Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells

Immunology Letters

Volumn 91, Issue 2-3, 2004, Pages 87-91

  Hansen, Peter Riis ^a   Rieneck, Klaus ^b   Bendtzen, Klaus ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Aldosterone; Canrenoic acid; Cytokines; Heart failure; Immunology; Inflammation; Interferon ; Interleukin 1 ; Interleukin 6; Real time PCR; Spironolactone; Tumour necrosis factor

Indexed keywords

ALDOSTERONE; ANTIANDROGEN; ANTIINFLAMMATORY AGENT; CANRENOIC ACID; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MINERALOCORTICOID ANTAGONIST; PHYTOHEMAGGLUTININ P; SPIRONOLACTONE; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT;

ALDOSTERONE; CANRENOATE POTASSIUM; CELLS, CULTURED; CYPROTERONE ACETATE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; PHYTOHEMAGGLUTININS; PREGNADIENES; RNA, MESSENGER; SPIRONOLACTONE; TRANSCRIPTION, GENETIC;

EID: 1542272535     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2003.11.008     Document Type: Article

References (18)

1. Seta Y., Shan K., Bozkurt B., Oral H., Mann D.L. J. Card. Fail. 2:1996;243-249.
2. Feldman A.M., Combes A., Wagner D., Kadakomi T., Kubota T., Li Y.Y., McTiernan C. J. Am. Coll. Cardiol. 35:2000;537-544.
3. Meldrum D.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. 274:1998;R577-R595.
4. Gullestad L., Aukrust P., Ueland T., Espevik T., Yee G., Vagelos R., Froland S.S., Fowler M. J. Am. Coll. Cardiol. 34:1999;2061-2067.
5. Ohtsuka T., Hamada M., Hiasa G., Sasaki O., Suzuki M., Hara Y., Shigematsu Y., Hiwada K. J. Am. Coll. Cardiol. 37:2001;412-417.
6. Pitt B., Zannad F., Remme W.J., Cody R., Castaigne A., Perez A., Palensky J., Wittes J. N. Engl. J. Med. 341:1999;709-717.
7. The RALES Investigators, Am. J. Cardiol. 78 (1996) 902-907.
8. Bendtzen K., Hansen P.R., Rieneck K. The Spironolactone/Arthritis Study Group. Clin. Exp. Immunol. 134:2003;151-158.
9. Gardiner P., Schrode K., Quinlan D., Martin B.K., Boreham D.R., Rogers M.S., Stubbs K., Smith M., Karim A. J. Clin. Pharmacol. 29:1989;342-347.
10. Hansen M.B., Svenson M., Bendtzen K. Immunol. Lett. 30:1991;133-140.
11. Svenson M., Hansen M.B., Heegaard P., Abell K., Bendtzen K. Cytokine. 5:1993;427-435.
12. Sutanto W., De Kloet E.R. Med. Res. Rev. 11:1991;617-639.
13. Farquharson C.A., Struthers A.D. Circulation. 101:2000;594-597.
14. Zannad F., Alla F., Dousset B., Perez A., Pitt B. Circulation. 102:2000;2700-2706.
15. Olivetti G., Abbi R., Quaini F., Kajstura J., Cheng W., Nitahara J.A., Quaini E., Di Loreto C., Beltrami C.A., Krajewski S., Reed J.C., Anversa P. N. Engl. J. Med. 336:1997;1131-1141.
16. Van Belle E., Bauters C., Wernert N., Hamon M., McFadden E.P., Racadot A., Dupuis B., Lablanche J.M., Bertrand M.E. Cardiovasc. Res. 29:1995;27-32.
17. Rajagopalan S., Duquaine D., King S., Pitt B., Patel P. Circulation. 105:2002;2212-2216.
18. Fiebeler A., Schmidt F., Muller D.N., Park J.K., Dechend R., Bieringer M., Shagdarsuren E., Breu V., Haller H., Luft F.C. Hypertension. 37:2001;787-793.