In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

Toxicology Letters

Volumn 228, Issue 2, 2014, Pages 93-102

  Belcher, Scott M ^a   Cookman, Clifford J ^a   Patisaul, Heather B ^b   Stapleton, Heather M ^c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

Apoptosis; Endocrine disruptor; Flame retardant; Nuclear receptors; Obesity; Peroxisome proliferator activated receptor

Indexed keywords

CELL NUCLEUS RECEPTOR; FIREMASTER 550; FLAME RETARDANT; HORMONE RECEPTOR; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATE; TRIBUTYLTIN; TRIPHENYLTIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; BRAIN TUMOR; BROMINATION; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENERGY BALANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

APOPTOSIS; ENDOCRINE DISRUPTOR; FLAME RETARDANT; NUCLEAR RECEPTORS; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR;

ADIPOCYTES; ANIMALS; CASPASE 3; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; ENDOCRINE DISRUPTORS; FLAME RETARDANTS; HUMANS; LIGANDS; ORGANOPHOSPHATES; ORGANOTIN COMPOUNDS; PPAR GAMMA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTIONAL ACTIVATION;

EID: 84901054266     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.04.017     Document Type: Article

References (31)

1. Belcher S.M., Le H.H., Spurling L., Wong J.K. Rapid estrogenic regulation of extracellular signal-regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A. Endocrinology 2005, 146:5397-5406.
2. Belcher S.M., Ma X., Le H.H. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology 2009, 150:1112-1121.
3. Cooper E.M., Covaci A., Nuijs A.L.N., Webster T.F., Stapleton H.M. Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2011, 401:2123-2132.
4. Dix D.J., Houck K.A., Martin M.T., Richard A.M., Setzer R.W., Kavlock R.J. The ToxCast Program for prioritizing toxicity testing of environmental chemicals. Toxicol. Sci. 2007, 95:5-12.
5. Grun F., Blumberg B. Minireview: the case for obesogens. Mol. Endocrinol. 2009, 23:1127-1134.
6. Grün F., Watanabe H., Zamanian Z., Maeda L., Arima K., Cubacha R., Gardiner D.M., Kanno J., Iguchi T., Blumberg B. Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol. Endocrinol. 2006, 20:2141-2155.
7. Hiromori Y., Nishikawa J.-i., Yoshida I., Nagase H., Nakanishi T. Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) γ by organotin compounds. Chem. Biol. Interact. 2009, 180:238-244.
8. Honkakoski P., Palvimo J.J., Penttilä L., Vepsäläinen J., Auriola S. Effects of triaryl phosphates on mouse and human nuclear receptors. Biochem. Pharmacol. 2004, 67:97-106.
9. Iguchi T., Watanabe H., Ohta Y., Blumberg B. Developmental effects: oestrogen-induced vaginal changes and organotin-induced adipogenesis. Int. J. Androl. 2008, 31:263-268.
10. Ismail-Beigi F., Catalano P.M., Hanson R.W. Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E439-E440.
11. Janesick A., Blumberg B. Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity. Birth Defects Res. C Embryo Today 2011, 93:34-50.
12. Jugan M.-L., Levi Y., Blondeau J.-P. Endocrine disruptors and thyroid hormone physiology. Biochem. Pharmacol. 2010, 79:939-947.
13. Kojima H., Takeuchi S., Itoh T., Iida M., Kobayashi S., Yoshida T. In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors. Toxicology 2013, 314:76-83.
14. Lefebvre P., Benomar Y., Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol. Metab. 2010, 21:676-683.
15. Liu Y.-Y., Brent G.A. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol. Metab. 2010, 21:166-173.
16. McGee S.P., Konstantinov A., Stapleton H.M., Volz D.C. Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: potential role of the aryl hydrocarbon receptor. Toxicol. Sci. 2013, 133:144-156.
17. Nakanishi T. Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor. J. Toxicol. Sci. 2008, 33:269-276.
18. Patisaul H.B., Roberts S.C., Mabrey N., McCaffrey K.A., Gear R.B., Braun J., Belcher S.M., Stapleton H.M. Accumulation and endocrine disrupting effects of the flame retardant mixture firemaster((R)) 550 in rats: an exploratory assessment. J. Biochem. Mol. Toxicol. 2013, 27:124-136.
19. Prasad H., Ryan D.A., Celzo M.F., Stapleton D. Metabolic syndrome: definition and therapeutic implications. Postgrad. Med. 2012, 124:21-30.
20. Roberts S.C., Macaulay L.J., Stapleton H.M. In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues. Chem. Res. Toxicol. 2012, 25:1435-1441.
21. Stapleton H.M., Allen J.G., Kelly S.M., Konstantinov A., Klosterhaus S., Watkins D., McClean M.D., Webster T.F. Alternate and new brominated flame retardants detected in U.S. house dust. Environ. Sci. Technol. 2008, 42:6910-6916.
22. Stapleton H.M., Eagle S., Sjodin A., Webster T.F. Serum PBDEs in a North Carolina Toddler Cohort: associations with hand wipes, house dust and socioeconomic variables. Environ. Health Perspect. 2012, 10.1289/ehp.1104802.
23. Stapleton H.M., Klosterhaus S., Eagle S., Fuh J., Meeker J.D., Blum A., Webster T.F. Detection of organophosphate flame retardants in furniture foam and U.S. house dust. Environ. Sci. Technol. 2009, 43:7490-7495.
24. Stapleton H.M., Klosterhaus S., Keller A., Ferguson P.L., van Bergen S., Cooper E., Webster T.F., Blum A. Identification of flame retardants in polyurethane foam collected from baby products. Environ. Sci. Technol. 2011, 45:5323-5331.
25. Stapleton H.M., Sharma S., Getzinger G., Ferguson P.L., Gabriel M., Webster T.F., Blum A. Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out. Environ. Sci. Technol. 2012, 46:13432-13439.
26. Thorne N., Shen M., Lea S.A., Simeonov A., Lovell S., Auld D.S., Inglese J. Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem. Biol. 2012, 19:1060-1072.
27. Van den Eede N., Maho W., Erratico C., Neels H., Covaci A. First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions. Toxicol. Lett. 2013, 223:9-15.
28. van der Veen I., de Boer J. Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis. Chemosphere 2012, 88:1119-1153.
29. Vazzana N., Santilli F., Sestili S., Cuccurullo C., Davi G. Determinants of increased cardiovascular disease in obesity and metabolic syndrome. Curr. Med. Chem. 2011, 18:5267-5280.
30. Wong J.K., Kennedy P.R., Belcher S.M. Simplified serum- and steroid-free culture conditions for high-throughput viability analysis of primary cultures of cerebellar granule neurons. J. Neurosci. Methods 2001, 110:45-55.
31. Wong J.K., Le H.H., Zsarnovszky A., Belcher S.M. Estrogens and ICI182,780 (Faslodex) modulate mitosis and cell death in immature cerebellar neurons via rapid activation of p44/p42 mitogen-activated protein kinase. J. Neurosci. 2003, 23:4984-4995.