Capsaicin as new orally applicable gastroprotective and therapeutic drug alone or in combination with nonsteroidal anti-inflammatory drugs in healthy human subjects and in patients

Progress in Drug Research

Volumn 68, Issue , 2014, Pages 209-258

  Mózsik, Gyula ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; DICLOFENAC; GLUCAGON; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SUBSTANCE P; VANILLOID RECEPTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CLINICAL PHARMACOLOGY; COLORECTAL POLYP; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DIGESTIVE SYSTEM ULCER; DRUG EFFECT; FEMALE; GASTRIC TRANSMUCOSAL POTENTIAL DIFFERENCE; GASTRITIS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; GLUCAGON RELEASE; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; SENSORY NERVE; STOMACH EMPTYING; STOMACH HEMORRHAGE; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH PROTECTION; STOMACH SECRETION; SUGAR LOADING TEST; THROMBOCYTE AGGREGATION; VAGUS NERVE;

ADMINISTRATION, ORAL; ADULT; AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPSAICIN; CYTOPROTECTION; GASTRIC ACID; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; GASTROINTESTINAL HEMORRHAGE; GLUCOSE; HUMANS; MIDDLE AGED; NEURONS, AFFERENT; TRPV CATION CHANNELS;

EID: 84901199988     PISSN: 0071786X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-0348-0828-6_9     Document Type: Article

References (77)

1. Abdel-Salam OME, Debreceni A, Mózsik Gy (1999) Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents. J Physiol Paris 93:443-4544
2. Abdel-Salam OME, Czimmer J, Debreceni A, Mózsik Gy (2001) Gastric mucosal integrity: Gastric mucosal blood flow and microcirculation. An overview. J Physiol Paris 95:105-1277
3. Aijoka H, Miyake H, Matsuura N (2000) Effect of FRG-8813, a new-Type histamine H2-receptor antagomist, on the recurrence of gastric ulcer healing by drug treatment. Pharmacology 61:83-900
4. Aijoka H, Matsuura N, Miyake H (2002) High quality of ulcer healing in rats by lafutidine and new-Type histamine H2-receptor antagonist: Involvement of capsaicin of sensitive sensory neurons. Inflammopharmacology 10:483-4933
5. Antal L, Mózsik Gy, Jávor T, Krausz M (1965) The electrolyte content of gastric juice after prolonged atropine treatment. In: Magyar I (ed) Acta tertii conventus medicinae internae hungarici. Gastroenterologia. Akadémiai Kiadó, Budapest, pp 167-1699
6. Bernard BK,Tsubuku S, Kayhara T, Maeda K, Hanada M, Nakamura T, Shirai Y, Nakayaha A, Ueno S, Mihara H (2008) Studies of the toxicological potential of capsaicinoids.X. Safety assessment and pharmacokinetics of capsaicinoids in healthy male vlonteers after single oral ingestion of CH-19 sweet extract. Int J Toxicol 27(Suppl 3):137-1477
7. Boros B, Dornyei Á, Felinger A (2008) Determination of capsaicin and dihydrocapsaicin in dog plasma by liquid chromatography-Mass Spectography (analytical method report). PTE TTK Analitikai Kémiai Tanszék, Pécs
8. Buck SH, Burks TF (1986) The neuropharmacology of capsaicin: A review of some recent observation. Pharmacol Rev 38:179-2266
9. Caterina MJ, Schumacher MA, Tominaga H, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: A heat-Activated ion channel in the pain pathway. Nature 389:816-8244
10. Chaiyasit E, Khovidhunkit W, Wittayertpanya S (2009) Pharmacokinetic and the effect of capsaicin in Capsicum flourescens on decreasing plasma glucose level. J Med Assoc Thai 92:108-1133
11. Csáky TZ (1969) Introduction to general pharmacology. Appleton-century-craft educational division. Meredith Corporation, New York, pp 17-344
12. Czimmer J, Szabó IL, Szolcsányi J, Mózsik Gy (2013) Capsaicin-sensitive afferentation represents a new mucosal defensive neural pathway system in the gastric mucosa in patients with chronic gastritis. In: Mozsik Gy (ed) Current topics in gastritis-2012. INTECH Publishers, Rijeka, pp 61-755
13. Debreceni A, Abdel-Salam OME, Figler M, Juricskay I, Szolcsányi J, Mózsik Gy (1999) Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoid acid breath test. J Physiol Paris 93:455-4600
14. Dömötör A, Zs Peidl, Vincze Á, Hunyady B, Szolcsányi J, Gy Szekeres, Mózsik Gy (2005) Immunohistochemical distribution of vanilloid receptor, calcitonin-gene related peptide and substance P in gastrointestinal mucosa of patients with different gastrointestinal disorders. Inflammopharmacology 13:161-1777
15. Dömötör A, Kereskay L, Gy Szekeres, Hunyady B, Szolcsányi J, Mózsik Gy (2006a) Participation of capsaicin sensitive afferent nerves in the gastric mucosa of patients with helicobacter pylori-positive or-negative chronic gastritis. Dig Dis Sci 52:411-4177
16. Dömötör A, Szolcsányi J, Mózsik Gy (2006b) Capsaicin and glucose absorption and utilization in healthy human subjects. Eur J Pharmacol 534:280-2833
17. Fisher MA, Hunt JN (1976) A sensitive method for measuring haemoglobin in the gastric juice. Digestion 14:409-4144
18. Gabella G, Pease H (1973) Number of axons in the abdominal vagus of the rat. Brain Res 58:465-4699
19. Grijalva CV, Novin D (1990) The role of hypothalamus and dorsal vagal complex in gastrointestinal function an pathophysiology. Ann N Y Acad Sci 597:207-2211
20. Hollander F (1934) The component of gastric secretion. Am J Dig Dis Sci 1:319-3299
21. Holzer P (1998) Neural emergency system in the stomachs. Gastroenterology 114:823-8399
22. Holzer P (1999) Capsaicin cellular targets. Mechanisms of action, as selectivity for thin sensory neurons. Phamacol Rev 43:143-2011
23. Holzer P (2013) Transient receptor potential (TRP) channels as drug targets for disesases of the gastrointestional system. Pharmacol Ther 131: 142-1700
24. Holzer P, Lippe IL (1988) Stimulation of afferent nerve endings by intragastric capsaicin against ethanol-induced damage of gastric mucosa. Neuroscinece 27:981-9877
25. Holzer P, Sametz W (1986) Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurones. Gastroenterology 91:975-9811
26. Hossenbocus A, Fitzpatrick P, Colin-Jones DG (1975) Measurement of gastric potential difference at endoscopy. Gut 14:410-4155
27. Inui T, Kinoshita J, Yamahuchi A, Yamatani T, Chiba T (1991) Linkage between capsaicin-stimulated calcitonin gene-related peptide and somatostatin release in the rat stomach. Am J Physiol 261:G770-G7744
28. Jancsó N, Jancsó-Gábor A, Szolcsányi J (1967) Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Brit J Pharmacol 31:138-1511
29. Jancsó N, Jancsó-Gábor A, Szolcsányi J (1968) The role of sensory nerves endings in the neurogen inflammation induced in human skin and in the eye and paw of the rat. Brit J Pharmacol 33:32-411
30. Jancsó-Gábor A, Szolcsányi J, Jancsó N (1970) Irreversible impairment of the irregulation induced by capsaicin and similar pungent substances in rat and guinea-pigs. J Physiol London 206:495-5077
31. Karádi O, Mózsik Gy (2000) Surgical and Chemical Vagotomy on the Gastrointestinal Mucosal Defense. Akadémiai Kiadó, Budapest
32. Kawai S, Nishida S, Kato M, Furumaya Y, Okamoto R, Koshino T, Mizushima Y (1998) Comparison of cyclooxygenase-1 and-2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol 347:87-944
33. Lakner L, Dömötör A, Cs Tóth, Szabo IL, Mecker Á, Hajós R, Kereskay L, Gy Szekeres, Döbrönte Z, Mózsik Gy (2011) Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with helicobacter pylori positive gastritis. World J Gastrointest Pharmacol Ther 2:36-411
34. Marfertheimer P, Megraud F, 0'Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ (2007) Current concept in the management of Helicobacter pylori infection: The Maastricht III consensus report. Gut 56: 772-7811
35. Mózsik Gy (2006) Molecular pharmacology and biochemistry of gastroduodenal mucosal damage and protection. In: Mózsik Gy (ed) Discoveries in gastroenterology: From basic research to clinical perspectives (1960-2005). Akadémiai Kiadó, Budapest, pp 139-2244
36. Mózsik Gy (2010) Gastric cytoprotection 30 years after its discovery by André Robert: A personal perspective. Inflammopharmacology 18:209-2211
37. Mózsik Gy, Jávor T, Dobi S (1965) Clinical-pharmaological analysis of long term parasympatholytic treatment. In: Magyar I (ed) Acta tertii conventus medicinae internae Hungarici. Gastroenterologia. Akadémiai Kiadó, Budapest, pp 709-7155
38. Mózsik Gy, Abdel-Salam OME, Szolcsányi J (1997) Capsaicin-sensitive afferent nerves in gastric mucosal damage and protection. Akadémiai Kiadó, Budapest Mózsik
39. Gy, Sarlos P, Racz I, Szolcsányi J (2003) Evidence for the direct protective effect of capsaicin in human healthy subjects. Gastroenterology 124(Suppl 1):A-4544
40. Mózsik Gy, Belágyi J, Szolcsányi J, Pár G, Pár A, Rumi Gy, Rácz I (2004a) Capsaicin-sensitive afferent nerves and gastric mucosal protection on human healthy subjects. A critical overview. In: Takeuchi K, Mozsik Gy (eds) Mediators in gastrointestinal protection and repair. Research Signpost, Kerala, pp 43-622
41. Mózsik Gy, Pár A, Pár G, Juricskay I, Figler M, Szolcsányi J (2004a) Insight into the molecular pharmacology to drugs acting on the afferent and efferent fibres of vagal nerve in the gastric mucosal protection. In: Sikirič P, Seiwerth P, Mózsik Gy, Arakawa T, Takeuchi K (eds) Proceedings of the 11th international conference on ulcer research. Monduzzi, Bologna, pp 163-1688
42. Mózsik Gy, Past T, Perjési P, Szolcsányi J (2008) Determination of capsaicin and dihydrocapsaicin content of dog's plasma by HPLC-FLD method. In: Mózsik Gy, Past T, Pejési P, Szolcsány J (eds) Original reports on toxicology of capsaicin.VII. 8 day oral tocicity study of test item capsaicin natural USP 37 in beagle dogs (final report). LAB International research Centre Hungary Ltd. Veszprém, Hungary by the date of final repot 13 June 2008. Study Code: 07/496-100 K, pp 1-35 text and 190 pages in Appendices (Appendix 2.11) pp 1-377
43. Mózsik Gy, Szabó IL,Dömötör A (2011b) Approach to role of capsaicin-sensitive afferent nerves in the development and healing in patients with chronic gastritis. In: Tonito P (ed) Gastritis and gastric cancer. New Insights in gastroprotection, diagnosis and treatments. INTECH Publishers, Rijeka, pp 25-466
44. Mózsik Gy, Szabó IL, Czimmer J (2014) Vulnerable points of the Helicobacter pylori story-based on animal and human observations (19752012). In: Buzas Gy (ed) Helicobacter pylori-A Worldwide Perspective 2013. Bentham Science Publishers, Oak Park (in press)
45. Mózsik Gy, Jávor T (1969b) Development of drug cross-Tolerance in patients treated chronically with atropine. Eur J Pharmacol 6:169-1744
46. Mózsik Gy, Jávor T, Dobi S, Petrássy K, Szabó A (1966) Development of "pharmacological denervation phenomenon" in patients treated with atropine. Eur J Pharmacol 1:391-3955
47. Mózsik Gy, Berstad A, Myren J, Setekleiv J (1969a) Absorption and urinary excretion oxyphencyclamin HCI in patients before and after a prolonged oxyphencyclimide treatment. Med Exp 19:10-166
48. Mózsik Gy, Moron F, Jávor T (1982) Cellular mechanisms of the development of gastric mucosal damage and of gastro protection induced by prostacyclin in rats. A pharmacological study. Prostagland Leukot Med 9:71-844
49. Mózsik Gy, Hunyady B, Garamszegi M, Németh A, Pakodi F, Vincze A (1994) Dynamism of cytoprotective and antisecretory drugs in patients with unhealed gastric and duodenal ulcers. J Gastroenterol Hepatol 9:S88-S922
50. Mózsik Gy, Debreceni A, Abdel-Salam OME, Szabó I, Figler M, Ludány A, Juricskay I, Szolcsányi J (1999) Small doses capsaicin given intragastrically inhibit gastric basal gastric secretion in healthy human subjects. J Physiol Paris 93:433-4366
51. Mózsik Gy, Vincze Á, Szolcsányi J (2001) Four responses of capsaicin sensitive primary afferent neurons to capsaicin and its analog. Gastric acid secretion, gastric mucosal damage and protection. J Gastroenterol Hepatol 16:193-1977
52. Mózsik Gy, Rácz I, Szolcsányi J (2005) Gastroprotection induced by capsaicin in human healthy subjects. World J Gastroenterol 11:5180-51844
53. Mózsik Gy, Szolcsányi J, Dömötör A (2007) Capsaicin research as a new tool to approach of the human gastrointestinal physiology, pathology and pharmacology. Inflammopharmacology 15:232-2455
54. Mózsik Gy, Dömötör A, Past T, Vas V, Perjési P, Kuzma M, Gy Blazics, Szolcsányi J (2009a) Capsaicinoids: From the plant cultivation to the production of the human medical therapy. Akadémiai Kiadó, Budapestt
55. Mózsik Gy, Past T, Abdel-Salam OME, Kuzma M, Perjési P (2009b) Interdisciplinary review for correlation between the plant origin capsaicinoids, nonsteroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings. Inflammopharmacology 17:113-1500
56. Mózsik Gy, Past T, Dömötör A, Kuzma M, Perjési P (2010) Production of orally applicable new drug or drug combinations from natural origin capsaicinoids for human medical therapy. Curr Pharm Des 16:1197-12088
57. Mózsik Gy, Szabo IL, Czimmer J (2011a) Approaches to gastrointestinal cytoprotection: From isolated cell, via animal experiments to healthy human subjects and patients with different gastrointestinal disorders. Curr Pharm Des 17:1556-15722
58. Myren J (1968) Gastric secretion following stimulation with histamine, histology and gastrin in man. In: Semb L, Myren J (eds) The physiology of gastric secretion. Universitetforlaget, Oslo, pp 413-4288
59. Nagy L, Mózsik Gy, Feledi É, Cs Ruzsa, Zs Vezekényi, Jávor T (1984) Gastric microbleeding measurements during 1 day treatment with indomethacin and indomethacin plus sodium salicylate (1:10) in patients. Acta Physiol Hung 64:373-3777
60. O'Neill J, Brock C, Olesen E, Andersen T, Nilsson M, Dickenson AH (2012) Unravelling the mystery of capsaicin: A tool to understand and treat pain. Pharmacol Rev 64:939-9977
61. Onodera S, Shibata M, Tanaka M (1999) Gastroprotective mechanisms of lafutidine, a novel anti-ulcer drug with histamine H2-receptor antagonist activity, Artneim. Forsch. Drug Res 49:519-5266
62. Patty I, Tárnok F, Simon L, Jávor T, Deák G, Sz Benedek, Kenéz P, Nagy L, Mózsik Gy (1984) A comparative dynamic study of the effectiveness of gastric cytoprotection by the vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (A multiclinical and randomized study). Acta Physiol Hung 64:379-3844
63. Robert A, Nemazis JE, Lancastter C, Hanchar A (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:4433-44433
64. Sarlós P, Rumi Gy, Szolcsányi J, Mózsik Gy, Vincze Á (2003) Capsaicin prevents the indomethacininduced gastric mucosal damage in human healthy subject. Gastroenterology 124(Suppl 1):A-5111
65. Sipos G, Altdorfer K, Pongor É, Chen LP, Fehér E (2006) Neuroimmune link in the mucosa of chronic gastritis with Helicobacter pylori infection. Dig Dis Sci 51:1810-18177
66. Szabo S, Taché Y, Tarnawski A (2012) The "Gastric Cytoprotection" concept of André Robert and the origins of a new series of international symposia. In: Filaretova LP, Takeuchi K (eds) Cell/Tissue injury and cytoprotection/organoprotection in the gastrointestinal tract. Front gastrointest res, vol 30. Karger, Basel, pp 1-233
67. Szabo IL, Czimmer J, Szolcsányi J, Mózsik Gy (2013) Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced hastric mucosal damage in human healthy subjects (mini review). Curr Pharm Des 19:84-899
68. Szállasi A, Blumberg M (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51:159-2111
69. Szolcsányi J (1984) Capsaicin sensitive chemoprotective neural system with dual sensory-Afferent function. In: Chalh LA, Szolcsányi J, Lembeck F (eds) Antidromic vasodilatation and neurogenic inflammation. Budapest, Akadémiai Kiadó, pp 27-566
70. Szolcsányi J (1997) A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J Physiol Paris 73:251-2599
71. Szolcsányi J (2004) Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptide 38:377-3844
72. Szolcsányi J, Barthó L (1981) Impaired defense mechanisms to peptic ulcer in the capsaicindesensitized rat. In: Mózsik Gy, Hänninen O, Jávor T (eds) Advances in physiological sciences, gastrointestinal defense mechanisms, vol 29. Pergamon Press, Oxford-Akadémiai Kiadó, Budapest, pp 39-511
73. Takeuchi K (2006) Unique profile of Lafutidine: A novel histamine H2-receptor antagonist: Mucosal protection throughout GI mucosal mediated by capsaicin-sensitive afferent nerves. Acta Pharmacol. (Sinica Suppl):27-355
74. Tárnok F, Jávor T, Mózsik Gy, Nagy L, Patty I, Gy Rumi, Solt I (1979) A prospective multiclinical study comparing the effects of placebo, carbenoxolone, atropine cimetidine in patients with duodenal ulcer. Drugs Exp Clin Res 5:157-1666
75. Tárnok F, Deák G, Jávor T, Mózsik Gy, Nagy L, Patty I (1983) Effect of combination atropine and cyproheptadine and atropine + carbenoxolone in duodenal ulcer therapy. Int J Tiss React 5:315-3211
76. Vincze A, Szekeres Gy, Király Á, Bódis B, Mózsik Gy (2004) The immunohistochemical distribution of capsaicin receptor, CGRP and SP in the human gastric mucosa in patients with different gastric disorders. In: Sikirič, Seiwert S, Mózsik Gy, Arakawa T, Takeuchi K (eds) Proceedings of 11th international congress of ulcer resarch. Monduzzi, Bologna, pp 149-1533
77. Wildersmith CH, Ernst T, Gennoni M, Zeyen B, Halter F, Merki HS (1990) Tolerance to H2-receptor antagonist. Dig Dis Sci 35:976-9833