Anti-inflammatory polymer electrodes for glial scar treatment: Bringing the conceptual idea to future results

Frontiers in Neuroengineering

Volumn 7, Issue MAY, 2014, Pages

  Asplund, Maria ^a   Boehler, Christian ^a   Stieglitz, Thomas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Conducting polymer; Dexamethasone; Drug delivery; Glial scarring; Neural interfaces

Indexed keywords

ADENOSINE TRIPHOSPHATE; CONDUCTING POLYMER; COUNTERION; DEXAMETHASONE; POLY (3,4 ETHYLENEDIOXYTHIOPHENE); POLYMER; POLYPYRROLE; POLYTERTHIOPHENE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; BIOSAFETY; BRAIN DEPTH STIMULATION; CELL ACTIVATION; CONTROLLED DRUG RELEASE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG PULSE THERAPY; ELECTRIC ACTIVITY; ELECTRIC CONDUCTIVITY; ELECTRIC CURRENT; ELECTROCHEMISTRY; ELECTRODE; ELECTRODE IMPLANT; ELECTROPORATION; GLIAL SCARRING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MICROELECTRODE; NERVE CELL EXCITABILITY; REVIEW; SCAR FORMATION; SINGLE DRUG DOSE; SUBTHALAMIC NUCLEUS; SYSTEMATIC ERROR;

EID: 84901299669     PISSN: 16626443     EISSN: None     Source Type: Journal    
DOI: 10.3389/fneng.2014.00009     Document Type: Review

References (58)

1. Abidian, M. R., Kim, D. H., and Martin, D. C. (2006). Conducting-polymer nanotubes for controlled drug release. Adv. Mater. 18, 405-409. doi: 10.1002/adma.200501726
2. Asplund, M., Von Holst, H., and Inganas, O. (2008). Composite biomolecule/PEDOT materials for neural electrodes. Biointerphases 3, 83-93. doi: 10.1116/1.2998407
3. Biran, R., Martin, D. C., and Tresco, P. A. (2005). Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp. Neurol. 195, 115-126. doi: 10.1016/j.expneurol.2005.04.020
4. Bobacka, J., Lewenstam, A., and Ivaska, A. (2000). Electrochemical impedance spectroscopy of oxidized poly(3,4-ethylenedioxythiophene) film electrodes in aqueous solutions. J. Electroanal. Chem. 489, 17-27. doi: 10.1016/S0022-0728(00)00206-0
5. Boehler, C., and Asplund, M. (in press). A detailed insight into drug delivery from PEDOT based on analytical methods: effects and side-effects. J. Biomed. Mater. Res. A.
6. Bridges, A. W., and Garcia, A. J. (2008). Anti-inflammatory polymeric coatings for implantable biomaterials and devices. J. Diabetes Sci. Technol. 2, 984-994.
7. Butterwick, A., Vankov, A., Huie, P., Freyvert, Y., and Palanker, D. (2007). Tissue damage by pulsed electrical stimulation. IEEE Trans. Biomed. Eng. 54, 2261-2267. doi: 10.1109/TBME.2007.908310
8. Cogan, S. F., Troyk, P. R., Ehrlich, J., Plante, T. D., and Detlefsen, D. E. (2006). Potential-biased, asymmetric waveforms for charge-injection with activated iridium oxide (AIROF) neural stimulation electrodes. IEEE Trans. Biomed. Eng. 53, 327-332. doi: 10.1109/tbme.2005.862572
9. Evans, A. J., Thompson, B. C., Wallace, G. G., Millard, R., O'leary, S. J., Clark, G. M., et al. (2009). Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes. J. Biomed. Mater. Res. A 91A, 241-250. doi: 10.1002/jbm.a.32228
10. Ge, D., Tian, X., Qi, R., Huang, S., Mu, J., Hong, S., et al. (2009). A polypyrrole-based microchip for controlled drug release. Electrochim. Acta 55, 271-275. doi: 10.1016/j.electacta.2009.08.049
11. Go, D. P., Palmer, J. A., Gras, S. L., and O'connor, A. J. (2012). Coating and release of an anti-inflammatory hormone from PLGA microspheres for tissue engineering. J. Biomed. Mater. Res. A 100A, 507-517. doi: 10.1002/jbm.a.33299
12. Golde, S., Coles, A., Lindquist, J. A., and Compston, A. (2003). Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro. Eur. J. Neurosci. 18, 2527-2537. doi: 10.1046/j.1460-9568.2003.02917.x
13. Grand, L., Wittner, L., Herwik, S., Gothelid, E., Ruther, P., Oscarsson, S., et al. (2010). Short and long term biocompatibility of NeuroProbes silicon probes. J. Neurosci. Methods 189, 216-229. doi: 10.1016/j.jneumeth.2010.04.009
14. Histed, M. H., Bonin, V., and Reid, R. C. (2009). Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. Neuron 63, 508-522. doi: 10.1016/j.neuron.2009.07.016
15. Islam, A. B., Haider, M. R., Atla, A., Islam, S. K., Croce, R., Vaddiraju, S., et al. (2010). "A potentiostat circuit for multiple implantable electrochemical sensors, " in Electrical and Computer Engineering (ICECE), 2010 International Conference, (Wuhan), 314-317.
16. Jager, E. W. H., Smela, E., and Inganas, O. (2000). Microfabricating conjugated polymer actuators. Science 290, 1540-1545. doi: 10.1126/science.290.5496.1540
17. Jiang, S., Sun, Y., Cui, X., Huang, X., He, Y., Ji, S., et al. (2013). Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release. Synth. Met. 163, 19-23. doi: 10.1016/j.synthmet.2012.12.010
18. Kane, S. R., Cogan, S. F., Ehrlich, J., Plante, T. D., and McCreery, D. B. (2011). Electrical performance of penetrating microelectrodes chronically implanted in cat cortex. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, 5416-5419. doi: 10.1109/iembs.2011.6091339
19. Kern, D. S., and Kumar, R. (2007). Deep brain stimulation. Neurologist 13, 237-252. doi: 10.1097/NRL.0b013e3181492c48
20. Kontturi, K., Pentti, P., and Sundholm, G. (1998). Polypyrrole as a model membrane for drug delivery. J. Electroanal. Chem. 453, 231-238. doi: 10.1016/s0022-0728(98)00246-0
21. Leprince, L., Dogimont, A., Magnin, D., and Demoustier-Champagne, S. (2010). Dexamethasone electrically controlled release from polypyrrole-coated nanostructured electrodes. J. Mater. Sci. Mater. Med. 21, 925-930. doi: 10.1007/s10856-010-4008-6
22. Li, L. D., and Huang, C. B. (2007). Electrochemical/electrospray mass spectrometric studies of electrochemically stimulated ATP release from PP/ATP films. J. Am. Soc. Mass Spectrom. 18, 919-926. doi: 10.1016/j.jasms.2007.01.015
23. Li, Y., Ewen, R. J., Campbell, S. A., and Smith, J. R. (2012). Electrochemically controlled release of antischistosomiasis agents from polypyrrole. J. Mater. Chem. 22, 2687-2694. doi: 10.1039/c2jm15298c
24. Luo, X., and Cui, X. T. (2009a). Sponge-like nanostructured conducting polymers for electrically controlled drug release. Electrochem. commun. 11, 1956-1959. doi: 10.1016/j.elecom.2009.08.027
25. Luo, X., Matranga, C., Tan, S., Alba, N., and Cui, X. T. (2011). Carbon nanotube nanoreservior for controlled release of anti-inflammatory dexamethasone. Biomaterials 32, 6316-6323. doi: 10.1016/j.biomaterials.2011.05.020
26. Luo, X. L., and Cui, X. T. (2009b). Electrochemically controlled release based on nanoporous conducting polymers. Electrochem. Commun. 11, 402-404. doi: 10.1016/j.elecom.2008.11.052
27. Majumdar, S., Kargupta, K., and Ganguly, S. (2008). Mathematical modeling for the ionic inclusion process inside conducting polymer-based thin-films. Polym. Eng. Sci. 48, 2229-2237. doi: 10.1002/pen.21170
28. McCreery, D. B., Agnew, W. F., Yuen, T. G., and Bullara, L. (1990). Charge density and charge per phase as cofactors in neural injury induced by electrical stimulation. IEEE Trans. Biomed. Eng. 37, 996-1001. doi: 10.1109/10.102812
29. Merrill, D. R., Bikson, M., and Jefferys, J. G. (2005). Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J. Neurosci. Methods 141, 171-198. doi: 10.1016/j.jneumeth.2004.10.020
30. Moulton, S. E., Imisides, M. D., Shepherd, R. L., and Wallace, G. G. (2008). Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release. J. Mater. Chem. 18, 3608-3613. doi: 10.1039/B805481a
31. Pernaut, J. M., and Reynolds, J. R. (2000). Use of conducting electroactive polymers for drug delivery and sensing of bioactive molecules. A redox chemistry approach. J. Phys. Chem. B 104, 4080-4090. doi: 10.1021/jp994274o
32. Pihel, K., Walker, Q. D., and Wightman, R. M. (1996). Overoxidized polypyrrole-coated carbon fiber microelectrodes for dopamine measurements with fast-scan cyclic voltammetry. Anal. Chem. 68, 2084-2089. doi: 10.1021/ac960153y
33. Potter, K. A., Buck, A. C., Self, W. K., and Capadona, J. R. (2012). Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses. J. Neural Eng. 9:046020. doi: 10.1088/1741-2560/9/4/046020
34. Pyo, M., Maeder, G., Kennedy, R. T., and Reynolds, J. R. (1994). Controlled release of biological molecules from conducting polymer modified electrodes: The potential dependent release of adenosine 5'-triphosphate from poly(pyrrole adenosine 5'-triphosphate) films. J. Electroanal. Chem. 368, 329-332. doi: 10.1016/0022-0728(93)03071-V
35. Richardson, R. T., Wise, A. K., Thompson, B. C., Flynn, B. O., Atkinson, P. J., Fretwell, N. J., et al. (2009). Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. Biomaterials 30, 2614-2624. doi: 10.1016/j.biomaterials.2009.01.015
36. Ru, X. N., Shi, W., Huang, X., Cui, X., Ren, B., and Ge, D. T. (2011). Synthesis of polypyrrole nanowire network with high adenosine triphosphate release efficiency. Electrochim. Acta 56, 9887-9892. doi: 10.1016/j.electacta.2011.08.063
37. Shain, W., Spataro, L., Dilgen, J., Haverstick, K., Retterer, S., Isaacson, M., et al. (2003). Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies. IEEE Trans. Neural Syst. Rehabil. Eng. 11, 186-188. doi: 10.1109/TNSRE.2003.814800
38. Shannon, R. V. (1992). A model of safe levels for electrical stimulation. IEEE Trans. Biomed. Eng. 39, 424-426. doi: 10.1109/10.126616
39. Sirivisoot, S., Pareta, R., and Webster, T. J. (2011). Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology 22:085101. doi: 10.1088/0957-4484/22/8/085101
40. Skotheim, T. A., and Reynolds, J. R. (2006). Conjugated Polymers: Theory, Synthesis, Properties and Characterization. Boca Raton: CRC Press.
41. Spataro, L., Dilgen, J., Retterer, S., Spence, A. J., Isaacson, M., Turner, J. N., et al. (2005). Dexamethasone treatment reduces astroglia responses to inserted neuroprosthetic devices in rat neocortex. Exp. Neurol. 194, 289-300. doi: 10.1016/j.expneurol.2004.08.037
42. Stevenson, G., Moulton, S. E., Innis, P. C., and Wallace, G. G. (2010). Polyterthiophene as an electrostimulated controlled drug release material of therapeutic levels of dexamethasone. Synth. Met. 160, 1107-1114. doi: 10.1016/j.synthmet.2010.02.035
43. Szarowski, D. H., Andersen, M. D., Retterer, S., Spence, A. J., Isaacson, M., Craighead, H. G., et al. (2003). Brain responses to micro-machined silicon devices. Brain Res. 983, 23-35. doi: 10.1016/S0006-8993(03)03023-3
44. Tehovnik, E. J. (1996). Electrical stimulation of neural tissue to evoke behavioral responses. J. Neurosci. Methods 65, 1-17. doi: 10.1016/0165-0270(95)00131-X
45. Tehovnik, E. J., Tolias, A. S., Sultan, F., Slocum, W. M., and Logothetis, N. K. (2006). Direct and indirect activation of cortical neurons by electrical microstimulation. J. Neurophysiol. 96, 512-521. doi: 10.1152/jn.00126.2006
46. Thaning, E. M., Asplund, M. L., Nyberg, T. A., Inganas, O. W., and von Holst, H. (2010). Stability of poly(3,4-ethylene dioxythiophene) materials intended for implants. J. Biomed. Mater. Res. B Appl. Biomater. 93, 407-415. doi: 10.1002/jbm.b.31597
47. Thompson, B. C., Chen, J., Moulton, S. E., and Wallace, G. G. (2010). Nanostructured aligned CNT platforms enhance the controlled release of a neurotrophic protein from polypyrrole. Nanoscale 2, 499-501. doi: 10.1039/b9nr00259f
48. Thompson, B. C., Moulton, S. E., Ding, J., Richardson, R., Cameron, A., O'leary, S., et al. (2006). Optimising the incorporation and release of a neurotrophic factor using conducting polypyrrole. J. Control. Release 116, 285-294. doi: 10.1016/j.jconrel.2006.09.004
49. Tolosa, V. M., Wassum, K. M., Maidment, N. T., and Monbouquette, H. G. (2013). Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode arraymicroprobe. Biosensors Bioelectron. 42, 256-260. doi: 10.1016/j.bios.2012.10.061
50. Turner, J. N., Shain, W., Szarowski, D. H., Andersen, M., Martins, S., Isaacson, M., et al. (1999). Cerebral astrocyte response to micromachined silicon implants. Exp. Neurol. 156, 33-49. doi: 10.1006/exnr.1998.6983
51. Veraart, C., Duret, F., Brelén, M., Oozeer, M., and Delbeke, J. (2004). Vision rehabilitation in the case of blindness. Expert Rev. Med. Devices 1, 139-153. doi: 10.1586/17434440.1.1.139
52. Wadhwa, R., Lagenaur, C. F., and Cui, X. T. (2006). Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. J. Control. Release 110, 531-541. doi: 10.1016/j.jconrel.2005.10.027
53. Xiao, Y., Che, J., Li, C. M., Sun, C. Q., Chua, Y. T., Lee, V. S., et al. (2007). Preparation of nano-tentacle polypyrrole with pseudo-molecular template for ATP incorporation. J. Biomed. Mater. Res. A 80, 925-931. doi: 10.1002/jbm.a.31001
54. Xiao, Y., Ye, X., He, L., and Che, J. (2012). New carbon nanotube-conducting polymer composite electrodes for drug delivery applications. Polym. Int. 61, 190-196. doi: 10.1002/pi.3168
55. Yamato, H., Ohwa, M., and Wernet, W. (1995). Stability of polypyrrole and poly(3,4-ethylene dioxythiophene) for biosensor application. J. Electroanal. Chem. 397, 163-170. doi: 10.1016/0022-0728(95)04156-8
56. Yue, Z., Moulton, S. E., Cook, M., O'leary, S., and Wallace, G. G. (2013). Controlled delivery for neuro-bionic devices. Adv. Drug Deliv. Rev. 65, 559-569. doi: 10.1016/j.addr.2012.06.002
57. Zhong, Y. H., and Bellamkonda, R. V. (2007). Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. Brain Res. 1148, 15-27. doi: 10.1016/j.brainres.2007.02.024
58. Zhong, Y., McConnell, G. C., Ross, J. D., Deweerth, S. P., and Bellamkonda, R. V. (2005). "A novel dexamethasone-releasing, anti-inflammatory coating for neural implants, " in Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference (Arlington), 522-525.