Spironolactone inhibits production of proinflammatory mediators in response to lipopolysaccharide via inactivation of nuclear factor-κB

Immunopharmacology and Immunotoxicology

Volumn 36, Issue 3, 2014, Pages 237-241

  Kato, Yoshiro ^a   Kamiya, Hideki ^a   Koide, Naoki ^b   Odkhuu, Erdenezaya ^b   Komatsu, Takayuki ^b   Dagvadorj, Jargalsaikhan ^b   Watarai, Atsuko ^a   Kondo, Masaki ^a   Kato, Koichi ^c   Nakamura, Jiro ^a   Yokochi, Takashi ^b  

^a AICHI MEDICAL UNIVERSITY   (Japan)

^b AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

I B kinase; Lipopolysaccharide; NF B; Nitric oxide; Prostaglandin E2; Spironolactone; Tumor necrosis factor

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PROSTAGLANDIN E2; SPIRONOLACTONE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ALDOSTERONE; AUTACOID;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; METABOLISM; PHOSPHORYLATION;

ALDOSTERONE; ANIMALS; CELLS, CULTURED; DINOPROSTONE; I-KAPPA B KINASE; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; SPIRONOLACTONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901295996     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2014.921690     Document Type: Article

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