Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: A new hypothesis

Pharmacology Biochemistry and Behavior

Volumn 121, Issue , 2014, Pages 189-194

  Waldinger, Marcel D ^a,b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b Physiotherapy private practice   (Netherlands)

^c Outpatient Department of Neurosexology   (Netherlands)

Author keywords

Detumescentia praecox; Erectio praecox; Hypertonic state; Lifelong premature ejaculation; Oxytocin; TRP ion channel

Indexed keywords

CITALOPRAM; OXYTOCIN; PAROXETINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SLC6A4 PROTEIN, HUMAN;

ARTICLE; DETUMESCENTIA PRAECOX; DISEASE CLASSIFICATION; EJACULATION; EJACULATION DISORDER; ERECTIO PRAECOX; GENETIC POLYMORPHISM; HUMAN; NEUROTRANSMISSION; NONHUMAN; OXYTOCIN RELEASE; PHENOTYPE; PREMATURE EJACULATION; PRIORITY JOURNAL; SEXUAL INTERCOURSE; SKIN RECEPTOR; BIOLOGICAL MODEL; FEMALE; GENETICS; MALE; PATHOPHYSIOLOGY; PENIS ERECTION; PHYSIOLOGY;

FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; OXYTOCIN; PENILE ERECTION; POLYMORPHISM, GENETIC; PREMATURE EJACULATION; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84901195076     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.12.004     Document Type: Article

References (74)

1. S. Ahlenius, K. Larsson, L. Svensson, S. Hjorth, A. Carlsson, and P. Lindberg et al. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior Pharmacol Biochem Behav 15 1981 785 792 (Pubitemid 12195265)
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-5) 5th ed. 2013 American Psychiatric Association Washington, DC
3. A. Argiolas, M.R. Melis, and G.L. Gessa Oxytocin: an extremely potent inducer of penile erection and yawning in male rats Eur J Pharmacol 130 1986 265 272 (Pubitemid 17193212)
4. A. Argiolas, M. Collu, P. DÁquila, G.L. Gessa, M.R. Melis, and G. Serra Apomorphine stimulation of male copulatory behavior is prevented by the oxytocin antagonist d(a)5Tyr (Me)-Orn8-vasotocin in rats Pharmacol Biochem Behav 33 1989 81 83 (Pubitemid 19202610)
5. H.H. Berendsen, and C.L. Broekkamp Drug-induced penile erections in rats: indications of serotonin 1B receptor mediation Eur J Pharmacol 135 1987 279 287 (Pubitemid 17057552)
6. E.Y. Bijlsma, J.S.W. Chan, B. Olivier, J.G. Veening, M.J. Millan, and M.D. Waldinger et al. Sexual side effects of serotonergic antidepressants: mediated by inhibition of serotonin on central dopamine release? Pharmacol Biochem Behav 121 2014 88 101 [in this volume]
7. C. Carani, A.M. Isidori, A. Granata, E. Carosa, M. Maggi, and A. Lenzi et al. Multicenter study on the prevalence of sexual symptoms in male hypo- and hyperthyroid patients J Clin Endocrinol Metab 90 2005 6472 6479 (Pubitemid 41759302)
8. M.S. Carmichael, R. Humbert, J. Dixen, G. Palmisano, W. Greenleaf, and J.M. Davidson Plasma oxytocin increases in the human sexual response J Clin Endocrinol Metab 64 1987 27 31 (Pubitemid 17015873)
9. J.S. Chan, M.D. Waldinger, B. Olivier, and R.S. Oosting Drug-induced sexual dysfunction in rats Curr Protoc Neurosci 2010 [Chapter 9; Unit 9.34]
10. J.S. Chan, E.M. Snoeren, E. Cuppen, M.D. Waldinger, B. Olivier, and R.S. Oosting The serotonin transporter plays an important role in male sexual behaviour: a study in serotonin transporter knockout rats J Sex Med 8 2011 97 108
11. K. Chen, and L.S. Chang Oxytocinergic neurotransmission at the hippocampus in the central neural regulation of penile erection in the rat Urology 58 2001 107 112 (Pubitemid 32633955)
12. G. Corona, E.A. Jannini, L. Vignozzi, G. Rastrelli, and M. Maggi The hormonal control of ejaculation Nat Rev Urol 9 2012 508 519
13. N. Damann, T. Voets, and B. Nilius TRPs in our senses Current Biology 18 2008 R880 R889
14. T.R. de Jong, J.G. Veening, B. Olivier, and M.D. Waldinger Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies J Sex Med 4 2007 14 28 (Pubitemid 46002363)
15. S. Filippi, L. Vignozzi, G.B. Vannelli, F. Ledda, G. Forti, and M. Maggi Role of oxytocin in the ejaculatory process J Endocrinol Invest 26 2003 82 86
16. M.M. Foreman, R.L. Love, and J.L. Hall Effects of LY237733, a selective 5-HT2 receptor antagonist, on copulatory behavior of male rats Soc Neurosci Abstr 14 1988 374
17. J. Gao, X. Zhang, P. Su, J. Liu, L. Xia, and J. Yang et al. Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes: a large observational study in china J Sex Med 10 2013 1874 1881
18. M. Gil, R. Bhatt, K.B. Picotte, and E.M. Hull Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat Horm Behav 59 2011 435 443
19. F. Giuliano, J. Pfaus, B. Srilatha, P. Hedlund, S. Hisasue, and L. Marson et al. Experimental models for the study of female and male sexual function J Sex Med 7 2010 2970 2995
20. M.L. Godpodinoff Premature ejaculation: clinical subgroups and etiology J Sex Marital Ther 15 1989 130 134 (Pubitemid 19213787)
21. A.M. Hughes, B.J. Everitt, S.L. Lightman, and K. Todd Oxytocin in the central nervous system and sexual behaviour in male rats Brain Res 414 1987 133 137 (Pubitemid 17103550)
22. E.M. Hull, and J.M. Dominguez Sexual behaviour in male rodents Horm Behav 52 2007 45 55
23. E.M. Hull, R. Meisel, and B. Sachs Male sexual behaviour D. Pfaff, A. Arnold, A. Etgen, S. Fahrbach, R. Rubin, Hormones, brain and behavior 2002 Academic Press New York 3 137
24. E.A. Jannini, F. Lombardo, and A. Lenzi Correlation between ejaculatory and erectile dysfunction Int J Androl 28 Suppl. 2 2005 40 45 (Pubitemid 41719772)
25. P.K. Janssen, S.C. Bakker, J. Réthelyi, A.H. Zwinderman, D.J. Touw, and B. Olivier et al. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation J Sex Med 6 2009 276 284
26. 1A receptor gene only the C(1019)G promoter polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation Pharmacol Biochem Behav 121 2014 184 188 [in this volume]
27. P.K.C. Janssen, R. van Schaik, B. Olivier, and M.D. Waldinger Of the largest coding region for the 5-HT 2C receptor gene only the Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation, Asian J Androl 2013 [in press]
28. Janssen PKC, Olivier B, Zwinderman AH, Waldinger MD. Measurement errors in polymerase chain reaction are a confounding factor for a right interpretation of 5-HTTLPR polymorphism effects on lifelong premature ejaculation: a critical analysis of six studies and of a meta-analysis (unpublished data).
29. P. Jern, P. Santtila, K. Witting, K. Alanko, N. Harlaar, and A. Johansson et al. Premature and delayed ejaculation: genetic and environmental effects in a population-based sample of Finnish twins J Sex Med 4 2007 1739 1749 (Pubitemid 47616867)
30. P. Jern, L. Westberg, A. Johansson, A. Gunst, E. Eriksson, and K. Sandnabba et al. A study of possible associations between single nucleotide polymorphisms in the serotonin receptor 1A, 1B, and 2C genes and self-reported ejaculation latency time J Sex Med 9 2012 866 872
31. P. Jern, E. Eriksson, and L. Westberg A reassessment of the possible effects of the serotonin transporter gene linked polymorphism 5-HTTLPR on premature ejaculation Arch Sex Behav 42 2013 45 49
32. T.H. Kruger, P. Haake, D. Chereath, W. Knapp, O.E. Janssen, and M.S. Exton et al. Specificity of the neuroendocrine response to orgasm during sexual arousal in men J Endocrinol 177 2003 57 64 (Pubitemid 36592587)
33. S.W. Luo, F. Wang, Z.Y. Xie, X.K. Huang, and Y.P. Lu Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population Beijing Da Xue Xue Bao 43 2011 514 518
34. C.G. McMahon, S. Althof, M.D. Waldinger, H. Porst, J. Dean, and I. Sharlip et al. An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation J Sex Med 5 2008 1590 1606 (Pubitemid 352044417)
35. M.R. Melis, A. Argiolas, and G.L. Gessa Oxytocin-induced penile erection and yawning: site of action in the brain Brain Res 398 1986 259 265 (Pubitemid 17210169)
36. M.R. Murphy, J.R. Seckl, S. Burton, S.A. Checkley, and S.L. Lightman Changes in oxytocin and vasopressin secretion during sexual activity in men J Clin Endocrinol Metab 65 1987 738 741 (Pubitemid 17157394)
37. B. Olivier, R. van Oorschot, and M.D. Waldinger Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour Int Clin Psychopharmacol 13 Suppl. 6 1998 S9 S14
38. B. Olivier, J.S. Chan, E.M. Snoeren, J.D. Olivier, J.G. Veening, and C.H. Vinkers et al. Differences in sexual behaviour in male and female rodents: role of serotonin Curr Top Behav Neurosci 8 2011 15 36
39. E. Ozbek, A.I. Tasci, V. Tugcu, Y.O. Ilbey, A. Simsek, and L. Ozcan et al. Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population Asian J Androl 11 2009 351 355
40. T. Pattij, T. de Jong, A. Uitterdijk, M.D. Waldinger, J.G. Veening, and P.H. van der Graaf et al. Individual differences in male rat ejaculatory behavior: searching for models to study ejaculation disorders Eur J Neurosci 22 2005 724 734 (Pubitemid 41192282)
41. M. Peeters, and F. Giuliano Central neurophysiology and dopaminergic control of ejaculation Neurosci Biobehav Rev 32 2008 438 453 (Pubitemid 351210623)
42. J.G. Pfaus Neurobiology of sexual behaviour Curr Opin Neurobiol 9 1999 751 758
43. M.R. Safarinejad Polymorphisms of the serotonin transporter gene and their relation to premature ejaculation in individuals from Iran J Urol 181 2009 2656 2661
44. B. Schapiro Premature ejaculation, a review of 1130 cases J Urol 50 1943 374 379
45. E. Screponi, E. Carosa, S.M. Di Stasi, M. Pepe, G. Carruba, and E.A. Jannini Prevalence of chronic prostatitis in men with premature ejaculation Urology 58 2001 198 202 (Pubitemid 32728055)
46. E.C. Serefoglu, H.I. Cimen, A.F. Atmaca, and M.D. Balbay The distribution of patients who seek treatment for the complaint of ejaculating prematurely according to the four premature ejaculation syndromes J Sex Med 7 2010 810 815
47. E.C. Serefoglu, O. Yaman, S. Cayan, R. Asci, I. Orhan, and M.F. Usta et al. Prevalence of the complaint of ejaculating prematurely and the four premature ejaculation syndromes: results from the Turkish Society of Andrology Sexual Health Survey J Sex Med 8 2 2011 540 548
48. A. Serretti, and A. Chiesa Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis J Clin Psychopharmacol 29 3 2009 259 266 [Jun]
49. M.D. Stoneham, B.J. Everitt, S. Hansen, S.L. Lightman, and K. Todd Oxytocin and sexual behaviour in the male rat and rabbit J Endocrinol 107 1985 97 106 (Pubitemid 16247400)
50. W.A. Truitt, and L.M. Coolen Identification of a potential ejaculation generator in the spinal cord Science 297 2002 1566 1569 (Pubitemid 34971006)
51. S. Uckert, A.J. Becker, B.O. Ness, C.G. Stief, F. Scheller, and W.H. Knapp et al. Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions World J Urol 20 2003 323 326 (Pubitemid 44175299)
52. J.G. Veening, and L.M. Coolen Neural activation following sexual behaviour in the male and female rat brain Behav Brain Res 92 1998 181 193 (Pubitemid 28223589)
53. J.G. Veening, and L.M. Coolen Neural mechanisms of sexual behavior in the male rat: emphasis on ejaculation-related circuits Pharmacol Biochem Behav 121 2014 170 183 [in this volume]
54. J.G. Veening, and B. Olivier Intranasal administration of oxytocin: behavioral and clinical effects. A review Neurosci Biobehav Rev 37 2013 1445 1465
55. J.G. Veening, T. de Jong, and H.P. Barendregt Oxytocin-messages via the cerebrospinal fluid: behavioral effects: a review Physiol Behav 101 2010 193 210
56. M.D. Waldinger The neurobiological approach to premature ejaculation J Urol 168 2002 2359 2367 (Pubitemid 35402615)
57. M.D. Waldinger Premature ejaculation: definition and drug treatment Drugs 67 2007 547 568 (Pubitemid 46440312)
58. M.D. Waldinger Premature ejaculation: different pathophysiologies and etiologies determine its treatment J Sex Marital Ther 34 2008 1 13 (Pubitemid 351517582)
59. M.D. Waldinger Toward evidence-based genetic research on lifelong premature ejaculation: a critical evaluation of methodology Kor J Urol 52 2011 1 8
60. M.D. Waldinger History of premature ejaculation E.A. Jannini, C.G. McMahon, M.D. Waldinger, Premature ejaculation. From etiology to diagnosis and treatment 2013 Springer-Verlag Italia 5 24
61. M.D. Waldinger Risk factors in premature ejaculation: the genetic risk factor E.A. Jannini, C.G. McMahon, M.D. Waldinger, Premature ejaculation. From etiology to diagnosis and treatment 2013 Springer-Verlag Italia 111 123
62. M.D. Waldinger Epilogue: future perspectives E.A. Jannini, C.G. McMahon, M.D. Waldinger, Premature ejaculation. From etiology to diagnosis and treatment 2013 Springer-Verlag 377 378
63. M.D. Waldinger, and D.H. Schweitzer The use of old and recent DSM definitions of premature ejaculation in observational studies: a contribution to the present debate for a new classification of PE in the DSM-V J Sex Med 5 2008 1079 1087 (Pubitemid 351606697)
64. M.D. Waldinger, M.W. Hengeveld, A.H. Zwinderman, and B. Olivier An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation Int J Psychiatry Clin Pract 2 1998 287 293 (Pubitemid 29023494)
65. M.D. Waldinger, M.W. Hengeveld, A.H. Zwinderman, and B. Olivier Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline J Clin Psychopharmacol 18 1998 274 281 (Pubitemid 28353869)
66. M.D. Waldinger, H.H.G. Berendsen, B.F.M. Blok, B. Olivier, and G. Holstege Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system Behav Brain Res 92 1998 111 118 (Pubitemid 28223582)
67. M.D. Waldinger, M. Rietschel, M.M. Nothen, M.W. Hengeveld, and B. Olivier Familial occurrence of primary premature ejaculation Psychiatr Genet 8 1998 37 40 (Pubitemid 28181559)
68. M.D. Waldinger, A. van de Plas, T. Pattij, R. van Oorschot, L.M. Coolen, and J.G. Veening et al. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment Psychopharmacology (Berl) 160 2002 283 289 (Pubitemid 34230680)
69. M.D. Waldinger, A.H. Zwinderman, D.H. Schweitzer, and B. Olivier Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis Int J Impot Res 16 2004 369 381 (Pubitemid 39273766)
70. M.D. Waldinger, P. Quinn, M. Dilleen, R. Mundayat, D.H. Schweitzer, and M. Boolell A multi-national population survey of intravaginal ejaculation latency time J Sex Med 2 2005 492 497 (Pubitemid 40975833)
71. M.D. Waldinger, J. McIntosh, and D.H. Schweitzer A five-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population J Sex Med 6 2009 2888 2895
72. X.H. Zhang, S. Filippi, L. Vignozzi, A. Morelli, R. Mancina, and M. Luconi et al. Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis J Endocrinol 184 2005 567 576 (Pubitemid 40426019)
73. X. Zhang, J. Gao, J. Liu, L. Xia, J. Yang, and Z. Hao et al. Distribution and factors associated with four premature ejaculation syndromes in outpatients complaining of ejaculating prematurely J Sex Med 10 2013 1603 1611
74. D. Zuccarello, M. Ghezzi, M. Pengo, M. Forzan, A.C. Frigo, and A. Ferlin et al. No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls J Sex Med 9 2012 1659 1668