Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: A dose-dependent role for amino acid and iron transporters

Inorganic Chemistry

Volumn 53, Issue 10, 2014, Pages 5150-5158

  Klajner, M ^a,c   Licona, C ^b,c   Fetzer, L ^c,d   Hebraud, P ^a,c   Mellitzer, G ^b,c   Pfeffer, M ^c,d   Harlepp, S ^a,c   Gaiddon, C ^b,c  

^a INSTITUT DE PHYSIQUE ET CHIMIE DES MATÉRIAUX DE STRASBOURG   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITÉ LOUIS PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; ANTINEOPLASTIC AGENT; CATION TRANSPORT PROTEIN; IRON; ORGANOMETALLIC COMPOUND; RUTHENIUM;

CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

AMINO ACID TRANSPORT SYSTEMS; ANTINEOPLASTIC AGENTS; CATION TRANSPORT PROTEINS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IRON; KINETICS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84900993002     PISSN: 00201669     EISSN: 1520510X     Source Type: Journal    
DOI: 10.1021/ic500250e     Document Type: Article

References (47)

1. Doherty, M. M.; Michael, M. Curr. Drug Metab. 2003, 4, 131-49
2. Bruijnincx, P. C.; Sadler, P. J. Curr. Opin. Chem. Biol. 2008, 12, 197-206
3. Jakupec, M. A.; Galanski, M.; Arion, V. B.; Hartinger, C. G.; Keppler, B. K. Dalton Trans. 2008, 183-94
4. Markman, M. Expert Opin. Drug Saf. 2003, 2, 597-607
5. Kelland, L. Nat. Rev. Cancer 2007, 7, 573-84
6. Allardyce, C. S.; Dyson, P. J. Platinum Met. Rev. 2001, 45, 62
7. Dyson, P. J.; Sava, G. Dalton Trans. 2006, 1929-33
8. Giraldi, T.; Sava, G.; Bertoli, G.; Mestroni, G.; Zassinovich, G. Cancer Res. 1977, 37, 2662-6
9. Keppler, B. K.; Balzer, W.; Seifried, V. Arzneim. Forsch. 1987, 37, 770-1
10. Sava, G.; Pacor, S.; Zorzet, S.; Alessio, E.; Mestroni, G. Pharmacol. Res. 1989, 21, 617-28
11. Fruhauf, S.; Zeller, W. J. Cancer Res. 1991, 51, 2943-8
12. Morris, R. E.; Aird, R. E.; Murdoch Pdel, S.; Chen, H.; Cummings, J.; Hughes, N. D.; Parsons, S.; Parkin, A.; Boyd, G.; Jodrell, D. I.; Sadler, P. J. J. Med. Chem. 2001, 44, 3616-21
13. Scolaro, C.; Bergamo, A.; Brescacin, L.; Delfino, R.; Cocchietto, M.; Laurenczy, G.; Geldbach, T. J.; Sava, G.; Dyson, P. J. J. Med. Chem. 2005, 48, 4161-71
14. Hartinger, C. G.; Zorbas-Seifried, S.; Jakupec, M. A.; Kynast, B.; Zorbas, H.; Keppler, B. K. J. Inorg. Biochem. 2006, 100, 891-904
15. Rademaker-Lakhai, J. M.; van den Bongard, D.; Pluim, D.; Beijnen, J. H.; Schellens, J. H. Clin. Cancer Res. 2004, 10, 3717-27
16. Mei, H. Y.; Barton, J. K. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 1339-43
17. Brabec, V. Prog. Nucleic Acid Res. Mol. Biol. 2002, 71, 1-68
18. Zeglis, B. M.; Pierre, V. C.; Barton, J. K. Chem. Commun. (Cambridge, U.K.) 2007, 4565-79
19. Gaiddon, C.; Jeannequin, P.; Bischoff, P.; Pfeffer, M.; Sirlin, C.; Loeffler, J. P. J. Pharmacol. Exp. Ther. 2005, 315, 1403-11
20. Hayward, R. L.; Schornagel, Q. C.; Tente, R.; Macpherson, J. S.; Aird, R. E.; Guichard, S.; Habtemariam, A.; Sadler, P.; Jodrell, D. I. Cancer Chemother. Pharmacol. 2005, 55, 577-83
21. Smalley, K. S.; Contractor, R.; Haass, N. K.; Kulp, A. N.; Atilla-Gokcumen, G. E.; Williams, D. S.; Bregman, H.; Flaherty, K. T.; Soengas, M. S.; Meggersqq, E.; Herlyn, M. Cancer Res. 2007, 67, 209-17
22. Ang, W. H.; De Luca, A.; Chapuis-Bernasconi, C.; Juillerat-Jeanneret, L.; Lo Bello, M.; Dyson, P. J. ChemMedChem. 2007, 2, 1799-1806
23. Dougan, S. J.; Habtemariam, A.; McHale, S. E.; Parsons, S.; Sadler, P. J. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 11628-33
24. Gava, B.; Zorzet, S.; Spessotto, P.; Cocchietto, M.; Sava, G. J. Pharmacol. Exp. Ther. 2006, 317, 284-91
25. Leyva, L.; Sirlin, C.; Rubio, L.; Franco, C.; Le Lagadec, R.; Spencer, J.; Bischoff, P.; Gaiddon, C.; Loeffler, J. P.; Pfeffer, M. Eur. J. Inorg. Chem. 2007, 3055-3066
26. Meng, X.; Leyva, M. L.; Jenny, M.; Gross, I.; Benosman, S.; Fricker, B.; Harlepp, S.; Hebraud, P.; Boos, A.; Wlosik, P.; Bischoff, P.; Sirlin, C.; Pfeffer, M.; Loeffler, J. P.; Gaiddon, C. Cancer Res. 2009, 69, 5458-5466
27. Vidimar, V.; Meng, X.; Klajner, M.; Licona, C.; Fetzer, L.; Harlepp, S.; Hebraud, P.; Sidhoum, M.; Sirlin, C.; Loeffler, J. P.; Mellitzer, G.; Sava, G.; Pfeffer, M.; Gaiddon, C. Biochem. Pharmacol. 2012, 84, 1428-36
28. Benosman, S.; Gross, I.; Clarke, N.; Jochemsen, A. G.; Okamoto, K.; Loeffler, J. P.; Gaiddon, C. Cell Death Differ. 2007, 14, 2047-2057
29. Benosman, S.; Meng, X.; Von Grabowiecki, Y.; Palamiuc, L.; Hritcu, L.; Gross, I.; Mellitzer, G.; Taya, Y.; Loeffler, J. P.; Gaiddon, C. J. Biol. Chem. 2011, 286, 43013-25
30. Bergamo, A.; Gaiddon, C.; Schellens, J. H.; Beijnen, J. H.; Sava, G. J. Inorg. Biochem. 2012, 106, 90-9
31. Klajner, M.; Hebraud, P.; Sirlin, C.; Gaiddon, C.; Harlepp, S. J. Phys. Chem. B 2010, 114, 14041-7
32. Boff, B.; Gaiddon, C.; Pfeffer, M. Inorg. Chem. 2013, 52, 2705-15
33. Fetzer, L.; Boff, B.; Ali, M.; Xiangjun, M.; Collin, J. P.; Sirlin, C.; Gaiddon, C.; Pfeffer, M. Dalton Trans. 2011, 40, 8869-78
34. Sohm, F.; Gaiddon, C.; Antoine, M.; Boutillier, A. L.; Loeffler, J. P. Oncogene 1999, 18, 2762-9
35. Rene, F.; Monnier, D.; Gaiddon, C.; Felix, J. M.; Loeffler, J. P. Neuroendocrinology 1996, 64, 2-13
36. Gaiddon, C.; Larmet, Y.; Trinh, E.; Boutillier, A. L.; Sommer, B.; Loeffler, J. P. J. Neurochem. 1999, 73, 1467-76
37. Gaiddon, C.; de Tapia, M.; Loeffler, J. P. Mol. Endocrinol. 1999, 13, 742-51
38. Gaiddon, C.; Tian, J.; Loeffler, J. P.; Bancroft, C. Endocrinology 1996, 137, 1286-91
39. Broadley, S. A.; Hartl, F. U. Trends Cell Biol. 2008, 18, 1-4
40. Puckett, C. A.; Barton, J. K. Biochemistry 2008, 47, 11711-6
41. Evstatiev, R.; Gasche, C. Gut 2012, 61, 933-52
42. Kratz, F.; Hartmann, M.; Keppler, B.; Messori, L. J. Biol. Chem. 1994, 269, 2581-8
43. Fotiadis, D.; Kanai, Y.; Palacin, M. Mol. Aspects Med. 2013, 34, 139-58
44. Nicklin, P.; Bergman, P.; Zhang, B.; Triantafellow, E.; Wang, H.; Nyfeler, B.; Yang, H.; Hild, M.; Kung, C.; Wilson, C.; Myer, V. E.; MacKeigan, J. P.; Porter, J. A.; Wang, Y. K.; Cantley, L. C.; Finan, P. M.; Murphy, L. O. Cell 2009, 136, 521-34
45. Groessl, M.; Zava, O.; Dyson, P. J. Metallomics 2011, 3, 591-9
46. Puckett, C. A.; Ernst, R. J.; Barton, J. K. Dalton Trans. 2010, 39, 1159-70
47. Romero-Canelon, I.; Pizarro, A. M.; Habtemariam, A.; Sadler, P. J. Metallomics 2012, 4, 1271-9