Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells

Developmental Biology

Volumn 391, Issue 2, 2014, Pages 230-240

  Ismailoglu, Ismail ^a   Chen, Qiuying ^b   Popowski, Melissa ^a   Yang, Lili ^b   Gross, Steven S ^b   Brivanlou, Ali H ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

AMP kinase; Embryonic stem cells; Glycolysis; Huntington's Disease; LC MS MS; Metabolism; Metabolomics; Mitochondria; Mitochondrial bioenergetics; Mitochondrial respiration; Oxygen consumption; Untargeted metabolite profiling

Indexed keywords

ADENOSINE TRIPHOSPHATE; HUNTINGTIN; NUCLEOSIDE TRIPHOSPHATE;

AEROBIC GLYCOLYSIS; ANIMAL CELL; ARTICLE; BIOENERGY; CELL METABOLISM; CELL STRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GAIN OF FUNCTION MUTATION; GLYCOLYSIS; KETOGENESIS; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PURINE SYNTHESIS; WILD TYPE;

AMP KINASE; EMBRYONIC STEM CELLS; GLYCOLYSIS; HUNTINGTONS DISEASE; LC-MS/MS; METABOLISM; METABOLOMICS; MITOCHONDRIA; MITOCHONDRIAL BIOENERGETICS; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; UNTARGETED METABOLITE PROFILING;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENERGY METABOLISM; GLYCOLYSIS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METABOLOME; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; NUCLEOTIDES;

EID: 84901290643     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.04.005     Document Type: Article

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