Cationic Antimicrobial Peptides Promote Microbial Mutagenesis and Pathoadaptation in Chronic Infections

PLoS Pathogens

Volumn 10, Issue 4, 2014, Pages

  Limoli, Dominique H ^a   Rockel, Andrea B ^b   Host, Kurtis M ^c   Jha, Anuvrat ^a   Kopp, Benjamin T ^a   Hollis, Thomas ^d   Wozniak, Daniel J ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b MARS HILL UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DNA POLYMERASE; GENOMIC DNA; REACTIVE OXYGEN METABOLITE; RIFAMPICIN; BACTERIAL DNA; BACTERIAL PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; MUCA PROTEIN, PSEUDOMONAS;

ADAPTATION; ANTIBIOTIC SENSITIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; COLONY FORMING UNIT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYSTIC FIBROSIS; ESCHERICHIA COLI; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; MUTAGENESIS; NEUTROPHIL; POLYMERASE CHAIN REACTION; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ADOLESCENT; ADULT; CHEMICAL STRUCTURE; CHEMISTRY; CHILD; CHRONIC DISEASE; FEMALE; GENETICS; MALE; METABOLISM; MOLECULAR EVOLUTION; PATHOLOGY; PSEUDOMONAS INFECTION; RANDOMIZED CONTROLLED TRIAL;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL PROTEINS; CHILD; CHRONIC DISEASE; CYSTIC FIBROSIS; DNA, BACTERIAL; EVOLUTION, MOLECULAR; FEMALE; HUMANS; MALE; MODELS, MOLECULAR; MUTAGENESIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 84901342125     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004083     Document Type: Article

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