A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors

Journal of Nuclear Medicine

Volumn 51, Issue 11, 2010, Pages 1756-1762

  Ross, Tobias L ^a   Honer, Michael ^a   Müller, Cristina ^b   Groehn, Viola ^c   Schibli, Roger ^a   Ametamey, Simon M ^a  

^a ETH Zurich   (Switzerland)

^b Center for Radiopharmaceutical Science of ETH   (Switzerland)

^c Merck and Cie   (Switzerland)

Author keywords

18F; Folate receptor; Folic acid; Pemetrexed; PET

Indexed keywords

FLUOROFOLIC ACID F 18; FOLATE RECEPTOR; FOLIC ACID; FOLIC ACID DERIVATIVE; N 2 (N,N DIMETHYLAMINO METHYLEN)2' NITROFOLIC ACID; RADIOPHARMACEUTICAL AGENT; TETRAHYDROFOLIC ACID; TRACER; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; FOLATE RECEPTOR 1; FOLIC ACID ANTAGONIST; GLUTAMIC ACID DERIVATIVE; GUANINE; LIGAND; PEMETREXED;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG BINDING; DRUG ELIMINATION; DRUG UPTAKE; EVALUATION; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; KIDNEY CLEARANCE; MOUSE; NONHUMAN; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RADIATION DOSE DISTRIBUTION; ANIMAL; CELL STRAIN KB; CHEMICAL PHENOMENA; DRUG EFFECT; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; METHODOLOGY; NEOPLASM; PHYSIOLOGY; RADIOCHEMISTRY; SCINTISCANNING; STAINING; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; FLUORINE RADIOISOTOPES; FOLATE RECEPTOR 1; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATES; GUANINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KB CELLS; KIDNEY; LIGANDS; MICE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; STAINING AND LABELING; SUBSTRATE SPECIFICITY;

EID: 79851482576     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.079756     Document Type: Article

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