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2O under the reaction conditions, deuterium was incorporated at position C4. We cannot exclude the potential proton transfer from C4 (intermediate C to D). However, the participation of a water molecule in the 1,3-proton transfer seems more likely based on theoretical studies in the literature, as the non-water assisted four-membered proton transfer was shown to have a high energy barrier, see:, V. K. Aggarwal, S. Y. Fulford, G. C. Lloyd-Jones, Angew. Chem. 2005, 117, 1734
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