Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans

Journal of Infectious Diseases

Volumn 210, Issue 1, 2014, Pages 4-13

  Syk, Anna ^a,b   Norman, Martin ^a,b   Fernebro, Jenny ^a   Gallotta, Marilena ^a   Farmand, Susan ^a,b   Sandgren, Andreas ^a   Normark, Staffan ^a,b   Henriques Normark, Birgitta ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Early clearance; Hydrogen peroxide; Macrophages; Phagocytosis; Pneumococcal virulence; SIGN R1; SpxB; Streptococcus pneumoniae

Indexed keywords

HYDROGEN PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BACTERIUM MUTANT; CELL LINE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYDROGEN PEROXIDE TTOLERANCE AND PRODUCTION ASSAY; IMMUNOASSAY; IN VITRO STUDY; MACROPHAGE; MALE; MORPHOTYPE; MORTALITY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; SPXB GENE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PNEUMONIAE SEROTYPE 1; THP1 CELL LINE;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; CELL LINE; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; MUTANT PROTEINS; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTIONS; SEROTYPING; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 84901050086     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu038     Document Type: Article

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