Hypoxia induces autophagic cell death through hypoxia-inducible factor 1α in microglia

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Yang, Zhao ^a   Zhao, Tian Zhi ^b   Zou, Yong Jie ^a   Zhang, John H ^a   Feng, Hua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; 3-METHYLADENINE; ADENINE;

ANIMAL CELL; ARTICLE; ATG5 GENE; AUTOPHAGY; BECN1 GENE; CELL ACTIVATION; CELL DEATH; CELL HYPOXIA; CONTROLLED STUDY; GENE ACTIVATION; IN VITRO STUDY; INFLAMMATION; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; UPREGULATION; ANALOGS AND DERIVATIVES; CELL LINE; CYTOLOGY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; METABOLISM; PHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY;

ADENINE; AUTOPHAGY; CELL HYPOXIA; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICROGLIA; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 84901250589     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096509     Document Type: Article

References (36)

1. Wong KS, Li H (2003) Long-term mortality and recurrent stroke risk among Chinese stroke patients with predominant intracranial atherosclerosis. Stroke 34: 2361-2366. (Pubitemid 37221942)
2. Weimar C, Goertler M, Harms L, Diener HC (2006) Distribution and outcome of symptomatic stenoses and occlusions in patients with acute cerebral ischemia. Arch Neurol 63: 1287-1291. (Pubitemid 44379831)
3. Stead LG, Gilmore RM, Decker WW, Weaver AL, Brown RD, Jr. (2005) Initial emergency department blood pressure as predictor of survival after acute ischemic stroke. Neurology 65: 1179-1183. (Pubitemid 41508207)
4. Lin B (2013) Encephalopathy: a vicious cascade following forebrain ischemia and hypoxia. Cent Nerv Syst Agents Med Chem 13: 57-70.
5. Mayo L, Levy A, Jacob-Hirsch J, Amariglio N, Rechavi G, et al. (2011) Bid regulates the immunological profile of murine microglia and macrophages. Glia 59: 397-412.
6. Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, et al. (2011) Caspase signalling controls microglia activation and neurotoxicity. Nature 472: 319-324.
7. Chen D, Thomas EL, Kapahi P (2009) HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 5: e1000486.
8. Han ZB, Ren H, Zhao H, Chi Y, Chen K, et al. (2008) Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis 29: 1853-1861.
9. Shi H (2009) Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke. Curr Med Chem 16: 4593-4600.
10. Matrone C, Pignataro G, Molinaro P, Irace C, Scorziello A, et al. (2004) HIF- 1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion. J Neurochem 90: 368-378. (Pubitemid 38938223)
11. Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, et al. (2000) Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48: 285-296.
12. Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, et al. (2009) HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemia. Dev Neurosci 31: 452-458.
13. Chen W, Jadhav V, Tang J, Zhang JH (2008) HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury. Acta Neurochir Suppl 102: 395-399.
14. Ryter SW, Nakahira K, Haspel JA, Choi AM (2012) Autophagy in pulmonary diseases. Annu Rev Physiol 74: 377-401.
15. Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B (2010) Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 6: 322-329.
16. Anand PK, Tait SW, Lamkanfi M, Amer AO, Nunez G, et al. (2011) TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem 286: 42981-42991.
17. Shahnazari S, Namolovan A, Mogridge J, Kim PK, Brumell JH (2011) Bacterial toxins can inhibit host cell autophagy through cAMP generation. Autophagy 7: 957-965.
18. Yokoyama T, Iwado E, Kondo Y, Aoki H, Hayashi Y, et al. (2008) Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells. Gene Ther 15: 1233-1239.
19. Yao L, Kan EM, Kaur C, Dheen ST, Hao A, et al. (2013) Notch-1 signaling regulates microglia activation via NF-kappaB pathway after hypoxic exposure in vivo and in vitro. PLoS One 8: e78439.
20. Shi Y, Tang B, Yu PW, Hao YX, Lei X, et al. (2012) Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS One 7: e51076.
21. Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, et al. (2003) YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 95: 516-525. (Pubitemid 36511622)
22. Ricker JL, Chen Z, Yang XP, Pribluda VS, Swartz GM, et al. (2004) 2- methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res 10: 8665-8673. (Pubitemid 40053435)
23. Wong CH, Jenne CN, Lee WY, Leger C, Kubes P (2011) Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 334: 101-105.
24. Wei Z, Chigurupati S, Arumugam TV, Jo DG, Li H, et al. (2011) Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke 42: 2589-2594.
25. Lv M, Liu Y, Zhang J, Sun L, Liu Z, et al. (2011) Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/ interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience 176: 162-172.
26. Finlay DK, Rosenzweig E, Sinclair LV, Feijoo-Carnero C, Hukelmann JL, et al. (2012) PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med 209: 2441-2453.
27. Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, et al. (2006) Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 66: 3567-3575.
28. Birse-Archbold JL, Kerr LE, Jones PA, McCulloch J, Sharkey J (2005) Differential profile of Nix upregulation and translocation during hypoxia/ ischaemia in vivo versus in vitro. J Cereb Blood Flow Metab 25: 1356-1365. (Pubitemid 41348737)
29. Graumann U, Reynolds R, Steck AJ, Schaeren-Wiemers N (2003) Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol 13: 554-573. (Pubitemid 37420699)
30. Schmid T, Zhou J, Brune B (2004) HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med 8: 423-431. (Pubitemid 44145475)
31. Bergmann A (2007) Autophagy and cell death: no longer at odds. Cell 131: 1032-1034.
32. Li ZL, Lerman LO (2012) Impaired myocardial autophagy linked to energy metabolism disorders. Autophagy 8: 992-994.
33. Jiang M, Liu K, Luo J, Dong Z (2010) Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol 176: 1181-1192.
34. Band M, Joel A, Hernandez A, Avivi A (2009) Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergi. FASEB J 23: 2327-2335.
35. Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, et al. (2013) Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol 106-107: 33-54.
36. Scott GB, Bowles PA, Wilson EB, Meade JL, Low BC, et al. (2010) Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing. Biochem J 431: 423-431.