Humanizing mouse folate metabolism: Conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure

FASEB Journal

Volumn 28, Issue 5, 2014, Pages 1998-2008

  Yang, Chen ^a,b   Xie, Lin Ying ^b   Windle, Jolene J ^a,b   Taylor, Shirley M ^a,b   Moran, Richard G ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Knockout mice; Protein translocation and degradation; Transcription; Transcriptional interference; Translation

Indexed keywords

FOLYLPOLYGLUTAMATE SYNTHASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXON; FOLATE METABOLISM; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENETIC TRANSCRIPTION; HOMOLOGOUS RECOMBINATION; IN VITRO GENE TRANSFER; KIDNEY; LIVER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; STEADY STATE; TRANSCRIPTION INITIATION SITE;

KNOCKOUT MICE; PROTEIN TRANSLOCATION AND DEGRADATION; TRANSCRIPTION; TRANSCRIPTIONAL INTERFERENCE; TRANSLATION;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; EMBRYONIC STEM CELLS; EXONS; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENE DELETION; GENE EXPRESSION PROFILING; GENETIC VECTORS; HOMOZYGOTE; HUMANS; LIVER; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDE SYNTHASES; PROMOTER REGIONS, GENETIC; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 84901008995     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-243261     Document Type: Article

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