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Volumn 37, Issue 5, 2014, Pages 559-566

Preclinical and clinical studies on cytokine-induced killer cells for the treatment of renal cell carcinoma

Author keywords

Clinical study; Cytokine induced killer cells; Preclinical study; Renal cell carcinoma

Indexed keywords

ANTINEOPLASTIC ACTIVITY; CANCER MODEL; CANCER PATIENT; CYTOKINE INDUCED KILLER CELL; EX VIVO STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LYMPHOCYTE ACTIVATION; NUDE MOUSE; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; REVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR XENOGRAFT; ANIMAL; CARCINOMA, RENAL CELL; DRUG SCREENING; IMMUNOLOGY; IMMUNOTHERAPY; KIDNEY NEOPLASMS; MOUSE; PATHOLOGY; PROCEDURES; TRANSPLANTATION;

EID: 84901261692     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-014-0381-x     Document Type: Review
Times cited : (8)

References (62)
  • 1
    • 0035031130 scopus 로고    scopus 로고
    • + cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation
    • Alvarnas, J.C., Y.C. Linn, E.G. Hope, and R.S. Negrin. 2001. Expansion of cytotoxic CD3 + CD56 + cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation 7: 216-222. (Pubitemid 32433248)
    • (2001) Biology of Blood and Marrow Transplantation , vol.7 , Issue.4 , pp. 216-222
    • Alvarnas, J.C.1    Linn, Y.-C.2    Hope, E.G.3    Negrin, R.S.4
  • 2
    • 0025993961 scopus 로고
    • Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma
    • Bukowski, R.M., W. Sharfman, S. Murthy, P. Rayman, R. Tubbs, J. Alexander, G.T. Budd, J.S. Sergi, L. Bauer, V. Gibson, et al. 1991. Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma. Cancer Research 51: 4199-4205.
    • (1991) Cancer Research , vol.51 , pp. 4199-4205
    • Bukowski, R.M.1    Sharfman, W.2    Murthy, S.3    Rayman, P.4    Tubbs, R.5    Alexander, J.6    Budd, G.T.7    Sergi, J.S.8    Bauer, L.9    Gibson, V.10
  • 4
    • 14044271554 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and interleukin-2: Dose and schedules of administration in the treatment of metastatic cancer
    • DOI 10.1089/cbr.2004.19.730
    • Dillman, R., P. Schiltz, C. Depriest, N. Barth, L. Beutel, C. De Leon, A. O'connor, and S. Nayak. 2004. Tumor-infiltrating lymphocytes and interleukin-2: Dose and schedules of administration in the treatment of metastatic cancer. Cancer Biotherapy and Radiopharmaceuticals 19: 730-737. (Pubitemid 40279581)
    • (2004) Cancer Biotherapy and Radiopharmaceuticals , vol.19 , Issue.6 , pp. 730-737
    • Dillman, R.1    Schiltz, P.2    DePriest, C.3    Barth, N.4    Beutel, L.5    De Leon, C.6    O'Connor, A.7    Nayak, S.8
  • 6
    • 84866594008 scopus 로고    scopus 로고
    • Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • E.G.W. Group
    • Escudier, B., T. Eisen, C. Porta, J.J. Patard, V. Khoo, F. Algaba, P. Mulders, V. Kataja, and E.G.W. Group. 2012. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology 23(Suppl 7): vii65-vii71.
    • (2012) Annals of Oncology , vol.23 , Issue.SUPPL. 7
    • Escudier, B.1    Eisen, T.2    Porta, C.3    Patard, J.J.4    Khoo, V.5    Algaba, F.6    Mulders, P.7    Kataja, V.8
  • 9
    • 84878834146 scopus 로고    scopus 로고
    • Targeting PI3 K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors
    • Figlin, R.A., I. Kaufmann, and J. Brechbiel. 2013. Targeting PI3 K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors. International Journal of Cancer 133: 788-796.
    • (2013) International Journal of Cancer , vol.133 , pp. 788-796
    • Figlin, R.A.1    Kaufmann, I.2    Brechbiel, J.3
  • 12
    • 0029094721 scopus 로고
    • Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: A pilot study
    • Goedegebuure, P.S., L.M. Douville, H. Li, G.C. Richmond, D.D. Schoof, M. Scavone, and T.J. Eberlein. 1995. Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: A pilot study. Journal of Clinical Oncology 13: 1939-1949.
    • (1995) Journal of Clinical Oncology , vol.13 , pp. 1939-1949
    • Goedegebuure, P.S.1    Douville, L.M.2    Li, H.3    Richmond, G.C.4    Schoof, D.D.5    Scavone, M.6    Eberlein, T.J.7
  • 13
    • 0032985806 scopus 로고    scopus 로고
    • Chemotherapy for renal cell carcinoma
    • Hartmann, J.T., and C. Bokemeyer. 1999. Chemotherapy for renal cell carcinoma. Anticancer Research 19: 1541-1543. (Pubitemid 29255643)
    • (1999) Anticancer Research , vol.19 , Issue.2 C , pp. 1541-1543
    • Hartmann, J.T.1    Bokemeyer, C.2
  • 15
    • 65949091346 scopus 로고    scopus 로고
    • Targeting mTOR in renal cell carcinoma
    • Hudes, G.R. 2009. Targeting mTOR in renal cell carcinoma. Cancer 115: 2313-2320.
    • (2009) Cancer , vol.115 , pp. 2313-2320
    • Hudes, G.R.1
  • 17
    • 47149114026 scopus 로고    scopus 로고
    • Renal cell cancer stage migration: Analysis of the National Cancer Data Base
    • DOI 10.1002/cncr.23518
    • Kane, C.J., K. Mallin, J. Ritchey, M.R. Cooperberg, and P.R. Carroll. 2008. Renal cell cancer stage migration: Analysis of the National Cancer Data Base. Cancer 113: 78-83. (Pubitemid 351976389)
    • (2008) Cancer , vol.113 , Issue.1 , pp. 78-83
    • Kane, C.J.1    Mallin, K.2    Ritchey, J.3    Cooperberg, M.R.4    Carroll, P.R.5
  • 20
    • 84863230396 scopus 로고    scopus 로고
    • Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma
    • Liu, L., W. Zhang, X. Qi, H. Li, J. Yu, S. Wei, X. Hao, and X. Ren. 2012. Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clinical Cancer Research 18: 1751-1759.
    • (2012) Clinical Cancer Research , vol.18 , pp. 1751-1759
    • Liu, L.1    Zhang, W.2    Qi, X.3    Li, H.4    Yu, J.5    Wei, S.6    Hao, X.7    Ren, X.8
  • 21
    • 60849131758 scopus 로고    scopus 로고
    • The antitumor effects of CIK cells combined with docetaxel against drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo
    • Liu, P., L. Chen, and X. Huang. 2009. The antitumor effects of CIK cells combined with docetaxel against drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo. Cancer Biotherapy Radiopharmaceuticals 24: 91-98.
    • (2009) Cancer Biotherapy Radiopharmaceuticals , vol.24 , pp. 91-98
    • Liu, P.1    Chen, L.2    Huang, X.3
  • 22
    • 0019835981 scopus 로고
    • Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor
    • Lotze, M.T., E.A. Grimm, A. Mazumder, J.L. Strausser, and S.A. Rosenberg. 1981. Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Research 41: 4420-4425. (Pubitemid 12201351)
    • (1981) Cancer Research , vol.41 , Issue.11 I , pp. 4420-4425
    • Lotze, M.T.1    Grimm, E.A.2    Mazumder, A.3
  • 26
    • 0021170244 scopus 로고
    • Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2
    • Mule, J.J., S. Shu, S.L. Schwarz, and S.A. Rosenberg. 1984. Adoptive immunotherapy of established pulmonary metastases with LAK cells and recombinant interleukin-2. Science 225: 1487-1489. (Pubitemid 14033135)
    • (1984) Science , vol.225 , Issue.4669 , pp. 1487-1489
    • Mule, J.J.1    Shu, S.2    Schwarz, S.L.3    Rosenberg, S.A.4
  • 28
    • 0023126984 scopus 로고
    • Long-term growth of lymphokine-activated killer (LAK) cells: Role of anti-CD3, beta-IL 1, interferon-γ and -beta
    • Ochoa, A.C., G. Gromo, B.J. Alter, P.M. Sondel, and F.H. Bach. 1987. Long-term growth of lymphokine-activated killer (LAK) cells: Role of anti-CD3, beta-IL 1, interferon-gamma and -beta. The Journal of Immunology 138: 2728-2733. (Pubitemid 17051856)
    • (1987) Journal of Immunology , vol.138 , Issue.8 , pp. 2728-2733
    • Ochoa, A.C.1    Gromo, G.2    Alter, B.J.3
  • 29
    • 80053465574 scopus 로고    scopus 로고
    • Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression
    • Parkhurst, M.R., J.P. Riley, M.E. Dudley, and S.A. Rosenberg. 2011. Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression. Clinical Cancer Research 17: 6287-6297.
    • (2011) Clinical Cancer Research , vol.17 , pp. 6287-6297
    • Parkhurst, M.R.1    Riley, J.P.2    Dudley, M.E.3    Rosenberg, S.A.4
  • 30
    • 80053192743 scopus 로고    scopus 로고
    • Dual-functional capability of CD3 + CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity
    • Pievani, A., G. Borleri, D. Pende, L. Moretta, A. Rambaldi, J. Golay, and M. Introna. 2011. Dual-functional capability of CD3 + CD56 + CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity. Blood 118: 3301-3310.
    • (2011) Blood , vol.118 , pp. 3301-3310
    • Pievani, A.1    Borleri, G.2    Pende, D.3    Moretta, L.4    Rambaldi, A.5    Golay, J.6    Introna, M.7
  • 31
    • 80052244762 scopus 로고    scopus 로고
    • Looking beyond inhibition of VEGF/mTOR: Emerging targets for renal cell carcinoma drug development
    • Rasmussen, N., and W.K. Rathmell. 2011. Looking beyond inhibition of VEGF/mTOR: Emerging targets for renal cell carcinoma drug development. Current Clinical Pharmacology 6: 199-206.
    • (2011) Current Clinical Pharmacology , vol.6 , pp. 199-206
    • Rasmussen, N.1    Rathmell, W.K.2
  • 32
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo, N.P., M.E. Dudley, and S.A. Rosenberg. 2012. Adoptive immunotherapy for cancer: Harnessing the T cell response. Nature Reviews Immunology 12: 269-281.
    • (2012) Nature Reviews Immunology , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 33
    • 70349385645 scopus 로고    scopus 로고
    • Resistance to targeted therapy in renal-cell carcinoma
    • Rini, B.I., and M.B. Atkins. 2009. Resistance to targeted therapy in renal-cell carcinoma. The Lancet Oncology 10: 992-1000.
    • (2009) The Lancet Oncology , vol.10 , pp. 992-1000
    • Rini, B.I.1    Atkins, M.B.2
  • 34
    • 0022349817 scopus 로고
    • Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
    • Rosenberg, S.A., M.T. Lotze, L.M. Muul, S. Leitman, A.E. Chang, S.E. Ettinghausen, Y.L. Matory, J.M. Skibber, E. Shiloni, J.T. Vetto, et al. 1985a. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. New England Journal of Medicine 313: 1485-1492. (Pubitemid 16212345)
    • (1985) New England Journal of Medicine , vol.313 , Issue.23 , pp. 1485-1492
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3
  • 36
    • 0021837706 scopus 로고
    • Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2
    • DOI 10.1084/jem.161.5.1169
    • Rosenberg, S.A., J.J. Mule, P.J. Spiess, C.M. Reichert, and S.L. Schwarz. 1985b. Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. Journal of Experimental Medicine 161: 1169-1188. (Pubitemid 15011332)
    • (1985) Journal of Experimental Medicine , vol.161 , Issue.5 , pp. 1169-1188
    • Rosenberg, S.A.1    Mule, J.J.2    Spiess, P.J.3
  • 37
    • 34147135185 scopus 로고    scopus 로고
    • The epidemiology of bladder and kidney cancer
    • DOI 10.1038/ncpuro0760, PII NCPURO0760
    • Scelo, G., and P. Brennan. 2007. The epidemiology of bladder and kidney cancer. Nature Clinical Practice Urology 4: 205-217. (Pubitemid 46567153)
    • (2007) Nature Clinical Practice Urology , vol.4 , Issue.4 , pp. 205-217
    • Scelo, G.1    Brennan, P.2
  • 41
    • 0025856106 scopus 로고
    • Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity
    • Schmidt-Wolf, I.G., R.S. Negrin, H.P. Kiem, K.G. Blume, and I.L. Weissman. 1991. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. Journal of Experimental Medicine 174: 139-149.
    • (1991) Journal of Experimental Medicine , vol.174 , pp. 139-149
    • Schmidt-Wolf, I.G.1    Negrin, R.S.2    Kiem, H.P.3    Blume, K.G.4    Weissman, I.L.5
  • 45
    • 0027973910 scopus 로고
    • LES TIL (TUMOR INFILTRATING LYMPHOCYTES) CD4 INDUISENT DES REPONSES COMPLETES CHEZ DES PATIENTS TRAITES PAR IL-2 (INTERLEUKINE-2). ETUDE PRELIMINAIRE
    • Thiounn, N., C. Mathiot, T. Flam, E. Tartour, C. Peyret, I. Joyeux, J.P. Abecassis, M. Zerbib, W.H. Fridman, and B. Debre. 1994. CD4 TIL (Tumor Infiltrating Lymphocytes) induce complete response in patients treated with IL-2 (Interleukin-2). Preliminary study. Journal of Urology (Paris) 100: 185-188. (Pubitemid 24350208)
    • (1994) Journal d'Urologie , vol.100 , Issue.4 , pp. 185-188
    • Thiounn, N.1    Mathiot, C.2    Flam, T.3    Tartour, E.4    Peyret, C.5    Joyeux, I.6    Abecassis, J.P.7    Zerbib, M.8    Fridman, W.H.9    Debre, B.10
  • 46
    • 0024492341 scopus 로고
    • Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells
    • Thompson, J.A., D.J. Lee, C.G. Lindgren, L.A. Benz, C. Collins, W.P. Shuman, D. Levitt, and A. Fefer. 1989. Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells. Cancer Research 49: 235-240. (Pubitemid 19024438)
    • (1989) Cancer Research , vol.49 , Issue.1 , pp. 235-240
    • Thompson, J.A.1    Lee, D.J.2    Lindgren, C.G.3    Benz, L.A.4    Collins, C.5    Shuman, W.P.6    Levitt, D.7    Fefer, A.8
  • 47
    • 0031907142 scopus 로고    scopus 로고
    • Adoptive immunotherapy of patients with metastatic renal cell cancer using lymphokine-activated killer cells, interleukin-2 and cyclophosphamide: Long-term results
    • Tomita, Y., A. Katagiri, K. Saito, T. Imai, T. Saito, T. Tanikawa, M. Terunuma, T. Nishiyama, and K. Takahashi. 1998. Adoptive immunotherapy of patients with metastatic renal cell cancer using lymphokine-activated killer cells, interleukin-2 and cyclophosphamide: Long-term results. International Journal of Urology 5: 16-21. (Pubitemid 28097225)
    • (1998) International Journal of Urology , vol.5 , Issue.1 , pp. 16-21
    • Tomita, Y.1    Katagiri, A.2    Saito, K.3    Imai, T.4    Saito, T.5    Tanikawa, T.6    Terunuma, M.7    Nishiyama, T.8    Takahashi, K.9
  • 49
    • 0036267111 scopus 로고    scopus 로고
    • + NK-T cells in humans and mice
    • DOI 10.1023/A:1015415928521
    • Verneris, M.R., J. Baker, M. Edinger, and R.S. Negrin. 2002. Studies of ex vivo activated and expanded CD8 + NK-T cells in humans and mice. Journal of Clinical Immunology 22: 131-136. (Pubitemid 34596936)
    • (2002) Journal of Clinical Immunology , vol.22 , Issue.3 , pp. 131-136
    • Verneris, M.R.1    Baker, J.2    Edinger, M.3    Negrin, R.S.4
  • 50
    • 1842526956 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1182/blood-2003-06-2125
    • Verneris, M.R., M. Karami, J. Baker, A. Jayaswal, and R.S. Negrin. 2004. Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8 + T cells. Blood 103: 3065-3072. (Pubitemid 38451682)
    • (2004) Blood , vol.103 , Issue.8 , pp. 3065-3072
    • Verneris, M.R.1    Karami, M.2    Baker, J.3    Jayaswal, A.4    Negrin, R.S.5
  • 51
    • 36849017520 scopus 로고    scopus 로고
    • Efficacy of autologous renal tumor cell lysate-loaded dendritic cell vaccine in combination with cytokine-induced killer cells on advanced renal cell carcinoma - A report of ten cases
    • Wang, H., F.J. Zhou, Q.J. Wang, Z.K. Qin, L.X. Huang, Z.W. Liu, H. Han, Y.Q. Li, S.P. Chen, and J.C. Xia. 2006. Efficacy of autologous renal tumor cell lysate-loaded dendritic cell vaccine in combination with cytokine-induced killer cells on advanced renal cell carcinoma - A report of ten cases. Ai Zheng 25: 625-630.
    • (2006) Ai Zheng , vol.25 , pp. 625-630
    • Wang, H.1    Zhou, F.J.2    Wang, Q.J.3    Qin, Z.K.4    Huang, L.X.5    Liu, Z.W.6    Han, H.7    Li, Y.Q.8    Chen, S.P.9    Xia, J.C.10
  • 52
    • 84890952595 scopus 로고    scopus 로고
    • Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients
    • Wang, Z., Y. Zhang, Y. Liu, L. Wang, L. Zhao, T. Yang, C. He, Y. Song, and Q. Gao. 2014. Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients. Journal of Immunotherapy 37: 43-50.
    • (2014) Journal of Immunotherapy , vol.37 , pp. 43-50
    • Wang, Z.1    Zhang, Y.2    Liu, Y.3    Wang, L.4    Zhao, L.5    Yang, T.6    He, C.7    Song, Y.8    Gao, Q.9
  • 53
    • 0028868564 scopus 로고
    • Increased LAK and T cell activation in responding renal cell carcinoma patients after low dose cyclophosphamide, IL-2 and alpha-IFN
    • Wersall, P., and H. Mellstedt. 1995. Increased LAK and T cell activation in responding renal cell carcinoma patients after low dose cyclophosphamide, IL-2 and alpha-IFN. Medical Oncology 12: 69-77.
    • (1995) Medical Oncology , vol.12 , pp. 69-77
    • Wersall, P.1    Mellstedt, H.2
  • 54
    • 84859471907 scopus 로고    scopus 로고
    • Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: Current status and future outlook
    • Wu, R., M.A. Forget, J. Chacon, C. Bernatchez, C. Haymaker, J.Q. Chen, P. Hwu, and L.G. Radvanyi. 2012. Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: Current status and future outlook. Cancer Journal 18: 160-175.
    • (2012) Cancer Journal , vol.18 , pp. 160-175
    • Wu, R.1    Forget, M.A.2    Chacon, J.3    Bernatchez, C.4    Haymaker, C.5    Chen, J.Q.6    Hwu, P.7    Radvanyi, L.G.8
  • 56
    • 46449117297 scopus 로고    scopus 로고
    • + CIKs) reversed resistance to fas-mediated apoptosis through CD40/CD40L ligation rather than IFN-γ stimulation
    • DOI 10.1089/cbr.2007.0454
    • Yu, J., W. Zhang, H. Jiang, H. Li, S. Cao, and X. Ren. 2008. CD4 + T cells in CIKs (CD4 + CIKs) reversed resistance to fas-mediated apoptosis through CD40/CD40L ligation rather than IFN-gamma stimulation. Cancer Biotherapy and Radiopharmaceuticals 23: 342-354. (Pubitemid 351931461)
    • (2008) Cancer Biotherapy and Radiopharmaceuticals , vol.23 , Issue.3 , pp. 342-354
    • Yu, J.1    Zhang, W.2    Jiang, H.3    Li, H.4    Cao, S.5    Ren, X.6
  • 57
    • 84869128048 scopus 로고    scopus 로고
    • A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma
    • Zhan, H.L., X. Gao, X.Y. Pu, W. Li, Z.J. Li, X.F. Zhou, and J.G. Qiu. 2012. A randomized controlled trial of postoperative tumor lysate-pulsed dendritic cells and cytokine-induced killer cells immunotherapy in patients with localized and locally advanced renal cell carcinoma. Chinese Medical Journal (England) 125: 3771-3777.
    • (2012) Chinese Medical Journal (England) , vol.125 , pp. 3771-3777
    • Zhan, H.L.1    Gao, X.2    Pu, X.Y.3    Li, W.4    Li, Z.J.5    Zhou, X.F.6    Qiu, J.G.7
  • 58
    • 23844500756 scopus 로고    scopus 로고
    • Antitumour activities of cytokine-induced killer cells and dendritic cells in vitro and in vivo
    • Zhang, S., S.J. Jiang, C.Q. Zhang, H.M. Wang, and C.X. Bai. 2005a. Antitumour activities of cytokine-induced killer cells and dendritic cells in vitro and in vivo. Chinese Medical Journal (England) 118: 1308-1312.
    • (2005) Chinese Medical Journal (England) , vol.118 , pp. 1308-1312
    • Zhang, S.1    Jiang, S.J.2    Zhang, C.Q.3    Wang, H.M.4    Bai, C.X.5
  • 61
    • 77956469373 scopus 로고    scopus 로고
    • Antitumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro
    • Zhao, Q., H. Zhang, Y. Li, J. Liu, X. Hu, and L. Fan. 2010. Antitumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro. Journal of Experiment and Clinical Cancer Research 29: 118.
    • (2010) Journal of Experiment and Clinical Cancer Research , vol.29 , pp. 118
    • Zhao, Q.1    Zhang, H.2    Li, Y.3    Liu, J.4    Hu, X.5    Fan, L.6
  • 62
    • 0042853141 scopus 로고    scopus 로고
    • Specific anti-leukemic cell effect mediated by dendritic cells pulsed with chronic myelogenous leukemia lysate antigen in vitro
    • Zhu, H.H., K.L. Xu, X.Y. Pan, J.Q. Liu, F.X. Chen, and Y.H. Huang. 2003. Specific anti-leukemic cell effect mediated by dendritic cells pulsed with chronic myelogenous leukemia lysate antigen in vitro. Zhongguo Shi Yan Xue Ye Xue Za Zhi 11: 278-281.
    • (2003) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.11 , pp. 278-281
    • Zhu, H.H.1    Xu, K.L.2    Pan, X.Y.3    Liu, J.Q.4    Chen, F.X.5    Huang, Y.H.6


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