Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes

Human Molecular Genetics

Volumn 9, Issue 20, 2000, Pages 2929-2935

  Stead, John D H ^a   Buard, Jérôme ^a,c   Todd, John A ^b   Jeffreys, Alec J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA MINISATELLITE; INSULIN; SOMATOMEDIN B;

ALLELE; ARTICLE; CLASSIFICATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA FLANKING REGION; FATHER; GENE FUNCTION; GENE LOCUS; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOSITY; HUMAN; INHERITANCE; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTECTION; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0034642289     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.20.2929     Document Type: Article

References (31)

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3. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome
4. Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity
5. Association of the INS VNTR with size at birth
6. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
7. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
8. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
9. Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele
10. Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population
11. Anomalous behaviour of the 5' insulin gene polymorphism allele 814: Lack of association with type I diabetes in Basques
12. Epigenetics: Regulation through repression
13. The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans
14. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
15. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
16. Structure-function correlations of the insulin-linked polymorphic region
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18. Minisatellite repeat coding as a digital approach to DNA typing
19. Allele diversity and germline mutation at the insulin minisatellite
20. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
21. Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11
22. Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH)
23. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
24. Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene
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26. Analysis of a 1963 bp polymorphic region flanking the human insulin gene
27. The search for IDDM susceptibility genes: The next generation
28. A log-linear approach to case-parent-triad data: Assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting
29. Methods for detection of parent-of-origin effects in genetic studies of case-parents triads
30. Imprinting at the mouse Ins2 locus: Evidence for cis- and trans-allelic interactions
31. Transmission ratio distortion at the INS-IGF2 VNTR