Kenyan purple tea anthocyanins ability to cross the blood brain barrier and reinforce brain antioxidant capacity in mice

Nutritional Neuroscience

Volumn 17, Issue 4, 2014, Pages 178-185

  Rashid, Khalid ^a,b   Wachira, Francis Nyamu ^b,c   Nyabuga, James Nyariki ^a   Wanyonyi, Bernard ^d   Murilla, Grace ^d   Isaac, Alfred Orina ^a,e  

^a EGERTON UNIVERSITY   (Kenya)

^b TEA RESEARCH FOUNDATION OF KENYA   (Kenya)

^c Association for Strengthening Agricultural Research in Eastern and Central Africa   (Uganda)

^d KENYA AGRICULTURAL RESEARCH INSTITUTE   (Kenya)

^e TECHNICAL UNIVERSITY OF KENYA   (Kenya)

Author keywords

Anthocyanins; Blood brain barrier; Glutathione; Kenyan purple tea

Indexed keywords

ANTHOCYANIN; CYANIDIN; CYANIDIN 3 GLUCOSIDE; DELPHINIDIN; GLUTATHIONE; MALVIDIN CHLORIDE; PELARGONIDIN; PEONIDIN; PLANT MEDICINAL PRODUCT; UBIDECARENONE; UNCLASSIFIED DRUG; ANTIOXIDANT; CARBON DIOXIDE; TEA; UBIQUINONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; FEMALE; HEMATOCRIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TEA; WEIGHT CHANGE; ANALOGS AND DERIVATIVES; ANIMAL; BODY WEIGHT; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM;

ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; BLOOD-BRAIN BARRIER; BODY WEIGHT; CARBON DIOXIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE; MICE; TEA; UBIQUINONE;

EID: 84901304250     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830513Y.0000000081     Document Type: Article

References (23)

1. Cabrera C, Gimenez R, Lopez CM. Determination of tea components with antioxidant activity. J Agric Food Chem 2003;51: 4427-35.
2. Sharangi AB. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.): a review. Food Res Int 2009;42:529-535.
3. Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM. The relative antioxidant activities of plant derived polyphenolic flavonoids. Free Radic Res 1995;22:375-83.
4. Chen WJ, Wan SQ. Research progress on polyphenols of tea. Nat Prod 1994;6:74-80.
5. Amie D, Amie DD, Beslo D, Trinajstie N. Structure-radical scavenging activity relationships of flavonoids. Croat Chem Acta 2003;76:55-61.
6. Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MBH. Green tea catechins as brain-permeable, natural iron chelatorsantioxidants for the treatment of neurodegenerative disorders. Mol Nutr Food Res 2006;50:229-34.
7. Zaveri NT. Green tea and its polyphenolic catechins: medicinal uses in cancer and non cancer applications. Life Sci 2006;78: 2073-80.
8. Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin rich berry extract formula. Biochemistry 2004;69: 75-80.
9. Chu YF, Sun J, Wu X, Liu RH. Antioxidant and anti-proliferative activities of vegetables. J Agric Food Chem 2002;50: 6910-16.
10. Hosseini-Beheshti E, Lund ST, Kitts DD. Characterization of antioxidant capacity from fruits with distinct anthocyanin biosynthetic pathways. Nutr Food Sci 2012;2:122-32.
11. Mancuso M, Orsucci D, Volpi L, Calsolaro V, Siciliano G. Coenzyme-Q10 in neuromuscular and neurodegenerative disorders. Curr Drug Targets 2010;11:111-21.
12. Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme-Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA 1998;95:8892-97.
13. Kerio LC, Wachira FN, Wanyoko JK, Rotich MK. Characterization of anthocyanins in Kenyan teas: extraction and identification. Food Chem 2012;131:31-8.
14. Woo PTK. The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis. Acta Trop 1970;27:384-6.
15. Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 2007;1:3159-65.
16. Kay CD. Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutr Res Rev 2006;19:137-46.
17. Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 2005;8:111-20.
18. Kalt W, Blumberg JB, McDonald JE, Vinqvist-Tymchuk MR, Fillmore SAE, Graf BA, et al. Identification of anthocyanins in the liver, eye and brain of blueberry-fed pigs. J Agric Food Chem 2008;56:705-12.
19. Weisel T, Baum M, Eisenbrand G, Dietrich H, Will F, Stockis J, et al. An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J 2006;4:388-97.
20. Shih HP, Yeh TC, Yen CG. Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J Agric Food Chem 2007;55:9427-35.
21. Bliznakov EG, Wilkins DJ. Biochemical and clinical consequences of inhibiting coenzyme Q biosynthesis by lipid-lowering HMG-CoA reductase inhibitors (statins): a critical overview. Adv Ther 1998;15:218-28.
22. Langsjoen PH, Langsjoen AM. The clinical use of HMG CoAreductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications. BioFactors 2003;18:101-11.
23. Alías CJ, Sosa T, Valares C, Escudero CJ, Chaves N. Seasonal variation of Cistus ladanifer L. diterpenes. Plants J 2012;1:6-15.