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Volumn 56, Issue 10, 1996, Pages 2331-2335

Augmentation of the therapeutic activity of lometrexol [(6-R)5,10-Dideazatetrahydrofolate] by oral folic acid

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; LOMETREXOL;

EID: 0029883293     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (63)

References (33)
  • 1
    • 0021813844 scopus 로고
    • Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin
    • Taylor, E. C., Harrington, P. J., Fletcher, S. R., Beardsley, G. P., and Moran, R. G. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin J. Med. Chem., 28: 914-921, 1935.
    • (1935) J. Med. Chem. , vol.28 , pp. 914-921
    • Taylor, E.C.1    Harrington, P.J.2    Fletcher, S.R.3    Beardsley, G.P.4    Moran, R.G.5
  • 2
    • 0024499104 scopus 로고
    • A new folate antimetabolite, 5,10-dideaza-5,6,7,8 tetrahydrofolate, is a potent inhibitor of de novo purine synthesis
    • Beardsley, G. P., Moroson, B. A., Taylor, E. C., and Moran, R. G A new folate antimetabolite, 5,10-dideaza-5,6,7,8 tetrahydrofolate, is a potent inhibitor of de novo purine synthesis. J Biol Chem., 264. 328-333, 1989.
    • (1989) J Biol Chem. , vol.264 , pp. 328-333
    • Beardsley, G.P.1    Moroson, B.A.2    Taylor, E.C.3    Moran, R.G.4
  • 3
    • 0024802389 scopus 로고
    • The 6-S and 6-R diastereomers of 5,10-dideaza-5,6,7,8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis
    • Moran, R G , Baldwin, S. W., Taylor, E. C., and Shih, C. The 6-S and 6-R diastereomers of 5,10-dideaza-5,6,7,8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis. J. Biol. Chem., 264: 21047-21051, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21047-21051
    • Moran, R.G.1    Baldwin, S.W.2    Taylor, E.C.3    Shih, C.4
  • 4
    • 0025752884 scopus 로고
    • Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleootide formyltransferase
    • Baldwin, S W , Tse, A., Gossett, L. S , Taylor, E. C., Rosowsky, A , Shih, C., and Moran, R. G Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleootide formyltransferase Biochemistry, 30: 1997-2006, 1991.
    • (1991) Biochemistry , vol.30 , pp. 1997-2006
    • Baldwin, S.W.1    Tse, A.2    Gossett, L.S.3    Taylor, E.C.4    Rosowsky, A.5    Shih, C.6    Moran, R.G.7
  • 5
    • 0027438763 scopus 로고
    • Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells
    • Smith, S. G , Lehman, N. L., and Moran, R G. Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells. Cancer Res., 53: 5697-5706, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 5697-5706
    • Smith, S.G.1    Lehman, N.L.2    Moran, R.G.3
  • 7
    • 0028008481 scopus 로고
    • Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells
    • Brigle, K. E., Spinella, M. J., Westin, E. H., and Goldman, I. D Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells. Biochem. Pharmacol , 47: 337-345, 1994.
    • (1994) Biochem. Pharmacol , vol.47 , pp. 337-345
    • Brigle, K.E.1    Spinella, M.J.2    Westin, E.H.3    Goldman, I.D.4
  • 8
    • 0025890055 scopus 로고
    • Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for antifolate compounds
    • Jansen, G , Westerhof, G. R., Kathmann, I , Rijksen, G., and Schornagel, J. H. Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for antifolate compounds. Cancer Chemother. Pharmacol., 28: 115-117, 1991.
    • (1991) Cancer Chemother. Pharmacol. , vol.28 , pp. 115-117
    • Jansen, G.1    Westerhof, G.R.2    Kathmann, I.3    Rijksen, G.4    Schornagel, J.H.5
  • 10
    • 0002696866 scopus 로고
    • In vivo antitumor activity of 5,10-dideazatetrahydrofolic acid (DDATHF) and its diastereomeric isomers
    • Shih, C , Grindey, G. B , Houghton, P. J., and Houghton, J. A In vivo antitumor activity of 5,10-dideazatetrahydrofolic acid (DDATHF) and its diastereomeric isomers. Proc Am Assoc. Cancer Res., 29: 283, 1988
    • (1988) Proc Am Assoc. Cancer Res. , vol.29 , pp. 283
    • Shih, C.1    Grindey, G.B.2    Houghton, P.J.3    Houghton, J.A.4
  • 11
    • 0025328483 scopus 로고
    • New pathways from pteridines. Design and synthesis of a new class of potent and selective antitumor agents
    • Taylor, E. C. New pathways from pteridines. Design and synthesis of a new class of potent and selective antitumor agents J. Heterocycl. Chem , 27. 1-11, 1990.
    • (1990) J. Heterocycl. Chem , vol.27 , pp. 1-11
    • Taylor, E.C.1
  • 14
    • 0013644110 scopus 로고
    • Phase I study of 5,10-dideazatetrahydrofolic acid (LY264618, DDATHF) given daily for 3 consecutive days
    • Sessa, C., Gumbell, L , Hatty, S., Kern, H., and Cavalli, F Phase I study of 5,10-dideazatetrahydrofolic acid (LY264618, DDATHF) given daily for 3 consecutive days. Ann. Oncol., 1 (Suppl.): 38, 1990.
    • (1990) Ann. Oncol. , vol.1 , Issue.SUPPL. , pp. 38
    • Sessa, C.1    Gumbell, L.2    Hatty, S.3    Kern, H.4    Cavalli, F.5
  • 15
    • 0027179429 scopus 로고
    • Phase I study of (6R) 5,10-dideaza-5,6,7,8-tetrahydrofolate-a folate antimetabolite inhibitory to de novo purine synthesis
    • Bethesda
    • Ray, M. S., Muggia, F. M., Leichman, G. C , Grunberg, S. G., Nelson, R L., Dyke, R W., and Moran, R. G Phase I study of (6R) 5,10-dideaza-5,6,7,8-tetrahydrofolate-a folate antimetabolite inhibitory to de novo purine synthesis. J Natl Cancer Inst. (Bethesda), 85: 1154-1159, 1993
    • (1993) J Natl Cancer Inst. , vol.85 , pp. 1154-1159
    • Ray, M.S.1    Muggia, F.M.2    Leichman, G.C.3    Grunberg, S.G.4    Nelson, R.L.5    Dyke, R.W.6    Moran, R.G.7
  • 16
    • 3142546829 scopus 로고
    • Evaluation of the mechanism of inhibition of the toxicity, but not the antitumor activity, of lometrexol (DDATHF) by folic acid
    • Alan, T., Shih, C., Pohland, R C , Lantz, R. J , and Grindey, G. B Evaluation of the mechanism of inhibition of the toxicity, but not the antitumor activity, of lometrexol (DDATHF) by folic acid. Proc. Am. Assoc. Cancer Res , 33: 407, 1992
    • (1992) Proc. Am. Assoc. Cancer Res , vol.33 , pp. 407
    • Alan, T.1    Shih, C.2    Pohland, R.C.3    Lantz, R.J.4    Grindey, G.B.5
  • 17
    • 0000424658 scopus 로고
    • Reversal of the toxicity but not the antitumor activity of lometrexol by folic acid
    • Grindey, G. B., Alati, T , and Shih, C Reversal of the toxicity but not the antitumor activity of lometrexol by folic acid. Proc. Am. Assoc. Cancer Res., 32: 324, 1991.
    • (1991) Proc. Am. Assoc. Cancer Res. , vol.32 , pp. 324
    • Grindey, G.B.1    Alati, T.2    Shih, C.3
  • 19
    • 0029560236 scopus 로고
    • Clinical pharmacokinetics of the antipurine antifolate (6A)-5,10-dideazatetrahydrofolate (lometrexol) administered with an oral folic acid supplement
    • Wedge, S. R., Laohavinij, S., Taylor, G. A , Boddy, A., Calvert, A. H., and Newell, D. R Clinical pharmacokinetics of the antipurine antifolate (6A)-5,10-dideazatetrahydrofolate (lometrexol) administered with an oral folic acid supplement. Clin. Cancer Res , 1: 1479-1486, 1995
    • (1995) Clin. Cancer Res , vol.1 , pp. 1479-1486
    • Wedge, S.R.1    Laohavinij, S.2    Taylor, G.A.3    Boddy, A.4    Calvert, A.H.5    Newell, D.R.6
  • 20
    • 0002265020 scopus 로고
    • Protocols for screening chemical agents and natural products against animal tumors and other biological systems
    • Geran, R. I., Greenberg, N. H., MacDonald, M. M., Schumacher, A. M., and Abbott, B. J. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother. Rep Part 3, 3: 51, 1972.
    • (1972) Cancer Chemother. Rep Part 3 , vol.3 , pp. 51
    • Geran, R.I.1    Greenberg, N.H.2    MacDonald, M.M.3    Schumacher, A.M.4    Abbott, B.J.5
  • 21
    • 0024987802 scopus 로고
    • Automated measurement of transplantable solid tumors using digital electronic calipers interfaced to a microcomputer
    • Worzalla, J. F., Bewley, J R., and Grindey, G B Automated measurement of transplantable solid tumors using digital electronic calipers interfaced to a microcomputer Invest. New Drugs, 8: 241-251, 1990.
    • (1990) Invest. New Drugs , vol.8 , pp. 241-251
    • Worzalla, J.F.1    Bewley, J.R.2    Grindey, G.B.3
  • 22
    • 0000313306 scopus 로고
    • Detection of folic acid deficiency in populations
    • H. P. Broquist, C E. Butterworth, Jr., and C. Wagner (eds.), Washington DC: National Academy of Sciences
    • Sauberlich, H. E. Detection of folic acid deficiency in populations. In: H. P. Broquist, C E. Butterworth, Jr., and C. Wagner (eds.), Folic Acid: Biochemistry and Physiology in Relation to Human Nutritional Requirements, pp. 213-231. Washington DC: National Academy of Sciences, 1977.
    • (1977) Folic Acid: Biochemistry and Physiology in Relation to Human Nutritional Requirements , pp. 213-231
    • Sauberlich, H.E.1
  • 23
    • 0023427819 scopus 로고
    • Making sense of laboratory tests of folate status: Folate requirements to sustain normality
    • Herbert, V. Making sense of laboratory tests of folate status: folate requirements to sustain normality. Am. J. Hematol., 26: 199-207, 1987.
    • (1987) Am. J. Hematol. , vol.26 , pp. 199-207
    • Herbert, V.1
  • 25
    • 0018816094 scopus 로고
    • Intestinal abruption and malabsorption of folates
    • Halsted, C. H. Intestinal abruption and malabsorption of folates. Annu. Rev Med., 31: 79-87, 1980.
    • (1980) Annu. Rev Med. , vol.31 , pp. 79-87
    • Halsted, C.H.1
  • 26
    • 0015837116 scopus 로고
    • Intestinal folate absorption. II. Conversion and retention of pteroylmonoglutamate by jejunum
    • Olinger, E. J., Bertino, J. R., and Binder, H. J. Intestinal folate absorption. II. Conversion and retention of pteroylmonoglutamate by jejunum J. Clin. Invest., 52: 2138-2145, 1973
    • (1973) J. Clin. Invest. , vol.52 , pp. 2138-2145
    • Olinger, E.J.1    Bertino, J.R.2    Binder, H.J.3
  • 27
    • 0025881828 scopus 로고
    • Competitive particle concentration fluorescence immunoassay for measuring 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) in seram
    • Taber, L D., O'Brien, P., Bowsher, R. R., and Sportsman, J. R. Competitive particle concentration fluorescence immunoassay for measuring 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) in seram. Clin. Chem., 37: 254-260, 1991.
    • (1991) Clin. Chem. , vol.37 , pp. 254-260
    • Taber, L.D.1    O'Brien, P.2    Bowsher, R.R.3    Sportsman, J.R.4
  • 28
    • 0028113221 scopus 로고
    • Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets
    • Pohland, R. C , Alati, T., Lantz, R. J., and Grindey, G. B Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets. J. Pharm. Sci., 83: 1396-1399, 1994.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1396-1399
    • Pohland, R.C.1    Alati, T.2    Lantz, R.J.3    Grindey, G.B.4
  • 29
    • 0021141123 scopus 로고
    • Measurement of folyl polyglutamate synthetase in mammalian tissue
    • Moran, R. G., and Colman, P. D. Measurement of folyl polyglutamate synthetase in mammalian tissue. Anal. Biochem., 140: 326-342, 1984.
    • (1984) Anal. Biochem. , vol.140 , pp. 326-342
    • Moran, R.G.1    Colman, P.D.2
  • 30
    • 3142545201 scopus 로고
    • Control of the polyglutamation of 5,10-dideazatetrahydrofolate by intracellular folate pools: A novel mechanism of resistance to antifolates
    • Tse, A , and Moran, R G Control of the polyglutamation of 5,10-dideazatetrahydrofolate by intracellular folate pools: a novel mechanism of resistance to antifolates. Proc. Am. Assoc. Cancer Res., 35: 304, 1994.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 304
    • Tse, A.1    Moran, R.G.2
  • 31
    • 0027981516 scopus 로고
    • Impact of dietary folic acid on reduced folates in mouse plasma and tissues Relationship to dideazatetrahydrofolate sensitivity
    • Schmitz, J. C., Grindey, G. B., Schultz, R M., and Priest, D. G Impact of dietary folic acid on reduced folates in mouse plasma and tissues Relationship to dideazatetrahydrofolate sensitivity Biochem Pharmacol., 48: 319-325, 1994.
    • (1994) Biochem Pharmacol. , vol.48 , pp. 319-325
    • Schmitz, J.C.1    Grindey, G.B.2    Schultz, R.M.3    Priest, D.G.4
  • 32
    • 0019486066 scopus 로고
    • Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug
    • Kamen, B A., Nylen, P. A , Camitta, B M., and Bertino, J R Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug Br J Haematol , 49: 355-360, 1981
    • (1981) Br J Haematol , vol.49 , pp. 355-360
    • Kamen, B.A.1    Nylen, P.A.2    Camitta, B.M.3    Bertino, J.R.4
  • 33
    • 0022547880 scopus 로고
    • Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients
    • Kremer, J M , Galivan, J , Streckfuss, A., and Kamen, B. Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Arthritis Rheum., 29, 832-835, 1986.
    • (1986) Arthritis Rheum. , vol.29 , pp. 832-835
    • Kremer, J.M.1    Galivan, J.2    Streckfuss, A.3    Kamen, B.4


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