Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Dautova, Yana ^a   Kozlova, Diana ^b   Skepper, Jeremy N ^c   Epple, Matthias ^b   Bootman, Martin D ^d   Proudfoot, Diane ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d OPEN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CALCIUM PHOSPHATE; FETUIN A; NANOPARTICLE; ALBUMINOID; CALCIUM; CYTOTOXIN;

ARTICLE; CALCIFICATION; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL AGING; CELL DEATH; CELL MEMBRANE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; HUMAN TISSUE; INVAGINATION; MEMBRANE DAMAGE; PINOCYTOSIS; PROTEIN FUNCTION; SLOW MUSCLE FIBER; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR SMOOTH MUSCLE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR SPACE; INTRACELLULAR SPACE; METABOLISM;

ALBUMINS; ALPHA-2-HS-GLYCOPROTEIN; CALCIUM; CALCIUM PHOSPHATES; CELL DEATH; CELL MEMBRANE; CYTOTOXINS; EXTRACELLULAR SPACE; HUMANS; INTRACELLULAR SPACE; MUSCLE, SMOOTH, VASCULAR; NANOPARTICLES;

EID: 84901336901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097565     Document Type: Article

References (43)

1. Proudfoot D, Shanahan CM (2001) Biology of calcification in vascular cells: intima versus media. Herz 26: 245-251. (Pubitemid 32612692)
2. Virmani R, Burke AP, Kolodgie FD, Farb A (2003) Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque. J Interv Cardiol 16: 267-272. (Pubitemid 36667908)
3. Ehara S, Kobayashi Y, Yoshiyama M, Shimada K, Shimada Y, et al. (2004) Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study. Circulation 110: 3424-3429. (Pubitemid 39602220)
4. Vengrenyuk Y, Carlier S, Xanthos S, Cardoso L, Ganatos P, et al. (2006) A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci U S A 103: 14678-14683. (Pubitemid 44527789)
5. Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, et al. (2007) Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 116: 2841-2850. (Pubitemid 350301146)
6. Molloy ES, McCarthy GM (2006) Calcium crystal deposition diseases: update on pathogenesis and manifestations. Rheum Dis Clin North Am 32: 383-400, vii. (Pubitemid 44250814)
7. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464: 1357-1361.
8. Ewence AE, Bootman M, Roderick HL, Skepper JN, McCarthy G, et al. (2008) Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res 103: e28-34.
9. Keeley FW, Sitarz EE (1983) Characterization of proteins from the calcified matrix of atherosclerotic human aorta. Atherosclerosis 46: 29-40. (Pubitemid 13180782)
10. Keeley FW, Sitarz EE (1985) Identification and quantitation of alpha 2-HS-glycoprotein in the mineralized matrix of calcified plaques of atherosclerotic human aorta. Atherosclerosis 55: 63-69. (Pubitemid 15064939)
11. Jahnen-Dechent W, Heiss A, Schafer C, Ketteler M (2011) Fetuin-A regulation of calcified matrix metabolism. Circ Res 108: 1494-1509.
12. Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, et al. (2003) The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112: 357-366. (Pubitemid 38063764)
13. Dietzel E, Wessling J, Floehr J, Schafer C, Ensslen S, et al. (2013) Fetuin-B, a liver-derived plasma protein is essential for fertilization. Dev Cell 25: 106-112.
14. Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, et al. (2003) Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 361: 827-833. (Pubitemid 36331846)
15. Moe SM, Reslerova M, Ketteler M, O'Neill K, Duan D, et al. (2005) Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD). Kidney Int 67: 2295-2304. (Pubitemid 41623389)
16. Herrmann M, Schafer C, Heiss A, Graber S, Kinkeldey A, et al. (2012) Clearance of fetuin-A-containing calciprotein particles is mediated by scavenger receptor-A. Circ Res 111: 575-584.
17. Terkeltaub RA, Santoro DA, Mandel G, Mandel N (1988) Serum and plasma inhibit neutrophil stimulation by hydroxyapatite crystals. Evidence that serum alpha 2-HS glycoprotein is a potent and specific crystal-bound inhibitor. Arthritis Rheum 31: 1081-1089.
18. Smith ER, Hanssen E, McMahon LP, Holt SG (2013) Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage. PLoS One 8: e60904.
19. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, et al. (2004) Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15: 2857-2867. (Pubitemid 41103395)
20. Heiss A, Jahnen-Dechent W, Endo H, Schwahn D (2007) Structural dynamics of a colloidal protein-mineral complex bestowing on calcium phosphate a high solubility in biological fluids. Biointerphases 2: 16-20.
21. Dengler WA, Schulte J, Berger DP, Mertelsmann R, Fiebig HH (1995) Development of a propidium iodide fluorescence assay for proliferation and cytotoxicity assays. Anticancer Drugs 6: 522-532.
22. Bootman MD, Rietdorf K, Collins T, Walker S, Sanderson M (2013) Converting fluorescence data into Ca2+ concentration. Cold Spring Harb Protoc 2013: 126-129.
23. Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, et al. (2000) Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87: 1055-1062.
24. Barros LF, Kanaseki T, Sabirov R, Morishima S, Castro J, et al. (2003) Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency. Cell Death Differ 10: 687-697. (Pubitemid 36675730)
25. Murshed M, Schinke T, McKee MD, Karsenty G (2004) Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165: 625-630. (Pubitemid 38765764)
26. Reynolds JL, Skepper JN, McNair R, Kasama T, Gupta K, et al. (2005) Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16: 2920-2930. (Pubitemid 44743490)
27. Wang AY, Woo J, Lam CW, Wang M, Chan IH, et al. (2005) Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant 20: 1676-1685. (Pubitemid 41418594)
28. Visser M, Kritchevsky SB, Newman AB, Goodpaster BH, Tylavsky FA, et al. (2005) Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study. Am J Clin Nutr 82: 531-537.
29. Burt HM, Jackson JK, Wu W (1991) Crystal-induced inflammation: studies of the mechanism of crystal-membrane interactions. Scanning Microsc 5: 273-279; discussion 279-280.
30. Potez S, Luginbuhl M, Monastyrskaya K, Hostettler A, Draeger A, et al. (2011) Tailored protection against plasmalemmal injury by annexins with different Ca2+ sensitivities. J Biol Chem 286: 17982-17991.
31. Reddy A, Caler EV, Andrews NW (2001) Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell 106: 157-169. (Pubitemid 32772627)
32. Smith ER, Cai MM, McMahon LP, Pedagogos E, Toussaint ND, et al. (2013) Serum fetuin-A concentration and fetuin-A-containing calciprotein particles in patients with chronic inflammatory disease and renal failure. Nephrology (Carlton) 18: 215-221.
33. Sokolova V, Kozlova D, Knuschke T, Buer J, Westendorf AM, et al. (2013) Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells. Acta Biomater 9: 7527-7535.
34. Proudfoot D, Davies JD, Skepper JN, Weissberg PL, Shanahan CM (2002) Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation 106: 3044-3050. (Pubitemid 35440286)
35. Wang F, Yu L, Monopoli MP, Sandin P, Mahon E, et al. (2013) The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes. Nanomedicine 9: 1159-1168.
36. Terkeltaub R, Tenner AJ, Kozin F, Ginsberg MH (1983) Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis. Arthritis Rheum 26: 775-783. (Pubitemid 13099998)
37. Woolf AD, Dieppe PA (1987) Mediators of crystal-induced inflammation in the joint. Br Med Bull 43: 429-444. (Pubitemid 17077725)
38. Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, et al. (2012) Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol 59: 1539-1548.
39. McCarthy GM, Mitchell PG, Cheung HS (1991) The mitogenic response to stimulation with basic calcium phosphate crystals is accompanied by induction and secretion of collagenase in human fibroblasts. Arthritis Rheum 34: 1021-1030.
40. Ea HK, Monceau V, Camors E, Cohen-Solal M, Charlemagne D, et al. (2008) Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals. Ann Rheum Dis 67: 1617-1625.
41. Motskin M, Muller KH, Genoud C, Monteith AG, Skepper JN (2011) The sequestration of hydroxyapatite nanoparticles by human monocyte-macrophages in a compartment that allows free diffusion with the extracellular environment. Biomaterials 32: 9470-9482.
42. Muller KH, Motskin M, Philpott AJ, Routh AF, Shanahan CM, et al. (2014) The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages. Biomaterials 35: 1074-1088.
43. Neumann S, Kovtun A, Dietzel ID, Epple M, Heumann R (2009) The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection. Biomaterials 30: 6794-6802.