Risk factors for physical impairment after acute lung injury in a national, multicenter study

American Journal of Respiratory and Critical Care Medicine

Volumn 189, Issue 10, 2014, Pages 1214-1224

  Needham, Dale M ^a   Wozniak, Amy W ^a,b   Hough, Catherine L ^c   Morris, Peter E ^d   Dinglas, Victor D ^a   Jackson, James C ^e   Mendez Tellez, Pedro A ^a   Shanholtz, Carl ^f   Ely, E Wesley ^e,g   Colantuoni, Elizabeth ^a,b   Hopkins, Ramona O ^h,i  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h INTERMOUNTAIN MEDICAL CENTER   (United States)

ⁱ BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Acute lung injury; Exercise test; Follow up studies; Muscle strength; Risk factors

Indexed keywords

ANTIOXIDANT; BENZODIAZEPINE DERIVATIVE; CORTICOSTEROID; OMEGA 3 FATTY ACID; OPIATE; PLACEBO; PROPOFOL; SALBUTAMOL;

ACUTE LUNG INJURY; ADULT; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CRITICAL ILLNESS; DEMOGRAPHY; ENTERIC FEEDING; FEMALE; FUNCTIONAL STATUS; HOSPITALIZATION; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE STRENGTH; OUTCOME ASSESSMENT; PHYSICAL DISEASE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SHORT FORM 36; SURVIVOR; WALKING;

ACUTE LUNG INJURY; ADULT; DRUG THERAPY, COMBINATION; EXERCISE TEST; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE WEAKNESS; NEUROMUSCULAR BLOCKING AGENTS; PROSPECTIVE STUDIES; QUALITY OF LIFE; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; UNITED STATES; WALKING;

EID: 84900993157     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201401-0158OC     Document Type: Article

References (75)

1. Fan E, Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, Himmelfarb CR, Desai SV, Ciesla N, Herridge MS, et al. Physical complications in acute lung injury survivors: a 2-year longitudinal prospective study. Crit Care Med 2014;42:849-859.
2. Herridge MS, Cheung AM, TanseyCM,Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, et al.; Canadian Critical Care Trials Group. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003;348:683-693.
3. Herridge MS, Tansey CM, MattéA, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, et al.; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011;364:1293-1304.
4. Barnato AE, Albert SM, Angus DC, Lave JR, Degenholtz HB. Disability among elderly survivors of mechanical ventilation. Am J Respir Crit Care Med 2011;183:1037-1042.
5. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010;304:1787-1794.
6. Iwashyna TJ, Netzer G, Langa KM, Cigolle C. Spurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions. Am J Respir Crit Care Med 2012;185:835-841.
7. Dowdy DW, Eid MP, Dennison CR, Mendez-Tellez PA, Herridge MS, Guallar E, Pronovost PJ, Needham DM. Quality of life after acute respiratory distress syndrome: a meta-analysis. Intensive Care Med 2006;32:1115-1124.
8. Iwashyna TJ. Trajectories of recovery and dysfunction after acute illness, with implications for clinical trial design. Am J Respir Crit Care Med 2012;186:302-304.
9. Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, Zawistowski C, Bemis-Dougherty A, Berney SC, Bienvenu OJ, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med 2012;40:502-509.
10. Iwashyna TJ, Netzer G. The burdens of survivorship: an approach to thinking about long-term outcomes after critical illness. Semin Respir Crit Care Med 2012;33:327-338.
11. De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, et al.; Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002;288:2859-2867.
12. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007;33:1876-1891.
13. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Phadke R, Dew T, Sidhu PS, et al. Acute skeletal muscle wasting in critical illness. JAMA 2013;310:1591-1600.
14. Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A, Langhans C, Haas K, Radtke T, Kleber C, et al. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med 2014;40:528-538.
15. Hough CL, Steinberg KP, Taylor Thompson B, Rubenfeld GD, Hudson LD. Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med 2009;35:63-68.
16. Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P; NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA 2011;306:1574-1581.
17. Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, et al.; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Randomized, placebo-controlled clinical trial of an aerosolized b-agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011;184:561-568.
18. Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, Morris A, Dong N, Rock P; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 2012;307:795-803.
19. Needham DM, Dinglas VD, Morris PE, Jackson JC, Hough CL, Mendez-Tellez PA, Wozniak AW, Colantuoni E, Ely EW, Rice TW, et al.; NIH NHLBI ARDS Network. Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 2013;188:567-576.
20. Needham DM, Dinglas VD, Bienvenu OJ, Colantuoni E, Wozniak AW, Rice TW, Hopkins RO. One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 2013;346:f1532.
21. Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A; The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342:1301-1308.
22. Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006;354:2564-2575.
23. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994;47:1245-1251.
24. Groll DL, To T, Bombardier C, Wright JG. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol 2005;58:595-602.
25. Groll DL, Heyland DK, Caeser M, Wright JG. Assessment of long-term physical function in acute respiratory distress syndrome (ARDS) patients: comparison of the Charlson Comorbidity Index and the Functional Comorbidity Index. Am J Phys Med Rehabil 2006;85:574-581.
26. Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the pharmacological basis of therapeutics, 11th ed. New York: McGraw-Hill; 2006.
27. Frisancho AR. Anthropometric standards for the assessment of growth and nutritional status. Ann Arbor, MI: The University of Michigan Press; 1990.
28. Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey: anthropometry procedures manual. Atlanta, GA: Centers for Disease Control and Prevention; 2009.
29. Fan E,CieslaND, Truong AD, Bhoopathi V, Zeger SL, NeedhamDM. Interrater reliability of manual muscle strength testing in ICU survivors and simulated patients. Intensive Care Med 2010;36:1038-1043.
30. Medical Research Council. Aids to the investigation of the peripheral nervous system. London: Her Majesty's Stationary Office; 1976.
31. Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S. Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil 1985;66:69-74.
32. Harik-Khan RI, Wise RA, Fozard JL; The Baltimore Longitudinal Study of Aging. Determinants of maximal inspiratory pressure. Am J Respir Crit Care Med 1998;158:1459-1464.
33. American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med 2002;166:518-624.
34. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994;49:M85-M94.
35. Guralnik JM, Ferrucci L, Pieper CF, Leveille SG, Markides KS, Ostir GV, Studenski S, Berkman LF, Wallace RB. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci 2000; 55:M221-M231.
36. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lowerextremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-561.
37. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:111-117.
38. Enright PL, Sherrill DL. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 1998;158:1384-1387.
39. Ware JE Jr, Kosinski M, Dewey JE. How to score Version 2 of the SF-36 Health Survey. Lincoln, RI: QualityMetric Incorporated; 2000.
40. Needham DM, Dennison CR, Dowdy DW, Mendez-Tellez PA, Ciesla N, Desai SV, Sevransky J, Shanholtz C, Scharfstein D, Herridge MS, et al. Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study. Crit Care 2006;10:R9.
41. Robinson KA, Dennison CR, Wayman DM, Pronovost PJ, Needham DM. Systematic review identifies number of strategies important for retaining study participants. J Clin Epidemiol 2007;60:757-765.
42. Tansey CM, MattéAL, Needham D, Herridge MS. Review of retention strategies in longitudinal studies and application to follow-up of ICU survivors. Intensive Care Med 2007;33:2051-2057.
43. Hall EA, Zuniga R, Cartier J, Anglin MD, Danila B, Ryan T, Mantius K. Staying in touch: a fieldwork manual of tracking procedures for locating substance abusers in follow-up studies, 2nd ed. Los Angeles, CA: UCLA Integrated Substance Abuse Programs; 2003.
44. Roary MC, Hill MN, Bone LR, Levine DM. Innovative strategies that dispel the myths about urban young black men with high blood pressure. Cardiovasc Rev Rep 2000;21:129-137.
45. Coday M, Boutin-Foster C, Goldman Sher T, Tennant J, Greaney ML, Saunders SD, Somes GW. Strategies for retaining study participants in behavioral intervention trials: retention experiences of the NIH Behavior Change Consortium. Ann Behav Med 2005;29:55-65.
46. Hunt JR, White E. Retaining and tracking cohort study members. Epidemiol Rev 1998;20:57-70.
47. Belsley DA, Kuh E, Welsch RE. Regression diagnostics: identifying influential data and sources of collinearity. New York: Wiley; 1980.
48. Harrell FE. Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis. New York: Springer; 2001.
49. Weisman IM, Zeballos RJ. Clinical exercise testing. Clin Chest Med 2001;22:679-701, viii.
50. Bienvenu OJ, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Shanholtz C, Husain N, Dennison CR, Herridge MS, Pronovost PJ, Needham DM. Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med 2012;185:517-524.
51. Sharshar T, Bastuji-Garin S, De Jonghe B, Stevens RD, Polito A, Maxime V, Rodriguez P, Cerf C, Outin H, Touraine P, et al. Hormonal status and ICU-acquired paresis in critically ill patients. Intensive Care Med 2010;36:1318-1326.
52. Kiser TH, Allen RR, Valuck RJ, Moss M, Vandivier RW. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014;189:1052-1064.
53. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373:1874-1882.
54. Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med 2008;36:2238-2243.
55. Zanni JM, Korupolu R, Fan E, Pradhan P, Janjua K, Palmer JB, Brower RG, Needham DM. Rehabilitation therapy and outcomes in acute respiratory failure: an observational pilot project. J Crit Care 2010;25: 254-262.
56. Hodgin KE, Nordon-Craft A, McFann KK, Mealer ML, Moss M. Physical therapy utilization in intensive care units: results from a national survey. Crit Care Med 2009;37:561-566, quiz 566-568.
57. Nydahl P, Ruhl AP, Bartoszek G, Dubb R, Filipovic S, Flohr HJ, Kaltwasser A, Mende H, Rothaug O, Schuchhardt D, et al. Early mobilization of mechanically ventilated patients: a 1-day pointprevalence study in Germany. Crit Care Med 2014;42:1178-1186.
58. Berney SC, Harrold M, Webb SA, Seppelt I, Patman S, Thomas PJ, Denehy L. Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit Care Resusc 2013;15:260-265.
59. Brower RG. Consequences of bed rest. Crit Care Med 2009; 37(10 Suppl):S422-S428.
60. Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil 2010;91:536-542.
61. Burtin C, Clerckx B, Robbeets C, Ferdinande P, Langer D, Troosters T, Hermans G, Decramer M, Gosselink R. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 2009;37:2499-2505.
62. Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis. Crit Care Med 2013; 41:1543-1554.
63. Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Crit Care Med 2013;41:717-724.
64. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-1477.
65. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008;371:126-134.
66. Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010;375:475-480.
67. Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G, Shannon W, Kollef MH. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med 1999;27: 2609-2615.
68. Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S, Ahrens TS, Shannon W, Baker-Clinkscale D. A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 1997;25:567-574.
69. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, Thompson BT, Ancukiewicz M; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006;354:1671-1684.
70. Varadhan R, Weiss CO, Segal JB, Wu AW, Scharfstein D, Boyd C. Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applications. Med Care 2010; 48(6, Suppl)S96-S105.
71. Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med 2009;37:1594-1603.
72. SchreiberMP, Colantuoni E, BienvenuOJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM. Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med (In press)
73. Karir V, Cooke CR, Andersson L, Caldwell E, Rubenfeld GD. Practice variability in the assessment and treatment of critical illness-related corticosteroid insufficiency. J Crit Care 2010;25:363, e9-e363, e14.
74. Horinouchi H, Kumamoto T, Kimura N, Ueyama H, Tsuda T. Myosin loss in denervated rat soleus muscle after dexamethasone treatment. Pathobiology 2005;72:108-116.
75. Di Giovanni S, Mirabella M, D'Amico A, Tonali P, Servidei S. Apoptotic features accompany acute quadriplegic myopathy. Neurology 2000; 55:854-858.