Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 290-298

  Lieber, Gissela B ^a   Fernandez, Xiomara ^a   Mingo, Garfield G ^a   Jia, Yanlin ^a   Caniga, Michael ^a   Gil, Malgorzata A ^a   Keshwani, Shanil ^a   Woodhouse, Janice D ^a   Cicmil, Milenko ^a   Moy, Lily Y ^a   Kelly, Nancy ^a   Jimenez, Johanna ^a   Crawley, Yvette ^a   Anthes, John C ^a   Klappenbach, Joel ^a   Ma, Yu Lu ^a   McLeod, Robbie L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Eplerenone; Mineralocorticoid; Pulmonary fibrosis; Pulmonary inflammation

Indexed keywords

BETAMETHASONE; BLEOMYCIN; CAPTOPRIL; CYTOKINE; EPLERENONE; HYDROCORTISONE; HYDROXYPROLINE; MIFEPRISTONE; MINERALOCORTICOID ANTAGONIST; PIRFENIDONE; PREDNISOLONE; SPIRONOLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CONTROLLED STUDY; DRUG ACTIVITY; IN VIVO STUDY; INFLAMMATION; LUNG COMPLIANCE; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; MACROPHAGE; MALE; NASAL LAVAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT;

EPLERENONE; MINERALOCORTICOID; PULMONARY FIBROSIS; PULMONARY INFLAMMATION;

ANIMALS; BLEOMYCIN; DISEASE MODELS, ANIMAL; ELASTICITY; FIBROSIS; HYDROXYPROLINE; HYPERSENSITIVITY; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MINERALOCORTICOID RECEPTOR ANTAGONISTS; PNEUMONIA; PULMONARY VENTILATION; RATS; RECEPTORS, MINERALOCORTICOID;

EID: 84887042999     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.019     Document Type: Article

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