메뉴 건너뛰기




Volumn 5, Issue 4, 2014, Pages

Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

Author keywords

Apoptosis; Autophagy; Betulinic acid; Cancer; LC3; Necroptosis

Indexed keywords

BETULIC ACID; CYCLOSPORIN A; CYCLOSPORIN; TRITERPENE;

EID: 84900993031     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.139     Document Type: Article
Times cited : (64)

References (49)
  • 2
    • 34249930599 scopus 로고    scopus 로고
    • Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells
    • Rzeski W, Stepulak A, Szymanski M, Sifringer M, Kaczor J, Wejksza K et al. Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells. Naunyn Schmiedebergs Arch Pharmacol 2006; 374: 11-20.
    • (2006) Naunyn Schmiedebergs Arch Pharmacol , vol.374 , pp. 11-20
    • Rzeski, W.1    Stepulak, A.2    Szymanski, M.3    Sifringer, M.4    Kaczor, J.5    Wejksza, K.6
  • 4
    • 34247120086 scopus 로고    scopus 로고
    • Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types
    • Kessler JH, Mullauer FB, de Roo GM, Medema JP. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett 2007; 251: 132-145.
    • (2007) Cancer Lett , vol.251 , pp. 132-145
    • Kessler, J.H.1    Mullauer, F.B.2    De Roo, G.M.3    Medema, J.P.4
  • 5
    • 0030815250 scopus 로고    scopus 로고
    • Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
    • Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M et al. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-4964.
    • (1997) Cancer Res , vol.57 , pp. 4956-4964
    • Fulda, S.1    Friesen, C.2    Los, M.3    Scaffidi, C.4    Mier, W.5    Benedict, M.6
  • 6
    • 0032189535 scopus 로고    scopus 로고
    • Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
    • Fulda S, Susin SA, Kroemer G, Debatin KM. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 1998; 58: 4453-4460.
    • (1998) Cancer Res , vol.58 , pp. 4453-4460
    • Fulda, S.1    Susin, S.A.2    Kroemer, G.3    Debatin, K.M.4
  • 7
    • 0032545386 scopus 로고    scopus 로고
    • Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
    • Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME et al. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 1998; 273: 33942-33948.
    • (1998) J Biol Chem , vol.273 , pp. 33942-33948
    • Fulda, S.1    Scaffidi, C.2    Susin, S.A.3    Krammer, P.H.4    Kroemer, G.5    Peter, M.E.6
  • 8
    • 58849088375 scopus 로고    scopus 로고
    • Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion
    • Mullauer FB, Kessler JH, Medema JP. Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis 2009; 14: 191-202.
    • (2009) Apoptosis , vol.14 , pp. 191-202
    • Mullauer, F.B.1    Kessler, J.H.2    Medema, J.P.3
  • 9
    • 33947714475 scopus 로고    scopus 로고
    • Caspase inhibitors promote alternative cell death pathways
    • Vandenabeele P, Vanden Berghe T, Festjens N. Caspase inhibitors promote alternative cell death pathways. Sci STKE 2006; 2006: e44.
    • (2006) Sci STKE , vol.2006
    • Vandenabeele, P.1    Vanden Berghe, T.2    Festjens, N.3
  • 11
    • 79960921946 scopus 로고    scopus 로고
    • The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
    • Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011; 43: 432-448.
    • (2011) Mol Cell , vol.43 , pp. 432-448
    • Tenev, T.1    Bianchi, K.2    Darding, M.3    Broemer, M.4    Langlais, C.5    Wallberg, F.6
  • 12
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112-119.
    • (2005) Nat Chem Biol , vol.1 , pp. 112-119
    • Degterev, A.1    Huang, Z.2    Boyce, M.3    Li, Y.4    Jagtap, P.5    Mizushima, N.6
  • 14
    • 84878643872 scopus 로고    scopus 로고
    • Lysosomal cell death at a glance
    • Aits S, Jaattela M. Lysosomal cell death at a glance. J Cell Sci 2013; 126(Pt 9): 1905-1912.
    • (2013) J Cell Sci , vol.126 , Issue.PART 9 , pp. 1905-1912
    • Aits, S.1    Jaattela, M.2
  • 15
    • 84892569830 scopus 로고    scopus 로고
    • An overview of autophagy: Morphology, mechanism, and regulation
    • Parzych KR, Klionsky DJ. An Overview of Autophagy: Morphology, Mechanism, and Regulation. Antioxid Redox Signal 2014; 20: 460-473.
    • (2014) Antioxid Redox Signal , vol.20 , pp. 460-473
    • Parzych, K.R.1    Klionsky, D.J.2
  • 16
    • 0034520466 scopus 로고    scopus 로고
    • Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells
    • Saeki K, Yuo A, Okuma E, Yazaki Y, Susin SA, Kroemer G et al. Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ 2000; 7: 1263-1269.
    • (2000) Cell Death Differ , vol.7 , pp. 1263-1269
    • Saeki, K.1    Yuo, A.2    Okuma, E.3    Yazaki, Y.4    Susin, S.A.5    Kroemer, G.6
  • 17
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death
    • Baehrecke EH. Autophagy: dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 18
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen N, Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biol Ther 2011; 11: 157-168.
    • (2011) Cancer Biol Ther , vol.11 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 19
    • 79959415069 scopus 로고    scopus 로고
    • Biogenesis and cargo selectivity of autophagosomes
    • Weidberg H, Shvets E, Elazar Z. Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem 2011; 80: 125-156.
    • (2011) Annu Rev Biochem , vol.80 , pp. 125-156
    • Weidberg, H.1    Shvets, E.2    Elazar, Z.3
  • 20
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria, and oxidative stress: Cross-talk and redox signalling
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria, and oxidative stress: cross-talk and redox signalling. Biochem J 2012; 441: 523-540.
    • (2012) Biochem J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 23
    • 84863726751 scopus 로고    scopus 로고
    • Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process
    • Gonzalez P, Mader I, Tchoghandjian A, Enzenmuller S, Cristofanon S, Basit F et al. Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Cell Death Differ 2012; 19: 1337-1346.
    • (2012) Cell Death Differ , vol.19 , pp. 1337-1346
    • Gonzalez, P.1    Mader, I.2    Tchoghandjian, A.3    Enzenmuller, S.4    Cristofanon, S.5    Basit, F.6
  • 24
    • 84870782845 scopus 로고    scopus 로고
    • Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro
    • Yang LJ, Chen Y, He J, Yi S, Wen L, Zhao J et al. Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro. Acta Pharmacol Sin 2012; 33: 1542-1548.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1542-1548
    • Yang, L.J.1    Chen, Y.2    He, J.3    Yi, S.4    Wen, L.5    Zhao, J.6
  • 25
    • 4344712684 scopus 로고    scopus 로고
    • Methods for monitoring autophagy
    • Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol 2004; 36: 2491-2502.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2491-2502
    • Mizushima, N.1
  • 26
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3: 542-545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 27
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4: 151-175.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3    Agrawal, D.K.4    Aliev, G.5    Askew, D.S.6
  • 29
    • 0023065242 scopus 로고
    • Intracellular protein catabolism and its control during nutrient deprivation and supply
    • Mortimore GE, Poso AR. Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 1987; 7: 539-564.
    • (1987) Annu Rev Nutr , vol.7 , pp. 539-564
    • Mortimore, G.E.1    Poso, A.R.2
  • 30
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3: 452-460.
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 31
    • 0036007116 scopus 로고    scopus 로고
    • A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
    • Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell 2002; 2: 55-67.
    • (2002) Dev Cell , vol.2 , pp. 55-67
    • Scorrano, L.1    Ashiya, M.2    Buttle, K.3    Weiler, S.4    Oakes, S.A.5    Mannella, C.A.6
  • 32
    • 0037459081 scopus 로고    scopus 로고
    • Mitochondria: Releasing power for life and unleashing the machineries of death
    • Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003; 112: 481-490.
    • (2003) Cell , vol.112 , pp. 481-490
    • Newmeyer, D.D.1    Ferguson-Miller, S.2
  • 33
    • 34247485841 scopus 로고    scopus 로고
    • Role of the mitochondrial membrane permeability transition in cell death
    • Tsujimoto Y, Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007; 12: 835-840.
    • (2007) Apoptosis , vol.12 , pp. 835-840
    • Tsujimoto, Y.1    Shimizu, S.2
  • 35
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I et al. Impairment of starvationinduced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169: 425-434.
    • (2005) J Cell Biol , vol.169 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3    Iwata, J.4    Murata, S.5    Tanida, I.6
  • 36
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-1036.
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3    Yamamoto, A.4    Nakaya, H.5    Yoshimori, T.6
  • 37
    • 84883627583 scopus 로고    scopus 로고
    • Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of Acid sphingomyelinase
    • Petersen NH, Olsen OD, Groth-Pedersen L, Ellegaard AM, Bilgin M, Redmer S et al. Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of Acid sphingomyelinase. Cancer Cell 2013; 24: 379-393.
    • (2013) Cancer Cell , vol.24 , pp. 379-393
    • Petersen, N.H.1    Olsen, O.D.2    Groth-Pedersen, L.3    Ellegaard, A.M.4    Bilgin, M.5    Redmer, S.6
  • 38
    • 0034983544 scopus 로고    scopus 로고
    • Lysosomal involvement in apoptosis
    • Brunk UT, Neuzil J, Eaton JW. Lysosomal involvement in apoptosis. Redox Rep 2001; 6: 91-97.
    • (2001) Redox Rep , vol.6 , pp. 91-97
    • Brunk, U.T.1    Neuzil, J.2    Eaton, J.W.3
  • 39
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2: 589-598.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 41
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5: 886-897.
    • (2005) Nat Rev Cancer , vol.5 , pp. 886-897
    • Kroemer, G.1    Jaattela, M.2
  • 42
    • 54949137644 scopus 로고    scopus 로고
    • Lysosomal membrane permeabilization in cell death
    • Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene 2008; 27: 6434-6451.
    • (2008) Oncogene , vol.27 , pp. 6434-6451
    • Boya, P.1    Kroemer, G.2
  • 43
    • 84876087934 scopus 로고    scopus 로고
    • Combating apoptosis and multidrug resistant cancers by targeting lysosomes
    • Groth-Pedersen L, Jaattela M. Combating apoptosis and multidrug resistant cancers by targeting lysosomes. Cancer Lett 2013; 332: 265-274.
    • (2013) Cancer Lett , vol.332 , pp. 265-274
    • Groth-Pedersen, L.1    Jaattela, M.2
  • 44
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 2001; 15: 2286-2287.
    • (2001) FASEB J , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 45
    • 4344583901 scopus 로고    scopus 로고
    • Role of mitochondrial permeability transition pores in mitochondrial autophagy
    • Rodriguez-Enriquez S, He L, Lemasters JJ. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol 2004; 36: 2463-2472.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2463-2472
    • Rodriguez-Enriquez, S.1    He, L.2    Lemasters, J.J.3
  • 47
    • 34249279169 scopus 로고    scopus 로고
    • GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    • Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L et al. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 2007; 129: 983-997.
    • (2007) Cell , vol.129 , pp. 983-997
    • Colell, A.1    Ricci, J.E.2    Tait, S.3    Milasta, S.4    Maurer, U.5    Bouchier-Hayes, L.6
  • 48
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271-279.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 49


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.