Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A2A receptor

Arthritis and Rheumatism

Volumn 63, Issue 11, 2011, Pages 3364-3371

  Bitto, Alessandra ^a   Polito, Francesca ^a   Irrera, Natasha ^a   D'Ascola, Angela ^a   Avenoso, Angela ^a   Nastasi, Giancarlo ^a   Campo, Giuseppe M ^a   Micali, Antonio ^a   Bagnato, Gianfilippo ^a   Minutoli, Letteria ^a   Marini, Herbert ^a   Rinaldi, Mariagrazia ^a   Squadrito, Francesco ^a   Altavilla, Domenica ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,7 DIMETHYLPROPARGYLXANTHINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; COLLAGEN TYPE 2; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; POLYDEOXYRIBONUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CARTILAGE CELL; CELL STIMULATION; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG MECHANISM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE A2 RECEPTOR AGONISTS; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CHONDROCYTES; COLLAGEN TYPE II; HMGB1 PROTEIN; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MICE; POLYDEOXYRIBONUCLEOTIDES; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80155152569     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30538     Document Type: Article

References (33)

1. Choy EH, Panayi GS,. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001; 344: 907-16. (Pubitemid 32224400)
2. Muller-Ladner U, Pap T, Gay RE, Neidhart M, Gay S,. Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 2005; 1: 102-10.
3. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR,. Macrophages in rheumatoid arthritis. Arthritis Res 2000; 2: 189-202. (Pubitemid 32223726)
4. Firestein GS, Zvaifler NJ,. How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end [review]. Arthritis Rheum 2002; 46: 298-308. (Pubitemid 34136567)
5. Kasama T, Miwa Y, Isozaki T, Odai T, Adachi M, Kunkel SL,. Neutrophil-derived cytokines: potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy 2005; 4: 273-9. (Pubitemid 40873111)
6. Miossec P,. An update on the cytokine network in rheumatoid arthritis. Curr Opin Rheumatol 2004; 16: 218-22. (Pubitemid 38530489)
7. Firestein GS,. Evolving concepts of rheumatoid arthritis. Nature 2003; 423: 356-61. (Pubitemid 40852711)
8. Jacobson KA, Gao ZG,. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 2006; 5: 247-64. (Pubitemid 43336037)
9. Cronstein BN,. Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 1994; 76: 5-13. (Pubitemid 24048220)
10. Gomez G, Sitkovsky MV,. Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo. Int J Biochem Cell Biol 2003; 35: 410-4. (Pubitemid 36142059)
11. Hasko G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES,. Adenosine receptor agonists differentially regulate IL-10, TNF-α, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol 1996; 157: 4634-40. (Pubitemid 126449386)
12. Link AA, Kino T, Worth JA, McGuire JL, Crane ML, Chrousos GP, et al. Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. J Immunol 2000; 164: 436-42. (Pubitemid 30013019)
13. Asako H, Wolf RE, Granger DN,. Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. Gastroenterology 1993; 104: 31-7. (Pubitemid 23040003)
14. Cronstein BN, Naime D, Ostad E,. The antiinflammatory effects of methotrexate are mediated by adenosine. Adv Exp Med Biol 1994; 370: 411-6.
15. Montesinos MC, Yap JS, Desai A, Posadas I, McCrary CT, Cronstein BN,. Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis Rheum 2000; 43: 656-63. (Pubitemid 30394958)
16. 3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum 2003; 48: 240-7. (Pubitemid 36091669)
17. Altavilla D, Bitto A, Polito F, Marini H, Minutoli L, Di Stefano V, et al. Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Cardiovasc Hematol Agents Med Chem 2009; 7: 313-21.
18. Bitto A, Polito F, Altavilla D, Minutoli L, Migliorato A, Squadrito F,. Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease. J Vasc Surg 2008; 48: 1292-300.
19. Bitto A, Galeano M, Squadrito F, Minutoli L, Polito F, Dye JF, et al. Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury. Crit Care Med 2008; 36: 1594-602. (Pubitemid 351620667)
20. Watanabe T, Kubota S, Nagaya M, Ozaki S, Nagafuchi H, Akashi K, et al. The role of HMGB-1 on the development of necrosis during hepatic ischemia and hepatic ischemia/reperfusion injury in mice. J Surg Res 2005; 124: 59-66. (Pubitemid 40269802)
21. Campbell IK, Rich MJ, Bischof RJ, Dunn AR, Grail D, Hamilton JA,. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol 1998; 161: 3639-44.
22. Firestein GS,. Evolving concepts of rheumatoid arthritis. Nature 2003; 423: 356-61. (Pubitemid 40852711)
23. Kunz M, Ibrahim SM,. Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm 2009; 2009: 979258.
24. Mussener A, Litton MJ, Lindroos E, Klareskog L,. Cytokine production in synovial tissue of mice with collagen-induced arthritis (CIA). Clin Exp Immunol 1997; 107: 485-93. (Pubitemid 27102136)
25. Marinova-Mutafchieva L, Williams RO, Mason LJ, Mauri C, Feldmann M, Maini RN,. Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin Exp Immunol 1997; 107: 507-12. (Pubitemid 27102139)
26. Lubberts E, Joosten LA, van den Bersselaar L, Helsen MM, Bakker AC, Xing Z, et al. Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw. Clin Exp Immunol 2000; 120: 375-83. (Pubitemid 30304237)
27. Vaccari T, Beltrame M, Ferrari S, Bianchi ME,. Hmg4, a new member of the Hmg1/2 gene family. Genomics 1998; 49: 247-52. (Pubitemid 28240691)
28. Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000; 192: 565-70. (Pubitemid 30666257)
29. Yang H, Wang H, Czura CJ, Tracey KJ,. The cytokine activity of HMGB1. J Leukoc Biol 2005; 78: 1-8. (Pubitemid 40979937)
30. Andersson U, Tracey KJ,. HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis. Rheum Dis Clin North Am 2004; 30: 627-37. (Pubitemid 38917005)
31. Andersson U, Erlandsson-Harris H,. HMGB1 is a potent trigger of arthritis. J Intern Med 2004; 255: 344-50. (Pubitemid 38315275)
32. Chan ES, Fernandez P, Cronstein BN,. Adenosine in inflammatory joint diseases. Purinergic Signal 2007; 3: 145-52.
33. Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, et al. Suppression of macrophage inflammatory protein (MIP)-1α production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol 1998; 125: 379-87. (Pubitemid 28425204)