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Volumn 4 MAR, Issue , 2014, Pages

Molecular therapeutic approaches for pediatric acute myeloid leukemia

Author keywords

Acute myeloid leukemia; Clinical trial; Demethylating agents; Monoclonal antibodies; Pediatric; Precision medicine; Targeted therapy; Tyrosine kinase inhibitors

Indexed keywords

1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; 2 (6 AMINO 9H PURIN 9 YL) 5 [[[3 [2 (5 TERT BUTYL 1H BENZIMIDAZOL 2 YL)ETHYL]CYCLOBUTYL](ISOPROPYL)AMINO]METHYL]TETRAHYDROFURAN 3,4 DIOL; 5 AZA 2' DEOXYCYTIDINE; ACTINIUM 225; ALISERTIB; AMG 330; AMG 900; AML02; ASP 2215; AZACITIDINE; BLINATUMOMAB; BORTEZOMIB; BRENTUXIMAB VEDOTIN; CARFILZOMIB; CART 123; CART 33; CRENOLANIB; CSL 362; EVEROLIMUS; GEMTUZUMAB OZOGAMICIN; IGN523; IPILIMUMAB; JQ 1; LESTAURTINIB; LINIFANIB; LINTUZUMAB; MIDOSTAURIN; OXT 015; PANOBINOSTAT; PLX3397; QUIZARTINIB; RAPAMYCIN; SELINEXOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VORINOSTAT; [4 [2 (1H INDAZOL 3 YL)VINYL]PHENYL](1 PIPERAZINYL)METHANONE;

EID: 84901036213     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00055     Document Type: Review
Times cited : (33)

References (143)
  • 1
    • 34147145338 scopus 로고    scopus 로고
    • Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia
    • doi:10.1634/theoncologist.12-3-341
    • Meshinchi S, Arceci RJ. Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia. Oncologist (2007) 12(3):341-55. doi:10.1634/theoncologist.12-3-341.
    • (2007) Oncologist , vol.12 , Issue.3 , pp. 341-355
    • Meshinchi, S.1    Arceci, R.J.2
  • 2
    • 79952078495 scopus 로고    scopus 로고
    • Biology, risk stratification, and therapy of pediatric acute leukemias: an update
    • doi:10.1200/JCO.2010.30.7405
    • Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol (2011) 29(5):551-65. doi:10.1200/JCO.2010.30.7405.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 551-565
    • Pui, C.H.1    Carroll, W.L.2    Meshinchi, S.3    Arceci, R.J.4
  • 3
    • 84880289614 scopus 로고    scopus 로고
    • Novel therapies for children with acute myeloid leukaemia
    • doi:10.1038/leu.2013.106
    • Moore AS, Kearns PR, Knapper S, Pearson AD, Zwaan CM. Novel therapies for children with acute myeloid leukaemia. Leukemia (2013) 27(7):1451-60. doi:10.1038/leu.2013.106.
    • (2013) Leukemia , vol.27 , Issue.7 , pp. 1451-1460
    • Moore, A.S.1    Kearns, P.R.2    Knapper, S.3    Pearson, A.D.4    Zwaan, C.M.5
  • 4
    • 84868129082 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel
    • doi:10.1182/blood-2012-03-362608
    • Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, et al. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood (2012) 120(16):3187-205. doi:10.1182/blood-2012-03-362608.
    • (2012) Blood , vol.120 , Issue.16 , pp. 3187-3205
    • Creutzig, U.1    van den Heuvel-Eibrink, M.M.2    Gibson, B.3    Dworzak, M.N.4    Adachi, S.5    de Bont, E.6
  • 5
    • 84874957831 scopus 로고    scopus 로고
    • Epidemiology of childhood acute myeloid leukemia
    • doi:10.1002/pbc.24464
    • Puumala SE, Ross JA, Aplenc R, Spector LG. Epidemiology of childhood acute myeloid leukemia. Pediatr Blood Cancer (2013) 60(5):728-33. doi:10.1002/pbc.24464.
    • (2013) Pediatr Blood Cancer , vol.60 , Issue.5 , pp. 728-733
    • Puumala, S.E.1    Ross, J.A.2    Aplenc, R.3    Spector, L.G.4
  • 6
    • 77958499209 scopus 로고    scopus 로고
    • Prognostic factors in pediatric acute myeloid leukemia
    • doi:10.1007/s11899-010-0060-z
    • Radhi M, Meshinchi S, Gamis A. Prognostic factors in pediatric acute myeloid leukemia. Curr Hematol Malig Rep (2010) 5(4):200-6. doi:10.1007/s11899-010-0060-z.
    • (2010) Curr Hematol Malig Rep , vol.5 , Issue.4 , pp. 200-206
    • Radhi, M.1    Meshinchi, S.2    Gamis, A.3
  • 7
    • 84856860527 scopus 로고    scopus 로고
    • Genetic and epigenetic similarities and differences between childhood and adult AML
    • doi:10.1002/pbc.23397
    • Juhl-Christensen C, Ommen HB, Aggerholm A, Lausen B, Kjeldsen E, Hasle H, et al. Genetic and epigenetic similarities and differences between childhood and adult AML. Pediatr Blood Cancer (2012) 58(4):525-31. doi:10.1002/pbc.23397.
    • (2012) Pediatr Blood Cancer , vol.58 , Issue.4 , pp. 525-531
    • Juhl-Christensen, C.1    Ommen, H.B.2    Aggerholm, A.3    Lausen, B.4    Kjeldsen, E.5    Hasle, H.6
  • 8
    • 84887536558 scopus 로고    scopus 로고
    • Somatic characterization of pediatric acute myeloid leukemia using next-generation sequencing
    • doi:10.1053/j.seminhematol.2013.09.003
    • Schuback HL, Arceci RJ, Meshinchi S. Somatic characterization of pediatric acute myeloid leukemia using next-generation sequencing. Semin Hematol (2013) 50(4):325-32. doi:10.1053/j.seminhematol.2013.09.003.
    • (2013) Semin Hematol , vol.50 , Issue.4 , pp. 325-332
    • Schuback, H.L.1    Arceci, R.J.2    Meshinchi, S.3
  • 9
    • 84860333177 scopus 로고    scopus 로고
    • Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
    • doi:10.1182/blood-2011-12-398370
    • Pollard JA, Alonzo TA, Loken M, Gerbing RB, Ho PA, Bernstein ID, et al. Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML. Blood (2012) 119(16):3705-11. doi:10.1182/blood-2011-12-398370.
    • (2012) Blood , vol.119 , Issue.16 , pp. 3705-3711
    • Pollard, J.A.1    Alonzo, T.A.2    Loken, M.3    Gerbing, R.B.4    Ho, P.A.5    Bernstein, I.D.6
  • 10
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
    • doi:10.1021/bc010021y
    • Hamann PR, Hinman LM, Hollander I, Beyer CF, Lindh D, Holcomb R, et al. Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem (2002) 13(1):47-58. doi:10.1021/bc010021y.
    • (2002) Bioconjug Chem , vol.13 , Issue.1 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3    Beyer, C.F.4    Lindh, D.5    Holcomb, R.6
  • 11
    • 34248338806 scopus 로고    scopus 로고
    • CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
    • doi:10.1182/blood-2006-09-047399
    • Walter RB, Gooley TA, van der Velden VH, Loken MR, van Dongen JJ, Flowers DA, et al. CD33 expression and P-glycoprotein-mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy. Blood (2007) 109(10):4168-70. doi:10.1182/blood-2006-09-047399.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4168-4170
    • Walter, R.B.1    Gooley, T.A.2    van der Velden, V.H.3    Loken, M.R.4    van Dongen, J.J.5    Flowers, D.A.6
  • 12
    • 18244428964 scopus 로고    scopus 로고
    • Differences in CD33 intensity between various myeloid neoplasms
    • doi:10.1309/1WMW-CMXX-4WN4-T55U
    • Jilani I, Estey E, Huh Y, Joe Y, Manshouri T, Yared M, et al. Differences in CD33 intensity between various myeloid neoplasms. Am J Clin Pathol (2002) 118(4):560-6. doi:10.1309/1WMW-CMXX-4WN4-T55U.
    • (2002) Am J Clin Pathol , vol.118 , Issue.4 , pp. 560-566
    • Jilani, I.1    Estey, E.2    Huh, Y.3    Joe, Y.4    Manshouri, T.5    Yared, M.6
  • 13
    • 0035397980 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
    • Sievers EL, Larson RA, Stadtmauer EA, Estey E, Lowenberg B, Dombret H, et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol (2001) 19(13):3244-54.
    • (2001) J Clin Oncol , vol.19 , Issue.13 , pp. 3244-3254
    • Sievers, E.L.1    Larson, R.A.2    Stadtmauer, E.A.3    Estey, E.4    Lowenberg, B.5    Dombret, H.6
  • 14
    • 25144485908 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
    • doi:10.1002/cncr.21326
    • Larson RA, Sievers EL, Stadtmauer EA, Lowenberg B, Estey EH, Dombret H, et al. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer (2005) 104(7):1442-52. doi:10.1002/cncr.21326.
    • (2005) Cancer , vol.104 , Issue.7 , pp. 1442-1452
    • Larson, R.A.1    Sievers, E.L.2    Stadtmauer, E.A.3    Lowenberg, B.4    Estey, E.H.5    Dombret, H.6
  • 15
    • 10744230708 scopus 로고    scopus 로고
    • A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia
    • doi:10.1182/blood-2003-05-1620
    • Kell WJ, Burnett AK, Chopra R, Yin JA, Clark RE, Rohatiner A, et al. A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. Blood (2003) 102(13):4277-83. doi:10.1182/blood-2003-05-1620.
    • (2003) Blood , vol.102 , Issue.13 , pp. 4277-4283
    • Kell, W.J.1    Burnett, A.K.2    Chopra, R.3    Yin, J.A.4    Clark, R.E.5    Rohatiner, A.6
  • 16
    • 3943088435 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin (Mylotarg) in children with refractory or relapsed acute myeloid leukemia
    • doi:10.1159/000075606
    • Reinhardt D, Diekamp S, Fleischhack G, Corbacioglu C, Jurgens H, Dworzak M, et al. Gemtuzumab ozogamicin (Mylotarg) in children with refractory or relapsed acute myeloid leukemia. Onkologie (2004) 27(3):269-72. doi:10.1159/000075606.
    • (2004) Onkologie , vol.27 , Issue.3 , pp. 269-272
    • Reinhardt, D.1    Diekamp, S.2    Fleischhack, G.3    Corbacioglu, C.4    Jurgens, H.5    Dworzak, M.6
  • 17
    • 76449104667 scopus 로고    scopus 로고
    • Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study
    • doi:10.1111/j.1365-2141.2009.08011.x
    • Zwaan CM, Reinhardt D, Zimmerman M, Hasle H, Stary J, Stark B, et al. Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study. Br J Haematol (2010) 148(5):768-76. doi:10.1111/j.1365-2141.2009.08011.x.
    • (2010) Br J Haematol , vol.148 , Issue.5 , pp. 768-776
    • Zwaan, C.M.1    Reinhardt, D.2    Zimmerman, M.3    Hasle, H.4    Stary, J.5    Stark, B.6
  • 18
    • 84855604981 scopus 로고    scopus 로고
    • A Phase I study of gemtuzumab ozogamicin (GO) in combination with busulfan and cyclophosphamide (Bu/Cy) and allogeneic stem cell transplantation in children with poor-risk CD33+ AML: a new targeted immunochemotherapy myeloablative conditioning (MAC) regimen
    • doi:10.1016/j.bbmt.2011.11.007
    • Satwani P, Bhatia M, Garvin JH Jr, George D, Dela Cruz F, Le Gall J, et al. A Phase I study of gemtuzumab ozogamicin (GO) in combination with busulfan and cyclophosphamide (Bu/Cy) and allogeneic stem cell transplantation in children with poor-risk CD33+ AML: a new targeted immunochemotherapy myeloablative conditioning (MAC) regimen. Biol Blood Marrow Transplant (2012) 18(2):324-9. doi:10.1016/j.bbmt.2011.11.007.
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.2 , pp. 324-329
    • Satwani, P.1    Bhatia, M.2    Garvin Jr., J.H.3    George, D.4    Dela Cruz, F.5    Le Gall, J.6
  • 19
    • 26444515033 scopus 로고    scopus 로고
    • Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia
    • doi:10.1158/1078-0432.CCR-1004-0018
    • Roman E, Cooney E, Harrison L, Militano O, Wolownik K, Hawks R, et al. Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with CD33+ acute myeloid leukemia. Clin Cancer Res (2005) 11(19 Pt 2):7164s-70s. doi:10.1158/1078-0432.CCR-1004-0018.
    • (2005) Clin Cancer Res , vol.11 , Issue.19 PART 2
    • Roman, E.1    Cooney, E.2    Harrison, L.3    Militano, O.4    Wolownik, K.5    Hawks, R.6
  • 20
    • 23744511263 scopus 로고    scopus 로고
    • Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia
    • doi:10.1182/blood-2004-10-3821
    • Arceci RJ, Sande J, Lange B, Shannon K, Franklin J, Hutchinson R, et al. Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia. Blood (2005) 106(4):1183-8. doi:10.1182/blood-2004-10-3821.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1183-1188
    • Arceci, R.J.1    Sande, J.2    Lange, B.3    Shannon, K.4    Franklin, J.5    Hutchinson, R.6
  • 21
    • 3242749618 scopus 로고    scopus 로고
    • Pharmacokinetics of gemtuzumab ozogamicin as a single-agent treatment of pediatric patients with refractory or relapsed acute myeloid leukemia
    • doi:10.1177/0091270004267595
    • Buckwalter M, Dowell JA, Korth-Bradley J, Gorovits B, Mayer PR. Pharmacokinetics of gemtuzumab ozogamicin as a single-agent treatment of pediatric patients with refractory or relapsed acute myeloid leukemia. J Clin Pharmacol (2004) 44(8):873-80. doi:10.1177/0091270004267595.
    • (2004) J Clin Pharmacol , vol.44 , Issue.8 , pp. 873-880
    • Buckwalter, M.1    Dowell, J.A.2    Korth-Bradley, J.3    Gorovits, B.4    Mayer, P.R.5
  • 22
    • 84887079391 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia
    • doi:10.1002/cncr.28334
    • O'Hear C, Inaba H, Pounds S, Shi L, Dahl G, Bowman WP, et al. Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia. Cancer (2013) 119(22):4036-43. doi:10.1002/cncr.28334.
    • (2013) Cancer , vol.119 , Issue.22 , pp. 4036-4043
    • O'Hear, C.1    Inaba, H.2    Pounds, S.3    Shi, L.4    Dahl, G.5    Bowman, W.P.6
  • 23
    • 44249087421 scopus 로고    scopus 로고
    • Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group
    • doi:10.1200/JCO.2007.13.0096
    • Aplenc R, Alonzo TA, Gerbing RB, Lange BJ, Hurwitz CA, Wells RJ, et al. Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group. J Clin Oncol (2008) 26(14):2390-3295. doi:10.1200/JCO.2007.13.0096.
    • (2008) J Clin Oncol , vol.26 , Issue.14 , pp. 2390-3295
    • Aplenc, R.1    Alonzo, T.A.2    Gerbing, R.B.3    Lange, B.J.4    Hurwitz, C.A.5    Wells, R.J.6
  • 24
    • 80055064760 scopus 로고    scopus 로고
    • AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group
    • doi:10.1002/cncr.26190
    • Cooper TM, Franklin J, Gerbing RB, Alonzo TA, Hurwitz C, Raimondi SC, et al. AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group. Cancer (2012) 118(3):761-9. doi:10.1002/cncr.26190.
    • (2012) Cancer , vol.118 , Issue.3 , pp. 761-769
    • Cooper, T.M.1    Franklin, J.2    Gerbing, R.B.3    Alonzo, T.A.4    Hurwitz, C.5    Raimondi, S.C.6
  • 25
    • 84864548693 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004
    • doi:10.1182/blood-2012-03-416701
    • Hasle H, Abrahamsson J, Forestier E, Ha SY, Heldrup J, Jahnukainen K, et al. Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004. Blood (2012) 120(5):978-84. doi:10.1182/blood-2012-03-416701.
    • (2012) Blood , vol.120 , Issue.5 , pp. 978-984
    • Hasle, H.1    Abrahamsson, J.2    Forestier, E.3    Ha, S.Y.4    Heldrup, J.5    Jahnukainen, K.6
  • 26
    • 84901003824 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin (GO) in children with de novo acute myeloid leukemia (AML) improves event-free survival (EFS) by reducing relapse risk-results from the randomized Phase III Children's Oncology Group (COG) trial, AAML0531
    • Gamis A, Aplenc R, Alonzo TA, Sung L, Meshinchi S, Gerbing RB, et al. Gemtuzumab ozogamicin (GO) in children with de novo acute myeloid leukemia (AML) improves event-free survival (EFS) by reducing relapse risk-results from the randomized Phase III Children's Oncology Group (COG) trial, AAML0531. Blood (2013) 122(21):355.
    • (2013) Blood , vol.122 , Issue.21 , pp. 355
    • Gamis, A.1    Aplenc, R.2    Alonzo, T.A.3    Sung, L.4    Meshinchi, S.5    Gerbing, R.B.6
  • 27
    • 84901026811 scopus 로고    scopus 로고
    • Negative prognostic impact of high CD33 expression is negated with the use of gemtuzumab ozogamicin: a report from the Children's Oncology Group
    • Pollard JA, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch B, Aplenc R, et al. Negative prognostic impact of high CD33 expression is negated with the use of gemtuzumab ozogamicin: a report from the Children's Oncology Group. Blood (2013) 122(21):491.
    • (2013) Blood , vol.122 , Issue.21 , pp. 491
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3    Raimondi, S.C.4    Hirsch, B.5    Aplenc, R.6
  • 28
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • doi:10.1182/blood-2013-01-466706
    • Petersdorf SH, Kopecky KJ, Slovak M, Willman C, Nevill T, Brandwein J, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood (2013) 121(24):4854-60. doi:10.1182/blood-2013-01-466706.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6
  • 30
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial
    • doi:10.1200/JCO.2010.31.4310
    • Burnett AK, Hills RK, Milligan D, Kjeldsen L, Kell J, Russell NH, et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol (2011) 29(4):369-77. doi:10.1200/JCO.2010.31.4310.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6
  • 31
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • doi:10.1200/JCO.2012.42.2964
    • Burnett AK, Russell NH, Hills RK, Kell J, Freeman S, Kjeldsen L, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol (2012) 30(32):3924-31. doi:10.1200/JCO.2012.42.2964.
    • (2012) J Clin Oncol , vol.30 , Issue.32 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Kell, J.4    Freeman, S.5    Kjeldsen, L.6
  • 32
    • 84873409057 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison
    • doi:10.1038/leu.2012.229
    • Burnett AK, Hills RK, Hunter AE, Milligan D, Kell WJ, Wheatley K, et al. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia (2013) 27(1):75-81. doi:10.1038/leu.2012.229.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 75-81
    • Burnett, A.K.1    Hills, R.K.2    Hunter, A.E.3    Milligan, D.4    Kell, W.J.5    Wheatley, K.6
  • 33
    • 84901054039 scopus 로고    scopus 로고
    • Health USNIo. Clinical Trials. [cited 2014 Jan 21]
    • Health USNIo. Clinical Trials. (2013) [cited 2014 Jan 21]. Available from: www.clinicaltrials.gov.
    • (2013)
  • 34
    • 84880531303 scopus 로고    scopus 로고
    • Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin
    • doi:10.2741/4181
    • Cowan AJ, Laszlo GS, Estey EH, Walter RB. Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin. Front Biosci (2013) 18:1311-34. doi:10.2741/4181.
    • (2013) Front Biosci , vol.18 , pp. 1311-1334
    • Cowan, A.J.1    Laszlo, G.S.2    Estey, E.H.3    Walter, R.B.4
  • 35
    • 84886825064 scopus 로고    scopus 로고
    • SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
    • doi:10.1182/blood-2013-03-491506
    • Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H, et al. SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood (2013) 122(8):1455-63. doi:10.1182/blood-2013-03-491506.
    • (2013) Blood , vol.122 , Issue.8 , pp. 1455-1463
    • Kung Sutherland, M.S.1    Walter, R.B.2    Jeffrey, S.C.3    Burke, P.J.4    Yu, C.5    Kostner, H.6
  • 36
    • 84871491706 scopus 로고    scopus 로고
    • Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • doi:10.1182/blood-2012-07-441030
    • Topp MS, Gokbuget N, Zugmaier G, Degenhard E, Goebeler ME, Klinger M, et al. Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood (2012) 120(26):5185-7. doi:10.1182/blood-2012-07-441030.
    • (2012) Blood , vol.120 , Issue.26 , pp. 5185-5187
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3    Degenhard, E.4    Goebeler, M.E.5    Klinger, M.6
  • 37
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • doi:10.1200/JCO.2010.32.7270
    • Topp MS, Kufer P, Gokbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol (2011) 29(18):2493-8. doi:10.1200/JCO.2010.32.7270.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 38
    • 84897019168 scopus 로고    scopus 로고
    • CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330
    • doi:10.1182/blood-2013-08-523548
    • Krupka C, Kufer P, Kischel R, Zugmaier G, Bogeholz J, Kohnke T, et al. CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330. Blood (2014) 123(3):356-65. doi:10.1182/blood-2013-08-523548.
    • (2014) Blood , vol.123 , Issue.3 , pp. 356-365
    • Krupka, C.1    Kufer, P.2    Kischel, R.3    Zugmaier, G.4    Bogeholz, J.5    Kohnke, T.6
  • 39
    • 84897018823 scopus 로고    scopus 로고
    • Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML
    • doi:10.1182/blood-2013-09-527044
    • Laszlo GS, Gudgeon CJ, Harrington KH, Dell'Aringa J, Newhall KJ, Means GD, et al. Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML. Blood (2014) 123(4):554-61. doi:10.1182/blood-2013-09-527044.
    • (2014) Blood , vol.123 , Issue.4 , pp. 554-561
    • Laszlo, G.S.1    Gudgeon, C.J.2    Harrington, K.H.3    Dell'Aringa, J.4    Newhall, K.J.5    Means, G.D.6
  • 40
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
    • doi:10.1038/leu.2012.341
    • Aigner M, Feulner J, Schaffer S, Kischel R, Kufer P, Schneider K, et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia (2013) 27(5):1107-15. doi:10.1038/leu.2012.341.
    • (2013) Leukemia , vol.27 , Issue.5 , pp. 1107-1115
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3    Kischel, R.4    Kufer, P.5    Schneider, K.6
  • 41
    • 84859238174 scopus 로고    scopus 로고
    • What happened to anti-CD33 therapy for acute myeloid leukemia?
    • doi:10.1007/s11899-011-0103-0
    • Jurcic JG. What happened to anti-CD33 therapy for acute myeloid leukemia? Curr Hematol Malig Rep (2012) 7(1):65-73. doi:10.1007/s11899-011-0103-0.
    • (2012) Curr Hematol Malig Rep , vol.7 , Issue.1 , pp. 65-73
    • Jurcic, J.G.1
  • 42
    • 33845254595 scopus 로고    scopus 로고
    • Clinical implications of FLT3 mutations in pediatric AML
    • doi:10.1182/blood-2006-03-009233
    • Meshinchi S, Alonzo TA, Stirewalt DL, Zwaan M, Zimmerman M, Reinhardt D, et al. Clinical implications of FLT3 mutations in pediatric AML. Blood (2006) 108(12):3654-61. doi:10.1182/blood-2006-03-009233.
    • (2006) Blood , vol.108 , Issue.12 , pp. 3654-3661
    • Meshinchi, S.1    Alonzo, T.A.2    Stirewalt, D.L.3    Zwaan, M.4    Zimmerman, M.5    Reinhardt, D.6
  • 43
    • 33750614145 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia
    • doi:10.1182/blood-2006-04-012260
    • Pollard JA, Alonzo TA, Gerbing RB, Woods WG, Lange BJ, Sweetser DA, et al. FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia. Blood (2006) 108(8):2764-9. doi:10.1182/blood-2006-04-012260.
    • (2006) Blood , vol.108 , Issue.8 , pp. 2764-2769
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3    Woods, W.G.4    Lange, B.J.5    Sweetser, D.A.6
  • 44
    • 84877795436 scopus 로고    scopus 로고
    • Salvage therapy using FLT3 inhibitors may improve long-term outcome of relapsed or refractory AML in patients with FLT3-ITD
    • doi:10.1111/bjh.12299
    • Takahashi K, Kantarjian H, Pemmaraju N, Andreeff M, Borthakur G, Faderl S, et al. Salvage therapy using FLT3 inhibitors may improve long-term outcome of relapsed or refractory AML in patients with FLT3-ITD. Br J Haematol (2013) 161(5):659-66. doi:10.1111/bjh.12299.
    • (2013) Br J Haematol , vol.161 , Issue.5 , pp. 659-666
    • Takahashi, K.1    Kantarjian, H.2    Pemmaraju, N.3    Andreeff, M.4    Borthakur, G.5    Faderl, S.6
  • 45
    • 41949087055 scopus 로고    scopus 로고
    • Prognostic relevance of FLT3-TKD mutations in AML: the combination matters-an analysis of 3082 patients
    • doi:10.1182/blood-2007-05-091215
    • Bacher U, Haferlach C, Kern W, Haferlach T, Schnittger S. Prognostic relevance of FLT3-TKD mutations in AML: the combination matters-an analysis of 3082 patients. Blood (2008) 111(5):2527-37. doi:10.1182/blood-2007-05-091215.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2527-2537
    • Bacher, U.1    Haferlach, C.2    Kern, W.3    Haferlach, T.4    Schnittger, S.5
  • 46
    • 42449145174 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML
    • doi:10.1182/blood-2007-05-092510
    • Sallmyr A, Fan J, Datta K, Kim KT, Grosu D, Shapiro P, et al. Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood (2008) 111(6):3173-82. doi:10.1182/blood-2007-05-092510.
    • (2008) Blood , vol.111 , Issue.6 , pp. 3173-3182
    • Sallmyr, A.1    Fan, J.2    Datta, K.3    Kim, K.T.4    Grosu, D.5    Shapiro, P.6
  • 47
    • 79955732430 scopus 로고    scopus 로고
    • Survey of activated FLT3 signaling in leukemia
    • doi:10.1371/journal.pone.0019169
    • Gu TL, Nardone J, Wang Y, Loriaux M, Villen J, Beausoleil S, et al. Survey of activated FLT3 signaling in leukemia. PLoS One (2011) 6(4):e19169. doi:10.1371/journal.pone.0019169.
    • (2011) PLoS One , vol.6 , Issue.4
    • Gu, T.L.1    Nardone, J.2    Wang, Y.3    Loriaux, M.4    Villen, J.5    Beausoleil, S.6
  • 48
    • 77949887020 scopus 로고    scopus 로고
    • FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
    • doi:10.1182/blood-2009-09-242859
    • Pratz KW, Sato T, Murphy KM, Stine A, Rajkhowa T, Levis M. FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood (2010) 115(7):1425-32. doi:10.1182/blood-2009-09-242859.
    • (2010) Blood , vol.115 , Issue.7 , pp. 1425-1432
    • Pratz, K.W.1    Sato, T.2    Murphy, K.M.3    Stine, A.4    Rajkhowa, T.5    Levis, M.6
  • 49
    • 77954494236 scopus 로고    scopus 로고
    • FLT3 inhibitors for the treatment of acute myeloid leukemia
    • Wiernik PH. FLT3 inhibitors for the treatment of acute myeloid leukemia. Clin Adv Hematol Oncol (2010) 8(6):429-36.
    • (2010) Clin Adv Hematol Oncol , vol.8 , Issue.6 , pp. 429-436
    • Wiernik, P.H.1
  • 50
    • 39149129114 scopus 로고    scopus 로고
    • Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia
    • doi:10.1093/jnci/djm328
    • Zhang W, Konopleva M, Shi YX, McQueen T, Harris D, Ling X, et al. Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst (2008) 100(3):184-98. doi:10.1093/jnci/djm328.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.3 , pp. 184-198
    • Zhang, W.1    Konopleva, M.2    Shi, Y.X.3    McQueen, T.4    Harris, D.5    Ling, X.6
  • 51
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • doi:10.1182/blood-2010-08-301796
    • Levis M, Ravandi F, Wang ES, Baer MR, Perl A, Coutre S, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood (2011) 117(12):3294-301. doi:10.1182/blood-2010-08-301796.
    • (2011) Blood , vol.117 , Issue.12 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3    Baer, M.R.4    Perl, A.5    Coutre, S.6
  • 52
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • doi:10.1182/blood-2006-04-015560
    • Knapper S, Burnett AK, Littlewood T, Kell WJ, Agrawal S, Chopra R, et al. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood (2006) 108(10):3262-70. doi:10.1182/blood-2006-04-015560.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3    Kell, W.J.4    Agrawal, S.5    Chopra, R.6
  • 53
    • 79958789936 scopus 로고    scopus 로고
    • Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia
    • doi:10.1093/jnci/djr107
    • Hu S, Niu H, Inaba H, Orwick S, Rose C, Panetta JC, et al. Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia. J Natl Cancer Inst (2011) 103(11):893-905. doi:10.1093/jnci/djr107.
    • (2011) J Natl Cancer Inst , vol.103 , Issue.11 , pp. 893-905
    • Hu, S.1    Niu, H.2    Inaba, H.3    Orwick, S.4    Rose, C.5    Panetta, J.C.6
  • 54
    • 1842430924 scopus 로고    scopus 로고
    • Small molecule FLT3 tyrosine kinase inhibitors
    • doi:10.2174/1381612043452604
    • Levis M, Small D. Small molecule FLT3 tyrosine kinase inhibitors. Curr Pharm Des (2004) 10(11):1183-93. doi:10.2174/1381612043452604.
    • (2004) Curr Pharm Des , vol.10 , Issue.11 , pp. 1183-1193
    • Levis, M.1    Small, D.2
  • 55
    • 84867396974 scopus 로고    scopus 로고
    • Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia
    • doi:10.1038/leu.2012.114
    • Swords R, Freeman C, Giles F. Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia. Leukemia (2012) 26(10):2176-85. doi:10.1038/leu.2012.114.
    • (2012) Leukemia , vol.26 , Issue.10 , pp. 2176-2185
    • Swords, R.1    Freeman, C.2    Giles, F.3
  • 56
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
    • doi:10.1182/blood-2009-05-222034
    • Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood (2009) 114(14):2984-92. doi:10.1182/blood-2009-05-222034.
    • (2009) Blood , vol.114 , Issue.14 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3    Gardner, M.F.4    Brigham, D.5    Belli, B.6
  • 57
    • 62949087552 scopus 로고    scopus 로고
    • A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
    • doi:10.1182/blood-2008-09-177030
    • Pratz KW, Cortes J, Roboz GJ, Rao N, Arowojolu O, Stine A, et al. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response. Blood (2009) 113(17):3938-46. doi:10.1182/blood-2008-09-177030.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3938-3946
    • Pratz, K.W.1    Cortes, J.2    Roboz, G.J.3    Rao, N.4    Arowojolu, O.5    Stine, A.6
  • 58
    • 84901054040 scopus 로고    scopus 로고
    • The novel inhibitor PLX3397 effectively inhibits FLT3-mutant AML
    • Burton E, Wong B, Zhang J, West B, Bollag G, Habets G, et al. The novel inhibitor PLX3397 effectively inhibits FLT3-mutant AML. Blood (2011) 118(21):3632.
    • (2011) Blood , vol.118 , Issue.21 , pp. 3632
    • Burton, E.1    Wong, B.2    Zhang, J.3    West, B.4    Bollag, G.5    Habets, G.6
  • 59
    • 84864264337 scopus 로고    scopus 로고
    • Phase 1 trial of linifanib (ABT-869) in patients with refractory or relapsed acute myeloid leukemia
    • doi:10.3109/10428194.2012.660631
    • Wang ES, Yee K, Koh LP, Hogge D, Enschede S, Carlson DM, et al. Phase 1 trial of linifanib (ABT-869) in patients with refractory or relapsed acute myeloid leukemia. Leuk Lymphoma (2012) 53(8):1543-51. doi:10.3109/10428194.2012.660631.
    • (2012) Leuk Lymphoma , vol.53 , Issue.8 , pp. 1543-1551
    • Wang, E.S.1    Yee, K.2    Koh, L.P.3    Hogge, D.4    Enschede, S.5    Carlson, D.M.6
  • 60
    • 62949093541 scopus 로고    scopus 로고
    • Mechanisms of resistance to FLT3 inhibitors
    • doi:10.1016/j.drup.2008.12.001
    • Chu SH, Small D. Mechanisms of resistance to FLT3 inhibitors. Drug Resist Updat (2009) 12(1-2):8-16. doi:10.1016/j.drup.2008.12.001.
    • (2009) Drug Resist Updat , vol.12 , Issue.1-2 , pp. 8-16
    • Chu, S.H.1    Small, D.2
  • 61
    • 77956943977 scopus 로고    scopus 로고
    • Drug resistance in mutant FLT3-positive AML
    • doi:10.1038/onc.2010.273
    • Weisberg E, Sattler M, Ray A, Griffin JD. Drug resistance in mutant FLT3-positive AML. Oncogene (2010) 29(37):5120-34. doi:10.1038/onc.2010.273.
    • (2010) Oncogene , vol.29 , Issue.37 , pp. 5120-5134
    • Weisberg, E.1    Sattler, M.2    Ray, A.3    Griffin, J.D.4
  • 62
    • 84873567125 scopus 로고    scopus 로고
    • Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
    • doi:10.1038/leu.2012.191
    • Williams AB, Nguyen B, Li L, Brown P, Levis M, Leahy D, et al. Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors. Leukemia (2013) 27(1):48-55. doi:10.1038/leu.2012.191.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 48-55
    • Williams, A.B.1    Nguyen, B.2    Li, L.3    Brown, P.4    Levis, M.5    Leahy, D.6
  • 63
    • 84888263107 scopus 로고    scopus 로고
    • Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia
    • doi:10.1182/blood-2013-07-513044
    • Zimmerman EI, Turner DC, Buaboonnam J, Hu S, Orwick S, Roberts MS, et al. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood (2013) 122(22):3607-15. doi:10.1182/blood-2013-07-513044.
    • (2013) Blood , vol.122 , Issue.22 , pp. 3607-3615
    • Zimmerman, E.I.1    Turner, D.C.2    Buaboonnam, J.3    Hu, S.4    Orwick, S.5    Roberts, M.S.6
  • 64
    • 84891814607 scopus 로고    scopus 로고
    • Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
    • doi:10.1182/blood-2013-10-529313
    • Galanis A, Ma H, Rajkhowa T, Ramachandran A, Small D, Cortes J, et al. Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants. Blood (2014) 123(1):94-100. doi:10.1182/blood-2013-10-529313.
    • (2014) Blood , vol.123 , Issue.1 , pp. 94-100
    • Galanis, A.1    Ma, H.2    Rajkhowa, T.3    Ramachandran, A.4    Small, D.5    Cortes, J.6
  • 65
    • 84865074356 scopus 로고    scopus 로고
    • Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors
    • doi:10.1158/1078-0432.CCR-12-0625
    • Heinrich MC, Griffith D, McKinley A, Patterson J, Presnell A, Ramachandran A, et al. Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors. Clin Cancer Res (2012) 18(16):4375-84. doi:10.1158/1078-0432.CCR-12-0625.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4375-4384
    • Heinrich, M.C.1    Griffith, D.2    McKinley, A.3    Patterson, J.4    Presnell, A.5    Ramachandran, A.6
  • 66
    • 84861516763 scopus 로고    scopus 로고
    • FLT3 signaling and the development of inhibitors that target FLT3 kinase activity
    • doi:10.1615/CritRevOncog.v17.i2.50
    • Langdon WY. FLT3 signaling and the development of inhibitors that target FLT3 kinase activity. Crit Rev Oncog (2012) 17(2):199-209. doi:10.1615/CritRevOncog.v17.i2.50.
    • (2012) Crit Rev Oncog , vol.17 , Issue.2 , pp. 199-209
    • Langdon, W.Y.1
  • 67
    • 84879132548 scopus 로고    scopus 로고
    • FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance
    • doi:10.1007/s12185-013-1334-8
    • Grunwald MR, Levis MJ. FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance. Int J Hematol (2013) 97(6):683-94. doi:10.1007/s12185-013-1334-8.
    • (2013) Int J Hematol , vol.97 , Issue.6 , pp. 683-694
    • Grunwald, M.R.1    Levis, M.J.2
  • 68
    • 84894052589 scopus 로고    scopus 로고
    • Results of a Phase 1 study of quizartinib (AC220, ASP2689) in combination with induction and consolidation chemotherapy in younger patients with newly diagnosed acute myeloid leukemia
    • Altman JK, Foran JM, Pratz KW, Trone D, Gammon G, Cortes JE, et al. Results of a Phase 1 study of quizartinib (AC220, ASP2689) in combination with induction and consolidation chemotherapy in younger patients with newly diagnosed acute myeloid leukemia. Blood (2013) 122(21):623.
    • (2013) Blood , vol.122 , Issue.21 , pp. 623
    • Altman, J.K.1    Foran, J.M.2    Pratz, K.W.3    Trone, D.4    Gammon, G.5    Cortes, J.E.6
  • 69
    • 84901049209 scopus 로고    scopus 로고
    • AC220 (Quizartinib) can be safely combined with conventional chemotherapy in older patients with newly diagnosed acute myeloid leukaemia: experience from the AML18 pilot trial
    • Burnett AK, Bowen D, Russell N, Knapper S, Milligan D, Hunter AE, et al. AC220 (Quizartinib) can be safely combined with conventional chemotherapy in older patients with newly diagnosed acute myeloid leukaemia: experience from the AML18 pilot trial. Blood (2013) 122(21)622.
    • (2013) Blood , vol.122 , Issue.21 , pp. 622
    • Burnett, A.K.1    Bowen, D.2    Russell, N.3    Knapper, S.4    Milligan, D.5    Hunter, A.E.6
  • 70
    • 4444342401 scopus 로고    scopus 로고
    • Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition
    • doi:10.1182/blood-2004-03-1034
    • Brown P, Meshinchi S, Levis M, Alonzo TA, Gerbing R, Lange B, et al. Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition. Blood (2004) 104(6):1841-9. doi:10.1182/blood-2004-03-1034.
    • (2004) Blood , vol.104 , Issue.6 , pp. 1841-1849
    • Brown, P.1    Meshinchi, S.2    Levis, M.3    Alonzo, T.A.4    Gerbing, R.5    Lange, B.6
  • 71
    • 11244300074 scopus 로고    scopus 로고
    • FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
    • doi:10.1182/blood-2004-06-2498
    • Brown P, Levis M, Shurtleff S, Campana D, Downing J, Small D. FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. Blood (2005) 105(2):812-20. doi:10.1182/blood-2004-06-2498.
    • (2005) Blood , vol.105 , Issue.2 , pp. 812-820
    • Brown, P.1    Levis, M.2    Shurtleff, S.3    Campana, D.4    Downing, J.5    Small, D.6
  • 72
    • 33746149660 scopus 로고    scopus 로고
    • Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
    • doi:10.1038/sj.leu.2404277
    • Brown P, Levis M, McIntyre E, Griesemer M, Small D. Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia (2006) 20(8):1368-76. doi:10.1038/sj.leu.2404277.
    • (2006) Leukemia , vol.20 , Issue.8 , pp. 1368-1376
    • Brown, P.1    Levis, M.2    McIntyre, E.3    Griesemer, M.4    Small, D.5
  • 73
    • 84901066288 scopus 로고    scopus 로고
    • Treatment of infant leukemias: challenge and promise
    • doi:10.1182/asheducation-2013.1.596
    • Brown P. Treatment of infant leukemias: challenge and promise. Hematology Am Soc Hematol Educ Program (2013) 2013:596-600. doi:10.1182/asheducation-2013.1.596.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 596-600
    • Brown, P.1
  • 74
    • 84868543745 scopus 로고    scopus 로고
    • A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report
    • doi:10.1158/1078-0432.CCR-11-3284
    • Widemann BC, Kim A, Fox E, Baruchel S, Adamson PC, Ingle AM, et al. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report. Clin Cancer Res (2012) 18(21):6011-22. doi:10.1158/1078-0432.CCR-11-3284.
    • (2012) Clin Cancer Res , vol.18 , Issue.21 , pp. 6011-6022
    • Widemann, B.C.1    Kim, A.2    Fox, E.3    Baruchel, S.4    Adamson, P.C.5    Ingle, A.M.6
  • 75
    • 84864928986 scopus 로고    scopus 로고
    • Sorafenib as treatment for relapsed or refractory pediatric acute myelogenous leukemia
    • doi:10.1002/pbc.23394
    • Watt TC, Cooper T. Sorafenib as treatment for relapsed or refractory pediatric acute myelogenous leukemia. Pediatr Blood Cancer (2012) 59(4):756-7. doi:10.1002/pbc.23394.
    • (2012) Pediatr Blood Cancer , vol.59 , Issue.4 , pp. 756-757
    • Watt, T.C.1    Cooper, T.2
  • 76
    • 80052017961 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia
    • doi:10.1200/JCO.2011.34.7427
    • Inaba H, Rubnitz JE, Coustan-Smith E, Li L, Furmanski BD, Mascara GP, et al. Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia. J Clin Oncol (2011) 29(24):3293-300. doi:10.1200/JCO.2011.34.7427.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3293-3300
    • Inaba, H.1    Rubnitz, J.E.2    Coustan-Smith, E.3    Li, L.4    Furmanski, B.D.5    Mascara, G.P.6
  • 77
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • doi:10.1200/JCO.2009.25.4888
    • Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY, et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol (2010) 28(11):1856-62. doi:10.1200/JCO.2009.25.4888.
    • (2010) J Clin Oncol , vol.28 , Issue.11 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3    Faderl, S.4    Garcia-Manero, G.5    Konopleva, M.Y.6
  • 78
    • 84886534519 scopus 로고    scopus 로고
    • Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial
    • doi:10.1200/JCO.2012.46.4990
    • Serve H, Krug U, Wagner R, Sauerland MC, Heinecke A, Brunnberg U, et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. J Clin Oncol (2013) 31(25):3110-8. doi:10.1200/JCO.2012.46.4990.
    • (2013) J Clin Oncol , vol.31 , Issue.25 , pp. 3110-3118
    • Serve, H.1    Krug, U.2    Wagner, R.3    Sauerland, M.C.4    Heinecke, A.5    Brunnberg, U.6
  • 79
    • 84901054041 scopus 로고    scopus 로고
    • Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD+ AML
    • Pollard JA, Chang BH, Cooper TM, Gross T, Gupta S, Ho PA, et al. Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD+ AML. Blood (2013) 122(21):3969.
    • (2013) Blood , vol.122 , Issue.21 , pp. 3969
    • Pollard, J.A.1    Chang, B.H.2    Cooper, T.M.3    Gross, T.4    Gupta, S.5    Ho, P.A.6
  • 80
    • 77950612017 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML
    • doi:10.1182/blood-2009-09-241075
    • Pollard JA, Alonzo TA, Gerbing RB, Ho PA, Zeng R, Ravindranath Y, et al. Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood (2010) 115(12):2372-9. doi:10.1182/blood-2009-09-241075.
    • (2010) Blood , vol.115 , Issue.12 , pp. 2372-2379
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3    Ho, P.A.4    Zeng, R.5    Ravindranath, Y.6
  • 81
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a Phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation
    • Levis MJ, Perl AE, Dombret H, Dohner H, Steffen B, Rousselot P, et al. Final results of a Phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation. Blood (2012) 120(21):673.
    • (2012) Blood , vol.120 , Issue.21 , pp. 673
    • Levis, M.J.1    Perl, A.E.2    Dombret, H.3    Dohner, H.4    Steffen, B.5    Rousselot, P.6
  • 82
    • 84901030045 scopus 로고    scopus 로고
    • A Phase I study of AC220 (Quizartinib) in combination with cytarabine and etoposide in relapsed/refractory childhood ALL and AML: a therapeutic advances in childhood leukemia & lymphoma (TACL) study
    • Cooper TM, Malvar J, Cassar J, Eckroth E, Sposto R, Gaynon P, et al. A Phase I study of AC220 (Quizartinib) in combination with cytarabine and etoposide in relapsed/refractory childhood ALL and AML: a therapeutic advances in childhood leukemia & lymphoma (TACL) study. Blood (2013) 122(21):624.
    • (2013) Blood , vol.122 , Issue.21 , pp. 624
    • Cooper, T.M.1    Malvar, J.2    Cassar, J.3    Eckroth, E.4    Sposto, R.5    Gaynon, P.6
  • 83
    • 84890603543 scopus 로고    scopus 로고
    • Large-scale analysis of PDGFRA mutations in melanomas and evaluation of their sensitivity to tyrosine kinase inhibitors imatinib and crenolanib
    • doi:10.1158/1078-0432.CCR-13-1266
    • Dai J, Kong Y, Si L, Chi Z, Cui C, Sheng X, et al. Large-scale analysis of PDGFRA mutations in melanomas and evaluation of their sensitivity to tyrosine kinase inhibitors imatinib and crenolanib. Clin Cancer Res (2013) 19(24):6935-42. doi:10.1158/1078-0432.CCR-13-1266.
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6935-6942
    • Dai, J.1    Kong, Y.2    Si, L.3    Chi, Z.4    Cui, C.5    Sheng, X.6
  • 84
    • 84979796721 scopus 로고    scopus 로고
    • The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia
    • doi:10.1200/EdBook_AM.2013.33.313
    • Smith CC, Shah NP. The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. Am Soc Clin Oncol Educ Book (2013) 33:313-8. doi:10.1200/EdBook_AM.2013.33.313.
    • (2013) Am Soc Clin Oncol Educ Book , vol.33 , pp. 313-318
    • Smith, C.C.1    Shah, N.P.2
  • 85
    • 77952299648 scopus 로고    scopus 로고
    • Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia
    • doi:10.3324/haematol.2009.013797
    • Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L, et al. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica (2010) 95(5):819-28. doi:10.3324/haematol.2009.013797.
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 819-828
    • Park, S.1    Chapuis, N.2    Tamburini, J.3    Bardet, V.4    Cornillet-Lefebvre, P.5    Willems, L.6
  • 86
    • 84858228734 scopus 로고    scopus 로고
    • Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy
    • doi:10.1158/1078-0432.CCR-11-2346
    • Perl AE, Kasner MT, Shank D, Luger SM, Carroll M. Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy. Clin Cancer Res (2012) 18(6):1716-25. doi:10.1158/1078-0432.CCR-11-2346.
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1716-1725
    • Perl, A.E.1    Kasner, M.T.2    Shank, D.3    Luger, S.M.4    Carroll, M.5
  • 87
    • 79960271775 scopus 로고    scopus 로고
    • Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
    • doi:10.1038/leu.2011.46
    • Martelli AM, Evangelisti C, Chappell W, Abrams SL, Basecke J, Stivala F, et al. Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway. Leukemia (2011) 25(7):1064-79. doi:10.1038/leu.2011.46.
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1064-1079
    • Martelli, A.M.1    Evangelisti, C.2    Chappell, W.3    Abrams, S.L.4    Basecke, J.5    Stivala, F.6
  • 88
    • 84555178663 scopus 로고    scopus 로고
    • The in vivo evaluation of active-site TOR inhibitors in models of BCR-ABL+ leukemia
    • doi:10.1007/978-1-61779-430-8_15
    • Janes MR, Fruman DA. The in vivo evaluation of active-site TOR inhibitors in models of BCR-ABL+ leukemia. Methods Mol Biol (2012) 821:251-65. doi:10.1007/978-1-61779-430-8_15.
    • (2012) Methods Mol Biol , vol.821 , pp. 251-265
    • Janes, M.R.1    Fruman, D.A.2
  • 89
    • 78349277366 scopus 로고    scopus 로고
    • Target of rapamycin signaling in leukemia and lymphoma
    • doi:10.1158/1078-0432.CCR-10-0480
    • Vu C, Fruman DA. Target of rapamycin signaling in leukemia and lymphoma. Clin Cancer Res (2010) 16(22):5374-80. doi:10.1158/1078-0432.CCR-10-0480.
    • (2010) Clin Cancer Res , vol.16 , Issue.22 , pp. 5374-5380
    • Vu, C.1    Fruman, D.A.2
  • 90
    • 84876035526 scopus 로고    scopus 로고
    • Targeted inhibition of phosphatidyl inositol-3-kinase p110beta, but not p110alpha, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
    • doi:10.1007/s10495-013-0807-9
    • Jeong JY, Kim KS, Moon JS, Song JA, Choi SH, Kim KI, et al. Targeted inhibition of phosphatidyl inositol-3-kinase p110beta, but not p110alpha, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers. Apoptosis (2013) 18(4):509-20. doi:10.1007/s10495-013-0807-9.
    • (2013) Apoptosis , vol.18 , Issue.4 , pp. 509-520
    • Jeong, J.Y.1    Kim, K.S.2    Moon, J.S.3    Song, J.A.4    Choi, S.H.5    Kim, K.I.6
  • 91
    • 77950949478 scopus 로고    scopus 로고
    • Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias
    • doi:10.1038/leu.2010.15
    • Moore AS, Blagg J, Linardopoulos S, Pearson AD. Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia (2010) 24(4):671-8. doi:10.1038/leu.2010.15.
    • (2010) Leukemia , vol.24 , Issue.4 , pp. 671-678
    • Moore, A.S.1    Blagg, J.2    Linardopoulos, S.3    Pearson, A.D.4
  • 92
    • 84875222759 scopus 로고    scopus 로고
    • Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target
    • doi:10.1038/leu.2012.256
    • Hartsink-Segers SA, Zwaan CM, Exalto C, Luijendijk MW, Calvert VS, Petricoin EF, et al. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target. Leukemia (2013) 27(3):560-8. doi:10.1038/leu.2012.256.
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 560-568
    • Hartsink-Segers, S.A.1    Zwaan, C.M.2    Exalto, C.3    Luijendijk, M.W.4    Calvert, V.S.5    Petricoin, E.F.6
  • 93
    • 84864621502 scopus 로고    scopus 로고
    • Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL
    • doi:10.1016/j.cell.2012.06.032
    • Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell (2012) 150(3):575-89. doi:10.1016/j.cell.2012.06.032.
    • (2012) Cell , vol.150 , Issue.3 , pp. 575-589
    • Wen, Q.1    Goldenson, B.2    Silver, S.J.3    Schenone, M.4    Dancik, V.5    Huang, Z.6
  • 94
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • doi:10.1182/blood.V98.8.2301
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood (2001) 98(8):2301-7. doi:10.1182/blood.V98.8.2301.
    • (2001) Blood , vol.98 , Issue.8 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 95
    • 33847410207 scopus 로고    scopus 로고
    • The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells
    • doi:10.1111/j.1365-2141.2007.06504.x
    • Stapnes C, Doskeland AP, Hatfield K, Ersvaer E, Ryningen A, Lorens JB, et al. The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. Br J Haematol (2007) 136(6):814-28. doi:10.1111/j.1365-2141.2007.06504.x.
    • (2007) Br J Haematol , vol.136 , Issue.6 , pp. 814-828
    • Stapnes, C.1    Doskeland, A.P.2    Hatfield, K.3    Ersvaer, E.4    Ryningen, A.5    Lorens, J.B.6
  • 96
    • 20144387627 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
    • doi:10.1182/blood-2004-07-2911
    • Orlowski RZ, Voorhees PM, Garcia RA, Hall MD, Kudrik FJ, Allred T, et al. Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood (2005) 105(8):3058-65. doi:10.1182/blood-2004-07-2911.
    • (2005) Blood , vol.105 , Issue.8 , pp. 3058-3065
    • Orlowski, R.Z.1    Voorhees, P.M.2    Garcia, R.A.3    Hall, M.D.4    Kudrik, F.J.5    Allred, T.6
  • 97
    • 84875693885 scopus 로고    scopus 로고
    • Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502
    • doi:10.1200/JCO.2012.45.2177
    • Attar EC, Johnson JL, Amrein PC, Lozanski G, Wadleigh M, DeAngelo DJ, et al. Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502. J Clin Oncol (2013) 31(7):923-9. doi:10.1200/JCO.2012.45.2177.
    • (2013) J Clin Oncol , vol.31 , Issue.7 , pp. 923-929
    • Attar, E.C.1    Johnson, J.L.2    Amrein, P.C.3    Lozanski, G.4    Wadleigh, M.5    DeAngelo, D.J.6
  • 98
    • 84862726260 scopus 로고    scopus 로고
    • Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia
    • doi:10.1182/blood-2012-03-413898
    • Blum W, Schwind S, Tarighat SS, Geyer S, Eisfeld AK, Whitman S, et al. Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia. Blood (2012) 119(25):6025-31. doi:10.1182/blood-2012-03-413898.
    • (2012) Blood , vol.119 , Issue.25 , pp. 6025-6031
    • Blum, W.1    Schwind, S.2    Tarighat, S.S.3    Geyer, S.4    Eisfeld, A.K.5    Whitman, S.6
  • 99
    • 84872470330 scopus 로고    scopus 로고
    • A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916)
    • doi:10.1002/pbc.24271
    • Muscal JA, Thompson PA, Horton TM, Ingle AM, Ahern CH, McGovern RM, et al. A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916). Pediatr Blood Cancer (2013) 60(3):390-5. doi:10.1002/pbc.24271.
    • (2013) Pediatr Blood Cancer , vol.60 , Issue.3 , pp. 390-395
    • Muscal, J.A.1    Thompson, P.A.2    Horton, T.M.3    Ingle, A.M.4    Ahern, C.H.5    McGovern, R.M.6
  • 100
    • 84864045203 scopus 로고    scopus 로고
    • Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
    • doi:10.1182/blood-2012-04-418640
    • Messinger YH, Gaynon PS, Sposto R, van der Giessen J, Eckroth E, Malvar J, et al. Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. Blood (2012) 120(2):285-90. doi:10.1182/blood-2012-04-418640.
    • (2012) Blood , vol.120 , Issue.2 , pp. 285-290
    • Messinger, Y.H.1    Gaynon, P.S.2    Sposto, R.3    van der Giessen, J.4    Eckroth, E.5    Malvar, J.6
  • 101
    • 77955108100 scopus 로고    scopus 로고
    • Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium
    • doi:10.1002/pbc.22456
    • Messinger Y, Gaynon P, Raetz E, Hutchinson R, Dubois S, Glade-Bender J, et al. Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium. Pediatr Blood Cancer (2010) 55(2):254-9. doi:10.1002/pbc.22456.
    • (2010) Pediatr Blood Cancer , vol.55 , Issue.2 , pp. 254-259
    • Messinger, Y.1    Gaynon, P.2    Raetz, E.3    Hutchinson, R.4    Dubois, S.5    Glade-Bender, J.6
  • 102
    • 33947362982 scopus 로고    scopus 로고
    • A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study
    • doi:10.1158/1078-0432.CCR-06-2173
    • Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, et al. A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clin Cancer Res (2007) 13(5):1516-22. doi:10.1158/1078-0432.CCR-06-2173.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1516-1522
    • Horton, T.M.1    Pati, D.2    Plon, S.E.3    Thompson, P.A.4    Bomgaars, L.R.5    Adamson, P.C.6
  • 103
    • 84901054042 scopus 로고    scopus 로고
    • Bortezomib reinduction therapy to improve response rates in pediatric ALL in first relapse: a Children's Oncology Group (COG) study (AALL07P1)
    • Horton TM, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, et al. Bortezomib reinduction therapy to improve response rates in pediatric ALL in first relapse: a Children's Oncology Group (COG) study (AALL07P1). J Clin Oncol (2013) 31(Suppl):10003.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. , pp. 10003
    • Horton, T.M.1    Lu, X.2    O'Brien, M.M.3    Borowitz, M.J.4    Devidas, M.5    Raetz, E.A.6
  • 104
    • 84898438519 scopus 로고    scopus 로고
    • A Phase 2 study of bortezomib combined with reinduction chemotherapy in children and young adults with recurrent, refractory or secondary acute myeloid leukemia: a Children's Oncology Group (COG) Study
    • Horton TM, Perentesis J, Gamis AS, Alonzo TA, Gerbing RB, Ballard J, et al. A Phase 2 study of bortezomib combined with reinduction chemotherapy in children and young adults with recurrent, refractory or secondary acute myeloid leukemia: a Children's Oncology Group (COG) Study. Blood (2012) 120(21):3580.
    • (2012) Blood , vol.120 , Issue.21 , pp. 3580
    • Horton, T.M.1    Perentesis, J.2    Gamis, A.S.3    Alonzo, T.A.4    Gerbing, R.B.5    Ballard, J.6
  • 105
    • 80755140131 scopus 로고    scopus 로고
    • Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups
    • doi:10.1038/leu.2011.142
    • Damm F, Thol F, Hollink I, Zimmermann M, Reinhardt K, van den Heuvel-Eibrink MM, et al. Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups. Leukemia (2011) 25(11):1704-10. doi:10.1038/leu.2011.142.
    • (2011) Leukemia , vol.25 , Issue.11 , pp. 1704-1710
    • Damm, F.1    Thol, F.2    Hollink, I.3    Zimmermann, M.4    Reinhardt, K.5    van den Heuvel-Eibrink, M.M.6
  • 106
    • 77952424259 scopus 로고    scopus 로고
    • Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study
    • doi:10.1038/leu.2010.56
    • Ho PA, Alonzo TA, Kopecky KJ, Miller KL, Kuhn J, Zeng R, et al. Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study. Leukemia (2010) 24(5):909-13. doi:10.1038/leu.2010.56.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 909-913
    • Ho, P.A.1    Alonzo, T.A.2    Kopecky, K.J.3    Miller, K.L.4    Kuhn, J.5    Zeng, R.6
  • 107
    • 80055096047 scopus 로고    scopus 로고
    • Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG
    • doi:10.1182/blood-2011-04-348888
    • Ho PA, Kopecky KJ, Alonzo TA, Gerbing RB, Miller KL, Kuhn J, et al. Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG. Blood (2011) 118(17):4561-6. doi:10.1182/blood-2011-04-348888.
    • (2011) Blood , vol.118 , Issue.17 , pp. 4561-4566
    • Ho, P.A.1    Kopecky, K.J.2    Alonzo, T.A.3    Gerbing, R.B.4    Miller, K.L.5    Kuhn, J.6
  • 108
    • 84879431557 scopus 로고    scopus 로고
    • Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A
    • doi:10.1182/blood-2012-06-436782
    • Liang DC, Liu HC, Yang CP, Jaing TH, Hung IJ, Yeh TC, et al. Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A. Blood (2013) 121(15):2988-95. doi:10.1182/blood-2012-06-436782.
    • (2013) Blood , vol.121 , Issue.15 , pp. 2988-2995
    • Liang, D.C.1    Liu, H.C.2    Yang, C.P.3    Jaing, T.H.4    Hung, I.J.5    Yeh, T.C.6
  • 109
    • 79961085843 scopus 로고    scopus 로고
    • DNMT3A mutations are rare in childhood acute myeloid leukemia
    • doi:10.3324/haematol.2011.046839
    • Thol F, Heuser M, Damm F, Klusmann JH, Reinhardt K, Reinhardt D. DNMT3A mutations are rare in childhood acute myeloid leukemia. Haematologica (2011) 96(8):1238-40. doi:10.3324/haematol.2011.046839.
    • (2011) Haematologica , vol.96 , Issue.8 , pp. 1238-1240
    • Thol, F.1    Heuser, M.2    Damm, F.3    Klusmann, J.H.4    Reinhardt, K.5    Reinhardt, D.6
  • 110
    • 84860772157 scopus 로고    scopus 로고
    • DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
    • doi:10.1038/leu.2011.342
    • Metzeler KH, Walker A, Geyer S, Garzon R, Klisovic RB, Bloomfield CD, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia (2012) 26(5):1106-7. doi:10.1038/leu.2011.342.
    • (2012) Leukemia , vol.26 , Issue.5 , pp. 1106-1107
    • Metzeler, K.H.1    Walker, A.2    Geyer, S.3    Garzon, R.4    Klisovic, R.B.5    Bloomfield, C.D.6
  • 111
    • 84876165672 scopus 로고    scopus 로고
    • Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults
    • doi:10.1111/bjh.12268
    • Phillips CL, Davies SM, McMasters R, Absalon M, O'Brien M, Mo J, et al. Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults. Br J Haematol (2013) 161(3):406-10. doi:10.1111/bjh.12268.
    • (2013) Br J Haematol , vol.161 , Issue.3 , pp. 406-410
    • Phillips, C.L.1    Davies, S.M.2    McMasters, R.3    Absalon, M.4    O'Brien, M.5    Mo, J.6
  • 112
    • 84890651093 scopus 로고    scopus 로고
    • Interim report of a randomized, open-label, multicenter study to evaluate the safety and efficacy of decitabine as an epigenetic priming agent when combined with induction chemotherapy in pediatric patients (pts) with newly diagnosed acute myelogenous leukemia (AML)
    • Gore L, Macy ME, Mechinaud F, Narendran A, Alvaro F, Arndt CAS, et al. Interim report of a randomized, open-label, multicenter study to evaluate the safety and efficacy of decitabine as an epigenetic priming agent when combined with induction chemotherapy in pediatric patients (pts) with newly diagnosed acute myelogenous leukemia (AML). Blood (2012) 120(21):1517.
    • (2012) Blood , vol.120 , Issue.21 , pp. 1517
    • Gore, L.1    Macy, M.E.2    Mechinaud, F.3    Narendran, A.4    Alvaro, F.5    Arndt, C.A.S.6
  • 113
    • 84900411368 scopus 로고    scopus 로고
    • Myeloid leukemia cells with MLL partial tandem duplication are sensitive to pharmacological inhibition of the H3K79 methyltransferase DOT1L
    • Kuhn MWM, Hadler M, Daigle SR, Chen C-W, Sinha AU, Krivtsov AV, et al. Myeloid leukemia cells with MLL partial tandem duplication are sensitive to pharmacological inhibition of the H3K79 methyltransferase DOT1L. Blood (2012) 120(21):1256.
    • (2012) Blood , vol.120 , Issue.21 , pp. 1256
    • Kuhn, M.W.M.1    Hadler, M.2    Daigle, S.R.3    Chen, C.-W.4    Sinha, A.U.5    Krivtsov, A.V.6
  • 114
    • 79960044951 scopus 로고    scopus 로고
    • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • doi:10.1016/j.ccr.2011.06.010
    • Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell (2011) 20(1):66-78. doi:10.1016/j.ccr.2011.06.010.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 66-78
    • Bernt, K.M.1    Zhu, N.2    Sinha, A.U.3    Vempati, S.4    Faber, J.5    Krivtsov, A.V.6
  • 115
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • doi:10.1016/j.ccr.2011.06.009
    • Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 20(1):53-65. doi:10.1016/j.ccr.2011.06.009.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 53-65
    • Daigle, S.R.1    Olhava, E.J.2    Therkelsen, C.A.3    Majer, C.R.4    Sneeringer, C.J.5    Song, J.6
  • 116
    • 79959318635 scopus 로고    scopus 로고
    • Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia
    • doi:10.1200/JCO.2010.34.4226
    • Garcia-Manero G, Gore SD, Cogle C, Ward R, Shi T, Macbeth KJ, et al. Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia. J Clin Oncol (2011) 29(18):2521-7. doi:10.1200/JCO.2010.34.4226.
    • (2011) J Clin Oncol , vol.29 , Issue.18 , pp. 2521-2527
    • Garcia-Manero, G.1    Gore, S.D.2    Cogle, C.3    Ward, R.4    Shi, T.5    Macbeth, K.J.6
  • 117
    • 51649097598 scopus 로고    scopus 로고
    • A pilot pharmacokinetic study of oral azacitidine
    • doi:10.1038/leu.2008.145
    • Garcia-Manero G, Stoltz ML, Ward MR, Kantarjian H, Sharma S. A pilot pharmacokinetic study of oral azacitidine. Leukemia (2008) 22(9):1680-4. doi:10.1038/leu.2008.145.
    • (2008) Leukemia , vol.22 , Issue.9 , pp. 1680-1684
    • Garcia-Manero, G.1    Stoltz, M.L.2    Ward, M.R.3    Kantarjian, H.4    Sharma, S.5
  • 118
    • 79952710830 scopus 로고    scopus 로고
    • Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas
    • doi:10.1158/1078-0432.CCR-10-1893
    • Stathis A, Hotte SJ, Chen EX, Hirte HW, Oza AM, Moretto P, et al. Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas. Clin Cancer Res (2011) 17(6):1582-90. doi:10.1158/1078-0432.CCR-10-1893.
    • (2011) Clin Cancer Res , vol.17 , Issue.6 , pp. 1582-1590
    • Stathis, A.1    Hotte, S.J.2    Chen, E.X.3    Hirte, H.W.4    Oza, A.M.5    Moretto, P.6
  • 119
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • doi:10.1158/0008-5472.CAN-06-0080
    • Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, Carducci M, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res (2006) 66(12):6361-9. doi:10.1158/0008-5472.CAN-06-0080.
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.B.5    Carducci, M.6
  • 120
    • 84892614202 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in combination with vorinostat and azacitidine in older patients with relapsed or refractory acute myeloid leukemia: a phase I/II study
    • doi:10.3324/haematol.2013.096545
    • Walter RB, Medeiros BC, Gardner KM, Orlowski KF, Gallegos L, Scott BL, et al. Gemtuzumab ozogamicin in combination with vorinostat and azacitidine in older patients with relapsed or refractory acute myeloid leukemia: a phase I/II study. Haematologica (2014) 99(1):54-9. doi:10.3324/haematol.2013.096545.
    • (2014) Haematologica , vol.99 , Issue.1 , pp. 54-59
    • Walter, R.B.1    Medeiros, B.C.2    Gardner, K.M.3    Orlowski, K.F.4    Gallegos, L.5    Scott, B.L.6
  • 121
    • 84892413294 scopus 로고    scopus 로고
    • Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome
    • doi:10.1038/bcj.2013.68
    • Tan P, Wei A, Mithraprabhu S, Cummings N, Liu HB, Perugini M, et al. Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood Cancer J (2014) 4:e170. doi:10.1038/bcj.2013.68.
    • (2014) Blood Cancer J , vol.4
    • Tan, P.1    Wei, A.2    Mithraprabhu, S.3    Cummings, N.4    Liu, H.B.5    Perugini, M.6
  • 123
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • doi:10.1038/nature10334
    • Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature (2011) 478(7370):524-8. doi:10.1038/nature10334.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3    Rappaport, A.R.4    Herrmann, H.5    Sison, E.A.6
  • 124
    • 84874720284 scopus 로고    scopus 로고
    • Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor-cells in acute myeloid leukemia AML
    • Herrmann H, Blatt K, Shi J, Gleixner KV, Cerny-Reiterer S, Mullauer L, et al. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor-cells in acute myeloid leukemia AML. Oncotarget (2012) 3(12):1588-99.
    • (2012) Oncotarget , vol.3 , Issue.12 , pp. 1588-1599
    • Herrmann, H.1    Blatt, K.2    Shi, J.3    Gleixner, K.V.4    Cerny-Reiterer, S.5    Mullauer, L.6
  • 125
    • 84899893338 scopus 로고    scopus 로고
    • Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myeloid leukemia (AML) cells
    • doi:10.1158/1535-7163.MCT-13-0770.
    • Fiskus W, Sharma S, Qi J, Valenta JA, Schaub LJ, Shah B, et al. Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myeloid leukemia (AML) cells. Mol Cancer Ther (2014). doi:10.1158/1535-7163.MCT-13-0770.
    • (2014) Mol Cancer Ther
    • Fiskus, W.1    Sharma, S.2    Qi, J.3    Valenta, J.A.4    Schaub, L.J.5    Shah, B.6
  • 126
    • 84901054032 scopus 로고    scopus 로고
    • Combined therapy with BRD4 antagonist and FLT3 inhibitor exerts synergistic activity against cultured and primary AML blast progenitors expressing FLT-ITD
    • Rodriguez M, Fiskus W, Sharma S, Qi J, Valenta JA, Schaub LJ, et al. Combined therapy with BRD4 antagonist and FLT3 inhibitor exerts synergistic activity against cultured and primary AML blast progenitors expressing FLT-ITD. Blood (2013) 122(21):3821.
    • (2013) Blood , vol.122 , Issue.21 , pp. 3821
    • Rodriguez, M.1    Fiskus, W.2    Sharma, S.3    Qi, J.4    Valenta, J.A.5    Schaub, L.J.6
  • 127
    • 84901054033 scopus 로고    scopus 로고
    • Preclinical study of the bromodomain inhibitor OTX015 in acute myeloid (AML) and lymphoid (ALL) leukemias
    • Braun T, Coude MM, Berrou J, Bertrand S, Riveiro E, Heralt P, et al. Preclinical study of the bromodomain inhibitor OTX015 in acute myeloid (AML) and lymphoid (ALL) leukemias. Blood (2013) 122(21):4218.
    • (2013) Blood , vol.122 , Issue.21 , pp. 4218
    • Braun, T.1    Coude, M.M.2    Berrou, J.3    Bertrand, S.4    Riveiro, E.5    Heralt, P.6
  • 128
    • 84875052270 scopus 로고    scopus 로고
    • KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia
    • doi:10.1111/bjh.12231
    • Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, et al. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol (2013) 161(1):117-27. doi:10.1111/bjh.12231.
    • (2013) Br J Haematol , vol.161 , Issue.1 , pp. 117-127
    • Etchin, J.1    Sanda, T.2    Mansour, M.R.3    Kentsis, A.4    Montero, J.5    Le, B.T.6
  • 129
    • 84870502798 scopus 로고    scopus 로고
    • Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
    • doi:10.1182/blood-2012-05-429506
    • Lapalombella R, Sun Q, Williams K, Tangeman L, Jha S, Zhong Y, et al. Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood (2012) 120(23):4621-34. doi:10.1182/blood-2012-05-429506.
    • (2012) Blood , vol.120 , Issue.23 , pp. 4621-4634
    • Lapalombella, R.1    Sun, Q.2    Williams, K.3    Tangeman, L.4    Jha, S.5    Zhong, Y.6
  • 130
    • 84873570648 scopus 로고    scopus 로고
    • Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
    • doi:10.1038/leu.2012.219
    • Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia (2013) 27(1):66-74. doi:10.1038/leu.2012.219.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 66-74
    • Etchin, J.1    Sun, Q.2    Kentsis, A.3    Farmer, A.4    Zhang, Z.C.5    Sanda, T.6
  • 131
    • 84893562519 scopus 로고    scopus 로고
    • Chimeric antigen receptor therapy for cancer
    • doi:10.1146/annurev-med-060512-150254
    • Barrett DM, Singh N, Porter DL, Grupp SA, June CH. Chimeric antigen receptor therapy for cancer. Annu Rev Med (2014) 65:333-47. doi:10.1146/annurev-med-060512-150254.
    • (2014) Annu Rev Med , vol.65 , pp. 333-347
    • Barrett, D.M.1    Singh, N.2    Porter, D.L.3    Grupp, S.A.4    June, C.H.5
  • 132
    • 84891139376 scopus 로고    scopus 로고
    • Immunotherapy for pediatric leukemia
    • doi:10.3389/fonc.2013.00166
    • Shah NN, Dave H, Wayne AS. Immunotherapy for pediatric leukemia. Front Oncol (2013) 3:166. doi:10.3389/fonc.2013.00166.
    • (2013) Front Oncol , vol.3 , pp. 166
    • Shah, N.N.1    Dave, H.2    Wayne, A.S.3
  • 133
    • 84861122295 scopus 로고    scopus 로고
    • The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer
    • doi:10.1158/1078-0432.CCR-11-1920
    • Lee DW, Barrett DM, Mackall C, Orentas R, Grupp SA. The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer. Clin Cancer Res (2012) 18(10):2780-90. doi:10.1158/1078-0432.CCR-11-1920.
    • (2012) Clin Cancer Res , vol.18 , Issue.10 , pp. 2780-2790
    • Lee, D.W.1    Barrett, D.M.2    Mackall, C.3    Orentas, R.4    Grupp, S.A.5
  • 134
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • doi:10.1056/NEJMoa1215134
    • Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med (2013) 368(16):1509-18. doi:10.1056/NEJMoa1215134.
    • (2013) N Engl J Med , vol.368 , Issue.16 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3    Aplenc, R.4    Porter, D.L.5    Rheingold, S.R.6
  • 135
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • doi:10.1126/scitranslmed.3005930
    • Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med (2013) 5(177):177ra38. doi:10.1126/scitranslmed.3005930.
    • (2013) Sci Transl Med , vol.5 , Issue.177 , pp. 138-177
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3    Park, J.4    Wang, X.5    Cowell, L.G.6
  • 136
    • 77952420345 scopus 로고    scopus 로고
    • Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
    • doi:10.1038/gt.2010.21
    • Peinert S, Prince HM, Guru PM, Kershaw MH, Smyth MJ, Trapani JA, et al. Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther (2010) 17(5):678-86. doi:10.1038/gt.2010.21.
    • (2010) Gene Ther , vol.17 , Issue.5 , pp. 678-686
    • Peinert, S.1    Prince, H.M.2    Guru, P.M.3    Kershaw, M.H.4    Smyth, M.J.5    Trapani, J.A.6
  • 137
    • 84876163922 scopus 로고    scopus 로고
    • Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
    • doi:10.1111/bjh.12282
    • Tettamanti S, Marin V, Pizzitola I, Magnani CF, Giordano Attianese GM, Cribioli E, et al. Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. Br J Haematol (2013) 161(3):389-401. doi:10.1111/bjh.12282.
    • (2013) Br J Haematol , vol.161 , Issue.3 , pp. 389-401
    • Tettamanti, S.1    Marin, V.2    Pizzitola, I.3    Magnani, C.F.4    Giordano Attianese, G.M.5    Cribioli, E.6
  • 138
    • 84888226232 scopus 로고    scopus 로고
    • T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia
    • doi:10.1182/blood-2012-12-474056
    • Mardiros A, Dos Santos C, McDonald T, Brown CE, Wang X, Budde LE, et al. T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia. Blood (2013) 122(18):3138-48. doi:10.1182/blood-2012-12-474056.
    • (2013) Blood , vol.122 , Issue.18 , pp. 3138-3148
    • Mardiros, A.1    Dos Santos, C.2    McDonald, T.3    Brown, C.E.4    Wang, X.5    Budde, L.E.6
  • 139
    • 78649899281 scopus 로고    scopus 로고
    • Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors
    • doi:10.3324/haematol.2010.026310
    • Marin V, Pizzitola I, Agostoni V, Attianese GM, Finney H, Lawson A, et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica (2010) 95(12):2144-52. doi:10.3324/haematol.2010.026310.
    • (2010) Haematologica , vol.95 , Issue.12 , pp. 2144-2152
    • Marin, V.1    Pizzitola, I.2    Agostoni, V.3    Attianese, G.M.4    Finney, H.5    Lawson, A.6
  • 140
    • 84863019415 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor effect of anti-CD33 chimeric receptor-expressing EBV-CTL against CD33 acute myeloid leukemia
    • doi:10.1155/2012/683065
    • Dutour A, Marin V, Pizzitola I, Valsesia-Wittmann S, Lee D, Yvon E, et al. In vitro and in vivo antitumor effect of anti-CD33 chimeric receptor-expressing EBV-CTL against CD33 acute myeloid leukemia. Adv Hematol (2012) 2012:683065. doi:10.1155/2012/683065.
    • (2012) Adv Hematol , vol.2012 , pp. 683065
    • Dutour, A.1    Marin, V.2    Pizzitola, I.3    Valsesia-Wittmann, S.4    Lee, D.5    Yvon, E.6
  • 141
    • 84901703340 scopus 로고    scopus 로고
    • Efficacy against human acute myeloid leukemia and myeloablation of normal hematopoiesis in a mouse model using chimeric antigen receptor-modified T cells
    • doi:10.1182/blood-2013-09-529537.
    • Gill S, Tasian SK, Ruella M, Shestova O, Li Y, Porter DL, et al. Efficacy against human acute myeloid leukemia and myeloablation of normal hematopoiesis in a mouse model using chimeric antigen receptor-modified T cells. Blood (2014). doi:10.1182/blood-2013-09-529537.
    • (2014) Blood
    • Gill, S.1    Tasian, S.K.2    Ruella, M.3    Shestova, O.4    Li, Y.5    Porter, D.L.6
  • 143
    • 84887542642 scopus 로고    scopus 로고
    • Identification of novel somatic mutations, regions of recurrent loss of heterozygosity (LOH) and significant clonal evolution from diagnosis to relapse in childhood AML determined by exome capture sequencing-an NCI/COG target AML study
    • Meshinchi S, Ries RE, Trevino LR, Hampton OA, Alonzo TA, Farrar JE, et al. Identification of novel somatic mutations, regions of recurrent loss of heterozygosity (LOH) and significant clonal evolution from diagnosis to relapse in childhood AML determined by exome capture sequencing-an NCI/COG target AML study. Blood (2012) 120(21):123.
    • (2012) Blood , vol.120 , Issue.21 , pp. 123
    • Meshinchi, S.1    Ries, R.E.2    Trevino, L.R.3    Hampton, O.A.4    Alonzo, T.A.5    Farrar, J.E.6


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