Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 21-28

  Yang, Xiao Zhi ^a   Yang, Wen Hui ^a   Xu, Yun Gen ^a   Diao, Xiao Juan ^a   He, Guang Wei ^b   Gong, Guo Qing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Hefei Yi Gong Pharmaceutical Co Ltd   (China)

Author keywords

Anti platelet aggregation; Dabigatran; HTMP; Prevention and treatment of thrombosis; Thrombin inhibitors

Indexed keywords

2 HYDROXYMETHYL 3,5,6 TRIMETHYLPYRAZINE; 3 [[2 [[4 [AMINO(HEXYLOXYCARBONYLIMINO)METHYL]PHENYLAMINO]METHYL] 1 METHYL 1H BENZOIMIDAZOLE 5 CARBONYL]PYRIDIN 2 YLAMINO)PROPIONIC ACID (3,5,6 TRIMETHYLPYRAZIN 2 METHYLENE) ESTER; ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; DABIGATRAN ETEXILATE; PRODRUG; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; Y 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; RABBIT; RAT; TANDEM MASS SPECTROMETRY; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS; THROMBOSIS PREVENTION; VEIN THROMBOSIS;

ADENOSINE DIPHOSPHATE; ANIMALS; BENZIMIDAZOLES; BLOOD PLATELETS; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PRODRUGS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PYRAZINES; PYRIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; VENOUS THROMBOSIS;

EID: 84866981539     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.016     Document Type: Article

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