Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness

Intensive Care Medicine

Volumn 40, Issue 4, 2014, Pages 528-539

  Wollersheim, Tobias ^a   Woehlecke, Janine ^a   Krebs, Martin ^a   Hamati, Jida ^a   Lodka, Doerte ^a   Luther Schroeder, Anja ^a   Langhans, Claudia ^a   Haas, Kurt ^a   Radtke, Theresa ^a   Kleber, Christian ^a   Spies, Claudia ^a   Labeit, Siegfried ^b   Schuelke, Markus ^a   Spuler, Simone ^a   Spranger, Joachim ^a   Weber Carstens, Steffen ^a   Fielitz, Jens ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

dmCMAP; ICUAW; Inflammation; MuRF 1; Muscle atrophy; Myosin degradation

Indexed keywords

ATROGIN 1; CALPAIN 1; CASPASE 3; HYDROCORTISONE; MESSENGER RNA; MUSCLE RING FINGER 1 PROTEIN; MYOSIN; PROTEASOME; TRANSCRIPTION FACTOR FKHR;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; HIP ARTHROPLASTY; HUMAN; INTENSIVE CARE UNIT; INTENSIVE CARE UNIT ACQUIRED MUSCLE WASTING; LENGTH OF STAY; MALE; MOLECULAR DYNAMICS; MUSCLE ATROPHY; MUSCLE BIOPSY; MUSCLE WEAKNESS; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SKELETAL MUSCLE; UNIVERSITY HOSPITAL; VASTUS LATERALIS MUSCLE; CLINICAL TRIAL; CRITICAL ILLNESS; INTENSIVE CARE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; CRITICAL ILLNESS; FEMALE; HUMANS; INTENSIVE CARE; MALE; MIDDLE AGED; MUSCLE WEAKNESS; MYOSINS; PROSPECTIVE STUDIES;

EID: 84898908397     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-014-3224-9     Document Type: Article

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