Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

Cell

Volumn 157, Issue 5, 2014, Pages 1088-1103

  Cunningham, John T ^a   Moreno, Melissa V ^a   Lodi, Alessia ^a   Ronen, Sabrina M ^a   Ruggero, Davide ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E; NUCLEOTIDE; RIBOSEPHOSPHATE PYROPHOSPHOKINASE; RIBOSEPHOSPHATE PYROPHOSPHOKINASE 1; RIBOSEPHOSPHATE PYROPHOSPHOKINASE 2; UNCLASSIFIED DRUG; ENZYME;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL FUNCTION; CONTROLLED STUDY; FEMALE; FETUS; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HOMEOSTASIS; HUMAN; IN VIVO STUDY; MACROMOLECULE; MOUSE; NEOPLASM; NONHUMAN; NUCLEOTIDE METABOLISM; ONCOGENE MYC; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA TRANSLATION; TIGHT JUNCTION; CANCER CELL; EMBRYO; GENE ACTIVATION; HUMAN CELL; KNOCKOUT MOUSE; METABOLOMICS; MOLECULAR MECHANICS; ONCOGENE; PURINE SYNTHESIS; SURVIVAL; UPREGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; BURKITT LYMPHOMA; CARCINOGENESIS; CELL LINE, TUMOR; CELLS, CULTURED; EMBRYONIC STEM CELLS; EUKARYOTIC INITIATION FACTOR-4E; GENE KNOCKDOWN TECHNIQUES; HUMANS; ISOENZYMES; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; NUCLEOTIDES; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-MYC; RIBOSE-PHOSPHATE PYROPHOSPHOKINASE;

EID: 84901353547     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.03.052     Document Type: Article

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