol Med Rep 6: 848-854, 2012.
34. Sun H, Zhou F, Wang Y, Zhang Y, Chang A and Chen Q: Effects of beta-adrenoceptors overexpression on cell survival are mediated by Bax/Bcl-2 pathway in rat cardiac myocytes. Pharmacology 78: 98-104, 2006. (Pubitemid 44492190)
35. Wang YB, Qin J, Zheng XY, et al: Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine 17: 363-368, 2010.
36. Breivik L, Helgeland E, Aarnes EK, Mrdalj J and Jonassen AK: Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion. Basic Res Cardiol 106: 135-145, 2011.
37. Tamareille S, Mateus V, Ghaboura N, Jeanneteau J, Croué A, Henrion D, Furber A and Prunier F: RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning. Basic Res Cardiol 106: 1329-1339, 2011.
38. Mocanu MM, Bell RM and Yellon DM: PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol 34: 661-668, 2002. (Pubitemid 35222851)
39. Skyschally A, van Caster P, Boengler K, Gres P, Musiolik J, Schilawa D, Schulz R and Heusch G: Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res 104: 15-18, 2009.