Netrin-4 regulates angiogenic responses and tumor cell growth

Experimental Cell Research

Volumn 315, Issue 5, 2009, Pages 784-794

  Nacht, Mariana ^a   St Martin, Thia B ^a   Byrne, Ann ^a   Klinger, Katherine W ^a   Teicher, Beverly A ^a   Madden, Stephen L ^a   Jiang, Yide ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Akt; Angiogenesis; Jnk; Netrin 4; Phosphorylation; Tumor cells

Indexed keywords

AMINO ACID; GLYCOPROTEIN; NETRIN; NETRIN 4; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; BREAST CANCER; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MICROVASCULARIZATION; MORPHOGENESIS; NEURITE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TUMOR GROWTH; WESTERN BLOTTING;

EID: 59849106746     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.11.018     Document Type: Article

References (37)

1. Srinivasan K., Strickland P., Valdes A., Shin G.C., and Hinck L. Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev. Cell 4 (2003) 371-382
2. Liu Y., Stein E., Oliver T., Li Y., Brunken W.J., Koch M., Tessier-Lavigne M., and Hogan B.L. Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr. Biol. 14 (2004) 897-905
3. Mazelin L., Bernet A., Bonod-Bidaud C., Pays L., Arnaud S., Gespach C., Bredesen D.E., Scoazec J.Y., and Mehlen P. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431 (2004) 80-84
4. Park K.W., Crouse D., Lee M., Karnik S.K., Sorensen L.K., Murphy K.J., Kuo C.J., and Li D.Y. The axonal attractant Netrin-1 is an angiogenic factor. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16210-16215
5. Ly N.P., Komatsuzaki K., Fraser I.P., Tseng A.A., Prodhan P., Moore K.J., and Kinane T.B. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 14729-14734
6. Lu X., le Noble F., Yuan L., Jiang Q., de Lafarge B., Sugiyama D., Breant C., Claes F., De Smet F., Thomas J.-L., Autiero M., Carmeliet P., Tessier-Lavigne M., and Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432 (2004) 179-186
7. Wilson B.D., Ii M., Park K.W., Suli A., Sorensen L.K., Larrieu-Lahargue F., Urness L.D., Suh W., Asai J., Kock G.A., Thorne T., Silver M., Thomas K.R., Chien C.B., Losordo D.W., and Li D.Y. Netrins promote developmental and therapeutic angiogenesis. Science 313 (2006) 640-644
8. Liu G., Beggs H., Jurgensen C., Park H.T., Tang H., Gorski J., Jones K.R., Reichardt L.F., Wu J., and Rao Y. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat. Neurosci. 7 (2004) 1222-1232
9. Yang Y., Zou L., Wang Y., Xu K.S., Zhang J.X., and Zhang J.H. Axon Guidance Cue Netrin-1 has Dual Function in Angiogenesis. Cancer Biol. Ther. 6 (2007) 5
10. Nguyen A., and Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 6530-6535
11. Koch M., Murrell J.R., Hunter D.D., Olson P.F., Jin W., Keene D.R., Brunken W.J., and Burgeson R.E. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J. Cell Biol. 151 (2000) 221-234
12. Yin Y., Sanes J.R., and Miner J.H. Identification and expression of mouse netrin-4. Mech. Dev. 96 (2000) 115-119
13. Latil A., Chene L., Cochant-Priollet B., Mangin P., Fournier G., Berthon P., and Cussenot O. Quantification of expression of netrins, slits and their receptors in human prostate tumors. Int. J. Cancer 103 (2003) 306-315
14. Esseghir S., Kennedy A., Seedhar P., Nerurkar A., Poulsom R., Reis-Filho J.S., and Isacke C.M. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clin. Cancer Res. 13 (2007) 3164-3173
15. St Croix B., Rago C., Velculescu V., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., and Kinzler K.W. Genes expressed in human tumor endothelium. Science 289 (2000) 1197-1202
16. Ho M., Yang E., Matcuk G., Deng D., Sampas N., Tsalenko A., Tabibiazar R., Zhang Y., Chen M., Talbi S., Ho Y.D., Wang J., Tsao P.S., Ben-Dor A., Yakhini Z., Bruhn L., and Quertermous T. Identification of endothelial cell genes by combined database mining and microarray analysis. Physiol. Genomics 13 (2003) 249-262
17. Strizzi L., Bianco C., Raafat A., Abdallah W., Chang C., Raafat D., Hirota M., Hamada S., Sun Y., Normanno N., Callahan R., Hinck L., and Salomon D. Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo. J. Cell Sci. 118 (2005) 4633-4643
18. Song G., Ouyang G., and Bao S. The activation of Akt/PKB signaling pathway and cell survival. J. Cell. Mol. Med. 9 (2005) 59-71
19. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 103 (2000) 239-252
20. Kallunki T., Su B., Tsigelny I., Sluss H.K., Derijard B., Moore G., Davis R., and Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8 (1994) 2996-3007
21. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270 (1995) 16483-16486
22. Smeal T., Hibi M., and Karin M. Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. EMBO J. 13 (1994) 6006-6010
23. De Breuck S., Lardon J., Rooman I., and Bouwens L. Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 46 (2003) 926-933
24. Dalvin S., Anselmo M.A., Prodhan P., Komatsuzaki K., Schnitzer J.J., and Kinane T.B. Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. Gene Expr. Patterns 3 (2003) 279-283
25. Carmeliet P. Angiogenesis in life, disease and medicine. Nature 438 (2005) 932-936
26. Eichmann A., Makinen T., and Alitalo K. Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev. 19 (2005) 1013-1021
27. Suchting S., Bicknell R., and Eichmann A. Neuronal clues to vascular guidance. Exp. Cell Res. 312 (2006) 668-675
28. Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat. Rev., Cancer 4 (2004) 978-987
29. Campbell D.S., and Holt C.E. Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron 37 (2003) 939-952
30. Ennis B.W., Fultz K.E., Smith K.A., Westwick J.K., Zhu D., Boluro-Ajayi M., Bilter G.K., and Stein B. Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. J. Pharmacol. Exp. Ther. 313 (2005) 325-332
31. Karin M., Liu Z., and Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9 (1997) 240-246
32. Huang C., Jacobson K., and Schaller M.D. MAP kinases and cell migration. J. Cell Sci. 117 (2004) 4619-4628
33. Hirano T., Shino Y., Saito T., Komoda F., Okutomi Y., Takeda A., Ishihara T., Yamaguchi T., Saisho H., and Shirasawa H. Dominant negative MEKK1 inhibits survival of pancreatic cancer cells. Oncogene 21 (2002) 5923-5928
34. Chen J., Somanath P.R., Razorenova O., Chen W.S., Hay N., Bornstein P., and Byzova T.V. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat. Med. 11 (2005) 1188-1196
35. Faraldo M.M., Deugnier M.A., Thiery J.P., and Glukhova M.A. Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways. EMBO Rep. 2 (2001) 431-437
36. Schneiders F.I., Maertens B., Bose K., Li Y., Brunken W.J., Paulsson M., Smyth N., and Koch M. Binding of netrin-4 to laminin short arms regulates basement membrane assembly. J. Biol. Chem. 282 (2007) 23750-23758
37. Schneiders F.I., Maertens B., Bose K., Li Y., Brunken W.J., Paulsson M., Smyth N., and Koch M. Binding of netrin-4 to laminin short arms regulates basement membrane assembly. J. Biol. Chem. 22 (2007) 22