Endogenous and exogenous stem cells: A role in lung repair and use in airway tissue engineering and transplantation

Journal of Biomedical Science

Volumn 17, Issue 1, 2010, Pages

  Chistiakov, Dimitry A ^a  

^a STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COLLAGEN TYPE 6; COLLAGEN TYPE 9; DECORIN; FIBROMODULIN; FIBRONECTIN; HYALURONIC ACID; INTEGRIN; TISSUE SCAFFOLD;

ADULT STEM CELL; AMNIOTIC FLUID CELL; BIOENGINEERING; CARTILAGE CELL; CARTILAGE GRAFT; CELL ADHESION; CELL DEDIFFERENTIATION; CELL FREE SYSTEM; CELLULAR DISTRIBUTION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RESPIRATORY EPITHELIUM; REVIEW; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TISSUE REGENERATION; TRACHEA; TRACHEA INJURY; TRANSPLANTATION; UMBILICAL CORD BLOOD; ANIMAL; CYTOLOGY; LUNG; METHODOLOGY; PHYSIOLOGY; REGENERATIVE MEDICINE; WOUND HEALING;

ANIMALIA;

ADULT STEM CELLS; ANIMALS; BIOENGINEERING; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; LUNG; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TRACHEA; WOUND HEALING;

EID: 78649728792     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-17-92     Document Type: Review

References (88)

1. The Registry of the International Society for Heart and Lung Transplantation: Twenty-seventh official adult heart transplant report - 2010. J Stehlik LB Edwards AY Kucheryavaya P Aurora JD Christie R Kirk F Dobbels AO Rahmel MI Hertz, J Heart Lung Transplant 2010 29 1089 1103 10.1016/j.healun. 2010.08.007 20870164
2. Lung transplantation. SD Moffatt-Bruce, http://emedicine.medscape.com/ article/429499-overview
3. Clinical transplantation of a tissue-engineered airway. P Macchiarini P Jungebluth T Go MA Asnaghi LE Rees TA Cogan A Dodson J Martorell S Bellini PP Parnigotto SC Dickinson AP Hollander S Mantero MT Conconi MA Birchall, Lancet 2008 372 2023 2030 10.1016/S0140-6736(08)61598-6 19022496
4. Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease. E Puchelle JM Zahm JM Tournier C Coraux, Proc Am Thorac Soc 2006 3 726 733 10.1513/pats.200605-126SF 17065381
5. Heparin-modified dendrimer cross-linked collagen matrices for the delivery of basic fibroblast growth factor (FGF-2). MA Princz H Sheardown, J Biomater Sci Polym Ed 2008 19 1201 1218 10.1163/156856208785540181 18727861
6. Endogenous lung stem cells and contribution to disease. JC Snyder RM Teisanu BR Stripp, J Pathol 2009 217 254 264 10.1002/path.2473 19039828
7. Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells. R Reddy S Buckley M Doerken L Barsky K Weinberg KD Anderson D Warburton B Driscoll, Am J Physiol Lung Cell Mol Physiol 2004 286 658 L667 10.1152/ajplung.00159.2003 12922980
8. Contribution of proliferation and DNA damage repair to alveolar epithelial type 2 cell recovery from hyperoxia. J Lee R Reddy L Barsky K Weinberg B Driscoll, Am J Physiol Lung Cell Mol Physiol 2006 290 685 L694 10.1152/ajplung.00020.2005 16299057
9. Cell migration and proliferation during the in vitro wound repair of the respiratory epithelium. JM Zahm H Kaplan AL Herard F Doriot D Pierrot P Somelette E Puchelle, Cell Motil Cytoskeleton 1997 37 33 43 10.1002/(SICI)1097- 0169(1997)37:1<33::AID-CM4>3.0.CO;2-I 9142437
10. Epithelial barrier integrity during in vitro wound repair of the airway epithelium. AL Herard JM Zahm D Pierrot J Hinnrasky C Fuchey E Puchelle, Am J Respir Cell Mol Biol 1996 15 624 632 8918369 (Pubitemid 126440602)
11. Stem/progenitor cells in lung development, injury repair, and regeneration. D Warburton L Perin R DeFilippo S Bellusci W Shi B Driscoll, Proc Am Thorac Soc 2008 5 703 706 10.1513/pats.200801-012AW 18684721
12. Evidence for stem-cell niches in the tracheal epithelium. DW Borthwick M Shahbazian Q Todd Krantz J Dorin SH Randell, Am J Respir Cell Mol Biol 2001 24 662 670 11415930
13. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. KU Hong SD Reynolds S Watkins E Fuchs BR Stripp, Am J Physiol Lung Cell Mol Physiol 2004 286 643 L649 10.1152/ajplung.00155.2003 12871857
14. Aquaporin-3 expression in human fetal airway epithelial progenitor cells. A Avril-Delplanque I Casal N Castillon J Hinnrasky E Puchelle B Peault, Stem Cells 2005 23 992 1001 10.1634/stemcells.2004-0197 16043462
15. Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties. R Hajj T Baranek R Le Naour P Lesimple E Puchelle C Coraux, Stem Cells 2007 25 139 148 10.1634/stemcells.2006-0288 17008423
16. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. KU Hong SD Reynolds A Giangreco CM Hurley BR Stripp, Am J Respir Cell Mol Biol 2001 24 671 681 11415931
17. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. A Giangreco SD Reynolds BR Stripp, Am J Pathol 2002 161 173 182 12107102
18. Identification of bronchioalveolar stem cells in normal lung and lung cancer. CF Kim EL Jackson AE Woolfenden S Lawrence I Babar S Vogel D Crowley RT Bronson T Jacks, Cell 2005 121 823 835 10.1016/j.cell.2005.03.032 15960971
19. Isolation of stem/progenitor cells from normal lung tissue of adult humans. A Tesei W Zoli C Arienti G Storci AM Granato G Pasquinelli S Valente C Orrico M Rosetti I Vannini A Dubini D Dell'Amore D Amadori M Bonafe, Cell Prolif 2009 42 298 308 10.1111/j.1365-2184.2009.00594.x 19438897
20. Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. D Medici ED Hay BR Olsen, Mol Biol Cell 2008 19 4875 4887 10.1091/mbc.E08-05-0506 18799618
21. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. AA Mailleux R Kelly JM Veltmaat SP De Langhe S Zaffran JP Thiery S Bellusci, Development 2005 132 2157 2166 10.1242/dev.01795 15800000
22. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. PM Del Moral FG Sala D Tefft W Shi E Keshet S Bellusci D Warburton, Dev Biol 2006 290 177 188 10.1016/j.ydbio.2005.11.022 16375885
23. Ciliated cells differentiated from mouse embryonic stem cells. Y Nishimura TS Hamazaki S Komazaki S Kamimura H Okochi M Asashima, Stem Cells 2006 24 1381 1388 10.1634/stemcells.2005-0464 16410384
24. Following damage, the majority of bone marrow derived airway cells express an epithelial marker. H MacPherson PA Keir CJ Edwards S Webb J Dorin, Respir Res 2006 7 145 10.1186/1465-9921-7-145 17177981
25. Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury. BN Gomperts JA Belperio PN Rao SH Randell MC Fishbein MD Burdick RM Strieter, J Immunol 2006 176 1916 1927 16424223
26. Keratinocyte growth factor improves repair in the injured tracheal epithelium. BN Gomperts JA Belperio MC Fishbein MP Keane MD Burdick RM Strieter, Am J Respir Cell Mol Biol 2007 37 48 56 10.1165/rcmb.2006-0384OC 17332441
27. Novel strategy to engineer trachea cartilage graft with marrow mesenchymal stem cell macroaggregate and hydrolyzable scaffold. L Liu W Wu X Tuo W Geng J Zhao J Wei X Yan W Yang L Li F Chen, Artif Organs 2010 34 426 433 10.1111/j.1525-1594.2009.00884.x 20633157
28. Coculture of mesenchymal stem cells and respiratory epithelial cells to engineer a human composite respiratory mucosa. C Le Visage B Dunham P Flint KW Leong, Tissue Eng 2004 10 1426 1435 15588402
29. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. T Go P Jungebluth S Baiguero A Asnaghi J Martorell H Ostertag S Mantero M Birchall A Bader P Macchiarini, J Thorac Cardiovasc Surg 2010 139 437 443 10.1016/j.jtcvs.2009.10.002 19995663
30. Regeneration of the trachea using a bioengineered scaffold with adipose-derived stem cells. T Suzuki K Kobayashi Y Tada Y Suzuki I Wada T Nakamura K Omori, Ann Otol Rhinol Laryngol 2008 117 453 463 18646443
31. A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells. K Kobayashi T Suzuki Y Nomoto Y Tada M Miyake A Hazama I Wada T Nakamura K Omori, Biomaterials 2010 31 4855 4863 10.1016/j.biomaterials.2010.02.027 20347137
32. Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. YS Chang W Oh SJ Choi DK Sung SY Kim EY Choi S Kang HJ Jin YS Yang WS Park, Cell Transplant 2009 18 869 886 10.3727/096368909X471189 19500472
33. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Y Moodley D Atienza U Manuelpillai CS Samuel J Tchongue S Ilancheran R Boyd A Trounson, Am J Pathol 2009 175 303 313 10.2353/ajpath.2009.080629 19497992
34. Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. J Liang F Gu H Wang B Hua Y Hou S Shi L Lu L Sun, Nat Rev Rheumatol 2010 6 486 489 10.1038/nrrheum.2010.80 20517294
35. Isolation of amniotic stem cell lines with potential for therapy. P De Coppi G Bartsch Jr MM Siddiqui T Xu CC Santos L Perin G Mostoslavsky AC Serre EY Snyder JJ Yoo ME Furth S Soker A Atala, Nat Biotechnol 2007 25 100 106 10.1038/nbt1274 17206138
36. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. G Carraro L Perin S Sedrakyan S Giuliani C Tiozzo J Lee G Turcatel SP De Langhe B Driscoll S Bellusci P Minoo A Atala RE De Filippo D Warburton, Stem Cells 2008 26 2902 2911 10.1634/stemcells.2008-0090 18719226
37. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. K Takahashi S Yamanaka, Cell 2006 126 663 676 10.1016/j.cell.2006.07.024 16904174
38. Mouse induced pluripotent stem cells. E Geoghegan L Byrnes, Int J Dev Biol 2008 52 1015 1022 10.1387/ijdb.082640eg 18956334
39. Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. L Vallier T Touboul S Brown C Cho B Bilican M Alexander J Cedervall S Chandran L Ahrlund-Richter A Weber RA Pedersen, Stem Cells 2009 27 2655 2666 10.1002/stem.199 19688839
40. Disease-specific induced pluripotent stem cells. IH Park N Arora H Huo N Maherali T Ahfeldt A Shimamura MW Lensch C Cowan K Hochedlinger GQ Daley, Cell 2008 134 877 886 10.1016/j.cell.2008.07.041 18691744
41. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. JM Polo S Liu ME Figueroa W Kulalert S Eminli KY Tan E Apostolou M Stadtfeld Y Li T Shioda S Natesan AJ Wagers A Melnick T Evans K Hochedlinger, Nat Biotechnol 2010 28 848 855 10.1038/nbt.1667 20644536
42. Epigenetic memory in induced pluripotent stem cells. K Kim A Doi B Wen K Ng R Zhao P Cahan J Kim MJ Aryee H Ji LI Ehrlich A Yabuuchi A Takeuchi KC Cunniff H Hongguang S McKinney-Freeman O Naveiras TJ Yoon RA Irizarry N Jung J Seita J Hanna P Murakami R Jaenisch R Weissleder SH Orkin IL Weissman AP Feinberg GQ Daley, Nature
43. Senescence impairs successful reprogramming to pluripotent stem cells. A Banito ST Rashid JC Acosta S Li CF Pereira I Geti S Pinho JC Silva V Azuara M Walsh L Vallier J Gil, Genes Dev 2009 23 2134 2139 10.1101/gad.1811609 19696146
44. The Ink4/Arf locus is a barrier for iPS cell reprogramming. H Li M Collado A Villasante K Strati S Ortega M Cãamero MA Blasco M Serrano, Nature 2009 460 1136 1139 10.1038/nature08290 19668188
45. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. H Hong K Takahashi T Ichisaka T Aoi O Kanagawa M Nakagawa K Okita S Yamanaka, Nature 2009 460 1132 1135 10.1038/nature08235 19668191
46. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. S Eminli A Foudi M Stadtfeld N Maherali T Ahfeldt G Mostoslavsky H Hock K Hochedlinger, Nat Genet 2009 41 968 976 10.1038/ng.428 19668214
47. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. T Kawamura J Suzuki YV Wang S Menendez LB Morera A Raya GM Wahl JC Belmonte, Nature 2009 460 1140 1144 10.1038/nature08311 19668186
48. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. J Utikal JM Polo M Stadtfeld N Maherali W Kulalert RM Walsh A Khalil JG Rheinwald K Hochedlinger, Nature 2009 460 1145 1148 10.1038/nature08285 19668190
49. Transforming growth factor-beta1 increases airway wound repair via MMP-2 upregulation: a new pathway for epithelial wound repair? E Lechapt-Zalcman V Prulière-Escabasse D Advenier S Galiacy C Charrière-Bertrand A Coste A Harf MP d'Ortho E Escudier, Am J Physiol Lung Cell Mol Physiol 2006 290 1277 L1282 10.1152/ajplung.00149.2005 16414983
50. Biomaterials and scaffold design: key to tissue-engineering cartilage. J Raghunath J Rollo KM Sales PE Butler AM Seifalian, Biotechnol Appl Biochem 2007 46 73 84 10.1042/BA20060134 17227284
51. Recombinant protein-co-PEG networks as cell-adhesive and proteolytically degradable hydrogel matrixes. Part I: Development and physicochemical characteristics. SC Rizzi JA Hubbell, Biomacromolecules 2005 6 1226 1238 10.1021/bm049614c 15877337
52. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. J Zhu, Biomaterials 2010 31 4639 4656 10.1016/j.biomaterials.2010. 02.044 20303169
53. An animal model study for tissue-engineered trachea fabricated from a biodegradable scaffold using chondrocytes to augment repair of tracheal stenosis. M Komura H Komura Y Kanamori Y Tanaka K Suzuki M Sugiyama S Nakahara H Kawashima A Hatanaka K Hoshi Y Ikada Y Tabata T Iwanaka, J Pediatr Surg 2008 43 2141 2146 10.1016/j.jpedsurg.2008.08.038 19040922
54. Sequential release of bioactive IGF-I and TGF-beta 1 from PLGA microsphere-based scaffolds. A Jaklenec A Hinckfuss B Bilgen DM Ciombor R Aaron E Mathiowitz, Biomaterials 2008 29 1518 1525 10.1016/j.biomaterials.2007.12.004 18166223
55. The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions. M Morgelin D Heinegard J Engel M Paulsson, Biophys Chem 1994 50 113 128 10.1016/0301-4622(94)85024-0 8011926
56. Functions of hyaluronan in wound repair. WY Chen G Abatangelo, Wound Repair Regen 1999 7 79 89 10.1046/j.1524-475X.1999.00079.x 10231509
57. Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. C Chung JA Burdick, Tissue Eng Part A 2009 15 243 254 10.1089/ten.tea.2008.0067 19193129
58. Hyalograft C: Hyaluronan-based scaffolds in tissue-engineered cartilage. E Tognana A Borrione C De Luca A Pavesio, Cells Tissues Organs 2007 186 97 103 10.1159/000102539 17489021
59. Tissue-engineered allograft tracheal cartilage using fibrin/hyaluronan composite gel and its in vivo implantation. DY Kim J Pyun JW Choi JH Kim JS Lee HA Shin HJ Kim HN Lee BH Min HE Cha CH Kim, Laryngoscope 2010 120 30 38 10.1002/lary.21108 19877186
60. Hyaluronan-based scaffolds to tissue-engineer cartilage implants for laryngotracheal reconstruction. M Weidenbecher JH Henderson HM Tucker JZ Baskin A Awadallah JE Dennis, Laryngoscope 2007 117 1745 1749 10.1097/MLG. 0b013e31811434ae 17690606
61. Fabrication of a neotrachea using engineered cartilage. M Weidenbecher HM Tucker A Awadallah JE Dennis, Laryngoscope 2008 118 593 598 10.1097/MLG.0b013e318161f9f8 18197138
62. Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstruction. DA Gilpin MS Weidenbecher JE Dennis, Laryngoscope 2010 120 612 617 10.1002/lary.20750 20058322
63. Differentiated and functional human airway epithelium regeneration in tracheal xenografts. F Dupuit D Gaillard J Hinnrasky E Mongodin S de Bentzmann E Copreni E Puchelle, Am J Physiol Lung Cell Mol Physiol 2000 278 165 L176 10645904
64. Human airway xenograft models of epithelial cell regeneration. E Puchelle B Peault, Respir Res 2000 1 125 128 10.1186/rr21 11667974
65. Cell delivery in regenerative medicine: the cell sheet engineering approach. J Yang M Yamato K Nishida T Ohki M Kanzaki H Sekine T Shimizu T Okano, J Control Release 2006 116 193 203 10.1016/j.jconrel.2006.06.022 16890320
66. Regeneration of a well-differentiated human airway surface epithelium by spheroid and lentivirus vector-transduced airway cells. N Castillon A Avril-Delplanque C Coraux C Delenda B Peault O Danos E Puchelle, J Gene Med 2004 6 846 856 10.1002/jgm.570 15293343
67. Tissue engineering for regeneration of the tracheal epithelium. Y Nomoto T Suzuki Y Tada K Kobayashi M Miyake A Hazama I Wada S Kanemaru T Nakamura K Omori, Ann Otol Rhinol Laryngol 2006 115 501 506 16900804
68. A scanning electron microscopic study of in vivo tissue engineered respiratory epithelium in sheep. MY Heikal BS Aminuddin J Jeevanan HC Chen S Sharifah BH Ruszymah, Med J Malaysia 2008 63 Suppl A 34 19024970
69. Developing a tissue-engineered model of the human bronchiole. C Miller S George L Niklason, J Tissue Eng Regen Med 20603896
70. Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury. AL Leblond P Naud V Forest C Gourden C Sagan B Romefort E Mathieu B Delorme C Collin JC Pages L Sensebe B Pitard P Lemarchand, Hum Gene Ther 2009 20 1329 1343 10.1089/hum.2009.035 19606934
71. Experimental generation of a tissue-engineered functional and vascularized trachea. T Walles B Giere M Hofmann J Schanz F Hofmann H Mertsching P Macchiarini, J Thorac Cardiovasc Surg 2004 128 900 906 15573075
72. Potential application of mesenchymal stem cells in acute lung injury. JW Lee N Gupta V Serikov MA Matthay, Expert Opin Biol Ther 2009 9 1259 1270 10.1517/14712590903213651 19691441
73. Mesenchymal stem cells and inflammatory lung diseases. SS Iyer C Co M Rojas, Panminerva Med 2009 51 5 16 19352305
74. Adult mesenchymal stem cells: an innovative therapeutic for lung diseases. TL Bonfield AI Caplan, Discov Med 2010 9 337 345 20423678
75. Minimally cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury. M Kumamoto T Nishiwaki N Matsuo H Kimura K Matsushima, Eur Respir J 2009 34 740 748 10.1183/09031936.00128508 19324956
76. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. T van Haaften R Byrne S Bonnet GY Rochefort J Akabutu M Bouchentouf GJ Rey-Parra J Galipeau A Haromy F Eaton M Chen K Hashimoto D Abley G Korbutt SL Archer B Thébaud, Am J Respir Crit Care Med 2009 180 1131 1142 10.1164/rccm.200902-0179OC 19713449
77. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. K Nemeth A Keane-Myers JM Brown DD Metcalfe JD Gorham VG Bundoc MG Hodges I Jelinek S Madala S Karpati E Mezey, Proc Natl Acad Sci USA 2010 107 5652 5657 10.1073/pnas.0910720107 20231466
78. Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice. D Wang JE Morales DG Calame JL Alcorn RA Wetsel, Mol Ther 2010 18 625 634 10.1038/mt.2009.317 20087316
79. Regeneration of tracheal epithelium utilizing a novel bipotential collagen scaffold. Y Tada T Suzuki T Takezawa Y Nomoto K Kobayashi T Nakamura K Omori, Ann Otol Rhinol Laryngol 2008 117 359 365 18564533
80. Experimental regeneration of canine larynx: a trial with tissue engineering techniques. M Yamashita K Omori S Kanemaru A Magrufov Y Tamura H Umeda M Kishimoto T Nakamura J Ito, Acta Otolaryngol Suppl 2007 557 66 72 10.1080/00016480601068014 17453449
81. Regenerative medicine of the trachea: the first human case. K Omori T Nakamura S Kanemaru R Asato M Yamashita S Tanaka A Magrufov J Ito Y Shimizu, Ann Otol Rhinol Laryngol 2005 114 429 433 16042099
82. Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea. K Omori Y Tada T Suzuki Y Nomoto T Matsuzuka K Kobayashi T Nakamura S Kanemaru M Yamashita R Asato, Ann Otol Rhinol Laryngol 2008 117 673 678 18834070
83. Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach. A Bader P Macchiarini, J Cell Mol Med 2010 14 1877 1889 10.1111/j.1582-4934.2010.01073.x 20406329
84. Sox17 promotes cell cycle progression and inhibits TGF-/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. AW Lange AR Keiser JM Wells AM Zorn JA Whitsett, PLoS One 2009 4 5711 10.1371/journal.pone. 0005711 19479035
85. Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. C Gontan A de Munck M Vermeij F Grosveld D Tibboel R Rottier, Dev Biol 2008 317 296 309 10.1016/j.ydbio.2008.02.035 18374910
86. Novel therapeutic strategies for acute lung injury induced by lung damaging agents: The potential role of growth factors as treatment options. CD Lindsay, Hum Exp Toxicol
87. The non-haematopoietic biological effects of erythropoietin. MO Arcasoy, Br J Haematol 2008 141 14 31 10.1111/j.1365-2141.2008.07014.x 18324962
88. Recombinant human erythropoietin plays a pivotal role as a topical stem cell activator to reverse effects of damage to the skin in aging and trauma. A Bader HG Machens, Rejuvenation Res 20695821