메뉴 건너뛰기




Volumn 192, Issue 11, 2014, Pages 5245-5256

Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MEMBRANE PROTEIN; PEPTIDE S510; PEPTIDE S598; UNCLASSIFIED DRUG;

EID: 84901268342     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400111     Document Type: Article
Times cited : (9)

References (57)
  • 1
    • 79951918591 scopus 로고    scopus 로고
    • Peptidomimetics: Modifying peptides in the pursuit of better vaccines
    • Croft, N. P., and A. W. Purcell. 2011. Peptidomimetics: modifying peptides in the pursuit of better vaccines. Expert Rev. Vaccines 10: 211-226.
    • (2011) Expert Rev. Vaccines , vol.10 , pp. 211-226
    • Croft, N.P.1    Purcell, A.W.2
  • 2
    • 34247891741 scopus 로고    scopus 로고
    • More than one reason to rethink the use of peptides in vaccine design
    • Purcell, A. W., J. McCluskey, and J. Rossjohn. 2007. More than one reason to rethink the use of peptides in vaccine design. Nat. Rev. Drug Discov. 6: 404-414.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 404-414
    • Purcell, A.W.1    McCluskey, J.2    Rossjohn, J.3
  • 3
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93: 4102-4107.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4102-4107
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 4
    • 0033556322 scopus 로고    scopus 로고
    • High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
    • Zeh, H. J., III, D. Perry-Lalley, M. E. Dudley, S. A. Rosenberg, and J. C. Yang. 1999. High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J. Immunol. 162: 989-994.
    • (1999) J. Immunol. , vol.162 , pp. 989-994
    • Zeh III, H.J.1    Perry-Lalley, D.2    Dudley, M.E.3    Rosenberg, S.A.4    Yang, J.C.5
  • 5
    • 0032543212 scopus 로고    scopus 로고
    • Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    • Gallimore, A., T. Dumrese, H. Hengartner, R. M. Zinkernagel, and H. G. Rammensee. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J. Exp. Med. 187: 1647-1657.
    • (1998) J. Exp. Med. , vol.187 , pp. 1647-1657
    • Gallimore, A.1    Dumrese, T.2    Hengartner, H.3    Zinkernagel, R.M.4    Rammensee, H.G.5
  • 6
    • 0034130519 scopus 로고    scopus 로고
    • In vivo induction of a high-avidity, high-frequency cytotoxic Tlymphocyte response is associated with antiviral protective immunity
    • Sedlik, C., G. Dadaglio, M. F. Saron, E. Deriaud, M. Rojas, S. I. Casal, and C. Leclerc. 2000. In vivo induction of a high-avidity, high-frequency cytotoxic Tlymphocyte response is associated with antiviral protective immunity. J. Virol. 74: 5769-5775.
    • (2000) J. Virol. , vol.74 , pp. 5769-5775
    • Sedlik, C.1    Dadaglio, G.2    Saron, M.F.3    Deriaud, E.4    Rojas, M.5    Casal, S.I.6    Leclerc, C.7
  • 9
    • 0035889923 scopus 로고    scopus 로고
    • Manipulation of avidity to improve effectiveness of adoptively transferred CD8+ T cells for melanoma immunotherapy in human MHC class I-transgenic mice
    • Bullock, T. N., D. W. Mullins, T. A. Colella, and V. H. Engelhard. 2001. Manipulation of avidity to improve effectiveness of adoptively transferred CD8+ T cells for melanoma immunotherapy in human MHC class I-transgenic mice. J. Immunol. 167: 5824-5831.
    • (2001) J. Immunol. , vol.167 , pp. 5824-5831
    • Bullock, T.N.1    Mullins, D.W.2    Colella, T.A.3    Engelhard, V.H.4
  • 16
    • 17044415359 scopus 로고    scopus 로고
    • Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: Implications for vaccine design
    • Borbulevych, O. Y., T. K. Baxter, Z. Yu, N. P. Restifo, and B. M. Baker. 2005. Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design. J. Immunol. 174: 4812-4820.
    • (2005) J. Immunol. , vol.174 , pp. 4812-4820
    • Borbulevych, O.Y.1    Baxter, T.K.2    Yu, Z.3    Restifo, N.P.4    Baker, B.M.5
  • 18
    • 0037442219 scopus 로고    scopus 로고
    • Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8+ T cells
    • Bullock, T. N., D. W. Mullins, and V. H. Engelhard. 2003. Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8+ T cells. J. Immunol. 170: 1822-1829.
    • (2003) J. Immunol. , vol.170 , pp. 1822-1829
    • Bullock, T.N.1    Mullins, D.W.2    Engelhard, V.H.3
  • 20
    • 0033214423 scopus 로고    scopus 로고
    • The induction of virus-specific CTL as a function of increasing epitope expression: Responses rise steadily until excessively high levels of epitope are attained
    • Wherry, E. J., K. A. Puorro, A. Porgador, and L. C. Eisenlohr. 1999. The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained. J. Immunol. 163: 3735-3745.
    • (1999) J. Immunol. , vol.163 , pp. 3735-3745
    • Wherry, E.J.1    Puorro, K.A.2    Porgador, A.3    Eisenlohr, L.C.4
  • 22
    • 31544476315 scopus 로고    scopus 로고
    • Coronavirus infection of the central nervous system: Host-virus stand-off
    • Bergmann, C. C., T. E. Lane, and S. A. Stohlman. 2006. Coronavirus infection of the central nervous system: host-virus stand-off. Nat. Rev. Microbiol. 4: 121-132.
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 121-132
    • Bergmann, C.C.1    Lane, T.E.2    Stohlman, S.A.3
  • 24
    • 0028824901 scopus 로고
    • CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity
    • Castro, R. F., and S. Perlman. 1995. CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J. Virol. 69: 8127-8131.
    • (1995) J. Virol. , vol.69 , pp. 8127-8131
    • Castro, R.F.1    Perlman, S.2
  • 25
    • 0033485955 scopus 로고    scopus 로고
    • Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: Quantitative estimate of TCR diversity in the infected central nervous system
    • Pewe, L., S. B. Heard, C. Bergmann, M. O. Dailey, and S. Perlman. 1999. Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system. J. Immunol. 163: 6106-6113.
    • (1999) J. Immunol. , vol.163 , pp. 6106-6113
    • Pewe, L.1    Heard, S.B.2    Bergmann, C.3    Dailey, M.O.4    Perlman, S.5
  • 26
    • 0031775861 scopus 로고    scopus 로고
    • Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus
    • Pewe, L., S. Xue, and S. Perlman. 1998. Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus. J. Virol. 72: 5912-5918.
    • (1998) J. Virol. , vol.72 , pp. 5912-5918
    • Pewe, L.1    Xue, S.2    Perlman, S.3
  • 27
    • 0026095354 scopus 로고
    • Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins
    • Williams, R. K., G. S. Jiang, and K. V. Holmes. 1991. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc. Natl. Acad. Sci. USA 88: 5533-5536.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5533-5536
    • Williams, R.K.1    Jiang, G.S.2    Holmes, K.V.3
  • 28
    • 33745714786 scopus 로고    scopus 로고
    • Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis
    • Anghelina, D., L. Pewe, and S. Perlman. 2006. Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis. Am. J. Pathol. 169: 209-222.
    • (2006) Am. J. Pathol. , vol.169 , pp. 209-222
    • Anghelina, D.1    Pewe, L.2    Perlman, S.3
  • 30
    • 79956277775 scopus 로고    scopus 로고
    • Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring
    • Tan, C. T., N. P. Croft, N. L. Dudek, N. A. Williamson, and A. W. Purcell. 2011. Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring. Proteomics 11: 2336-2340.
    • (2011) Proteomics , vol.11 , pp. 2336-2340
    • Tan, C.T.1    Croft, N.P.2    Dudek, N.L.3    Williamson, N.A.4    Purcell, A.W.5
  • 31
    • 77950799203 scopus 로고    scopus 로고
    • De novo recruitment of antigenexperienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system
    • Zhao, J., J. Zhao, and S. Perlman. 2009. De novo recruitment of antigenexperienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system. J. Immunol. 183: 5163-5170.
    • (2009) J. Immunol. , vol.183 , pp. 5163-5170
    • Zhao, J.1    Zhao, J.2    Perlman, S.3
  • 32
    • 0034664053 scopus 로고    scopus 로고
    • CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination
    • Wu, G. F., A. A. Dandekar, L. Pewe, and S. Perlman. 2000. CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination. J. Immunol. 165: 2278-2286.
    • (2000) J. Immunol. , vol.165 , pp. 2278-2286
    • Wu, G.F.1    Dandekar, A.A.2    Pewe, L.3    Perlman, S.4
  • 33
    • 70149106207 scopus 로고    scopus 로고
    • A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation
    • Pham, N. L., V. P. Badovinac, and J. T. Harty. 2009. A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation. J. Immunol. 183: 2337-2348.
    • (2009) J. Immunol. , vol.183 , pp. 2337-2348
    • Pham, N.L.1    Badovinac, V.P.2    Harty, J.T.3
  • 35
    • 76449106188 scopus 로고    scopus 로고
    • Integration, scaling, space-group assignment and post-refinement
    • Kabsch, W. 2010. Integration, scaling, space-group assignment and post-refinement. Acta Crystallogr. D Biol. Crystallogr. 66: 133-144.
    • (2010) Acta Crystallogr. D Biol. Crystallogr. , vol.66 , pp. 133-144
    • Kabsch, W.1
  • 36
    • 0035788107 scopus 로고    scopus 로고
    • Pushing the boundaries of molecular replacement with maximum likelihood
    • Read, R. J. 2001. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr. D Biol. Crystallogr. 57: 1373-1382.
    • (2001) Acta Crystallogr. D Biol. Crystallogr. , vol.57 , pp. 1373-1382
    • Read, R.J.1
  • 37
    • 0028103275 scopus 로고    scopus 로고
    • The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D Biol
    • Collaborative Computational Project, Number 4. 1994
    • Collaborative Computational Project, Number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50: 760-763.
    • Crystallogr. , vol.50 , pp. 760-763
  • 41
    • 0031569179 scopus 로고    scopus 로고
    • MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies
    • Anton, L. C., J. W. Yewdell, and J. R. Bennink. 1997. MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158: 2535-2542.
    • (1997) J. Immunol. , vol.158 , pp. 2535-2542
    • Anton, L.C.1    Yewdell, J.W.2    Bennink, J.R.3
  • 42
    • 0030849769 scopus 로고    scopus 로고
    • Localization, quantitation, and in situ detection of specific peptide-MHC class i complexes using a monoclonal antibody
    • Porgador, A., J. W. Yewdell, Y. Deng, J. R. Bennink, and R. N. Germain. 1997. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6: 715-726.
    • (1997) Immunity , vol.6 , pp. 715-726
    • Porgador, A.1    Yewdell, J.W.2    Deng, Y.3    Bennink, J.R.4    Germain, R.N.5
  • 45
    • 84867418338 scopus 로고    scopus 로고
    • A structural voyage toward an understanding of the MHC-Irestricted immune response: Lessons learned and much to be learned
    • Gras, S., S. R. Burrows, S. J. Turner, A. K. Sewell, J. McCluskey, and J. Rossjohn. 2012. A structural voyage toward an understanding of the MHC-Irestricted immune response: lessons learned and much to be learned. Immunol. Rev. 250: 61-81.
    • (2012) Immunol. Rev. , vol.250 , pp. 61-81
    • Gras, S.1    Burrows, S.R.2    Turner, S.J.3    Sewell, A.K.4    McCluskey, J.5    Rossjohn, J.6
  • 47
    • 0042836805 scopus 로고    scopus 로고
    • Design of multi-epitope, analogue-based cancer vaccines
    • Fikes, J. D., and A. Sette. 2003. Design of multi-epitope, analogue-based cancer vaccines. Expert Opin. Biol. Ther. 3: 985-993.
    • (2003) Expert Opin. Biol. Ther. , vol.3 , pp. 985-993
    • Fikes, J.D.1    Sette, A.2
  • 48
    • 0026682592 scopus 로고
    • Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection
    • Speiser, D. E., D. Kyburz, U. Stubi, H. Hengartner, and R. M. Zinkernagel. 1992. Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection. J. Immunol. 149: 972-980.
    • (1992) J. Immunol. , vol.149 , pp. 972-980
    • Speiser, D.E.1    Kyburz, D.2    Stubi, U.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 49
    • 84874998451 scopus 로고    scopus 로고
    • Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism
    • Dijkman, R., M. F. Jebbink, S. M. Koekkoek, M. Deijs, H. R. Jónsdóttir, R.Molenkamp,M. Ieven, H. Goossens, V. Thiel, and L. van der Hoek. 2013. Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J. Virol. 87: 6081-6090.
    • (2013) J. Virol. , vol.87 , pp. 6081-6090
    • Dijkman, R.1    Jebbink, M.F.2    Koekkoek, S.M.3    Deijs, M.4    Jónsdóttir, H.R.5    Ieven, R.MolenkampM.6    Goossens, H.7    Thiel, V.8    Hoek Der L.Van9
  • 50
    • 0036569213 scopus 로고    scopus 로고
    • Generation of CD8+ T cell memory in response to low, high, and excessive levels of epitope
    • Wherry, E. J., M. J. McElhaugh, and L. C. Eisenlohr. 2002. Generation of CD8+ T cell memory in response to low, high, and excessive levels of epitope. J. Immunol. 168: 4455-4461.
    • (2002) J. Immunol. , vol.168 , pp. 4455-4461
    • Wherry, E.J.1    McElhaugh, M.J.2    Eisenlohr, L.C.3
  • 51
    • 0034162484 scopus 로고    scopus 로고
    • The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice
    • Bullock, T. N., T. A. Colella, and V. H. Engelhard. 2000. The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice. J. Immunol. 164: 2354-2361.
    • (2000) J. Immunol. , vol.164 , pp. 2354-2361
    • Bullock, T.N.1    Colella, T.A.2    Engelhard, V.H.3
  • 55
    • 0027399243 scopus 로고
    • Peptides naturally presented by MHC class i molecules
    • Rammensee, H. G., K. Falk, and O. Rötzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11: 213-244.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 213-244
    • Rammensee, H.G.1    Falk, K.2    Rötzschke, O.3
  • 56
    • 77956038851 scopus 로고    scopus 로고
    • T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice
    • Zhao, J., J. Zhao, and S. Perlman. 2010. T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. J. Virol. 84: 9318-9325.
    • (2010) J. Virol. , vol.84 , pp. 9318-9325
    • Zhao, J.1    Zhao, J.2    Perlman, S.3
  • 57
    • 73449099678 scopus 로고    scopus 로고
    • Evasion by stealth: Inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice
    • Zhao, J., J. Zhao, N. Van Rooijen, and S. Perlman. 2009. Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog. 5: e1000636.
    • (2009) PLoS Pathog. , vol.5
    • Zhao, J.1    Zhao, J.2    Van Rooijen, N.3    Perlman, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.