Use of polydeoxyribonucleotide for peritendon injection treatment;Utilizzo del polidesossiribonucleotide per trattamento iniettivo peritendineo

Minerva Ortopedica e Traumatologica

Volumn 65, Issue 1, 2014, Pages 51-56

  Gervaso, P ^a  

^a General Hospital of Voghera   (Italy)

Author keywords

DNA ligases; Injections; Tendinopathy

Indexed keywords

EID: 84901064619     PISSN: 00264911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Gibson T. Is there a place for corticosteroid injection in the management of Achilles' tendon lesions? Brit J Rheumatol 1991;30:436.
2. Hang DW, Bach BR, Bojchuk J. Partial Achilles tendon rupture following corticosteroid injecton. Phys Sportsmed 1995;23:57-66.
3. Registration Dossier, Italian Ministry of Health; 1995.
4. Sini P, Denti A, Cattarini G, Daglio M, Tira ME, Balduini C. Effect of polydeoxyribonucleotides on human fibroblasts in primary culture. Cell Biochem Funct 1999;17:107-14.
5. Thellung S, Florio T, Maragliano A, Cattarini G, Schettini G. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes. Life Sci 1999;64:1661-74.
6. Bitto A, Polito F, Altavilla D, Minutoli L, Migliorato A, Squadrito F. Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease. J Vase Surg 2008;48:1292-300.
7. Altavilla D, Squadrito F, Polito F, Irrera N, Calo M, Lo Cascio P et al. Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice. Surgery 2011;149:253-61.
8. Valdatta L, Thione A, Mortarino C, Buoro M, Tuinder S. Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study. Curr Med Res Opin 2004;20:403-8.
9. Rubegni P, De Aloe G, Mazzatenta C, Cattarini L, Fimiani M. Clinical evaluation of the trophic effect of polydeoxyribonucleotide (PDRN) in patients undergoing skin explants. A Pilot Study. Curr Med Res Opin 2001;17:128-31.
10. De Aloe G, Rubegni P, Biagioli M, Taddeucci P, Fimiani M. Skin graft donor site and use of polydeoxyribonucleotide as a treatment for skin regeneration: a randomized, controlled, double-blind, clinical trial. Wounds 2004;16:258-63.
11. Lazzarotto M, Tomasello EM, Caporossi A. Clinical evaluation of corneal epithelialization after photorefractive keratectomy in patients treated with polydeoxyribonucleotide (PDRN) eye drops:a randomized, double-blind, placebo-controlled trial. Eur J Ophthalmol 2004;14:284-9.
12. Altavilla D, Bitto A, Polito F, Marini H, Minutoli L, Di Stefano V et al. Polydeoxyribonucleotide (PDRN):a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovasc Hematol Agents Med Chem 2009;7:313-21.
13. Surace A, Previtera AM, Mineo G, Barberis F. Valutazione dell'efncacia degli estratti placentari sulla sintomatologia atgica dell'artrosi. Ortopedia e Traumatologia Oggi 1987; VII: 47-56.
14. Galli U, Monti G. Effetto terapeutico di un polidesossiribonucleotide sulle tendinopatie. Medicina dello Sport 1990;43:285-28.
15. Darbisi M, Firenze A, Vitale F, Di Benedetto C. Trattamento di artropatie e tenopatie di origine traumatica o degenerativa mediante somministrazione di Polidesossiribonucleotide (PDRN). Europa Medicophysica 2005;41:1151-3.
16. Montesinos MC, Yap JS, Desai A, Posadas I, McCrary CT, Cronstein BN. Reversal of the antinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis Rheum 2000;43:656-63.
17. Montesinos MC, Desai A, Delano D, Chen JF, Fink JS, Jacobson MA et al. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum 2003;48:240-7.
18. Bitto A, Polito F, Irrera N, D'Ascola A, Avenoso A, Nastasi G et al. Polydeoxyribonucleotide (PDRN) reduces cytokine production and die severity of collagen-induced arthritis by stimulation of adenosine A (2A) receptor. Arthritis Rheum 2011;63:3364-71.
19. Gomez G, Sitkovsky MV. Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo. Int J Biochem Cell Biol 2003;35:410-4.
20. Haskó G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES. Adenosine receptor agonists differentially regulate IL-10, TNF-Alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol 1996;157:4634-40.
21. Link AA, Kino T, Worth JA, McGuire JL, Crane ML, Chrousos GP et al. Ligand-Activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. J Immunol 2000;164:436-42.
22. Cronstein BN. Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 1994;76:5-13
23. Chan ESL, Fernandez P, Cronstein BN. Adenosine in inflammatory joint diseases. Purin Signal 2007;3:145-52.
24. Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP et al. Suppression of macrophage inflammatory protein (MlP)-lalpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol 1998;125:379-87.
25. Varani K, Vincenzi F, Tosi A, Targa M, Masieri FF, Ongaro A et al. Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br J Pharmacol 2010;160:101-15.
26. Bitto A, Oteri G, Pisano M, Polito F, Irrera N, Minutoli L et al. Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis. J Clin Periodontol 2013;40:20-32.
27. Langley GB, Sheppeard H. The visual analogue scale: its use in pain measurement. Rheumatol Int 1985;5:145-8.