Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation in experimental periodontitis

Journal of Clinical Periodontology

Volumn 40, Issue 1, 2013, Pages 26-32

  Bitto, Alessandra ^a   Oteri, Giacomo ^a   Pisano, Michele ^a   Polito, Francesca ^a   Irrera, Natasha ^a   Minutoli, Letteria ^a   Squadrito, Francesco ^a,b   Altavilla, Domenica ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

adenosine receptor; HMGB 1, MAPKs; PDRN; periodontitis; polynucleotides

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 3,7-DIMETHYL-1-PROPARGYLXANTHINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; AUTACOID; DRUG DERIVATIVE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; POLYDEOXYRIBONUCLEOTIDE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; THEOBROMINE; TUMOR NECROSIS FACTOR ALPHA;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; DRUG EFFECT; MALE; METABOLISM; PERIODONTITIS; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ALVEOLAR BONE LOSS; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HMGB1 PROTEIN; INFLAMMATION MEDIATORS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; PERIODONTITIS; POLYDEOXYRIBONUCLEOTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; THEOBROMINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84870954326     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/jcpe.12010     Document Type: Article

References (35)

1. Altavilla, D., Bitto, A., Polito, F., Marini, H., Minutoli, L., Di Stefano, V., Cattarini, G., &, Squadrito, F., (2009) Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovascular & Hematological Agents in Medicinal Chemistry 7, 313-321.
2. Bascones, A., Noronha, S., Gómez, M., Mota, P., Gónzalez Moles, M. A., &, Villarroel Dorremo, M., (2005) Tissue destruction in periodontitis: bacteria or cytokines fault? Quintessence International 36, 299-306.
3. Bhatavadekar, N. B., &, Williams, R. C., (2009) New directions in host modulation for the management of periodontal disease. Journal of Clinical Periodontology 36, 124-126.
4. Cai, X., Li, C., Du, G., &, Cao, Z., (2008) Protective effects of baicalin on ligature-induced periodontitis in rats. Journal of Periodontal Research 43, 14-21.
5. Cetiner, D., Unsal, B., Saygun, I., &, Baris, E,. (2009) Interrelationship between diabetes and periodontal disease: the role of IL-6, TNF-a and iNOS activities in diabetic rats with periodontitis. Poster abstracts. Journal of Clinical Periodontology 36, 40-220.
6. Cochran, D. L., (2008) Inflammation and bone loss in periodontal disease. Journal of Periodontology 79, 1569-1576.
7. Delima, A. J., Oates, T., Assuma, R., Schwartz, Z., Cochran, D., Amar, S., &, Graves, D. T., (2001) Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. Journal of Clinical Periodontology 28, 233-240.
8. Di Paola, R., Mazzon, E., Muià, C., Terrana, D., Greco, S., Britti, D., Santori, D., Oteri, G., Cordasco, G., &, Cuzzocrea, S., (2007) 5-Aminoisoquinolin-1(2H)-one, a water-soluble poly (ADP-ribose) polymerase (PARP) inhibitor reduces the evolution of experimental periodontitis in rats. Journal of Clinical Periodontology 34, 95-102.
9. Feghali, K., Iwasaki, K., Tanaka, K., Komaki, M., Machigashira, M., Ishikawa, I., &, Izumi, Y., (2009) Human gingival fibroblasts release high-mobility group box-1 protein through active and passive pathways. Oral Microbiology and Immunology 24, 292-298.
10. Fentoǧlu, Ö., Köroǧlu, B. K., Hiçyilmaz, H., Sert, T., Özdem, M., Sütçü, R., Tamer, M. N., Orhan, H., Ay, Z. Y., Öztürk Tonguç, M., &, Kirzioǧlu, F. Y., (2011) Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. Journal of Clinical Periodontology 38, 8-16.
11. Fredholm, B. B., Chern, Y., Franco, R., &, Sitkovsky, M., (2007) Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology 83, 263-276.
12. Gamonal, J., Bascones, A., Acevedo, A., Blanco, E., &, Silva, A., (2001) Apoptosis in chronic adult periodontitis analyzed by in situ DNA breaks, electron microscopy, and immunohistochemistry. Journal of Periodontology 72, 517-525.
13. Garcia de Aquino, S., Manzolli Leite, F. R., Stach-Machado, D. R., Francisco da Silva, J. A., Spolidorio, L. C., &, Rossa, C. Jr, (2009) Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis. Life Science 84, 745-754.
14. Gemmell, E., Marshall, R. I., &, Seymour, G. J., (1997) Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontology 2000 14, 112-143.
15. Graves, D. T., (1999) The potential role of chemokines and inflammatory cytokines in periodontal disease progression. Clinical Infectious Diseases 28, 482-490.
16. Graves, D. T., &, Cochran, D., (2003) The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. Journal of Periodontology 74, 391-401.
17. Hashikawa, T., Takedachi, M., Terakura, M., Saho, T., Yamada, S., Thompson, L. F., Shimabukuro, Y., &, Murakami, S., (2003) Involvement of CD73 (ecto-5'-nucleotidase) in adenosine generation by human gingival fibroblasts. Journal of Dental Research 82, 888-892.
18. Hashikawa, T., Takedachi, M., Terakura, M., Yamada, S., Thompson, L. F., Shimabukuro, Y., &, Murakami, S., (2006) Activation of adenosine receptor on gingival fibroblasts. Journal of Dental Research 85, 739-744.
19. Haskó, G., Linden, J., Cronstein, B., &, Pacher, P., (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nature Reviews Drug Discovery 7, 759-770.
20. Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., &, Van Dyke, T. E., (2006) RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB Journal 20, 401-403.
21. Howells, G. L., (1995) Cytokine networks in destructive periodontal disease. Oral Diseases 1, 266-270.
22. Huang, R., Chen, J., Lu, S., Yuh, D., Cheng, G., Cheng, W., &, Fu, E,. (2012) Curcumin ameliorates the evolutional alveolar bone changes in ligature-induced periodontitis in rats. Poster abstracts. Journal of Clinical Periodontology 39, 76-404.
23. Jewett, A., Hume, W. R., Le, H., Huynh, T. N., Han, Y. W., Cheng, G., &, Shi, W., (2000) Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum. Infection and Immunity 68, 1893-1898.
24. Kornman, K. S., (2008) Mapping the pathogenesis of periodontitis: a new look. Journal of Periodontology 79, 1560-1568.
25. Liu, Q., Li, J., Khoury, J., Colgan, S. P., &, Ibla, J. C., (2009) Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. Journal of Biological Chemistry 284, 13686-13695.
26. Murakami, S., Hashikawa, T., Saho, T., Takedachi, M., Nozaki, T., Shimabukuro, Y., &, Okada, H., (2001) Adenosine regulates the IL-1 beta-induced cellular functions of human gingival fibroblasts. International Immunology 13, 1533-1540.
27. Nemoto, E., Kunii, R., Tada, H., Tsubahara, T., Ishihata, H., &, Shimauchi, H., (2004) Expression of CD73/ecto-5'-nucleotidase on human gingival fibroblasts and contribution to the inhibition of interleukin-1alpha-induced granulocyte-macrophage colony stimulating factor production. Journal of Periodontal Research 39, 10-19.
28. Offenbacher, S., Barros, S. P., Singer, R. E., Moss, K., Williams, R. C., &, Beck, J. D., (2007) Periodontal disease at the biofilm-gingival interface. Journal of Periodontology 78, 1911-1925.
29. Page, R. C., Offenbacher, S., Schroeder, H. E., Seymour, G. J., &, Kornman, K. S., (1997) Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontology 2000 14, 216-248.
30. Pihlstrom, B. L., Michalowicz, B. S., &, Johnson, N. W., (2005) Periodontal diseases. Lancet 366, 1809-1820.
31. Preshaw, P. M., &, Taylor, J. J., (2011) How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? Journal of Clinical Periodontology 38, 60-84.
32. Rossomando, E. F., &, White, L., (1993) A novel method for the detection of TNF-alpha in gingival cervicular fluid. Journal of Periodontology 64, 445-459.
33. Tatakis, D. N., &, Kumar, P. S., (2005) Etiology and pathogenesis of periodontal diseases. Dental Clinics of North America 49, 491-516.
34. Van Dyke, T. E., (2008) The management of inflammation in periodontal disease. Journal of Periodontology 79, 1601-1608.
35. Yanti, Lee, M., Kim, D., &, Hwang, J. K., (2009) Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells. Biological and Pharmaceutical Bulletin 32, 1770-1775.