Differences in sexual behaviour in male and female rodents: Role of serotonin

Current Topics in Behavioral Neurosciences

Volumn 8, Issue , 2011, Pages 15-36

  Olivier, Berend ^a   Chan, Johnny S W ^a   Snoeren, Eelke M ^a   Olivier, Jocelien D A ^b   Veening, Jan G ^a   Vinkers, Christiaan H ^a   Waldinger, Marcel D ^a   Oosting, Ronald S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 HT; 5 HTT; 8 OH DPAT; Gender; Hypersexual behaviour; Hyposexual behaviour; Paroxetine; Premature ejaculation; Retarded ejaculation; Serotonin; Serotonin receptor knockout rat; Serotonin transporter; SERT polymorphism; Sexual behaviour; SSRI; WAY100635

Indexed keywords

CITALOPRAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PAROXETINE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2C AGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SEROTONIN RECEPTOR AFFECTING AGENT;

ACUTE DRUG ADMINISTRATION; ANIMAL BEHAVIOR; ANXIETY DISORDER; ARTICLE; CHRONIC DRUG ADMINISTRATION; DEPRESSION; DISEASE ASSOCIATION; DISEASE MODEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; GENE; GENE INACTIVATION; HUMAN; INHIBITION (PSYCHOLOGY); LATENT PERIOD; LOW DRUG DOSE; NONHUMAN; PREMATURE EJACULATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PSYCHOPHARMACOLOGY; SEROTONIN TRANSPORTER GENE; SEROTONINERGIC TRANSMISSION; SEX DIFFERENCE; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; ANIMAL; ANIMAL MODEL; FEMALE; GENETICS; MALE; METABOLISM; PHYSIOLOGY; RAT; REVIEW; SEX DIFFERENTIATION; TIME;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MODELS, ANIMAL; RATS; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGENTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX DIFFERENTIATION; SEXUAL BEHAVIOR, ANIMAL; TIME FACTORS;

EID: 80053324419     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2010_116     Document Type: Article

References (73)

1. 3 antagonists and benzodiazepines: their comparative behavioural pharmacology. Wiley, Chichester, pp 281-301
2. 1B receptors in the inhibition of male rat ejaculatory behaviour produced by 5-HTP. Psychopharmacology 137:374-382
3. 1A antagonist WAY-100635 and citalopram on male rat ejaculatory behaviour. Eur J Pharmacol 379:1-6
4. Ahlenius S, Larsson K, Svensson L (1980) Further evidence for an inhibitory role of central 5-HT in male rat sexual behaviour. Psychopharmacology 68:217-220
5. Ahlenius S, Fernandez-Guasti A, Hjorth S, Larsson K (1986) Suppression of lordosis behaviour by the putative 5-HT receptor agonist 8-OH-DPAT in the rat. Eur J Pharmacol 124:361-363
6. Albinsson A, Andersson G, Andersson K, VegaMatuszczyk J, Larsson K (1996) The effects of lesions in the mesencephalic raphe systems on male rat sexual behaviour and locomotor activity. Behav Brain Res 80:57-63
7. 2 antagonistic properties, on male-rat sexual-behaviour. Eur J Pharmacol 255:131-137
8. Argiolas A (1999) Neuropeptides and sexual behaviour. Neurosci Biobehav Rev 23:1127-1142
9. Balon R (2006) SSRI-associated sexual dysfunction. Am J psychiatry 163:1504-1509
10. Barfield RJ, Sachs BD (1968) Sexual behaviour: stimulation by painful electrical shock to skin in male rats. Science 161:392-395
11. Beach FA (1942) Comparison of copulatory behaviour of male rats raised in isolation, cohabitation, and segregation. J Genet Psychol 60:3-13
12. Beach FA (1948) Hormones and behaviour. Hoeber Harber, New York
13. Bitran D, Hull EM (1987) Pharmacological analysis of male rat sexual behaviour. Neurosci Biobehav Rev 11:365-389
14. Cantor J, Binik I, Pfaus JG (1999) Chronic fluoxetine inhibits sexual behaviour in the male rat: reversal with oxytocin. Psychopharmacology 144:355-362
15. Chan JSW, Waldinger MD, Olivier B, Oosting RS (2010) Drug-induced sexual dysfunction in rats. Curr protoc Neurosci 53:9.34.1-9.34.11
16. Chan JSW, Snoeren EMS, Cuppen E, Waldinger MD, Olivier B, Oosting RS (2011) The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. J Sex Medicine 8:97-108
17. Cyranowski JM, Bromberger J, Youk A, Matthews K, Kravitz HM, Powell LH (2004) Lifetime depression history and sexual function in women at midlife. Arch Sex Behav 33:539-548
18. De Jong TR, Pattij T, Veening JG, Dederen PFJ, Waldinger MD, Cools AR, Olivier B (2005a) Citalopram combined with WAY100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity. Eur J Pharmacol 509:49-59
19. De Jong TR, Pattij T, Veening JG, Waldinger MD, Cools AR, Olivier B (2005b) Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology 179:509-515
20. De Jong TR, Veening JG, Waldinger MD, Cools AR, Olivier B (2006) Serotonin and the neurobiology of the ejaculation threshold. Neurosci Biobehav Rev 30:893-907
21. De Jong TR, Veening JG, Olivier B, Waldinger MD (2007) Oxytocin involvement in SSRIinduced delayed ejaculation: a review of animal studies. J Sex Med 4:14-28
22. Dornan WA, Katz JL, Ricaurte GA (1991) The effects of repeated administration ofMDMA on the expression of sexual behaviour in the male rat. Pharmacol Biochem Behav 39:813-816
23. Ferrari F, Giuliani D (1994) The selective D-2 dopamine-receptor antagonist eticlopride counteracts the ejaculatio-praecox induced by the selective D-2-dopamine agonist SND-919 in the rat. Life Sci 55:1155-1162
24. Foreman MM, Hall JL, Love RL (1992) Effects of fenfluramine and para-chloroamphetamine on sexual behaviour of male rats. Psychopharmacology 107:327-330
25. Frank JL, Hendricks SE, Olson CH (2000) Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behaviour. Pharmacol Biochem Behav 66:337-342
26. Frye CA, Petralia SM, Rhodes ME, Stein B (2003) Fluoxetine may influence lordosis of rats through effects on midbrain 3 alpha, 5 alpha-THP concentrations. Ann RNY Acad Sci 1007:37-41
27. Gonzales G, Mendoza L, Ruiz J, Torrejon J (1982) A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behaviour in male rats. Life Sci 31:2775-2781
28. 1A receptors. J Neurosci 18:10150-10156
29. Haensel SM, Slob AK (1997) Flesinoxan: a prosexual drug for male rats. Eur J Pharmacol 330:1-9
30. 1B receptor agonists 8-OH-DPAT and anpirtoline, as evidenced by use of the corresponding new and selective receptor antagonists NAD-299 and NAS-181. Br J Pharmacol 125:1733-1743
31. Hunter AJ, Hole DR, Wilson CA (1985) Studies into the dual effects of serotonergic pharmacological agents on female sexual behaviour in the rat: preliminary evidence that endogenous 5-HT is stimulatory. Pharmacol Biochem Behav 22:5-13
32. Kendurkar A, Kaur B (2008) Major depressive disorder, obsessive-compulsive disorder, and generalized anxiety disorder: do the sexual dysfunctions differ? Primary Care Companion J Clin Psychiatry 10:299-305
33. Kennedy SH, Rizvi S (2009) Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol 29:157-164
34. 2 antagonist by attenuating DOI-induced inhibition of male rat sexual behaviour. Psychopharmacology 119:291-294
35. Klint T, Dahlgren IL, Larsson K (1992) The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behaviour. Eur J Pharmacol 212:241-246
36. Kugaya A, Seneca NM, Snyder PJ, Williams SA, Malison RT, Baldwin RM, Seibyl JP, Innis RB (2003) Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 28:413-420
37. 1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 39:110-122
38. Leyton M, Stewart J (1996) Acute and repeated activation of male sexual behaviour by tail pinch: opioid and dopaminergic mechanisms. Physiol Behav 60:77-85
39. Looney C, Thor KB, Ricca D, Marson L (2005) Differential effects of simultaneous or sequential administration of paroxetine and WAY-100, 635 on ejaculatory behaviour. Pharmacol Biochem Behav 82:427-433
40. Maswood N, Sarkar J, Uphouse L (2008) Modest effects of repeated fluoxetine on estrous cyclicity and sexual behaviour in Sprague Dawley female rats. Brain Res 1745:53-60
41. Matuszcyk JV, Larsson K, Eriksson E (1998) The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 60:527-532
42. 1A antagonist. Brain Res 820:55-62
43. Melis MR, Argiolas A (1995) Dopamine and sexual behaviour. Neurosci Biobehav Rev 19:19-38
44. Mendelson SD (1992) A review and reevaluation of the role of serotonin in the modulation of lordosis behaviour in the female rat. Neurosci Biobehav Rev 16:309-350
45. Mendelson SD, Gorzalka BB (1985) A facilitatory role for serotonin in the sexual behaviour of the female rat. Pharmacol Biochem Behav 22:1025-1033
46. 1A receptors: differential involvement in female and male sexual behaviour in the rat. Eur J Pharmacol 132:323-326
47. Mendelson SD, Gorzalka BB (1990) Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine an 1-(m-chlorophenyl) piperazine on copulatory behaviour in the rat. Neuropharmacology 29:783-786
48. Montgomery SA, Baldwin DS, Riley A (2002) Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 69(1-3):119-140
49. Mos J, Olivier B, Bloetjes K, Poth M (1990) Drug-induced facilitation of sexual behaviour in the male rat: behavioural and pharmacological aspects. In: Slob AK, Baum MJ (eds) Psychoneuroendocrinology of growth and development. Medicom Publishers, Rotterdam, pp 221-232
50. Mos J, Van Logten J, Bloetjes K, Olivier B (1991) The effects of idazoxan and 8-OH-DPAT on sexual behaviour and associated ultrasonic vocalizations in the rat. Neurosci Biobehav Rev 15:505-515
51. Mos J, Mollet I, Tolboom JTBM, Waldinger MD, Olivier B (1999) A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol 9:123-135
52. Murphy DL, Lesch KP (2008) Targeting the murine serotonin transporter insights into human neurobiology. Nat Rev Neurosci 9:85-96
53. Olivier J, Cools A, Ellenbroek B, Cuppen E, Homberg J (2010) The serotonin transporter knockout rat: a review. In Kalueff AV, LaPorte JL (eds) Experimental models in serotonin transporter research. Cambridge University Press, Cambridge, PP170-213
54. Pattij T, de Jong TR, Uitterdijk A, Waldinger MD, Veening JG, Cools AR, van der Graaf PH, Olivier B (2005) Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. Eur J Neurosci 22:724-734
55. Regitz-Zagrosek V, Schubert C, Kruger S (2008) Gesclechterunterschiede in der neuropsychiatrischen Pharmakotherapie. Der Internist 12:1516-1523
56. Sarkar J, Hiegel C, Ginis E, Hilbun E, Uphouse L (2008) Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behaviour. Brain Res 1190:58-64
57. Siddiqui A, Niazi A, Shahariar S, Wilson CA (2007) The 5-Ht(7) receptor is involved in the regulation of female sexual behaviour in the rat. Pharmacol Biochem Behave 87:386-392
58. Smits BM, Mudde JB, van de Belt J, Verheul M, Olivier JD, Homberg J, Gurvey V, Cools AR, Ellenbroek BA, Cuppen E (2006) Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target selected mutagenesis. Pharmacogenet Genomics 16:159-169
59. 1A receptor desensitization. J Sex Med 7:2424-2434
60. Sugden K, Tichopad A, Khan N, Craig IW, D'Souza UM (2009) Genes within the serotonergic system are differentially expressed I the human brain. BMC Neurosci 10:50
61. Sura A, Overstreet DH, Marson L (2001) Selectively bred male rat lines differ in nai{dotless}̈ve and experienced sexual behaviour. Physiol Behav 72:13-20
62. Tagliamonte A, Tagliamonte P, Gessa GL, Brodie BB (1969) Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science 166:1433-1435
63. Uphouse L (2000) Female gonadal hormones, serotonin and sexual receptivity. Brain Res Rev 33:242-257
64. Uphouse L, Guptarak J (2010) Serotonin and sexual behaviour. In: M̈uller C, Jacobs B (eds) Handbook of behavioural neurobiology of serotonin. Elsevier, Amsterdam, pp 347-365
65. Uphouse L, Hiegel C, Guptarak J, Maswood N (2009) Progesterone reduces the effect of the serotonin 1B/1D receptor antagonist GR127935, on lordosis behaviour. Horm Behav 55(1):169-174
66. Waldinger MD (2002) The neurobiological approach to premature ejaculation (review article). J Urol 168:2359-2367
67. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18:274-281
68. Waldinger MD, Plas A VD, Pattij T, Oorschot R v, Coolen LM, Veening JG, Olivier B (2001a) The SSRIs fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacology 160:283-289
69. Waldinger MD, Zwinderman AH, Olivier B (2001b) SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 21:556-560
70. Wang L, Hull EM (1980) Tail pinch induces sexual behaviour in olfactory bulbectomized male rats. Physiol Behav 24:211-215
71. 2 antagonists. Pharmacol Biochem Behav 39:605-621
72. Williams VSL, Baldwin DS, Hogue SL, Fehnel SE, Hollis KA, Edin HM (2006) Estimating the prevalence and impact of antidepressant-induced sexual dysfunction in 2 European countries< a cross-sectional patient survey. J Clin Psychiatry 67:204-210
73. Zemishlany Z, Weizman A (2008) The impact of mental illness on sexual dysfunction. Adv Psychosom Med 29:89-106