Clinical applications of mesenchymal stem cells in chronic diseases

Stem Cells International

Volumn 2014, Issue , 2014, Pages

  Farini, Andrea ^a   Sitzia, Clementina ^a   Erratico, Silvia ^a   Meregalli, Mirella ^a   Torrente, Yvan ^a  

^a Centro Dino Ferrari   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CARDIOVASCULAR DISEASE; CELL FUNCTION; CELL ISOLATION; CHRONIC DISEASE; HUMAN; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; LIVER DISEASE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MUSCULOSKELETAL DISEASE; NONHUMAN; PARKINSON DISEASE; REVIEW; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 84901272462     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2014/306573     Document Type: Review

References (156)

1. Friedenstein A. J., Gorskaja J. F., Kulagina N. N., Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Experimental Hematology 1976 4 5 267 274 2-s2.0-0017119380
2. Caplan A. I., Mesenchymal stem cells. Journal of Orthopaedic Research 1991 9 5 641 650 2-s2.0-0026228558
3. Owen M., Marrow stromal stem cells. Journal of Cell Science. Supplement 1988 10 63 76 2-s2.0-0024147344 (Pubitemid 19096575)
4. Haynesworth S. E., Baber M. A., Caplan A. I., Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992 13 1 69 80 2-s2.0-0026525255
5. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells. Science 1999 284 5411 143 147 2-s2.0-0033618585 (Pubitemid 29282067)
6. Mahmood A., Lu D., Lu M., Chopp M., Amar A. P., Brawanski A., Valadka A. B., Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 2003 53 3 697 703 2-s2.0-0041854545 (Pubitemid 37055948)
7. Murphy J. M., Fink D. J., Hunziker E. B., Barry F. P., Stem cell therapy in a caprine model of osteoarthritis. Arthritis and Rheumatism 2003 48 12 3464 3474 2-s2.0-0348111230 10.1002/art.11365 (Pubitemid 37531912)
8. Block G. J., Ohkouchi S., Fung F., Frenkel J., Gregory C., Pochampally R., Dimattia G., Sullivan D. E., Prockop D. J., Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells 2009 27 3 670 681 2-s2.0-65249161144 10.1634/stemcells.2008-0742
9. Chen L., Tredget E. E., Wu P. Y. G., Wu Y., Wu Y., Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE 2008 3 4 2-s2.0-44849121129 10.1371/journal. pone.0001886 e1886 (Pubitemid 351943822)
10. Karp J. M., Teo G. S. L., Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 2009 4 3 206 216 2-s2.0-60849136593 10.1016/j.stem.2009.02.001
11. Alhadlaq A., Mao J. J., Mesenchymal stem cells: isolation and therapeutics. Stem Cells and Development 2004 13 4 436 448 2-s2.0-4544359550 10.1089/scd.2004.13.436 (Pubitemid 39223294)
12. Nardi N. B., da Silva Meirelles L., Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handbook of Experimental Pharmacology 2006 174 249 282 2-s2.0-33644796337
13. le Blanc K., Pittenger M. F., Mesenchymal stem cells: progress toward promise. Cytotherapy 2005 7 1 36 45 2-s2.0-17444410347 10.1080/14653240510018118 (Pubitemid 40542402)
14. Miura M., Gronthos S., Zhao M., Lu B., Fisher L. W., Robey P. G., Shi S., SHED: stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences of the United States of America 2003 100 10 5807 5812 2-s2.0-0037687418 10.1073/pnas.0937635100 (Pubitemid 36576889)
15. Hoogduijn M. J., Crop M. J., Peeters A. M. A., van Osch G. J. V. M., Balk A. H. M. M., Ijzermans J. N. M., Weimar W., Baan C. C., Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities. Stem Cells and Development 2007 16 4 597 604 2-s2.0-34548508410 10.1089/scd.2006.0110 (Pubitemid 47378732)
16. Sondergaard C. S., Hodonsky C. J., Khait L., Shaw J., Sarkar B., Birla R., Bove E., Nolta J., Si M.-S., Human thymus mesenchymal stromal cells augment force production in self-organized cardiac tissue. Annals of Thoracic Surgery 2010 90 3 796 803 2-s2.0-77956148089 10.1016/j.athoracsur.2010.04.080
17. Barry F. P., Murphy J. M., Mesenchymal stem cells: clinical applications and biological characterization. International Journal of Biochemistry and Cell Biology 2004 36 4 568 584 2-s2.0-1542286220 10.1016/j.biocel.2003.11.001 (Pubitemid 38324589)
18. Caplan A. I., Why are MSCs therapeutic? New data: new insight. The Journal of Pathology 2009 217 2 318 324 2-s2.0-58449135981 10.1002/path.2469
19. Dore-Duffy P., Katychev A., Wang X., Van Buren E., CNS microvascular pericytes exhibit multipotential stem cell activity. Journal of Cerebral Blood Flow and Metabolism 2006 26 5 613 624 2-s2.0-33646383618 10.1038/sj.jcbfm. 9600272
20. Meyrick B., Reid L., The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Laboratory Investigation 1978 38 2 188 200 2-s2.0-0017836440 (Pubitemid 8290111)
21. Majumdar M. K., Thiede M. A., Mosca J. D., Moorman M., Gerson S. L., Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. Journal of Cellular Physiology 1998 176 1 57 66 (Pubitemid 28277195)
22. Chamberlain G., Fox J., Ashton B., Middleton J., Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007 25 11 2739 2749 2-s2.0-36248932643 10.1634/stemcells.2007-0197 (Pubitemid 350127858)
23. Penn M. S., Importance of the SDF-1: CXCR4 axis in myocardial repair. Circulation Research 2009 104 10 1133 1135 2-s2.0-66949157963 10.1161/CIRCRESAHA.109.198929
24. Schönemeier B., Schulz S., Hoellt V., Stumm R., Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain. Journal of Neuroimmunology 2008 198 1-2 39 45 2-s2.0-47249141913 10.1016/j.jneuroim.2008.04.010
25. Tan B. T. G., Lee M. M. G., Ruan R., Bone marrow-derived cells that home to acoustic deafened cochlea preserved their hematopoietic identity. Journal of Comparative Neurology 2008 509 2 167 179 2-s2.0-46949099037 10.1002/cne.21729 (Pubitemid 351960781)
26. Avniel S., Arik Z., Maly A., Sagie A., Basst H. B., Yahana M. D., Weiss I. D., Pal B., Wald O., Ad-El D., Fujii N., Arenzana-Seisdedos F., Jung S., Galun E., Gur E., Peled A., Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. Journal of Investigative Dermatology 2006 126 2 468 476 2-s2.0-33644640532 10.1038/sj.jid.5700069 (Pubitemid 43323185)
27. Fox A., Smythe J., Fisher N., Tyler M. P. H., McGrouther D. A., Watt S. M., Harris A. L., Mobilization of endothelial progenitor cells into the circulation in burned patients. British Journal of Surgery 2008 95 2 244 251 2-s2.0-38349103987 10.1002/bjs.5913
28. Kitaori T., Ito H., Schwarz E. M., Tsutsumi R., Yoshitomi H., Oishi S., Nakano M., Fujii N., Nagasawa T., Nakamura T., Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis and Rheumatism 2009 60 3 813 823 2-s2.0-61649090805 10.1002/art.24330
29. Gao J., Dennis J. E., Muzic R. F., Lundberg M., Caplan A. I., The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 2001 169 1 12 20 2-s2.0-0035010796 10.1159/000047856 (Pubitemid 32437040)
30. Herrera M. B., Bussolati B., Bruno S., Fonsato V., Romanazzi G. M., Camussi G., Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. International Journal of Molecular Medicine 2004 14 6 1035 1041 2-s2.0-19544364818
31. Jackson K. A., Majka S. M., Wang H., Pocius J., Hartley C. J., Majesky M. W., Entman M. L., Michael L. H., Hirschi K. K., Goodell M. A., Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. The Journal of Clinical Investigation 2001 107 11 1395 1402 2-s2.0-0034988491 (Pubitemid 32522033)
32. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S. M., Li B., Pickel J., McKay R., Nadal-Ginard B., Bodine D. M., Leri A., Anversa P., Bone marrow cells regenerate infarcted myocardium. Nature 2001 410 6829 701 705 2-s2.0-0035810240 10.1038/35070587 (Pubitemid 32290358)
33. Orlic D., Kajstura J., Chimenti S., Limana F., Jakoniuk I., Quaini F., Nadal-Ginard B., Bodine D. M., Leri A., Anversa P., Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proceedings of the National Academy of Sciences of the United States of America 2001 98 18 10344 10349 2-s2.0-17944371854 10.1073/pnas.181177898 (Pubitemid 32803022)
34. Gojo S., Gojo N., Takeda Y., Mori T., Abe H., Kyo S., Hata J.-I., Umezawa A., In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells. Experimental Cell Research 2003 288 1 51 59 2-s2.0-0038487656 10.1016/S0014-4827(03)00132-0 (Pubitemid 36870997)
35. Zhang D., Zhang F., Zhang Y., Gao X., Li C., Yang N., Cao K., Combining erythropoietin infusion with intramyocardial delivery of bone marrow cells is more effective for cardiac repair. Transplant International 2007 20 2 174 183 2-s2.0-33846292613 10.1111/j.1432-2277.2006.00407.x (Pubitemid 46121995)
36. Hofstetter C. P., Schwarz E. J., Hess D., Widenfalk J., El Manira A., Prockop D. J., Olson L., Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proceedings of the National Academy of Sciences of the United States of America 2002 99 4 2199 2204 2-s2.0-0037133174 10.1073/pnas.042678299 (Pubitemid 34169038)
37. Kode J. A., Mukherjee S., Joglekar M. V., Hardikar A. A., Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 2009 11 4 377 391 2-s2.0-68049122875 10.1080/14653240903080367
38. Fibbe W. E., Nauta A. J., Roelofs H., Modulation of immune responses by mesenchymal stem cells. Annals of the New York Academy of Sciences 2007 1106 272 278 2-s2.0-34548401289 10.1196/annals.1392.025 (Pubitemid 47443061)
39. + regulatory T cells. Stem Cells 2008 26 1 212 222 2-s2.0-38349053355 10.1634/stemcells.2007-0554
40. Zhao Z.-G., Li W.-M., Chen Z.-C., You Y., Zou P., Immunosuppressive properties of mesenchymal stem cells derived from bone marrow of patients with chronic myeloid leukemia. Immunological Investigations 2008 37 7 726 739 2-s2.0-52949115668 10.1080/08820130802349940
41. Nasef A., Mazurier C., Bouchet S., François S., Chapel A., Thierry D., Gorin N.-C., Fouillard L., Leukemia inhibitory factor: role in human mesenchymal stem cells mediated immunosuppression. Cellular Immunology 2008 253 1-2 16 22 2-s2.0-51649108020 10.1016/j.cellimm.2008.06.002
42. Sheng H., Wang Y., Jin Y., Zhang Q., Zhang Y., Wang L., Shen B., Yin S., Liu W., Cui L., Li N., A critical role of IFN γ in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Research 2008 18 8 846 857 2-s2.0-49149120713 10.1038/cr.2008.80
43. Ren G., Zhang L., Zhao X., Xu G., Zhang Y., Roberts A. I., Zhao R. C., Shi Y., Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008 2 2 141 150 2-s2.0-38649105374 10.1016/j.stem.2007.11.014 (Pubitemid 351181031)
44. Spaggiari G. M., Capobianco A., Becchetti S., Mingari M. C., Moretta L., Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 2006 107 4 1484 1490 2-s2.0-32644438233 10.1182/blood-2005-07-2775 (Pubitemid 43242385)
45. Poggi A., Prevosto C., Massaro A.-M., Negrini S., Urbani S., Pierri I., Saccardi R., Gobbi M., Zocchi M. R., Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. The Journal of Immunology 2005 175 10 6352 6360 2-s2.0-27744541175 (Pubitemid 41598875)
46. Stagg J., Immune regulation by mesenchymal stem cells: two sides to the coin. Tissue Antigens 2007 69 1 1 9 2-s2.0-33845885144 10.1111/j.1399-0039.2006. 00739.x
47. Jewett A., Arasteh A., Tseng H.-C., Behel A., Arasteh H., Yang W., Cacalano N. A., Paranjpe A., Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity. PloS ONE 2010 5 3 e9874 2-s2.0-77955389449
48. Giuliani M., Bennaceur-Griscelli A., Nanbakhsh A., Oudrhiri N., Chouaib S., Azzarone B., Durrbach A., Lataillade J.-J., TLR ligands stimulation protects MSC from NK killing. Stem Cells 2014 32 1 290 300 10.1002/stem.1563
49. Zheng B., Cao B., Crisan M., Sun B., Li G., Logar A., Yap S., Pollett J. B., Drowley L., Cassino T., Gharaibeh B., Deasy B. M., Huard J., Péault B., Prospective identification of myogenic endothelial cells in human skeletal muscle. Nature Biotechnology 2007 25 1025 1034 10.1038/nbt1334 (Pubitemid 47517642)
50. Nesti L. J., Jackson W. M., Shanti R. M., Koehler S. M., Aragon A. B., Bailey J. R., Sracic M. K., Freedman B. A., Giuliani J. R., Tuan R. S., Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue. Journal of Bone and Joint Surgery A 2008 90 11 2390 2398 2-s2.0-55849121133 10.2106/JBJS.H.00049
51. Gonçalves M. A. F. V., de Vries A. A. F., Holkers M., van de Watering M. J. M., van der Velde I., van Nierop G. P., Valerio D., Knaän-Shanzer S., Human mesenchymal stem cells ectopically expressing full-length dystrophin can complement Duchenne muscular dystrophy myotubes by cell fusion. Human Molecular Genetics 2006 15 2 213 221 2-s2.0-31144464491 10.1093/hmg/ddi438 (Pubitemid 43125976)
52. Németh K., Leelahavanichkul A., Yuen P. S. T., Mayer B., Parmelee A., Doi K., Robey P. G., Leelahavanichkul K., Koller B. H., Brown J. M., Hu X., Jelinek I., Star R. A., Mezey É., Bone marrow stromal cells attenuate sepsis via prostaglandin E 2-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nature Medicine 2009 15 1 42 49 2-s2.0-58149326737 10.1038/nm.1905
53. Asakura A., Seale P., Girgis-Gabardo A., Rudnicki M. A., Myogenic specification of side population cells in skeletal muscle. The Journal of Cell Biology 2002 159 1 123 134 2-s2.0-0037078327 10.1083/jcb.200202092 (Pubitemid 35191524)
54. Qu-Petersen Z., Deasy B., Jankowski R., Ikezawa M., Cummins J., Pruchnic R., Mytinger J., Cao B., Gates C., Wernig A., Huard J., Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. The Journal of Cell Biology 2002 157 5 851 864 2-s2.0-18444409048 10.1083/jcb.200108150 (Pubitemid 34847822)
55. de Bari C., Dell'Accio F., Vandenabeele F., Vermeesch J. R., Raymackers J.-M., Luyten F. P., Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. The Journal of Cell Biology 2003 160 6 909 918 2-s2.0-0037451171 10.1083/jcb.200212064 (Pubitemid 36350845)
56. Gang E. J., Jeong J. A., Hong S. H., Hwang S. H., Kim S. W., Yang I. H., Ahn C., Han H., Kim H., Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood. Stem Cells 2004 22 4 617 624 2-s2.0-3542994447 (Pubitemid 39014577)
57. Rafei M., Campeau P. M., Aguilar-Mahecha A., Buchanan M., Williams P., Birman E., Yuan S., Young Y. K., Boivin M.-N., Forner K., Basik M., Galipeau J., Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. The Journal of Immunology 2009 182 10 5994 6002 2-s2.0-70349881103 10.4049/jimmunol.0803962
58. Yang Y.-W., Bai H., Wang C.-B., Lin M., Wu L.-Q., Experimental study on influence of bone marrow mesenchymal stem cells on activation and function of mouse peritoneal macrophages. Zhonghua Xue Ye Xue Za Zhi 2008 29 8 540 543 2-s2.0-64149102164
59. Casiraghi F., Azzollini N., Cassis P., Imberti B., Morigi M., Cugini D., Cavinato R. A., Todeschini M., Solini S., Sonzogni A., Perico N., Remuzzi G., Noris M., Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells. The Journal of Immunology 2008 181 6 3933 3946 2-s2.0-56149110595
60. Campioni D., Rizzo R., Stignani M., Melchiorri L., Ferrari L., Moretti S., Russo A., Bagnara G. P., Bonsi L., Alviano F., Lanzoni G., Cuneo A., Baricordi O. R., Lanza F., A decreased positivity for CD90 on human mesenchymal stromal cells (MSCs) is associated with a loss of immunosuppressive activity by MSCs. Cytometry B: Clinical Cytometry 2009 76 3 225 230 2-s2.0-66949138068 10.1002/cyto.b.20461
61. Jones B. J., Brooke G., Atkinson K., McTaggart S. J., Immunosuppression by placental indoleamine 2,3-dioxygenase: A role for mesenchymal stem cells. Placenta 2007 28 11-12 1174 1181 2-s2.0-35348823105 10.1016/j.placenta.2007.07. 001 (Pubitemid 47570911)
62. Chan J., Waddington S. N., O'Donoghue K., Kurata H., Guillot P. V., Gotherstrom C., Themis M., Morgan J. E., Fisk N. M., Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. Stem Cells 2007 25 4 875 884 2-s2.0-34147151813 10.1634/stemcells.2006-0694 (Pubitemid 46572584)
63. MacKenzie T. C., Kobinger G. P., Kootstra N. A., Radu A., Sena-Esteves M., Bouchard S., Wilson J. M., Verma I. M., Flake A. W., Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Molecular Therapy 2002 6 3 349 358 2-s2.0-0346035738 10.1006/mthe.2002.0681 (Pubitemid 36305337)
64. + adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in MDX Mice. Stem Cells and Development 2007 16 5 695 706 2-s2.0-36249003921 10.1089/scd.2006.0118 (Pubitemid 350125220)
65. Feng S.-W., Lu X.-L., Liu Z.-S., Zhang Y.-N., Liu T.-Y., Li J.-L., Yu M.-J., Zeng Y., Zhang C., Dynamic distribution of bone marrow-derived mesenchymal stromal cells and change of pathology after infusing into mdx mice. Cytotherapy 2008 10 3 254 264 2-s2.0-42449095031 10.1080/14653240802020381 (Pubitemid 351566527)
66. Kong K. Y., Ren J., Kraus M., Finklestein S. P., Brown R. H. Jr., Human umbilical cord blood cells differentiate into muscle in sjl muscular dystrophy mice. Stem Cells 2004 22 6 981 993 2-s2.0-8644240306 (Pubitemid 39507085)
67. Rauh J., Milan F., Günther K.-P., Stiehler M., Bioreactor systems for bone tissue engineering. Tissue Engineering B: Reviews 2011 17 4 263 280 2-s2.0-79960621058 10.1089/ten.teb.2010.0612
68. Tuan R. S., Role of adult stem/progenitor cells in osseointegration and implant loosening. The International Journal of Oral & Maxillofacial Implants 2011 26 supplement 50 69 2-s2.0-79957835208
69. Bianco P., Robey P. G., Stem cells in tissue engineering. Nature 2001 414 6859 118 121 2-s2.0-0035499350 10.1038/35102181 (Pubitemid 33041636)
70. Cancedda R., Bianchi G., Derubeis A., Quarto R., Cell therapy for bone disease: A review of current status. Stem Cells 2003 21 5 610 619 2-s2.0-0344394386 (Pubitemid 37444117)
71. Kawate K., Yajima H., Ohgushi H., Kotobuki N., Sugimoto K., Ohmura T., Kobata Y., Shigematsu K., Kawamura K., Tamai K., Takakura Y., Tissue-engineered approach for the treatment of steroid-induced osteonecrosis of the femoral head: transplantation of autologous mesenchymal stem cells cultured with beta-tricalcium phosphate ceramics and free vascularized fibula. Artificial Organs 2006 30 12 960 962 2-s2.0-33845480596 10.1111/j.1525-1594.2006.00333.x (Pubitemid 44915585)
72. Nöth U., Reichert J., Reppenhagen S., Steinert A., Rackwitz L., Eulert J., Beckmann J., Tingart M., Cell based therapy for the treatment of femoral head necrosis. Orthopade 2007 36 5 466 471 2-s2.0-34250181299 10.1007/s00132-007-1087-2 (Pubitemid 46895883)
73. Pneumaticos S. G., Triantafyllopoulos G. K., Chatziioannou S., Basdra E. K., Papavassiliou A. G., Biomolecular strategies of bone augmentation in spinal surgery. Trends in Molecular Medicine 2011 17 4 215 222 2-s2.0-79954619841 10.1016/j.molmed.2010.12.002
74. Neen D., Noyes D., Shaw M., Gwilym S., Fairlie N., Birch N., Healos and bone marrow aspirate used for lumbar spine fusion: A case controlled study comparing healos with autograft. Spine 2006 31 18 E636 E640 2-s2.0-33747364474 10.1097/01.brs.0000232028.97590.12
75. Zhang P., Gan Y.-K., Tang J., Hao Y.-Q., Wang Y., Sun Y.-H., Zhu Z.-A., Dai K.-R., Clinical study of lumbar fusion by hybrid construct of stem cells technique and biodegradable material. Zhonghua Wai Ke Za Zhi 2008 46 7 493 496 2-s2.0-57749103238
76. Horwitz E. M., Gordon P. L., Koo W. K. K., Marx J. C., Neel M. D., McNall R. Y., Muul L., Hofmann T., Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proceedings of the National Academy of Sciences of the United States of America 2002 99 13 8932 8937 2-s2.0-0037173116 10.1073/pnas.132252399 (Pubitemid 34693661)
77. Horwitz E. M., Prockop D. J., Fitzpatrick L. A., Koo W. W. K., Gordon P. L., Neel M., Sussman M., Orchard P., Marx J. C., Pyeritz R. E., Brenner M. K., Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nature Medicine 1999 5 3 309 313 2-s2.0-0032976690 10.1038/6529 (Pubitemid 29124367)
78. Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., Sano M., Takahashi T., Hori S., Abe H., Hata J.-I., Umezawa A., Ogawa S., Cardiomyocytes can be generated from marrow stromal cells in vitro. The Journal of Clinical Investigation 1999 103 5 697 705 2-s2.0-0033106384 (Pubitemid 29122423)
79. Xu W., Zhang X., Qian H., Zhu W., Sun X., Hu J., Zhou H., Chen Y., Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Experimental Biology and Medicine 2004 229 7 623 631 2-s2.0-3042856796 (Pubitemid 38878907)
80. Nagaya N., Fujii T., Iwase T., Ohgushi H., Itoh T., Uematsu M., Yamagishi M., Mori H., Kangawa K., Kitamura S., Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. American Journal of Physiology-Heart and Circulatory Physiology 2004 287 6 H2670 H2676 2-s2.0-9344265225 10.1152/ajpheart.01071.2003 (Pubitemid 39557139)
81. Shake J. G., Gruber P. J., Baumgartner W. A., Senechal G., Meyers J., Redmond J. M., Pittenger M. F., Martin B. J., Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. The Annals of Thoracic Surgery 2002 73 6 1919 1926 2-s2.0-0036266426 10.1016/S0003-4975(02)03517-8 (Pubitemid 34596742)
82. Nagaya N., Kangawa K., Itoh T., Iwase T., Murakami S., Miyahara Y., Fujii T., Uematsu M., Ohgushi H., Yamagishi M., Tokudome T., Mori H., Miyatake K., Kitamura S., Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005 112 8 1128 1135 2-s2.0-24044535092 10.1161/CIRCULATIONAHA.104.500447 (Pubitemid 41216119)
83. Wollert K. C., Meyer G. P., Lotz J., Ringes-Lichtenberg S., Lippolt P., Breidenbach C., Fichtner S., Korte T., Hornig B., Messinger D., Arseniev L., Hertenstein B., Ganser A., Drexler H., Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. The Lancet 2004 364 9429 141 148 2-s2.0-3042710733 10.1016/S0140-6736(04) 16626-9 (Pubitemid 38891685)
84. Katritsis D. G., Sotiropoulou P. A., Karvouni E., Karabinos I., Korovesis S., Perez S. A., Voridis E. M., Papamichail M., Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium. Catheterization and Cardiovascular Interventions 2005 65 3 321 329 2-s2.0-21244442301 10.1002/ccd.20406 (Pubitemid 40898172)
85. Chen S.-L., Fang W.-W., Ye F., Liu Y.-H., Qian J., Shan S.-J., Zhang J.-J., Chunhua R. Z., Liao L.-M., Lin S., Sun J.-P., Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. The American Journal of Cardiology 2004 94 1 92 95 2-s2.0-3042662157 10.1016/j.amjcard.2004.03.034 (Pubitemid 38813459)
86. Takahashi M., Li T.-S., Suzuki R., Kobayashi T., Ito H., Ikeda Y., Matsuzaki M., Hamano K., Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. American Journal of Physiology-Heart and Circulatory Physiology 2006 291 2 H886 H893 2-s2.0-33746836891 10.1152/ajpheart.00142.2006 (Pubitemid 44175098)
87. Wang S., Qu X., Zhao R. C., Clinical applications of mesenchymal stem cells. Journal of Hematology & Oncology 2012 5 article 19 10.1186/1756-8722-5-19
88. van Poll D., Parekkadan B., Cho C. H., Berthiaume F., Nahmias Y., Tilles A. W., Yarmush M. L., Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology 2008 47 5 1634 1643 2-s2.0-43949143205 10.1002/hep.22236 (Pubitemid 351702746)
89. Mohamadnejad M., Alimoghaddam K., Mohyeddin-Bonab M., Bagheri M., Bashtar M., Ghanaati H., Baharvand H., Ghavamzadeh A., Malekzadeh R., Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. Archives of Iranian Medicine 2007 10 4 459 466 2-s2.0-35548972917 (Pubitemid 350001896)
90. Kharaziha P., Hellström P. M., Noorinayer B., Farzaneh F., Aghajani K., Jafari F., Telkabadi M., Atashi A., Honardoost M., Zali M. R., Soleimani M., Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial. European Journal of Gastroenterology and Hepatology 2009 21 10 1199 1205 2-s2.0-70349733505 10.1097/MEG.0b013e32832a1f6c
91. Riordan N. H., Chan K., Marleau A. M., Ichim T. E., Cord blood in regenerative medicine: do we need immune suppression? Journal of Translational Medicine 2007 5 article 8 2-s2.0-33847183460 10.1186/1479-5876-5-8
92. González M. A., González-Rey E., Rico L., Büscher D., Delgado M., Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis and Rheumatism 2009 60 4 1006 1019 2-s2.0-65249161683 10.1002/art.24405
93. Walmsley M., Katsikis P. D., Abney E., Parry S., Williams R. O., Maini R. N., Feldmann M., Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis and Rheumatism 1996 39 3 495 503 2-s2.0-0029959940
94. Wehrens E. J., Prakken B. J., van Wijk F., T cells out of control-impaired immune regulation in the inflamed joint. Nature Reviews Rheumatology 2013 9 34 42 10.2174/1573397111309010009
95. Zheng Z. H., Li X. Y., Ding J., Jia J. F., Zhu P., Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis. Rheumatology 2008 47 1 22 30 2-s2.0-37349104020 10.1093/rheumatology/kem284 (Pubitemid 350286256)
96. Augello A., Tasso R., Negrini S. M., Cancedda R., Pennesi G., Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis and Rheumatism 2007 56 4 1175 1186 2-s2.0-34247231682 10.1002/art.22511 (Pubitemid 46608642)
97. Mao F., Xu W.-R., Qian H., Zhu W., Yan Y.-M., Shao Q.-X., Xu H.-X., Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis. Inflammation Research 2010 59 3 219 225 2-s2.0-77949261589 10.1007/s00011-009-0090-y
98. Choi J.-J., Yoo S.-A., Park S.-J., Kang Y.-J., Kim W.-U., Oh I.-H., Cho C.-S., Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice. Clinical and Experimental Immunology 2008 153 2 269 276 2-s2.0-47249155734 10.1111/j.1365-2249.2008.03683.x (Pubitemid 351989157)
99. Djouad F., Fritz V., Apparailly F., Louis-Plence P., Bony C., Sany J., Jorgensen C., Noël D., Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor α in collagen-induced arthritis. Arthritis and Rheumatism 2005 52 5 1595 1603 2-s2.0-18644370435 10.1002/art.21012 (Pubitemid 40663952)
100. Schurgers E., Kelchtermans H., Mitera T., Geboes L., Matthys P., Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Research & Therapy 2010 12 1, article R31 2-s2.0-77649298684 10.1186/ar2939
101. + regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Annals of the Rheumatic Diseases 2009 68 5 744 750 2-s2.0-66149146340 10.1136/ard.2007.086066
102. + regulatory T cells. Arthritis and Rheumatism 2005 52 7 2212 2221 2-s2.0-22244448391 10.1002/art.21195 (Pubitemid 40994344)
103. Bouffi C., Bony C., Courties G., Jorgensen C., Noël D., IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis. PLoS ONE 2010 5 12 2-s2.0-78650085746 10.1371/journal.pone.0014247 e14247
104. Borchers A. T., Keen C. L., Shoenfeld Y., Gershwin M. E., Surviving the butterfly and the wolf: mortality trends in systemic lupus erythematosus. Autoimmunity Reviews 2004 3 6 423 453 2-s2.0-4444291079 10.1016/j.autrev.2004. 04.002 (Pubitemid 39194631)
105. + cells and correlation with disease activity in patients with systemic lupus erythematosus. Clinical Rheumatology 2007 26 12 2073 2079 2-s2.0-36248958730 10.1007/s10067-007-0621-2 (Pubitemid 350120345)
106. Kushida T., Inaba M., Hisha H., Ichioka N., Esumi T., Ogawa R., Iida H., Ikehara S., Intra-bone marrow injection of allogeneic bone marrow cells: A powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice. Blood 2001 97 10 3292 3299 2-s2.0-0035874547 10.1182/blood.V97.10. 3292
107. Sun L. Y., Zhang H. Y., Feng X. B., Hou Y. Y., Lu L. W., Fan L. M., Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007 16 2 121 128 2-s2.0-33847374613 10.1177/0961203306075793 (Pubitemid 46347934)
108. Zhou K., Zhang H., Jin O., Feng X., Yao G., Hou Y., Sun L., Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cellular and Molecular Immunology 2008 5 6 417 424 2-s2.0-62449102751 10.1038/cmi.2008.52
109. Inverardi L., Kenyon N. S., Ricordi C., Islet transplantation: immunological perspectives. Current Opinion in Immunology 2003 15 5 507 511 2-s2.0-0141629542 10.1016/S0952-7915(03)00115-8 (Pubitemid 37130189)
110. Zulewski H., Abraham E. J., Gerlach M. J., Daniel P. B., Moritz W., Müller B., Vallejo M., Thomas M. K., Habener J. F., Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001 50 3 521 533 2-s2.0-0035119871 (Pubitemid 32195216)
111. Huang H., Tang X., Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas. Laboratory Investigation 2003 83 4 539 547 2-s2.0-0037394382 (Pubitemid 36457708)
112. Atouf F., Cheol H. P., Pechhold K., Ta M., Choi Y., Lumelsky N. L., No evidence for mouse pancreatic β -cell epithelial-mesenchymal transition in vitro. Diabetes 2007 56 3 699 702 2-s2.0-33847357833 10.2337/db06-1446 (Pubitemid 46348469)
113. Chase L. G., Ulloa-Montoya F., Kidder B. L., Verfaillie C. M., Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 2007 56 1 3 7 2-s2.0-33847016930 10.2337/db06-1165
114. Gershengorn M. C., Hardikar A. A., Wei C., Ceras-Raaka E., Marcus-Samuels B., Raaka B. M., Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004 306 5705 2261 2264 2-s2.0-11144315998 10.1126/science.1101968 (Pubitemid 40024464)
115. Ouziel-Yahalom L., Zalzman M., Anker-Kitai L., Knoller S., Bar Y., Glandt M., Herold K., Efrat S., Expansion and redifferentiation of adult human pancreatic islet cells. Biochemical and Biophysical Research Communications 2006 341 2 291 298 2-s2.0-31444455909 10.1016/j.bbrc.2005.12.187 (Pubitemid 43152104)
116. Ianus A., Holz G. G., Theise N. D., Hussain M. A., In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. The Journal of Clinical Investigation 2003 111 6 843 850 2-s2.0-0037364517 10.1172/JCI200316502 (Pubitemid 37074959)
117. Phadnis S. M., Joglekar M. V., Dalvi M. P., Muthyala S., Nair P. D., Ghaskadbi S. M., Bhonde R. R., Hardikar A. A., Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo. Cytotherapy 2011 13 3 279 293 2-s2.0-79951713153 10.3109/14653249.2010. 523108
118. Prabakar K. R., Domínguez-Bendala J., Molano R. D., Pileggi A., Villate S., Ricordi C., Inverardi L., Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplantation 2011 21 6 1321 1339
119. Blanco Y., Saiz A., Carreras E., Graus F., Autologous haematopoietic-stem-cell transplantation for multiple sclerosis. The Lancet Neurology 2005 4 1 54 63 2-s2.0-11144305796 10.1016/S1474-4422(04)00966-4 (Pubitemid 40023236)
120. Rice C. M., Kemp K., Wilkins A., Scolding N. J., Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases. The Lancet 2013 382 9899 1204 1213 10.1016/S0140-6736(13)61810-3
121. Karussis D., Karageorgiou C., Vaknin-Dembinsky A., Gowda-Kurkalli B., Gomori J. M., Kassis I., Bulte J. W. M., Petrou P., Ben-Hur T., Abramsky O., Slavin S., Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Archives of Neurology 2010 67 10 1187 1194 2-s2.0-77957964299 10.1001/archneurol.2010.248
122. Prockop D. J., Youn Oh J., Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Molecular Therapy 2012 20 1 14 20 2-s2.0-84856973179 10.1038/mt.2011.211
123. Uccelli A., Pistoia V., Moretta L., Mesenchymal stem cells: A new strategy for immunosuppression? Trends in Immunology 2007 28 5 219 226 2-s2.0-34247645621 10.1016/j.it.2007.03.001 (Pubitemid 46667240)
124. Kemp K., Hares K., Mallam E., Heesom K. J., Scolding N., Wilkins A., Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival. Journal of Neurochemistry 2010 114 6 1569 1580 2-s2.0-77956319013 10.1111/j.1471-4159.2009.06553.x
125. Gordon D., Pavlovska G., Uney J. B., Wraith D. C., Scolding N. J., Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis. Journal of Neuropathology and Experimental Neurology 2010 69 11 1087 1095 2-s2.0-78049348334 10.1097/NEN.0b013e3181f97392
126. Osaka M., Honmou O., Murakami T., Nonaka T., Houkin K., Hamada H., Kocsis J. D., Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome. Brain Research 2010 1343 226 235 2-s2.0-77953618096 10.1016/j.brainres.2010.05.011
127. Zhang J., Li Y., Lu M., Cui Y., Chen J., Noffsinger L., Elias S. B., Chopp M., Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice. Journal of Neuroscience Research 2006 84 3 587 595 2-s2.0-33746862992 10.1002/jnr.20962 (Pubitemid 44196699)
128. Rice C. M., Mallam E. A., Whone A. L., Walsh P., Brooks D. J., Kane N., Butler S. R., Marks D. I., Scolding N. J., Safey and feasibility of autologous bone marrow cellular therapy in relapsing-progressive multiple sclerosis. Clinical Pharmacology and Therapeutics 2010 87 6 679 685 2-s2.0-77952583096 10.1038/clpt.2010.44
129. Yamout B., Hourani R., Salti H., Barada W., El-Hajj T., Al-Kutoubi A., Herlopian A., Baz E. K., Mahfouz R., Khalil-Hamdan R., Kreidieh N. M. A., El-Sabban M., Bazarbachi A., Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study. Journal of Neuroimmunology 2010 227 1-2 185 189 2-s2.0-77956651196 10.1016/j.jneuroim.2010.07.013
130. Suzuki M., McHugh J., Tork C., Shelley B., Hayes A., Bellantuono I., Aebischer P., Svendsen C. N., Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Molecular Therapy 2008 16 12 2002 2010 2-s2.0-56749154435 10.1038/mt.2008.197
131. Agid Y., Parkinson's disease: pathophysiology. The Lancet 1991 337 8753 1321 1324 2-s2.0-0025893945 10.1016/0140-6736(91)92989-F
132. Kish S. J., Shannak K., Hornykiewicz O., Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. The New England Journal of Medicine 1988 318 14 876 880 2-s2.0-0023874410 (Pubitemid 18090271)
133. Teixeira C. F. P., Zamunér S. R., Zuliani J. P., Fernandes C. M., Cruz-Hofling M. A., Fernandes I., Chaves F., Gutiérrez J. M., Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom. Muscle and Nerve 2003 28 4 449 459 2-s2.0-0141592399 10.1002/mus.10453 (Pubitemid 37193773)
134. Kan I., Ben-Zur T., Barhum Y., Levy Y. S., Burstein A., Charlow T., Bulvik S., Melamed E., Offen D., Dopaminergic differentiation of human mesenchymal stem cells-Utilization of bioassay for tyrosine hydroxylase expression. Neuroscience Letters 2007 419 1 28 33 2-s2.0-34248152082 10.1016/j.neulet.2007.03.070 (Pubitemid 46711134)
135. Wang F., Yasuhara T., Shingo T., Kameda M., Tajiri N., Yuan W. J., Kondo A., Kadota T., Baba T., Tayra J. T., Kikuchi Y., Miyoshi Y., Date I., Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1 α BMC Neuroscience 2010 11 article 52 2-s2.0-77951248824 10.1186/1471-2202-11-52
136. Wilkins A., Kemp K., Ginty M., Hares K., Mallam E., Scolding N., Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro. Stem Cell Research 2009 3 1 63 70 2-s2.0-67649863882 10.1016/j.scr.2009.02.006
137. Moloney T. C., Rooney G. E., Barry F. P., Howard L., Dowd E., Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain. Brain Research 2010 1359 33 43 2-s2.0-77957986219 10.1016/j.brainres.2010.08.040
138. Barzilay R., Ben-Zur T., Bulvik S., Melamed E., Offen D., Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells. Stem Cells and Development 2009 18 4 591 601 2-s2.0-67549114835 10.1089/scd.2008.0138
139. Borlongan C. V., Recent preclinical evidence advancing cell therapy for Alzheimer's disease. Experimental Neurology 2012 237 1 142 146 10.1016/j.expneurol.2012.06.024
140. Shin J. Y., Park H. J., Kim H. N., Oh S. H., Bae J. S., Ha H. J., Lee P. H., Mesenchymal stem cells enhance autophagy and increase beta-amyloid clearance in Alzheimer disease models. Autophagy 2014 10 1 32 44 10.4161/auto.26508
141. Ma T., Gong K., Ao Q., Yan Y., Song B., Huang H., Zhang X., Gong Y., Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice. Cell Transplantation 2013 22 supplement 1 S113 S126 10.3727/096368913X672181
142. + T regulatory cells in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease 2010 21 3 927 938 2-s2.0-77957283905 10.3233/JAD-2010- 091696
143. Walsh J. T., Kipnis J., Regulatory T cells in CNS injury: the simple, the complex and the confused. Trends in Molecular Medicine 2011 17 10 541 547 2-s2.0-80053574871 10.1016/j.molmed.2011.05.012
144. Yang H., Yang H., Xie Z., Wei L., Bi J., Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AbetaPPswe/PS1dE9 transgenic mice. PLoS ONE 2013 8 e69129
145. Ortiz L. A., Gambelli F., McBride C., Gaupp D., Baddoo M., Kaminski N., Phinney D. G., Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proceedings of the National Academy of Sciences of the United States of America 2003 100 14 8407 8411 2-s2.0-0037478581 10.1073/pnas.1432929100 (Pubitemid 36842558)
146. Spaeth E., Klopp A., Dembinski J., Andreeff M., Marini F., Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Therapy 2008 15 10 730 738 2-s2.0-43049139914 10.1038/gt.2008.39 (Pubitemid 351627356)
147. Yagi T., Ito D., Okada Y., Akamatsu W., Nihei Y., Yoshizaki T., Yamanaka S., Okano H., Suzuki N., Modeling familial Alzheimer's disease with induced pluripotent stem cells. Human Molecular Genetics 2011 20 23 4530 4539 2-s2.0-81255169342 10.1093/hmg/ddr394 ddr394
148. Lazarus H. M., Haynesworth S. E., Gerson S. L., Rosenthal N. S., Caplan A. I., Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplantation 1995 16 4 557 564 2-s2.0-0028881201
149. le Blanc K., Rasmusson I., Sundberg B., Götherström C., Hassan M., Uzunel M., Ringdén O., Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. The Lancet 2004 363 9419 1439 1441 2-s2.0-2342482526 10.1016/S0140-6736(04)16104-7 (Pubitemid 38586721)
150. le Blanc K., Frassoni F., Ball L., Locatelli F., Roelofs H., Lewis I., Lanino E., Sundberg B., Bernardo M. E., Remberger M., Dini G., Egeler R. M., Bacigalupo A., Fibbe W., Ringdén O., Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. The Lancet 2008 371 9624 1579 1586 2-s2.0-43049103438 10.1016/S0140-6736(08)60690-X (Pubitemid 351626841)
151. Ringdén O., Uzunel M., Rasmusson I., Remberger M., Sundberg B., Lönnies H., Marschall H.-U., Dlugosz A., Szakos A., Hassan Z., Omazic B., Aschan J., Barkholt L., Le Blanc K., Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006 81 10 1390 1397 2-s2.0-33744913533 10.1097/01.tp.0000214462.63943.14 (Pubitemid 43847148)
152. Djouad F., Plence P., Bony C., Tropel P., Apparailly F., Sany J., Noël D., Jorgensen C., Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 2003 102 10 3837 3844 2-s2.0-0242410394 10.1182/blood-2003-04-1193 (Pubitemid 37409409)
153. Karnoub A. E., Dash A. B., Vo A. P., Sullivan A., Brooks M. W., Bell G. W., Richardson A. L., Polyak K., Tubo R., Weinberg R. A., Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007 449 7162 557 563 2-s2.0-34948896045 10.1038/nature06188 (Pubitemid 47525152)
154. Prockop D. J., Brenner M., Fibbe W. E., Horwitz E., le Blanc K., Phinney D. G., Simmons P. J., Sensebe L., Keating A., Defining the risks of mesenchymal stromal cell therapy. Cytotherapy 2010 12 5 576 578 2-s2.0-77956052070 10.3109/14653249.2010.507330
155. + mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6. Clinical and Experimental Immunology 2010 159 3 292 302 2-s2.0-74549151228 10.1111/j.1365-2249.2009.04069.x
156. Bernardo M. E., Locatelli F., Fibbe W. E., Mesenchymal stromal cells: A novel treatment modality for tissue repair. Annals of the New York Academy of Sciences 2009 1176 101 117 2-s2.0-70349817816 10.1111/j.1749-6632.2009.04607.x