Constrasting effect of oncogene expression on two carrier-mediated systems internalizing folate compounds in fisher rat 3T3 cells

Journal of Cellular Physiology

Volumn 184, Issue 3, 2000, Pages 364-372

  Kühnel, Jean Marc ^a   Chiao, Judy H ^a   Sirotnak, F M ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; FOLIC ACID DERIVATIVE; LUCIFERASE; MESSENGER RNA; METHOTREXATE; PHOSPHATE; PROBENECID; CARRIER PROTEIN; FOLIC ACID; MEMBRANE PROTEIN; PRIMER DNA; REDUCED FOLATE CARRIER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG TRANSPORT; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTERNALIZATION; NONHUMAN; ONCOGENE; PH; PRIORITY JOURNAL; RAT; ACTIVE TRANSPORT; ANIMAL; CELL LINE; COMPARATIVE STUDY; GENETIC TRANSFECTION; GENETICS; KINETICS; LEUKEMIA L 1210; METABOLISM; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; ONCOGENE RAS;

ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL LINE; DNA PRIMERS; FOLIC ACID; GENE EXPRESSION; GENES, MYC; GENES, RAS; HYDROGEN-ION CONCENTRATION; KINETICS; LEUKEMIA L1210; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; RATS; TRANSFECTION;

EID: 0033624018     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4652(200009)184:3<364::AID-JCP11>3.0.CO;2-N     Document Type: Article

References (31)

1. Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in Chinese hamster ovary cells
2. A simple, rapid method for the purification of poly A+ RNA
3. Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo-or heteropeptides bearing a C-terminal glutamyl moiety
4. Natural occurence of pterins and folate derivatives
5. A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells
6. Kinetic studies of transport across red cell membranes
7. The cellular pharmacology of methotrexate
8. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
9. Characteristics of a novel transport system for folate compounds in wild-type and methotrexate resistant L1210 cells
10. Anion exchange mechanism for transport of methrotrexate in L1210 cells
11. The biochemistry of folates
12. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
13. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport deficient, methotrexate-resistant human breast cancer cells
14. Molecular cloning of the human placental folate transporter
15. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro
16. DNA sequencing with chain-terminating inhibitors
17. ATP-dependent efflux of 2,4-dinitrophenyl-S-glutathione. Properties of two distinct transport systems in inside-out vesicles from L1210 cells and variant subline with altered efflux of methotrexate and cholate
18. Energy dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane
19. Isolation of a transforming sequence from a human bladder carcinoma cell line
20. pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 Leukemia cells
21. Correlates of folate analog transport, pharmacokinetics and selective antitumor action
22. Obligate genetic expressing in tumor cells of a fetal membrane property mediating folate transport: Biological significance and implications for improved therapy of human cancer
23. Alteration of folate analogue transport following induced maturation of HL-60 leukemia cells. Early decline in mediated influx relationship to commitment and functional dissociation of entry and exit routes
24. Carrier-mediated membrane transport of folates in mammalian cells
25. Differential responsiveness of myc- and ras-transfected cells to growth factors: Selective stimulation of myc-transfected cells by epidermal growth factor
26. Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity
27. Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity
28. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate up-take
29. Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake
30. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells
31. Alteration of folate analogue transport inward after induced maturation of HL-60 leukemia cells. Molecular properties of the transporter in an overproducing variant and evidence for downregulation of its synthesis in maturating cells