Gene markers of cellular aging in human multipotent stromal cells in culture

Stem Cell Research and Therapy

Volumn 5, Issue 2, 2014, Pages

  Bellayr, Ian H ^a   Catalano, Jennifer G ^a   Lababidi, Samir ^a   Yang, Amy X ^a   Lo Surdo, Jessica L ^a   Bauer, Steven R ^a   Puri, Raj K ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MALE; MARKER GENE; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; UNINDEXED SEQUENCE; CELL CULTURE; GENE EXPRESSION; GENETIC MARKER; GENETICS; MESENCHYMAL STROMA CELL; PHYSIOLOGY;

GENETIC MARKER;

CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; GENETIC MARKERS; HUMANS; MESENCHYMAL STROMAL CELLS;

EID: 84901039802     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/scrt448     Document Type: Article

References (90)

1. One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating. Liu Y, Goldberg AJ, Dennis JE, Gronowicz GA, Kuhn LT, PLoS One 2012 7 33225 10.1371/journal.pone. 0033225 22457746
2. Mesenchymal stem cells as trophic mediators. Caplan AI, Dennis JE, J Cell Biochem 2006 98 1076 1084 10.1002/jcb.20886 16619257 (Pubitemid 44128350)
3. Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation. Patel AN, Park E, Kuzman M, Benetti F, Silva FJ, Allickson JG, Cell Transplant 2008 17 303 311 10.3727/ 096368908784153922 18522233 (Pubitemid 351717333)
4. The National Institute of Health Clinical Trials. [ http://www. clinicaltrials.gov/ ]
5. Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine. Lau D, Ogbogu U, Taylor B, Stafinski T, Menon D, Caulfield T, Cell Stem Cell 2008 3 591 594 10.1016/j.stem.2008.11.001 19041775
6. Differentiation potential of human muscle-derived cells towards chondrogenic phenotype in alginate beads culture. Andriamanalijaona R, Duval E, Raoudi M, Lecourt S, Vilquin JT, Marolleau JP, Pujol JP, Galera P, Boumediene K, Osteoarthritis Cartilage 2008 16 1509 1518 10.1016/j.joca.2008.04.018 18554936
7. Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis. Riekstina U, Cakstina I, Parfejevs V, Hoogduijn M, Jankovskis G, Muiznieks I, Muceniece R, Ancans J, Stem Cell Rev 2009 5 378 386 10.1007/s12015-009-9094-9 20058201
8. Adipose-derived stem cells differentiate to keratocytes in vitro. Du Y, Roh DS, Funderburgh ML, Mann MM, Marra KG, Rubin JP, Li X, Funderburgh JL, Mol Vis 2010 16 2680 2689 21179234
9. Proteome analysis during chondrocyte differentiation in a new chondrogenesis model using human umbilical cord stroma mesenchymal stem cells. De la Fuente A, Mateos J, Lesende-Rodriguez I, Calamia V, Fuentes-Boquete I, de Toro FJ, Arufe MC, Blanco FJ, Mol Cell Proteom 2012 11 010496
10. A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells. Barradas AM, Fernandes HA, Groen N, Chai YC, Schrooten J, van de Peppel J, van Leeuwen JP, van Blitterswijk CA, de Boer J, Biomaterials 2012 33 3205 3215 10.1016/j. biomaterials.2012.01.020 22285104
11. Biological characterization of long-term cultured human mesenchymal stem cells. Kim J, Kang JW, Park JH, Choi Y, Choi KS, Park KD, Baek DH, Seong SK, Min HK, Kim HS, Arch Pharm Res 2009 32 117 126 10.1007/s12272-009-1125-1 19183884
12. Isolation, characterization, and transduction of endometrial decidual tissue multipotent mesenchymal stromal/stem cells from menstrual blood. Rossignoli F, Caselli A, Grisendi G, Piccinno S, Burns JS, Murgia A, Veronesi E, Loschi P, Masini C, Conte P, Paolucci P, Horwiz EM, Dominici M, Biomed Res Int 2013 2013 901821 23607099
13. Minimal criteria for defining multipotent mesenchymal stromal cells: The International Society for Cellular Therapy position statement. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E, Cytotherapy 2006 8 315 317 10.1080/14653240600855905 16923606 (Pubitemid 44269669)
14. Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation. Cutler AJ, Limbani V, Girdlestone J, Navarrete CV, J Immunol 2010 185 6617 6623 10.4049/jimmunol.1002239 20980628
15. Analysis of the chondrogenic potential and secretome of mesenchymal stem cells derived from human umbilical cord stroma. Arufe MC, De la Fuente A, Fuentes J, Mateos I, De Toro FJ, Blanco FJ, Stem Cells Dev 2011 20 1199 1212 10.1089/scd.2010.0315 20977334
16. Proteomic definitions of mesenchymal stem cells. Maurer MH, Stem Cells Int 2011 2011 704256 21437194
17. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y, Cell Stem Cell 2008 2 141 150 10.1016/j.stem.2007. 11.014 18371435 (Pubitemid 351181031)
18. Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols. Hermann A, Liebau S, Gastl R, Fickert S, Habisch HJ, Fiedler J, Schwarz J, Brenner R, Storch A, J Neurosci Res 2006 83 1502 1514 10.1002/jnr.20840 16612831 (Pubitemid 43844995)
19. Blood-derived stem cells (BDSCs) plasticity: in vitro hepatic differentiation. Alaimo G, Cozzoli E, Marfe G, Esposito L, Ranalli M, Hmada D, Giordano A, Gambacurta A, J Cell Physiol 2012 228 1249 1254
20. Flow cytometric characterization of myogenic cell populations obtained via the preplate technique: potential for rapid isolation of muscle-derived stem cells. Jankowski RJ, Haluszczak C, Trucco M, Huard J, Hum Gene Ther 2001 12 619 628 10.1089/104303401300057306 11426462 (Pubitemid 32506941)
21. Differentiation of adipose-derived stromal vascular fraction culture cells into chondrocytes using the method of cell sorting with a mesenchymal stem cell marker. Ishimura D, Yamamoto N, Tajima K, Ohno A, Yamamoto Y, Washimi O, Yamada H, Tohoku J Exp Med 2008 216 149 156 10.1620/tjem.216.149 18832797
22. A simple modification of the separation method reduces heterogeneity of adipose-derived stem cells. Griesche N, Luttmann W, Luttmann A, Stammermann T, Geiger H, Baer PC, Cells Tissues Organs 2010 192 106 115 10.1159/000289586 20185896
23. Functional differences between mesenchymal stem cell populations are reflected by their transcriptome. Jansen BJ, Gilissen C, Roelofs H, Schaap-Oziemlak A, Veltman JA, Raymakers RA, Jansen JH, Kogler G, Figdor CG, Torensma R, Adema GJ, Stem Cells Dev 2010 19 481 490 10.1089/scd.2009.0288 19788395
24. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Rebelatto CK, Aguiar AM, Moretao MP, Senegaglia AC, Hansen P, Barchiki F, Oliveira J, Martins J, Kuligovski C, Mansur F, Christofis A, Amaral VF, Brofman PS, Goldenberg S, Nakao LS, Correa A, Exp Biol Med (Maywood) 2008 233 901 913 10.3181/0712-RM-356 18445775
25. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Wagner W, Wein F, Seckinger A, Frankhauser M, Wirkner U, Krause U, Blake J, Schwager C, Eckstein V, Ansorge W, Ho AD, Exp Hematol 2005 33 1402 1416 10.1016/j.exphem.2005.07.003 16263424 (Pubitemid 41541969)
26. Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood. Secco M, Moreira YB, Zucconi E, Vieira NM, Jazedje T, Muotri AR, Okamoto OK, Verjovski-Almeida S, Zatz M, Stem Cell Rev 2009 5 387 401 10.1007/s12015-009-9098-5 20058202
27. Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. Phinney DG, Kopen G, Righter W, Webster S, Tremain N, Prockop DJ, J Cell Biochem 1999 75 424 436 10.1002/(SICI)1097-4644(19991201) 75:3<424::AID-JCB8>3.0.CO;2-8 10536366 (Pubitemid 29521651)
28. Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. Phinney DG, Kopen G, Isaacson RL, Prockop DJ, J Cell Biochem 1999 72 570 585 10.1002/(SICI)1097-4644(19990315)72:4<570::AID-JCB12>3.0.CO;2-W 10022616 (Pubitemid 29088308)
29. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. Muraglia A, Cancedda R, Quarto R, J Cell Sci 2000 113 1161 1166 10704367 (Pubitemid 30229533)
30. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, Gimble JM, J Cell Physiol 2006 206 229 237 10.1002/jcp.20463 16021633 (Pubitemid 41740736)
31. Population dynamics of mesenchymal stromal cells during culture expansion. Schellenberg A, Stiehl T, Horn P, Joussen S, Pallua N, Ho AD, Wagner W, Cytotherapy 2012 14 401 411 10.3109/14653249.2011.640669 22149184
32. Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: implication to age-associated bone diseases and defects. Kim M, Kim C, Choi YS, Park C, Suh Y, Mech Ageing Dev 2012 133 215 225 10.1016/j.mad.2012.03.014 22738657
33. Long-term serial passage and neuronal differentiation capability of human bone marrow mesenchymal stem cells. Khoo ML, Shen B, Tao H, Ma DD, Stem Cells Dev 2008 17 883 896 10.1089/scd.2007.0185 18826370
34. Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes. Parsch D, Fellenberg J, Brummendorf TH, Eschlbeck AM, Richter W, J Mol Med (Berl) 2004 82 49 55 10.1007/s00109-003-0506-z 14647922 (Pubitemid 38168101)
35. How to track cellular aging of mesenchymal stromal cells? Wagner W, Bork S, Lepperdinger G, Joussen S, Ma N, Strunk D, Koch C, Aging (Albany NY) 2010 2 224 230 20453259
36. Replicative senescence of mesenchymal stem cells: a continuous and organized process. Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, Saffrich R, Benes V, Blake J, Pfister S, Eckstein V, Ho AD, PLoS One 2008 3 2213 10.1371/journal.pone.0002213 18493317
37. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Baer PC, Geiger H, Stem Cells Int 2012 2012 812693 22577397
38. The origins of mesenchymal stromal cell heterogeneity. Pevsner-Fischer M, Levin S, Zipori D, Stem Cell Rev 2011 7 560 568 10.1007/s12015-011-9229-7 21437576
39. Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells. Lo Surdo J, Bauer SR, Tissue Eng Part C Methods 2012 18 877 889 10.1089/ten.tec.2011.0736 22563812
40. Gene expression in human embryonic stem cell lines: unique molecular signature. Bhattacharya B, Miura T, Brandenberger R, Mejido J, Luo Y, Yang AX, Joshi BH, Ginis I, Thies RS, Amit M, Lyons I, Condie BG, Itskovitz-Eldor J, Rao MS, Puri RK, Blood 2004 103 2956 2964 10.1182/blood-2003-09-3314 15070671 (Pubitemid 38451667)
41. Novel multiple 5′-amino-modified primer for DNA microarrays. Han J, Lee H, Nguyen NY, Beaucage SL, Puri RK, Genomics 2005 86 252 258 10.1016/j.ygeno.2005.04.009 15949917 (Pubitemid 40917229)
42. ArrayTrack: an FDA and public genomic tool. Fang H, Harris SC, Su Z, Chen M, Qian F, Shi L, Perkins R, Tong W, Methods Mol Biol 2009 563 379 398 10.1007/978-1-60761-175-2-20 19597796
43. Technical variability is greater than biological variability in a microarray experiment but both are outweighed by changes induced by stimulation. Bryant PA, Smyth GK, Robins-Browne R, Curtis N, PLoS One 2011 6 19556 10.1371/journal.pone.0019556 21655321
44. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Benjamini Y, Hochberg Y, J R Stat Soc Series B-Method 1995 57 289 300
45. Fold change and p-value cutoffs significantly alter microarray interpretations. Dalman MR, Deeter A, Nimishakavi G, Duan ZH, BMC Bioinformat 2012 13 11
46. Microarray data analysis: a practical approach for selecting differentially expressed genes. Mutch DM, Berger A, Mansourian R, Rytz A, Roberts MA, Genome Biol 2001 2 REPRINT0009 11790248
47. Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells. Lo Surdo JL, Millis BA, Bauer SR, Cytotherapy 2013 15 1527 1540 10.1016/j.jcyt.2013.04.010 23992827
48. Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. Kulterer B, Friedl G, Jandrositz A, Sanchez-Cabo F, Prokesch A, Paar C, Scheideler M, Windhager R, Preisegger KH, Trajanoski Z, BMC Genom 2007 8 70 10.1186/1471-2164-8-70
49. Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture. Tanabe S, Sato Y, Suzuki T, Suzuki K, Nagao T, Yamaguchi T, J Biochem 2008 144 399 408 10.1093/jb/mvn082 18550633
50. Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence. Ren J, Stroncek DF, Zhao Y, Jin P, Castiello L, Civini S, Wang H, Feng J, Tran K, Kuznetsov SA, Robey PG, Sabatino M, Stem Cell Res 2013 11 1060 1073 10.1016/j.scr.2013.07.005 23959330
51. The human keratins: biology and pathology. Moll R, Divo M, Langbein L, Histochem Cell Biol 2008 129 705 733 10.1007/s00418-008-0435-6 18461349
52. Phenotypic modulation of keratins, vimentin, and alpha-fetoprotein in cultured rat liver epithelial cells after chemical, oncogene, and spontaneous transformation. Bisgaard HC, Ton PT, Nagy P, Thorgeirsson SS, J Cell Physiol 1994 159 485 494 10.1002/jcp.1041590313 7514612 (Pubitemid 24188989)
53. Cytokeratins and cell differentiation in the pancreas. Bouwens L, J Pathol 1998 184 234 239 10.1002/(SICI)1096-9896(199803)184:3<234::AID- PATH28>3.0.CO;2-D 9614373 (Pubitemid 28112777)
54. Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. Chen X, Whitney EM, Gao SY, Yang VW, J Mol Biol 2003 326 665 677 10.1016/S0022-2836(02)01449-3 12581631 (Pubitemid 36279310)
55. Differentiation-dependent expression of keratins in human oral epithelia. Clausen H, Vedtofte P, Moe D, Dabelsteen E, Sun TT, Dale B, J Invest Dermatol 1986 86 249 254 10.1111/1523-1747.ep12285369 2427604 (Pubitemid 16124157)
56. Molecular biology of keratinocyte differentiation. Eckert RL, Rorke EA, Environ Health Perspect 1989 80 109 116 2466639 (Pubitemid 19084668)
57. Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft-versus-host disease. Luft T, Conzelmann M, Benner A, Rieger M, Hess M, Strohhaecker U, Gorner M, Hegenbart U, Ho AD, Dreger P, Blood 2007 110 4535 4542 10.1182/blood-2006-10-049817 17702900 (Pubitemid 351377821)
58. Plasma biomarkers of lower gastrointestinal and liver acute GVHD. Harris AC, Ferrara JL, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Landfried K, Akashi K, Vander Lugt M, Couriel DR, Reddy P, Paczesny S, Blood 2012 119 2960 2963 10.1182/blood-2011-10-387357 22286196
59. Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer. Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T, Breast Cancer Res Treat 2010 122 699 710 10.1007/s10549-009-0600-1 19859801
60. The expression and function of netrin-4 in murine ocular tissues. Li YN, Pinzon-Duarte G, Dattilo M, Claudepierre T, Koch M, Brunken WJ, Exp Eye Res 2012 96 24 35 10.1016/j.exer.2012.01.007 22281059
61. Endothelium-derived Netrin-4 supports pancreatic epithelial cell adhesion and differentiation through integrins alpha2beta1 and alpha3beta1. Yebra M, Diaferia GR, Montgomery AM, Kaido T, Brunken WJ, Koch M, Hardiman G, Crisa L, Cirulli V, PLoS One 2011 6 22750 10.1371/journal.pone.0022750 21829502
62. Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis. Eveno C, Broqueres-You D, Feron JG, Rampanou A, Tijeras-Raballand A, Ropert S, Leconte L, Levy BI, Pocard M, Am J Pathol 2011 178 1861 1869 10.1016/j.ajpath.2010.12.019 21406174
63. Netrin-4 promotes glioblastoma cell proliferation through integrin beta4 signaling. Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiainen M, Neoplasia 2012 14 219 227 22496621
64. Netrin-4 regulates angiogenic responses and tumor cell growth. Nacht M, St Martin TB, Byrne A, Klinger KW, Teicher BA, Madden SL, Jiang Y, Exp Cell Res 2009 315 784 794 10.1016/j.yexcr.2008.11.018 19094984
65. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T, Hirano T, Proc Natl Acad Sci U S A 1994 91 5325 5329 10.1073/pnas.91.12.5325 8202488 (Pubitemid 24174319)
66. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. Itoh M, Ishihara K, Hiroi T, Lee BO, Maeda H, Iijima H, Yanagita M, Kiyono H, Hirano T, J Immunol 1998 161 3974 3983 9780166 (Pubitemid 28468974)
67. Identification of Pax5 target genes in early B cell differentiation. Pridans C, Holmes ML, Polli M, Wettenhall JM, Dakic A, Corcoran LM, Smyth GK, Nutt SL, J Immunol 2008 180 1719 1728 10.4049/jimmunol.180.3.1719 18209069
68. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Barkho BZ, Song H, Aimone JB, Smrt RD, Kuwabara T, Nakashima K, Gage FH, Zhao X, Stem Cells Dev 2006 15 407 421 10.1089/scd.2006.15.407 16846377 (Pubitemid 44100017)
69. In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Shahdadfar A, Fronsdal K, Haug T, Reinholt FP, Brinchmann JE, Stem Cells 2005 23 1357 1366 10.1634/stemcells.2005-0094 16081661 (Pubitemid 41504923)
70. Exploring the enkephalinergic differentiation potential in adult stem cells for cell therapy and drug screening implications. Hafizi M, Bakhshandeh B, Soleimani M, Atashi A, In Vitro Cell Dev Biol Anim 2012 48 562 569 10.1007/s11626-012-9546-4 23054438
71. Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues. Denning GM, Ackermann LW, Barna TJ, Armstrong JG, Stoll LL, Weintraub NL, Dickson EW, Peptides 2008 29 83 92 10.1016/j.peptides.2007.11. 004 18082911 (Pubitemid 50016591)
72. Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells. Tondreau T, Dejeneffe M, Meuleman N, Stamatopoulos B, Delforge A, Martiat P, Bron D, Lagneaux L, BMC Genomics 2008 9 166 10.1186/1471-2164-9-166 18405367 (Pubitemid 351611895)
73. Developmental regulation of proenkephalin gene expression in osteoblasts. Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z, Mol Endocrinol 1995 9 1621 1631 8584038
74. The enkephalinergic osteoblast. Rosen H, Krichevsky A, Bar-Shavit Z, J Bone Miner Res 1998 13 1515 1520 9783539 (Pubitemid 28465291)
75. Preproenkephalin (Penk) is expressed in differentiated osteoblasts, and its deletion in Hyp mice partially rescues their bone mineralization defect. Seitz S, Barvencik F, Gebauer M, Albers J, Schulze J, Streichert T, Amling M, Schinke T, Calcif Tissue Int 2010 86 282 293 10.1007/s00223-010-9344-5 20204609
76. Kruppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Moore DL, Apara A, Goldberg JL, Mol Cell Neurosci 2011 47 233 243 10.1016/j.mcn.2011.05.005 21635952
77. Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Laub F, Lei L, Sumiyoshi H, Kajimura D, Dragomir C, Smaldone S, Puche AC, Petros TJ, Mason C, Parada LF, Ramirez F, Mol Cell Biol 2005 25 5699 5711 10.1128/MCB.25.13.5699-5711.2005 15964824 (Pubitemid 40853603)
78. Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL, Blood 2006 107 1357 1365 10.1182/blood-2005-05-1916 16234353 (Pubitemid 43242369)
79. BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia. Tanner SM, Austin JL, Leone G, Rush LJ, Plass C, Heinonen K, Mrozek K, Sill H, Knuutila S, Kolitz JE, Archer KJ, Caligiuri MA, Bloomfield CD, de La Chapelle A, Proc Natl Acad Sci U S A 2001 98 13901 13906 10.1073/pnas.241525498 11707601 (Pubitemid 33115996)
80. Baalc, a marker of mesoderm and muscle. Satoskar AA, Tanner SM, Weinstein M, Qualman SJ, de la Chapelle A, Gene Expr Patterns 2005 5 463 473 10.1016/j.modgep.2004.12.008 15749074 (Pubitemid 40331385)
81. BAALC, a novel marker of human hematopoietic progenitor cells. Baldus CD, Tanner SM, Kusewitt DF, Liyanarachchi S, Choi C, Caligiuri MA, Bloomfield CD, de la Chapelle A, Exp Hematol 2003 31 1051 1056 14585369 (Pubitemid 37329749)
82. Ascorbic acid modulates proliferation and extracellular matrix accumulation of hyalocytes. Sommer F, Kobuch K, Brandl F, Wild B, Framme C, Weiser B, Tessmar J, Gabel VP, Blunk T, Goepferich A, Tissue Eng 2007 13 1281 1289 10.1089/ten.2006.0274 17518733 (Pubitemid 46986728)
83. Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation. Dehne T, Schenk R, Perka C, Morawietz L, Pruss A, Sittinger M, Kaps C, Ringe J, Gene 2010 462 8 17 10.1016/j.gene.2010.04.006 20433912
84. Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells. Weber GL, Parat MO, Binder ZA, Gallia GL, Riggins GJ, Oncotarget 2011 2 833 849 22064833
85. The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. Keita M, Bachvarova M, Morin C, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Trinh XB, Bachvarov D, Cell Cycle 2013 12 972 986 10.4161/cc.23963 23442798
86. Collagen 11a1 is indirectly activated by lymphocyte enhancer-binding factor 1 (Lef1) and negatively regulates osteoblast maturation. Kahler RA, Yingst SM, Hoeppner LH, Jensen ED, Krawczak D, Oxford JT, Westendorf JJ, Matrix Biol 2008 27 330 338 10.1016/j.matbio.2008.01.002 18280717
87. Gene expression patterns related to osteogenic differentiation of bone marrow-derived mesenchymal stem cells during ex vivo expansion. Granchi D, Ochoa G, Leonardi E, Devescovi V, Baglio SR, Osaba L, Baldini N, Ciapetti G, Tissue Eng Part C Methods 2010 16 511 524 10.1089/ten.tec.2009.0405 19686055
88. enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs. Ciapetti G, Granchi D, Devescovi V, Baglio SR, Leonardi E, Martini D, Jurado MJ, Olalde B, Armentano I, Kenny JM, Walboomers FX, Alava JI, Baldini N, Int J Mol Sci 2012 13 2439 2458 10.3390/ijms13022439 22408463
89. Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomics. Madeira A, da Silva CL, dos Santos F, Camafeita E, Cabral JM, Sa-Correia I, PLoS One 2012 7 43523 10.1371/journal.pone.0043523 22916271
90. MSC-based product characterization for clinical trials: an FDA perspective. Mendicino M, Bailey AM, Wonnacott K, Puri RK, Bauer SR, Cell Stem Cell 2014 14 141 145 10.1016/j.stem.2014.01.013 24506881