Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo

FEBS Journal

Volumn 277, Issue 2, 2010, Pages 413-427

  Calvo, Eric ^a,d   Tokumasu, Fuyuki ^a   Mizurini, Daniella M ^b   McPhie, Peter ^c   Narum, David L ^a   Ribeiro, José Marcos C ^a   Monteiro, Robson Q ^b   Francischetti, Ivo M B ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Aegyptin; Blood sucking; GPVI; Thrombosis; Yellow fever

Indexed keywords

AEGYPTIN; ARGINYLGLYCYLGLUTAMINYLPROLYLGLYCYLVALYLMETHIONYLGLYCYLPHENYLALANINE; COLLAGEN; GLYCOPROTEIN VI; HYDROXYPROLINE; INSECT PROTEIN; ROSE BENGAL; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BLEEDING; CAROTID ARTERY; CONTROLLED STUDY; FEMALE; GEL FILTRATION CHROMATOGRAPHY; HEAT; HEATING; IN VIVO STUDY; LASER; LIGHT SCATTERING; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SURFACE PLASMON RESONANCE; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

AEDES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; BIOPHYSICAL PHENOMENA; CAROTID ARTERY THROMBOSIS; COLLAGEN; DNA, COMPLEMENTARY; FEMALE; FIBRINOLYTIC AGENTS; HYDROXYPROLINE; INSECT PROTEINS; INTEGRIN ALPHA2BETA1; KINETICS; MALE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; RATS; RATS, WISTAR; SALIVARY PROTEINS AND PEPTIDES; SURFACE PLASMON RESONANCE; VON WILLEBRAND FACTOR;

RATTUS;

EID: 74549171003     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07494.x     Document Type: Article

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