Validation of uPA/SCID mouse with humanized liver as a human liver model: Protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

Drug Metabolism and Disposition

Volumn 42, Issue 6, 2014, Pages 1039-1043

  Ohtsuki, Sumio ^a   Kawakami, Hirotaka ^b   Inoue, Tae ^c   Nakamura, Kenji ^a   Tateno, Chise ^d   Katsukura, Yuki ^c   Obuchi, Wataru ^c   Uchida, Yasuo ^c   Kamiie, Junichi ^b   Horie, Toru ^e   Terasaki, Tetsuya ^c  

^a KUMAMOTO UNIVERSITY   (Japan)

^b AZABU UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d PhoenixBio USA Corporation   (Japan)

^e DeThree Research Laboratories   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BILE SALT EXPORT PUMP; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 4A11; GAMMA GLUTAMYLTRANSFERASE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2B7; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SOLUTE CARRIER TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FRACTIONATION; CHILD; CONTROLLED STUDY; DONOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER; LIVER BIOPSY; LIVER CELL; LIVER CELL MEMBRANE; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; TANDEM MASS SPECTROMETRY; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHIMERA; METABOLISM; PRESCHOOL CHILD; PROCEDURES; VALIDATION STUDY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CHILD; CHILD, PRESCHOOL; CHIMERA; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; MICE, SCID; TANDEM MASS SPECTROMETRY;

EID: 84901027384     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.057646     Document Type: Article

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