The 'gastric cytoprotection' concept of Andre Robert and the origins of a new series of international symposia

Frontiers of Gastrointestinal Research

Volumn 30, Issue , 2012, Pages 1-23

  Szabo, Sandor ^a,c   Tache, Yvette ^b,e   Tarnawski, Andrzej ^a,d  

^a VA Medical Centers   (United States)

^b VA Medical Centers   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTACID AGENT; CIMETIDINE; IBUPROFEN; INDOMETACIN; PROSTAGLANDIN;

CELL PROTECTION; CONFERENCE PAPER; DRUG MEGADOSE; DUODENUM ULCER; ELECTRON MICROSCOPY; EPITHELIUM CELL; HISTOLOGY; HUMAN; INFLAMMATION; KIDNEY TRANSPLANTATION; NONHUMAN; ORGAN PRESERVATION; PRIORITY JOURNAL; STOMACH ACID SECRETION; STOMACH EMPTYING; STOMACH LESION; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; SYMPOSIUM; TISSUE INJURY;

EID: 84863752184     PISSN: 03020665     EISSN: 16623754     Source Type: Book Series    
DOI: 10.1159/000338742     Document Type: Conference Paper

References (90)

1. Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979;77:433-443.
2. Robert A: Cytoprotection by prostaglandins. Gastroenterology 1979;77:761-767.
3. Robert A: Personal communications.
4. Guth PH, Aures D, Paulsen G: Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine and probanthine. Gastroenterology 1979;76:88-93.
5. Szabo S, Gallagher G, Horner HC, Frankel PW, Underwood RH, Konturek SJ, Brzozowski T, Trier JS: Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls and cimetidine in the rat. Gastroenterology 1983;85:1384-1390.
6. Szabo S, Gallagher GT, Horner HC, Frankel PW, Trier JS: Gastric cytoprotection: role of adrenal cortex and sulfhydryl-containing chemicals. Gastroenterology 1980;78:1273.
7. Szabo S, Trier JS, Frankel PW: Sulfhydryl compounds may mediate cytoprotection. Science 1981; 214:200-202.
8. Lacy ER, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 1982;83:619-625.
9. Lacy ER, Ito S: Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest 1984; 51:573-583.
10. Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985;88:228-236.
11. Trier JS, Szabo S, Allan CH: Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine. Gastroenterology 1987;92:13-22.
12. Miller TA: Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am J Physiol Gastrointest Liver Physiol 1983;245:G601-G623.
13. Szabo S, Szelenyi I: Cytoprotection in gastrointestinal pharmacology. Trends in Pharmacol Sci 1987; 8:149-154.
14. Robert A: Antisecretory and antiulcer properties of prostaglandins. Compr Ther 1978;4:10-13.
15. Robert A, Nezamis JE, Lancaster C: Duodenal ulcers produced in rats by propionitrile: factors inhibiting and aggravating such ulcers. Toxicol Appl Pharmacol 1975;31:201-207.
16. Tarnawski A, Stachura J, Ivey KJ, Mach T, Klimczyk B, Bogdal J: Protection by prostaglandin against ethanol-induced gastric mucosal damage in man. An endoscopic and histologic assessment. Gastroenterology 1981;80:1300.
17. Tarnawski A, Stachura J, Ivey KJ, Mach T, Bogdal J, Klimczyk B: Ethanol-induced duodenal lesions in man. Protective effect of prostaglandin. Prostaglandins 1981;21(suppl):147-153.
18. Tarnawski A, Hollander D, Stachura J, Klimczyk B, Mach T, Bogdal J: Prostaglandin protection of the human gastric mucosa against alcohol-induced injury. Endoscopic, histologic, and functional assessment. Scand J Gastroenterol 1986;21:165-169.
19. Ruppin H, Person B, Robert A, Domschke W: Gastric cytoprotection in man by prostaglandin E2. Scand J Gastroenterol 1981;16:647-652.
20. Stachura J, Tarnawski A, Szczudrawa J, Mach T, Bogdal J, Kirchmayer S: Histochemistry of cytoprotection of the rat liver. Folia Histochem Cytochem 1980;18:225-226.
21. Tarnawski A, Stachura J, Szczudrawa J, Bigaj M, Mach T: Cytoprotection of the liver by prostaglandins; in Van Maercke YMF, Van Moer EMJ, Pelckmans PAR (eds): Stomach Diseases -Current Status. Amsterdam, Excerpta Medica, 1981, pp 55-58.
22. Stachura J, Tarnawski A, Ivey KJ, Mach T, Bogdal J, Szczudrawa J, Klimczyk B: Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat. Gastroenterology 1981;81:211-217.
23. Ruwart MJ, Rush BD, Friedle N, Stachura J, Tarnawski A: 16,16-Dimethyl PGE2 protection against ANIT-induced experimental cholangitis in rats. Hepatology 1984;4:658-660.
24. Tarnawski A, Hollander D, Stachura J, Krause WJ: Arachidonic acid protection of gastric mucosa against alcohol injury: Sequential analysis of morphologic and functional changes. J Lab Clin Med 1983;102:34-51.
25. Tarnawski A: Prevention and treatment of gastric mucosal injury with cytoprotective agents. Med J Aust 1985;142:513-517.
26. Tarnawski A, Hollander D, Gergely H, Stachura J: Comparison of antacid, sucralfate, cimetidine and ranitidine in protection of the gastric mucosa against ethanol injury. Am J Med 1985;79:19-23.
27. Tarnawski A, Glick ME, Stachura J, Hollander D, Gergely H: Efficacy of sucralfate and cimetidine in protection of the human gastric mucosa against alcohol injury. Am J Med 1987;83:31-37.
28. Tarnawski A, Stachura J, Hollander D, Sarfeh IJ, Bogdal J: Cellular aspects of alcohol-induced injury and prostaglandin protection of the human gastric mucosa. Focus on the mucosal microvessels. J Clin Gastroenterol 1988;10:535-545.
29. Tarnawski A, Stachura J, Gergely H, Hollander D: Microvascular endothelium -a major target for alcohol injury of the human gastric mucosa. Histochemical and ultrastructural study. J Clin Gastroenterol 1988;10:S53-S64.
30. Tarnawski A, Brzozowski T, Sarfeh IJ, Krause WJ, Ulich TR, Gergely H, Hollander D: Prostaglandin protection of human isolated gastric glands against indomethacin and alcohol injury. Evidence for direct cellular action of prostaglandin. J Clin Invest 1988;81:1081-1089.
31. Pai R, Soreghan BA, Szabo IL, Pavelka M, Baatar D, Tarnawski AS: Prostaglandin E2 transactivates EGF receptor: a novel mechanisms for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 2002;8:289-293.
32. Graham DY, Agrawal NM, Roth SH: Prevention of NSAID-induced gastric ulcer with misoprostol: Multicentre, double-blind, placebo-controlled trial. Lancet 1988;ii:1277-80.
33. Singh J: Prostaglandin release from rat stomach following vagal stimulation or administration of acetylcholine. Eur J Immunol 1980;65:39-48.
34. Tache Y, Vale W, Rivier J, Brown M: Brain regulation of gastric secretion: influence of neuropeptides. Proc Natl Acad Sci USA 1980;77:5515-5519.
35. Yoneda M, Tache Y: Central thyrotropin-releasing factor analog prevents ethanol-induced gastric damage through prostaglandins in rats. Gastroenterology 1992;102:1568-1574.
36. Kato K, Yang H, Tache Y: Low doses of TRH analogue act in the dorsal motor nucleus to induce gastric protection in rats. Am J Physiol 1995;269: R1301-R1307.
37. Yoneda M, Tache Y: Vagal regulation of gastric prostaglandin E2 release by central TRH in rats. Am J Physiol 1993;264:G231-G236.
38. Kato K, Yang H, Tache Y: Role of prostaglandins and calcitonin gene-related peptide in central vagal cholinergic-dependent protection against gastric injury in urethane-anesthetized rats. Digestion 1996;57:322-327.
39. Mozsik Gy, Kiraly A, Garamszegi M, Javor T, Nagy L, Suto G, Toth Gy, Vincze A: Failure of prostacyclin, b-carotene, atropine and cimetidine to produce gastric cyto-and general mucosal protection in surgically vagotomized rats. Life Sci 1991;49:1383-1389.
40. Mozsik Gy: Gastric cytoprotection 30 years after its discovery by Andre Robert: a personal perspective. Inflammopharmacology 2010;18:209-221.
41. Kaneko H, Kaunitz J, Tache Y: Vagal mechanisms underlying gastric protection induced by chemical activation of the raphe pallidus in rats. Am J Physiol 1998;275:G1056-G1062.
42. Kaneko H, Kato K, Ohning G, Tache Y: Medullary thyrotropin-releasing hormone mediates vagaldependent adaptive gastric protection induced by mild acid in rats. Gastroenterology 1995;109:861-865.
43. Martinez V, Barrachina MD, Ohning G, Tache Y: Cephalic phase of acid secretion involves activation of medullary TRH receptor subtype 1 in rats. Am J Physiol Gastrointest Liver Physiol 2002;283: G1310-G1319.
44. Tache Y, Yang H, Miampamba M, Martinez V, Yuan PQ: Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding. Auton Neurosci 2006;125:42-52.
45. Tache Y: Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents. Curr Med Chem 2012;19:35-42.
46. Gyires K, Mullner K, Ronai AZ: Activation of central opioid receptors may induce gastric mucosal defense in the rat. J Physiol (Paris) 2001;95:189-196.
47. Gyires K, Zadori Zs, Shujaa N, Minorics R, Falkay G, Matyus P: Analysis of the role of central and peripheral alpha2-adrenoreceptor subtypes in gastric mucosal defense in the rat. Neurochem Int 2007;51:289-296.
48. Holzer P: Capsaicin: cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev 1991;43:144-202.
49. Szolcsanyi J, Bartho L: Impaired defense mechanism to peptic ulcer in the capsaicin-desensitised rat; in Mozsik Gy, Hanninen D, Javor T (eds): Gastrointestinal Defense Mechanisms. Pergamon, Oxford, 1981, pp 39-51.
50. Flemstrom G: Active alkalinization by amphibian gastric fundic mucosa. Am J Physiol 1977;233:E1-E12.
51. Allen A, Hunter AC, Mall AH: Mucus secretion; in Hollander D, Tarnawski AS (eds): Gastric Cytoprotection. A Clinician Guide. New York, Plenum Medical Book Co, 1989, pp 75-90.
52. Lamont JT, Ventola AS, Mauss EA, Szabo S: Cytoprotective doses of cysteamine and prostaglandin F2? stimulate rat gastric mucin release. Gastroenterology 1983;84:306-313.
53. Szabo S, Nagy L, Plebani M: Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin Chim Acta 1992;206:95-105.
54. Lichtenberger LM, Graziani LA, Dial EJ, Butler BD, Hills BA: Role of surface-active phospholipids in gastric cytoprotection. Science 1983;219:1327-1329.
55. Lanza FL, Marathi UK, Anand BS, Lichtenberger LM: Clinical trial: comparison of ibuprofenphosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients. Aliment Pharm Ther 2008;28:431-442.
56. Cryer B, Bhatt DL, Lanza FL, Dong J-F, Lichtenberger LM, Marathi UK: Low dose aspirin induced ulceration is attenuated by aspirin-phosphatidylcholine: a randomized clinical trial. Am J Gastroenterol 2011;106:272-277.
57. Anand BS, Romero JJ, Sanduja SK, Lichtenberger LM: Evidence that phospholipid association reduces the gastric mucosal toxicity of aspirin in human subjects. Am J Gastroenterol 1999;94:1818-1822.
58. Terano A, Ota S, Mach T, Hiraishi H, Stachura J, Tarnawski A, Ivey KJ: Prostaglandin protects against taurocholate-induced damage to rat gastric mucosal cell culture. Gastroenterology 1987;92:669-677.
59. Nagy L, Morales RE, Beinborn M, Vattay P, Szabo S: Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol 2000;279: G1201-G1208.
60. Pihan G, Majzoubi D, Haudenschild C, Trier JS, Szabo S: Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 1986;91:1415-1426.
61. Leung FW, Robert A, Guth PH: Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. Gastroenterology 1985;88:1948-1953.
62. Lane L, Takeuchi K, Tarnawski A: Gastric mucosal defense and cytoprotection. Bench to bedside. Gastroenterology 2008;135:41-60.
63. Kvietys PR, Twohig B, Danzell J, Specian RD: Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals. Gastroenterology 1990;98:909-920.
64. Pihan G, Regillo C, Szabo S: Free radical and lipid peroxidation in ethanol-or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987;32:1395-1401.
65. Morales RE, Johnson BR, Szabo S: Endothelin induces vascular and mucosal lesions, enhances the injury by HCl/ethanol, and the antibody exerts gastroprotection. FASEB J 1992;6:2354-2360.
66. Whittle BJR, Esplugues JV: Induction of rat gastric damage by the endothelium-derived peptide, endothelin. Br J Pharmacol 1988;95:1011-1013.
67. Wallace JL, Cirini G, DeNucci G, McNight W, MacNaughton GW: Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. Am J Physiol 1989;256:G661-G666.
68. Lambrecht N, Burchert M, Respondek M, Muller KM, Peskaar BM: Role of calcitonin-gene related peptide and nitric oxide in the gastroprotective effect of capsaicin. Gastroenterology 1993;104:1371-1380.
69. Wallace JL, Del Soldato P: The therapeutic potential of NO-NSAIDs. Fundam Clin Pharmacol 2003; 17:11-20.
70. Szabo S, Zetter BR, Tobias J, Pihan G, Raza A: Protection by prostaglandins (PG) and sulfhydryls (SH) against ethanol-induced endothelial injury in vitro and in vivo. Gastroenterology 1987:92;A381.
71. Szabo S, Pihan G, Spill WF, Zetter BR: Cellular approach to cytoprotection: conditional or no protection by prostaglandins (PG) and sulfhydryls (SH) against ethanol-or HCl-induced injury to isolated mucous, parietal and chief cells and cultured endothelial cells. Gastroenterology 1988;94:A451.
72. Pihan G, Szabo S: 16,16-dmPGE2 and thiosulfate decrease gastric mucosal penetration of hypertonic NaCl and increase net transmucosal water flux. Gastroenterology 1988;94:A354.
73. Dupuy D, Kronague JF, Jones AG, Szabo S: Gastric mucosal protection may be mediated through increases in vascular permeability which create a histodilutional barrier. Gastroenterology 1988;94: A615.
74. Robert A, Lancaster C, Davis JP, Field SO, Sinha AJ, Thornburgh BA: Cytoprotection by prostaglandin occurs in spite of penetration of absolute ethanol into the gastric mucosa. Gastroenterology 1985; 88:328-333.
75. Korman MG, Bolin TD, Szabo S, Hunt RH, Marks IN, Glise H: Sucralfate: the Bangkok review. J Gastroenterol Hepatol 1994;9:412-415.
76. Kumar V, Abbas AK, Fausto N, Aster JC: Robins and Cotran Pathologic Basis of Disease. Philadelphia, Saunders Elsevier, 2010.
77. Szabo S: Somatostatin stimulates clearance and hepatic uptake of colloidal carbon in the rat. Life Sci 1983;33:1975-1980.
78. Nagy L, Szabo S, Morales RE, Plebani M, Jenkins JM: Identification of subcellular targets and sensitive tests of ethanol-induced damage in isolated rat gastric mucosal cells. Gastroenterology 1994; 107:907-914.
79. Glavin GB, Johnson BR, Xing PL, Morales RE, Plebani M, Nagy L, Szabo S: Isolated rat gastric mucosal cells: optimal condition for cell harvesting, measures of viability and direct cytoprotection. J Pharmacol Exp Ther 1996;276:1174-1179.
80. Selye H: Hormones and Resistance. Springer, New York, 1971.
81. Filaretova LP, Filaretov AA, Makara GB: Corticosterone increase inhibits stress-induced gastric erosions in rats. Am J Physiol 1988;274: G1024-G1030.
82. Filaretova LP, Bagaeva TR, Makara GB: Aggravation of nonsteroidal anti-inflammatory drug gastropathy by glucocorticoid deficiency or blockage of glucocorticoid receptors in rats. Life Sci 2002;71:2457-2468.
83. Filaretova LP, Bagaeva TR, Amagase K, Takeuchi K: Contribution of glucocorticoids to protective influence of preconditioning mild stress against stressinduced gastric erosions. Ann NY Acad Sci 2008; 1148:209-212.
84. Szabo S: Gastroduodenal mucosal injury -acute and chronic: pathways, mediators and mechanisms. J Clin Gastroenterol 1991;13(suppl 1):S1-S8.
85. Takeuchi K, et al: Importance of gastric motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig Dis Sci 1986;31:1114-1122.
86. Takeuchi K, et al: Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice. J Pharmacol Exp Ther 2001;297:1160-1165.
87. Takeuchi K: Prostaglandin EP receptors and their roles in mucosal protection and ulcer healing in the gastrointestinal tract; in Makowski G (ed): Advances in Clinical Chemistry. New York, Academic Press, 2010, vol 51, pp 121-144.
88. Takeuchi K, et al: COX inhibition and NSAIDinduced gastric damage. Curr Top Pharmacol 2003; 6:69-81.
89. Szabo S, Trier JS, Brown A, LaRocque M: Protection against aspirin-induced hemorrhagic gastric erosions and mucosal vascular injury by coadministration of sulfhydryl drugs. Gastroenterology 1985;88:1604.
90. Wallace JL: Hydrogen sulfide-releasing antiinflammatory drugs. Trends Pharmacol Sci 2007; 28:501-505.