Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: Crosstalk with Nrf2 and HO-1

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Terti, Magdalena ^a,b,c   Skrzypek, Klaudia ^a,b,e   Florczyk, Urszula ^a   Weglarczyk, Kazimierz ^b,e   Was, Halina ^a,f   Collet, Guillaume ^b   Guichard, Alan ^b,g   Gil, Tomasz ^d   Kuzdzal, Jaroslaw ^d   Jozkowicz, Alicja ^a   Kieda, Claudine ^b   Pichon, Chantal ^b   Dulak, Jozef ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^c INSTITUTE OF PHARMACOLOGY   (Poland)

^d JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^e JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^f NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^g INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; THYMIDINE PHOSPHORYLASE; TRANSCRIPTION FACTOR NRF2; CYTOKINE; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CATALYSIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; OXYGENATION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; CELL MOTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NON SMALL CELL LUNG CANCER; PATHOLOGY; TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYTOKINES; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEME OXYGENASE-1; HUMANS; LUNG NEOPLASMS; MICE; NEOVASCULARIZATION, PATHOLOGIC; NF-E2-RELATED FACTOR 2; THYMIDINE PHOSPHORYLASE;

EID: 84901289951     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097070     Document Type: Article

References (44)

1. Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542-2550.
2. Schmid-Bindert G (2013) Update on antiangiogenic treatment of advanced nonsmall cell lung cancer (NSCLC). Target Oncol 8: 15-26.
3. Bronckaers A, Gago F, Balzarini J, Liekens S (2009) The dual role of thymidine phosphorylase in cancer development and chemotherapy. Med Res Rev 29: 903-953.
4. O'Byrne KJ, Koukourakis MI, Giatromanolaki A, Cox G, Turley H, et al. (2000) Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer. Br J Cancer 82: 1427-1432.
5. Brown NS, Jones A, Fujiyama C, Harris AL, Bicknell R (2000) Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 60: 6298-6302.
6. Sengupta S, Sellers LA, Matheson HB, Fan TP (2003) Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol 139: 219-231.
7. Liekens S, Bronckaers A, Perez-Perez MJ, Balzarini J (2007) Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy. Biochem Pharmacol 74: 1555-1567.
8. Lin Q, Meng FJ, Liu Y, Wang N, Ren XC, et al. (2012) Phase II trial of capecitabine combined with docetaxel in previously treated patients with non-small cell lung cancer: A randomized controlled study. Oncol Lett 3: 761-766.
9. Florczyk U, Loboda A, Stachurska A, Jozkowicz A, Dulak J (2010) [Role of Nrf2 transcription factor in cellular response to oxidative stress]. Postepy Biochem 56: 147-155.
10. Taguchi K, Motohashi H, Yamamoto M (2011) Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 16: 123-140.
11. Loboda A, Was H, Jozkowicz A, Dulak J (2008) Janus face of Nrf2-HO-1 axis in cancer - friend in chemoprevention, foe in anticancer therapy. Lung Cancer 60: 1-3.
12. Kim HR, Kim S, Kim EJ, Park JH, Yang SH, et al. (2008) Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin. Lung Cancer 60: 47-56.
13. Grochot-Przeczek A, Dulak J, Jozkowicz A (2012) Haem oxygenase-1: non-canonical roles in physiology and pathology. Clin Sci (Lond) 122: 93-103.
14. Zhang X, Chen X, Song H, Chen HZ, Rovin BH (2005) Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol 35: 3258-3267.
15. Loboda A, Stachurska A, Florczyk U, Rudnicka D, Jazwa A, et al. (2009) HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells. Antioxid Redox Signal 11: 1501-1517.
16. Florczyk U, Czauderna S, Stachurska A, Tertil M, Nowak W, et al. (2011) Opposite effects of HIF-1alpha and HIF-2alpha on the regulation of IL-8 expression in endothelial cells. Free Radic Biol Med 51: 1882-1892.
17. Calkins MJ, Jakel RJ, Johnson DA, Chan K, Kan YW, et al. (2005) Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proc Natl Acad Sci U S A 102: 244-249.
18. Kozakowska M, Ciesla M, Stefanska A, Skrzypek K, Was H, et al. (2012) Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs. Antioxid Redox Signal 16: 113-127.
19. Was H, Cichon T, Smolarczyk R, Rudnicka D, Stopa M, et al. (2006) Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice. Am J Pathol 169: 2181-2198.
20. Skrzypek K, Tertil M, Golda S, Ciesla M, Weglarczyk K, et al. (2013) Interplay Between Heme Oxygenase-1 and miR-378 Affects Non-Small Cell Lung Carcinoma Growth, Vascularization, and Metastasis. Antioxid Redox Signal 19: 644-660.
21. Jozkowicz A, Huk I, Nigisch A, Weigel G, Dietrich W, et al. (2003) Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxid Redox Signal 5: 155-162.
22. Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, et al. (2009) Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 15: 3423-3432.
23. Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, et al. (2004) The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. Cancer Sci 95: 851-857.
24. Saito S, Tsuno NH, Sunami E, Hori N, Kitayama J, et al. (2003) Expression of platelet-derived endothelial cell growth factor in inflammatory bowel disease. J Gastroenterol 38: 229-237.
25. Frick M, Dulak J, Cisowski J, Jozkowicz A, Zwick R, et al. (2003) Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells. Atherosclerosis 170: 229-236.
26. Harada S, Nagy JA, Sullivan KA, Thomas KA, Endo N, et al. (1994) Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest 93: 2490-2496.
27. Namiki A, Brogi E, Kearney M, Kim EA, Wu T, et al. (1995) Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 270: 31189-31195.
28. Lu H, Klein RS, Schwartz EL (2009) Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap. Clin Cancer Res 15: 5136-5144.
29. Torisu-Itakura H, Furue M, Kuwano M, Ono M (2000) Co-expression of thymidine phosphorylase and heme oxygenase-1 in macrophages in human malignant vertical growth melanomas. Jpn J Cancer Res 91: 906-910.
30. Li W, Tanaka K, Morioka K, Uesaka T, Yamada N, et al. (2005) Thymidine phosphorylase gene transfer inhibits vascular smooth muscle cell proliferation by upregulating heme oxygenase-1 and p27KIP1. Arterioscler Thromb Vasc Biol 25: 1370-1375.
31. Was H, Dulak J, Jozkowicz A (2010) Heme oxygenase-1 in tumor biology and therapy. Curr Drug Targets 11: 1551-1570.
32. Tsai MS, Weng SH, Kuo YH, Chiu YF, Lin YW (2011) Synergistic effect of curcumin and cisplatin via down-regulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1). Mol Pharmacol 80: 136-146.
33. Hotchkiss KA, Ashton AW, Schwartz EL (2003) Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. J Biol Chem 278: 19272-19279.
34. Nakajima Y, Gotanda T, Uchimiya H, Furukawa T, Haraguchi M, et al. (2004) Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res 64: 1794-1801.
35. Bijnsdorp IV, Capriotti F, Kruyt FA, Losekoot N, Fukushima M, et al. (2011) Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors. Br J Cancer 104: 1185-1192.
36. Kusabe T, Waguri-Nagaya Y, Tanikawa T, Aoyama M, Fukuoka M, et al. (2005) The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes. Rheumatol Int 25: 625-630.
37. Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, et al. (2011) Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis. J Immunol 186: 3462-3471.
38. Bayliss TJ, Smith JT, Schuster M, Dragnev KH, Rigas JR (2011) A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer. Expert Opin Biol Ther 11: 1663-1668.
39. Seike T, Fujita K, Yamakawa Y, Kido MA, Takiguchi S, et al. (2011) Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin Exp Metastasis 28: 13-25.
40. Ravichandran K, Tyagi A, Deep G, Agarwal C, Agarwal R (2011) Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Indian J Exp Biol 49: 840-847.
41. Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, et al. (2007) Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J Exp Med 204: 605-618.
42. Lin HH, Lai SC, Chau LY (2011) Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1. J Biol Chem 286: 3829-3838.
43. Miyake M, Fujimoto K, Anai S, Ohnishi S, Kuwada M, et al. (2011) Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder. Oncol Rep 25: 653-660.
44. Loboda A, Jazwa A, Grochot-Przeczek A, Rutkowski AJ, Cisowski J, et al. (2008) Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 10: 1767-1812.