Synthesis and identification of chiral aminomethylpiperidine carboxamides as inhibitor of collagen induced platelet activation

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 456-472

  Anil Kumar, K S ^a   Misra, Ankita ^a   Siddiqi, Tanveer Irshad ^a   Srivastava, Stuti ^a   Jain, Manish ^a   Bhatta, Rabi Sankar ^a   Barthwal, Manoj ^a   Dikshit, Madhu ^a   Dikshit, Dinesh K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Aminomethylpiperidine; Antiplatelet; Collagen; Epinephrine; Pyroglutamic acid; Thrombosis

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLSALICYLIC ACID; ADRENALIN; AMIDE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CLOPIDOGREL; COLLAGEN; CONVULXIN; PIPERIDINE DERIVATIVE; RISTOCETIN; TERT BUTYL[ 1 [ 1 ( 4 METHYLBENZYL) 5 OXOPYRROLIDINE 2 CARBONYL]PIPERIDIN 3 YL]METHYLCARBAMIC ACID; TERT BUTYL[ 1 [ 3 ( 4 METHYLBENZYL)THIAZOLIDINE 4 CARBONYL]PIPERIDIN 3 YL]METHYLCARBAMIC ACID; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLEEDING; CHIRALITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG EXPOSURE; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG EMBOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RABBIT; RACEMIC MIXTURE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD CLOTTING; BLOOD CLOTTING TEST; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETAMIDES; ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MOLECULAR CONFORMATION; PIPERIDINES; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901361050     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.017     Document Type: Article

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