Dopamine released by dendritic cells polarizes Th2 differentiation

International Immunology

Volumn 21, Issue 6, 2009, Pages 645-654

  Nakano, Kazuhisa ^a,b   Higashi, Takehiro ^a   Takagi, Rie ^a   Hashimoto, Kumiko ^a   Tanaka, Yoshiya ^b   Matsushita, Sho ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

CD4 T cells; Cell differentiation; Dendritic cells; Dopamine

Indexed keywords

CD3 ANTIBODY; COLCHICINE DERIVATIVE; CYCLIC AMP; DOPAMINE; DOPAMINE 1 LIKE RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR; EMONAPRIDE; FORSKOLIN; MONOCLONAL ANTIBODY CD28; SULPIRIDE; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL INTERACTION; CELL POLARITY; CONTROLLED STUDY; DENDRITIC CELL; DOPAMINE RELEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; MIXED LYMPHOCYTE REACTION; MONOCYTE; MONOCYTE DERIVED DENDRITIC CELL; PRIORITY JOURNAL; SECRETORY VESICLE; TH2 CELL;

BENZAMIDES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; COLCHICINE; CYCLIC AMP; DENDRITIC CELLS; DOPAMINE; FORSKOLIN; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SECRETORY VESICLES; SULPIRIDE; TH1 CELLS; TH2 CELLS;

EID: 66249088337     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp033     Document Type: Article

References (54)

1. Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. and Amigorena, S. 2002. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20:621.
2. Kaisho, T. and Akira, S. 2002. Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta. 1589:1.
3. Murphy, K. M., Ouyang, W., Farrar, J. D. et al. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18:451.
4. Caron, G., Delneste, Y., Roelandts, E. et al. 2001. Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells. J. Immunol. 167:3682.
5. Kalinski, P., Schuitemaker, J. H. N., Hilkens, C. M. U. and Kapsenberg, M. L. 1998. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol. 161:2804.
6. Mazzoni, A., Young, H. A., Spitzer, J. H., Visintin, A. and Segal, D. M. 2001. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J. Clin. Invest. 108:1865.
7. Kuchroo, V. K., Das, M. P., Brown, J. A. et al. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 80:707.
8. Freeman, G. J., Boussiotis, V. A., Anumanthan, A. et al. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
9. Gutzmer, R., Diestel, C., Mommert, S. et al. 2005. Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. J. Immunol. 174:5224.
10. Harizi, H., Juzan, M., Pitard, V., Moreau, J.-F. and Gualde, N. 2002. Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J. Immunol. 168:2255.
11. Norcross, M. A., Bentley, D. M., Margulies, D. H. and Germain, R. N. 1984. Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. J. Exp. Med. 160:1316.
12. Dustin, M. L. and Cooper, J. A. 2000. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nat. Immunol. 1:23.
13. O'Connell, P. J., Wang, X., Leon-Ponte, M., Griffiths, C., Pingle, S. C. and Ahern, G. P. 2006. A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 107:1010.
14. Pacheco, R., Oliva, H., Martinez-Navio, J. M. et al. 2006. Glutamate released by dendritic cells as a novel modulator of T cell activation. J. Immunol. 177:6695.
15. Roskoski, R. Jr and Roskoski, L. M. 1987. Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second messenger systems. J. Neurochem. 48:236.
16. Missale, C., Nash, S. R., Robinson, S. W., Jaber, M. and Caron, M. G. 1998. Dopamine receptors: From structure to function. Physiol. Rev. 78:189.
17. Basu, S. and Dasgupta, P. S. 2000. Dopamine, a neurotransmitter, influences the immune system. J. Neuroimmunol. 102:113.
18. Meredith, E. J., Chamba, A., Holder, M. J., Barnes, N. M. and Gordon, J. 2005. Close encounters of the monoamine kind: Immune cells betray their nervous disposition. Immunology 115:289.
19. Bergquist, J., Tarkowski, A., Ekman, R. and Ewing, A. 1994. Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. Proc. Natl Acad. Sci. USA 91:12912.
20. Cosentino, M., Fietta, A. M., Ferrari, M. et al. 2007. Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop. Blood 109:632.
21. Flierl, M. A., Rittirsch, D., Nadeau, B. A. et al. 2007. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 449:721.
22. Abi-Dargham, A., Rodenhiser, J., Printz, D. et al. 2000. From the cover: Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc. Natl Acad. Sci. USA 97:8104.
23. Seeman, P. and Niznik, H. B. 1990. Dopamine receptors and transporters in Parkinson's disease and schizophrenia. FASEB J. 4:2737.
24. Ilani, T., Ben-Shachar, D., Strous, R. D. et al. 2001. A peripheral marker for schizophrenia: Increased levels of D3 dopamine receptor mRNA in blood lymphocytes. Proc. Natl Acad. Sci. USA 98:625.
25. Boneberg, E. M., von Seydlitz, E., Propster, K., Watzl, H., Rockstroh, B. and Illges, H. 2006. D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4+ -T cells. J. Neuroimmunol. 173:180.
26. Kim, Y. K., Myint, A. M., Lee, B. H. et al. 2004. Th1, Th2 and Th3 cytokine alteration in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 28:1129.
27. Avgustin, B., Wraber, B. and Tavcar, R. 2005. Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia. Croat. Med. J. 46:268.
28. Nakano, K., Higashi, T., Hashimoto, K., Takagi, R., Tanaka, Y. and Matsushita, S. 2008. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem. Biophys. Res. Commun. 373:286.
29. Matsushita, S., Kohsaka, H. and Nishimura, Y. 1997. Evidence for self and nonself peptide partial agonists that prolong clonal survival of mature T cells in vitro. J. Immunol. 158:5685.
30. Matsushita, S., Yokomizo, H., Kohsaka, H. and Nishimura, Y. 1996. Diversity of a human CD4+ T cell repertoire recognizing one TCR ligand. Immunol. Lett. 51:191.
31. Dong, L., Chen, M., Zhang, Q., Li, L. Z., Xu, X. Q. and Xiao, W. 2006. T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients. Chin. Med. J. 119:1396.
32. Gordon, J. and Barnes, N. M. 2003. Lymphocytes transport serotonin and dopamine: Agony or ecstasy? Trends Immunol. 24:438.
33. Salah, R. S., Kuhn, D. M. and Galloway, M. P. 1989. Dopamine autoreceptors modulate the phosphorylation of tyrosine hydroxylase in rat striatal slices. J. Neurochem. 52:1517.
34. Klein-Hessling, S., Jha, M. K., Santner-Nanan, B. et al. 2003. Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cells. J. Immunol. 170:2956.
35. Roy, S., Wang, J., Charboneau, R., Loh, H. H. and Barke, R. A. 2005. Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J. Immunol. 175:6361.
36. Suarez, A., Mozo, L. and Gutierrez, C. 2002. Generation of CD4+CD45RA+ effector T cells by stimulation in the presence of cyclic adenosine 5′-monophosphate-elevating agents. J. Immunol. 169:1159.
37. Wakui, M., Nakano, K. and Matsushita, S. 2007. Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities. Biochem. Biophys. Res. Commun. 358:596.
38. Higashi, T., Wakui, M., Nakano, K. et al. 2008. Evaluation of adjuvant activities using human antigen presenting cells in vitro. Allergol. Int. 57:219.
39. Strange, P. G. 2001. Antipsychotic drugs: Importance of dopamine receptors for mechanisms of therapeutic actions and side effects. Pharmacol. Rev. 53:119.
40. Grakoui, A., Bromley, S. K., Sumen, C. et al. 1999. The immunological synapse: A molecular machine controlling T cell activation. Science 285:221.
41. Montoya, M. C., Sancho, D., Bonello, G. et al. 2002. Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat. Immunol. 3:159.
42. Caparros, E., Munoz, P., Sierra-Filardi, E. et al. 2006. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood 107:3950.
43. Wickens, J. R. and Arbuthnott, G. W. 2005. Structural and functional interactions in the striatum at the receptor level. In Dunnet, S. B., Bentivoglio, M., Bjorklund, A. and Hokfelt, T., eds, Handbook of Chemical Neuroanatomy, p. 199. Elsevier Science Publishing Co., Amsterdam, The Netherlands.
44. McIlroy, A., Caron, G., Blanchard, S. et al. 2006. Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Immunology 117:507.
45. Harizi, H., Grosset, C. and Gualde, N. 2003. Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes. J. Leukoc. Biol. 73:756.
46. Mosmann, T., Cherwinski, H., Bond, M., Giedlin, M. and Coffman, R. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
47. Bach, J. F. 2002. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347:911.
48. Krakowski, M. and Owens, T. 1996. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26:1641.
49. Willenborg, D. O., Fordham, S., Bernard, C. C., Cowden, W. B. and Ramshaw, I. A. 1996. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157:3223.
50. Manoury-Schwartz, B., Chiocchia, G., Bessis, N. et al. 1997. High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J. Immunol. 158:5501.
51. Vermeire, K., Heremans, H., Vandeputte, M., Huang, S., Billiau, A. and Matthys, P. 1997. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J. Immunol. 158:5507.
52. Caspi, R., Chan, C., Grubbs, B. et al. 1994. Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice. J. Immunol. 152:890.
53. Jones, L., Rizzo, L., Agarwal, R. et al. 1997. IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J. Immunol. 158:5997.
54. Ring, G. H., Dai, Z., Saleem, S., Baddoura, F. K. and Lakkis, F. G. 1999. Increased susceptibility to immunologically mediated glomerulonephritis in IFN-{gamma}-deficient mice. J. Immunol. 163:2243.