Serum amyloid a induces NLRP-3-mediated IL-1β secretion in neutrophils

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Migita, Kiyoshi ^a   Izumi, Yasumori ^a   Jiuchi, Yuka ^a   Kozuru, Hideko ^a   Kawahara, Chieko ^a   Nakamura, Minoru ^a   Nakamura, Tadashi ^b   Agematsu, Kazunaga ^c   Masumoto, Junya ^d   Yasunami, Michio ^e   Kawakami, Atsushi ^f   Eguchi, Katsumi ^g  

^a NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^b Kumamoto Shinto General Hospital   (Japan)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e NAGASAKI UNIVERSITY   (Japan)

^f NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^g Sasebo Shiritsu Sogo Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; ENZYME ANTIBODY; FOSTAMATINIB; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE SYK; SERUM AMYLOID A; CARRIER PROTEIN; IL1B PROTEIN, HUMAN; INFLAMMASOME; N4-(2,2-DIMETHYL-3-OXO-4H-PYRID(1,4)OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE; NLRP3 PROTEIN, HUMAN; OXAZINE DERIVATIVE; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; SIGNAL PEPTIDE;

ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; NEUTROPHIL; NLRP3 GENE; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; CYTOLOGY; DRUG EFFECTS; FEMALE; IMMUNOLOGY; LEUKOCYTE ACTIVATION; MALE; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

CARRIER PROTEINS; CASPASE 1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXAZINES; PROTEIN-TYROSINE KINASES; PYRIDINES; SERUM AMYLOID A PROTEIN; SIGNAL TRANSDUCTION;

EID: 84901319353     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096703     Document Type: Article

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