Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions

Cell Host and Microbe

Volumn 15, Issue 5, 2014, Pages 587-599

  Carter, Robert ^a   Wolf, Joshua ^a   Van Opijnen, Tim ^c   Muller, Martha ^a   Obert, Caroline ^a   Burnham, Corinna ^a   Mann, Beth ^a   Li, Yimei ^a   Hayden, Randall T ^a   Pestina, Tamara ^a   Persons, Derek ^a   Camilli, Andrew ^b,c   Flynn, Patricia M ^a   Tuomanen, Elaine I ^a   Rosch, Jason W ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN DERIVATIVE; PNEUMOCOCCUS VACCINE; BACTERIAL PROTEIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CAPSULE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE SEQUENCE; GENETIC ANALYSIS; HIGH RISK PATIENT; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MOUSE; MURINAE; MUTAGENESIS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; SEROTYPE; SICKLE CELL ANEMIA; STREPTOCOCCUS PNEUMONIAE; ADAPTATION; CLASSIFICATION; COMPLICATION; GENETICS; GENOMICS; HOST PATHOGEN INTERACTION; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR GENETICS; PHYLOGENY; PHYSIOLOGY; PNEUMOCOCCAL INFECTIONS; PRESCHOOL CHILD; PROSPECTIVE STUDY;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ANEMIA, SICKLE CELL; BACTERIAL PROTEINS; CHILD; CHILD, PRESCHOOL; FEMALE; GENOMICS; HOST-PATHOGEN INTERACTIONS; HUMANS; INFANT; MALE; MOLECULAR SEQUENCE DATA; PHYLOGENY; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; PROSPECTIVE STUDIES; STREPTOCOCCUS PNEUMONIAE;

EID: 84901054480     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2014.04.005     Document Type: Article

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