Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds

Tissue Engineering - Part A

Volumn 20, Issue 11-12, 2014, Pages 1735-1746

  Mendez, Julio J ^a   Ghaedi, Mahboobe ^a   Steinbacher, Derek ^b   Niklason, Laura E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BONE; CELL CULTURE; CELLS; FLOWCHARTING; PROTEINS; TISSUE; TRANSMISSION ELECTRON MICROSCOPY;

CULTURE CONDITIONS; EXTRACELLULAR MATRIX COMPONENTS; HUMAN ADIPOSE TISSUE; HUMAN BONE MARROW; LUNG EPITHELIAL CELLS; MESENCHYMAL STROMAL CELLS; PROTEIN SUBSTRATE; SURFACTANT PROTEINS;

SCAFFOLDS (BIOLOGY);

ADIPOSE TISSUE; ADULT; ANIMAL; BIOREACTOR; BONE MARROW CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL SEPARATION; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; LUNG; LUNG ALVEOLUS CELL; MALE; MESENCHYMAL STROMA CELL; METABOLISM; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SCAFFOLD; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; ANIMALS; BIOREACTORS; BONE MARROW CELLS; CELL ADHESION; CELL DIFFERENTIATION; CELL SEPARATION; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; LUNG; MALE; MESENCHYMAL STROMAL CELLS; PNEUMOCYTES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE SCAFFOLDS; YOUNG ADULT;

EID: 84901237161     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2013.0647     Document Type: Article

References (41)

1. Badylak, S.F., Weiss, D.J., Caplan, A., and Macchiarini, P. Engineered whole organs and complex tissues. Lancet 379, 943, 2012.
2. Soto-Gutierrez, A., Werner, S., Ott, H.C., and GILBERT, T. Perspectives on whole-organ assembly:moving toward transplantation on demand. J Clin Invest 122, 3817, 2013.
3. Song, J.J., and Ott, H.C. Organ engineering based on decellularized matrix scaffolds. Trends Mol Med 17, 424, 2011.
4. Wagner, D., et al. Can stem cells be used to generate new lungs? Ex vivo bioengineering with decellularized whole lung scaffolds. Respirology 18, 895, 2013.
5. Krause, D.S., et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 1, 2001.
6. Wong, A.P., Keating, A., and Waddell, T.K. Airway regeneration: the role of the Clara cell secretory protein and the cells that express it. Cytotherapy 11, 676, 2009.
7. Kotton, D.N., et al. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128, 5181, 2001.
8. Rojas, M., et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33, 145, 2005.
9. Krause, D.S. Bone marrow-derived cells and stem cells in lung repair. Proc Am Thoracic Soc 5, 323, 2008.
10. Baer, P.C., and Geiger, H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int 2012, 1, 2012.
11. Sng, J., and Lufkin, T. Emerging stem cell therapies: treatment, safety, and biology. Stem Cells Int 2012, 1, 2013.
12. Chistiakov, D.A. Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation. J Biomed Sci 17, 92, 2010.
13. Kolios, G., and Moodley, Y. Introduction to stem cells and regenerative medicine. Respiration 85, 3, 2013.
14. Li, M., and Ikehara, S. Bone-marrow-derived mesenchymal stem cells for organ repair. Stem Cells Int 2013, 1, 2013.
15. DelaRosa, O., et al. Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis. Stem Cells Dev 21, 1333, 2012.
16. Rasmusson, I., Ringdén, O., Sundberg, B., and Le Blanc, K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 76, 1208, 2003.
17. Lee, J.W., Fang, X., Krasnodembskaya, A., Howard, J.P., and Matthay, M.A. Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells 29, 913, 2011.
18. Ortiz, L.A., et al. Mesenchymal stem cell engraftment in lung isenhanced in response to bleomycin exposureand ameliorates its fibrotic effects. PNAS 100, 8408, 2003.
19. Petersen, T.H., et al. Tissue-engineered lungs for in vivo implantation. Science 329, 538, 2010.
20. Wong, A.P., et al. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Invest 119, 336, 2009.
21. Rackley, C.R., and Stripp, B.R. Building and maintaining the epithelium of the lung. J Clin Invest 122, 2724, 2012.
22. Lenssen, J., and Stolk, J. Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema. Int J COPD 2, 131, 2007.
23. Schmiedl, A., Ochs, M., Muhlfeld, C., Johnen, G., and Brasch, F. Distribution of surfactant proteins in type II pneumocytes of newborn, 14-day old, and adult rats: an immunoelectron microscopicand stereological study. Histochem Cell Biol 124, 465, 2005.
24. Kassmer, S.H., and Krause, D.S. Detection of bone marrowderived lung epithelial cells. Exp Hematol 38, 564, 2010.
25. Ghaedi, M., et al. Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. J Clin Invest 123, 4950, 2013.
26. Ghaedi, M., et al. Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor. Biomaterials 35, 699, 2014.
27. Petersen, T.H., Calle, E.A., Colehour, M.B., and Niklason, L.E. Matrix Composition and mechanics of decellularized lung scaffolds. Cells Tissues Organs 195, 222, 2012.
28. Cortiella, J., et al. Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation. Tissue Eng Part A 16, 2565, 2010.
29. Wong, A.P., et al. Targeted cell replacement with bone marrow cells for airway epithelial regeneration. Am J Physiol Lung Cell Mol Physiol 293, L740, 2007.
30. Wang, X., et al. Characterization of mesenchymal stem cells isolated from mouse fetal bone marrow. Stem Cells 24, 482, 2006.
31. Daly, A.B., et al. Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrowderived mesenchymal stromal cells. Tissue Eng Part A 18, 1, 2012.
32. Bonvillain, R.W., et al. A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells. Tissue Eng Part A 18, 2437, 2012.
33. VIDAL, M.A., et al. Comparison of chondrogenic potential in equine mesenchymal stromal cells derived from adipose tissue and bone marrow. Vet Surg 37, 713, 2008.
34. Al-Nbaheen, M., et al. Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential. Stem Cell Rev 9, 32, 2013.
35. Hoffman, A.M., et al. Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells Dev 20, 1779, 2011.
36. Pevsner-Fischer, M., Levin, S., and Zipori, D. The origins of mesenchymal stromal cell heterogeneity. Stem Cell Rev and Rep 7, 560, 2011.
37. Lama, V.N., et al. Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest 117, 989, 2007.
38. Jarvinen, L., et al. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol 181, 4389, 2008.
39. Kubo, H. Tissue engineering for pulmonary diseases: insights from the laboratory. Respirology 17, 445, 2012.
40. Weiss, D.J. Stem Cells, cell therapies and bioengineering in lung biology and diseases: comprehensive reviewof the recent literature 2010-2012. Ann Am Thorac Soc 10, S45, 2013.
41. Hayes, M., Curley, G., Ansari, B., and Laffey, J. Clinical review: stem cell therapies for acute lung injury/acute respiratory distress syndrome-hope or hype? Crit Care 16, 1, 2012.