Expression of dopaminergic receptors on human CD4+ T lymphocytes: Flow cytometric analysis of naive and memory subsets and relevance for the neuroimmunology of neurodegenerative disease

Journal of Neuroimmune Pharmacology

Volumn 9, Issue 3, 2014, Pages 302-312

  Kustrimovic, Natasa ^a   Rasini, Emanuela ^a   Legnaro, Massimiliano ^a   Marino, Franca ^a   Cosentino, Marco ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

Apoptosis; Dopamine; Dopaminergic receptors; Flow cytometry; T central memory; T effector memory

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE RECEPTOR;

ADULT; APOPTOSIS; BLOOD CELL COUNT; CD4+ T LYMPHOCYTE; CELL VIABILITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC SYSTEM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMORY T LYMPHOCYTE; NONHUMAN; PARKINSON DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; AGED; BIOSYNTHESIS; CD4 LYMPHOCYTE COUNT; CELL CULTURE; FEMALE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; T LYMPHOCYTE SUBPOPULATION;

AGED; APOPTOSIS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; RECEPTORS, DOPAMINE; T-LYMPHOCYTE SUBSETS;

EID: 84901278306     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9541-5     Document Type: Review

References (45)

1. Amenta F, Bronzetti E, Felici L, Ricci A, Tayebati SK (1999) Dopamine D2-like receptors on human peripheral blood lymphocytes: a radioligand binding assay and immunocytochemical study. J Auton Pharmacol 19:151-159 (Pubitemid 29443882)
2. Bas J, Calopa M, Mestre M, Mollevi DG, Cutillas B, Ambrosio S, Buendia E (2001) Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism. J Neuroimmunol 113:146-152 (Pubitemid 32008680)
3. Basu S, Dasgupta PS (2000) Dopamine, a neurotransmitter, influences the immune system. J Neuroimmunol 102:113-124
4. Beaulieu J-M, Gainetdinov RR (2011) The physiology, signalling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182-217
5. Bergquist J, Silberring J (1998) Identification of catecholamines in the immune system by electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 12:683-688 (Pubitemid 28244520)
6. Besser MJ, Ganor Y, Levite M (2005) Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFalpha or both. J Neuroimmunol 169:161-171 (Pubitemid 41528789)
7. Brito-Melo GE, Nicolato R, de Oliveira AC, Menezes GB, Lélis FJ, Avelar RS, Sá J, Bauer ME, Souza BR, Teixeira AL, Reis HJ (2012) Increase in dopaminergic, but not serotoninergic, receptors in T-cells as a marker for schizophrenia severity. J Psychiatr Res 46: 738-742
8. Calopa M, Bas J, Callen A, Mestre M (2010) Apoptosis of peripheral blood lymphocytes in Parkinson patients. Neurobiol Dis 38:1-7
9. Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J, Straub RH (2010) Catecholamine producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis 69:1853-1860
10. Cosentino M, Marino F (2013) Adrenergic and dopaminergic modulation of immunity in multiple sclerosis: teaching old drugs new tricks? J Neuroimmune Pharm 8:163-179
11. Cosentino M, Marino F, Bombelli R, Ferrari M, Lecchini S, Frigo G (1999) Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils. Life Sci 64:975-981 (Pubitemid 29130576)
12. Cosentino M, Bombelli R, Ferrari M, Marino F, Rasini E, Maestroni GJ, Conti A, Boveri M, Lecchini S, Frigo G (2000) HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines. Life Sci 68:283-295
13. Cosentino M, Marino F, Bombelli R, Ferrari M, Rasini E, Lecchini S, Frigo G (2002a) Stimulation with phytohaemagglutinin induces the synthesis of catecholamines in human peripheral blood mononuclear cells:role of protein kinase C and contribution of intracellular calcium. J Neuroimmunol 125:125-133 (Pubitemid 34327461)
14. Cosentino M, Zaffaroni M, Marino F, Bombelli R, Ferrari M, Rasini E, Lecchini S, Ghezzi A, Frigo G (2002b) Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients: effect of cell stimulation and possible relevance for activation-induced apoptosis. J Neuroimmunol 133:233-240 (Pubitemid 35346746)
15. Cosentino M, Rasini E, Colombo C, Marino F, Blandini F, Ferrari M, Samuele A, Lecchini S, Nappi G, Frigo G (2004) Dopaminergic modulation of oxidative stress and apoptosis in human peripheral blood lymphocytes: evidence for a D1-like receptor-dependent protective effect. Free Radic Biol Med 36:1233-1240 (Pubitemid 38526317)
16. Cosentino M, Zaffaroni M, Ferrari M, Marino F, Bombelli R, Rasini E, Frigo G, Ghezzi A, Comi G, Lecchini S (2005) Interferon-gamma and interferon-beta affect endogenous catecholamines in human peripheral blood mononuclear cells: implications for multiple sclerosis. J Neuroimmunol 162:112-121
17. Cosentino M, Fietta AM, Ferrari M, Rasini E, Bombelli R, Carcano E, Saporiti F, Meloni F, Marino F, Lecchini S (2007) Human CD4+ CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/ paracrine inhibitory functional loop. Blood 109:632-642 (Pubitemid 46105964)
18. Cosentino M, Zaffaroni M, Trojano M, Giorelli M, Pica C, Rasini E, Bombelli R, Ferrari M, Ghezzi A, Comi G, Livrea P, Lecchini S, Marino F (2012) Dopaminergic modulation of CD4+CD25(high) regulatory T lymphocytes in multiple sclerosis patients during interferon-β therapy. Neuroimmunomodulation 19:283-292
19. Dauer W, Przedborski S (2003) Parkinson's disease: mechanisms and models. Neuron 39:889-909 (Pubitemid 37130207)
20. Fiszer U, Piotrowska K, Korlak J, Czlonkowska A (1994) The immunological status in Parkinson's disease. Med Lab Sci 48:196-200
21. González H, Contreras F, Prado C, Elgueta D, Franz D, Bernales S, Pacheco R (2013) Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease. J Immunol 190:5048-5056
22. Harari A, Vallelian F, Pantaleo G (2004) Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load. Eur J Immunol 34:3525-3533 (Pubitemid 40012170)
23. Kustrimovic N, Rasini E, Legnaro M, Riboldazzi G, Bono G, Ghezzi C, Siani F, Blandini F, Marino F, Cosentino M (2013) Changes in CD4+ T lymphocyte subsets and expression of dopaminergic receptors in peripheral blood of patients with Parkinson's disease. J Neuroimmune Pharm 8(Suppl):S29
24. Lanzavecchia A, Sallusto F (2000) Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 290:92-97
25. Laurie C, Reynolds A, Coskun O, Bowman E, Gendelman HE, Mosley RL (2007)CD4+ Tcells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neuroimmunol 183:60-68 (Pubitemid 46204910)
26. Lecoeur H, Ledru E, Prévost MC, Gougeon ML (1997) Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods. J Immunol Methods 209:111-123 (Pubitemid 28055701)
27. Levite M (2012) Dopamine in the immune system: dopamine receptors in immune cells, potent effects, endogenous production and involvement in immune and neuropsychiatric diseases. In: Levite M (ed) Nerve-driven-immunity - neurotransmitters and neuropeptides in the immune system. Springer, Wien, pp 1-45
28. Levite M, Chowers Y, Ganor Y, Besser M, Hershkovits R, Cahalon L (2001) Dopamine interacts directly with its D3 and D2 receptors on normal human T cells, and activates β-integrin function. Eur J Immunol 31:3504-3512 (Pubitemid 34030963)
29. Marino F, Cosentino M, Bombelli R, Ferrari M, Lecchini S, Frigo G (1999) Endogenous catecholamine synthesis, metabolism storage, and uptake in human peripheral blood mononuclear cells. Exp Hematol 27:489-495 (Pubitemid 29125057)
30. McKenna F, McLaughlin PJ, Lewis BJ, Sibbring GC, Cummerson JA, Bowen-Jones D, Moots RJ (2002) Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study. J Neuroimmune 132:34-40 (Pubitemid 35333323)
31. Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, Matsushita S (2008) Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun 373:286-291
32. Nakano K, Higashi T, Takagi R, Hashimoto K, Tanaka Y, Matsushita S (2009) Dopamine released by dendritic cells polarizes Th2 differentiation. Int Immunol 21:645-654
33. Nakano K, Yamaoka K, Hanami K, Saito K, Sasaguri Y, Yanagihara N, Tanaka S, Katsuki I, Matsushita S, Tanaka Y (2011) Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model. J Immunol 186:3745-3752
34. Reynolds AD, Kadiu I, Garg SK, Glanzer JG, Nordgren T, Ciborowski P, Banerjee R, Gendelman HE (2008) Nitrated alpha-synuclein and microglial neuroregulatory activities. J Neuroimmune Pharm 3:59-74
35. Ricci A, Bronzetti E, Mignini F, Tayebati SK, Zaccheo D, Amenta F (1999) Dopamine D1-like receptor subtypes in human peripheral blood lymphocytes. J Neuroimmunol 96:234-240 (Pubitemid 29234498)
36. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708-712
37. Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22:745-763 (Pubitemid 38680440)
38. Sanchez-Guajardo V, Barnum CJ, Tansey MG, Romero-Ramos M (2013) Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity. ASN Neuro 5:113-139
39. Sarkar C, Das S, Chakroborty D, Chowdhury UR, Basu B, Dasgupta PS, Basu S (2006) Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. J Immunol 177:7525-7529 (Pubitemid 44846267)
40. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S (2010) The immunoregulatory role of dopamine: an update. Brain Behav Immun 24:525-528
41. Saunders JA, Estes KA, Kosloski LM, Allen HE, Dempsey KM, Torres-Russotto DR, Meza JL, Santamaria PM, Bertoni JM, Murman DL, Ali HH, Standaert DG, Mosley RL, Gendelman HE (2012) CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease. J Neuroimmune Pharm 7:927-38
42. Schetz JA (2009) Dopamine receptors, introduction. IUPHAR/BPS Guide to PHARMACOLOGY. http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward? familyId=20. Accessed on Jan 2014
43. Stone DK, Reynolds AD, Mosley RL, Gendelman HE (2009) Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxid Redox Signal 11:2151-66
44. Vile JM, Strange PG (1995) High-affinity binding sites for neuroleptic drugs in human peripheral blood lymphocytes and their relation to dopamine receptors. A long-standing controversy. Biochem Pharmacol 49:747-753
45. Zaffaroni M, Marino F, Bombelli R, Rasini E, Monti M, Ferrari M, Ghezzi A, Comi G, Lecchini S, Cosentino M (2008) Therapy with interferon-beta modulates endogenous catecholamines in lymphocytes of patients with multiple sclerosis. Exp Neurol 214: 315-321