-
1
-
-
0022406444
-
Amplification of a novel v-erbB-related gene in a human mammary carcinoma
-
King CR, Kraus MH, Aaronson SA. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science 1985; 229: 974-976.
-
(1985)
Science
, vol.229
, pp. 974-976
-
-
King, C.R.1
Kraus, M.H.2
Aaronson, S.A.3
-
2
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
3
-
-
66249091930
-
The HER- 2 receptor and breast cancer: Ten years of targeted anti-HER-2 therapy and personalized medicine
-
Ross JS, Slodkowska EA, Symmans WF, Pusztai L, Ravdin PM, Hortobagyi GN. The HER- 2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. Oncologist 2009; 14: 320-368.
-
(2009)
Oncologist
, vol.14
, pp. 320-368
-
-
Ross, J.S.1
Slodkowska, E.A.2
Symmans, W.F.3
Pusztai, L.4
Ravdin, P.M.5
Hortobagyi, G.N.6
-
4
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20: 719-726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
-
5
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE Jr, Davidson NE et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-1684.
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer Jr., C.E.5
Davidson, N.E.6
-
6
-
-
73949090721
-
Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutionalbased review
-
Dawood S, Broglio K, Buzdar AU, Hortobagyi GN, Giordano SH. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutionalbased review. J Clin Oncol 2010; 28: 92-98.
-
(2010)
J Clin Oncol
, vol.28
, pp. 92-98
-
-
Dawood, S.1
Broglio, K.2
Buzdar, A.U.3
Hortobagyi, G.N.4
Giordano, S.H.5
-
7
-
-
18344390418
-
ERBβ receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE, Lane HA. ERBβ receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-354.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
8
-
-
0022388402
-
The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor
-
Schechter AL, Hung MC, Vaidyanathan L, Weinberg RA, Yang-Feng TL, Francke U et al. The neu gene: An erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. Science 1985; 229: 976-978.
-
(1985)
Science
, vol.229
, pp. 976-978
-
-
Schechter, A.L.1
Hung, M.C.2
Vaidyanathan, L.3
Weinberg, R.A.4
Yang-Feng, T.L.5
Francke, U.6
-
9
-
-
0022399581
-
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
-
Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 1985; 230: 1132-1139.
-
(1985)
Science
, vol.230
, pp. 1132-1139
-
-
Coussens, L.1
Yang-Feng, T.L.2
Liao, Y.C.3
Chen, E.4
Gray, A.5
McGrath, J.6
-
10
-
-
0034638920
-
HER2/neu: Mechanisms of dimerization/oligomerization
-
Brennan PJ, Kumagai T, Berezov A, Murali R, Greene MI. HER2/neu: Mechanisms of dimerization/oligomerization. Oncogene 2000; 19: 6093-6101.
-
(2000)
Oncogene
, vol.19
, pp. 6093-6101
-
-
Brennan, P.J.1
Kumagai, T.2
Berezov, A.3
Murali, R.4
Greene, M.I.5
-
11
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all Erbβ receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all Erbβ receptors, is a mediator of lateral signaling. EMBO J 1997; 16: 1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
12
-
-
84873829861
-
Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling
-
Yang L, Li Y, Ding Y, Choi KS, Kazim AL, Zhang Y. Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling. J Biol Chem 2013; 288: 2365-2375.
-
(2013)
J Biol Chem
, vol.288
, pp. 2365-2375
-
-
Yang, L.1
Li, Y.2
Ding, Y.3
Choi, K.S.4
Kazim, A.L.5
Zhang, Y.6
-
13
-
-
77952092254
-
Identifying the structure of the active sites of human recombinant prolidase
-
Besio R, Alleva S, Forlino A, Lupi A, Meneghini C, Minicozzi V et al. Identifying the structure of the active sites of human recombinant prolidase. Eur Biophys J 2010; 39: 935-945.
-
(2010)
Eur Biophys J
, vol.39
, pp. 935-945
-
-
Besio, R.1
Alleva, S.2
Forlino, A.3
Lupi, A.4
Meneghini, C.5
Minicozzi, V.6
-
14
-
-
0033009389
-
Binding specificities and affinities of egf domains for Erbβ receptors
-
Jones JT, Akita RW, Sliwkowski MX. Binding specificities and affinities of egf domains for Erbβ receptors. FEBS Lett 1999; 447: 227-231.
-
(1999)
FEBS Lett
, vol.447
, pp. 227-231
-
-
Jones, J.T.1
Akita, R.W.2
Sliwkowski, M.X.3
-
15
-
-
1842605531
-
Insights into Erbβ signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into Erbβ signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004; 5: 317-328.
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
De Vos, A.M.5
Sliwkowski, M.X.6
-
16
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J. Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 2001; 61: 4744-4749.
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
17
-
-
55449129956
-
Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells
-
Barr DJ, Ostermeyer-Fay AG, Matundan RA, Brown DA. Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells. J Cell Sci 2008; 121: 3155-3166.
-
(2008)
J Cell Sci
, vol.121
, pp. 3155-3166
-
-
Barr, D.J.1
Ostermeyer-Fay, A.G.2
Matundan, R.A.3
Brown, D.A.4
-
18
-
-
38349175328
-
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism
-
Fan YX, Wong L, Ding J, Spiridonov NA, Johnson RC, Johnson GR. Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism. J Biol Chem 2008; 283: 1588-1596.
-
(2008)
J Biol Chem
, vol.283
, pp. 1588-1596
-
-
Fan, Y.X.1
Wong, L.2
Ding, J.3
Spiridonov, N.A.4
Johnson, R.C.5
Johnson, G.R.6
-
19
-
-
0029956462
-
Expression and molecular analysis of mutations in prolidase deficiency
-
Ledoux P, Scriver CR, Hechtman P. Expression and molecular analysis of mutations in prolidase deficiency. Am J Hum Genet 1996; 59: 1035-1039.
-
(1996)
Am J Hum Genet
, vol.59
, pp. 1035-1039
-
-
Ledoux, P.1
Scriver, C.R.2
Hechtman, P.3
-
20
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T, Furnari F, Newton AC. PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
21
-
-
0037929502
-
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity
-
Donella-Deana A, Cesaro L, Sarno S, Ruzzene M, Brunati AM, Marin O et al. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem J 2003; 372: 841-849.
-
(2003)
Biochem J
, vol.372
, pp. 841-849
-
-
Donella-Deana, A.1
Cesaro, L.2
Sarno, S.3
Ruzzene, M.4
Brunati, A.M.5
Marin, O.6
-
22
-
-
78249236544
-
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
-
Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G et al. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell 2010; 18: 423-435.
-
(2010)
Cancer Cell
, vol.18
, pp. 423-435
-
-
Liang, K.1
Esteva, F.J.2
Albarracin, C.3
Stemke-Hale, K.4
Lu, Y.5
Bianchini, G.6
-
23
-
-
0034693806
-
Selected glimpses into the activation and function of Src kinase
-
Bjorge JD, Jakymiw A, Fujita DJ. Selected glimpses into the activation and function of Src kinase. Oncogene 2000; 19: 5620-5635.
-
(2000)
Oncogene
, vol.19
, pp. 5620-5635
-
-
Bjorge, J.D.1
Jakymiw, A.2
Fujita, D.J.3
-
24
-
-
0037174166
-
Direct identification of PTEN phosphorylation sites
-
Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG. Direct identification of PTEN phosphorylation sites. FEBS Lett 2002; 528: 145-153.
-
(2002)
FEBS Lett
, vol.528
, pp. 145-153
-
-
Miller, S.J.1
Lou, D.Y.2
Seldin, D.C.3
Lane, W.S.4
Neel, B.G.5
-
25
-
-
0141994730
-
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades
-
Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D et al. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 2003; 278: 40057-40066.
-
(2003)
J Biol Chem
, vol.278
, pp. 40057-40066
-
-
Lu, Y.1
Yu, Q.2
Liu, J.H.3
Zhang, J.4
Wang, H.5
Koul, D.6
-
26
-
-
0028047315
-
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
-
Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol Cell Biol 1994; 14: 735-743.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 735-743
-
-
Muthuswamy, S.K.1
Siegel, P.M.2
Dankort, D.L.3
Webster, M.A.4
Muller, W.J.5
-
27
-
-
0032497249
-
C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells
-
Sheffield LG. C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells. Biochem Biophys Res Commun 1998; 250: 27-31.
-
(1998)
Biochem Biophys Res Commun
, vol.250
, pp. 27-31
-
-
Sheffield, L.G.1
-
28
-
-
48549088895
-
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation
-
Sigismund S, Argenzio E, Tosoni D, Cavallaro E, Polo S, Di Fiore PP. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell 2008; 15: 209-219.
-
(2008)
Dev Cell
, vol.15
, pp. 209-219
-
-
Sigismund, S.1
Argenzio, E.2
Tosoni, D.3
Cavallaro, E.4
Polo, S.5
Di Fiore, P.P.6
-
30
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004; 6: 117-127.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
-
31
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW Jr et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 2003; 421: 756-760.
-
(2003)
Nature
, vol.421
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
Stanley, A.M.4
Gabelli, S.B.5
Denney Jr., D.W.6
-
32
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 2001; 1: 85-94.
-
(2001)
Mol Cancer Ther
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
Wood, E.R.4
Alligood, K.J.5
Rhodes, N.6
-
33
-
-
0042307325
-
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
-
Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF 3rd, Hynes NE. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA 2003; 100: 8933-8938.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8933-8938
-
-
Holbro, T.1
Beerli, R.R.2
Maurer, F.3
Koziczak, M.4
Barbas III, C.F.5
Hynes, N.E.6
-
34
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
-
Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008; 68: 5878-5887.
-
(2008)
Cancer Res
, vol.68
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
Pham, T.4
Munroe, X.5
Hoeflich, K.P.6
-
35
-
-
84899928188
-
Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusion
-
Caliskan A, Yavuz C, Karahan O, Yazici S, Guclu O, Demirtas S et al. Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusion. J Thromb Thrombolysis 2014; 37: 464-468.
-
(2014)
J Thromb Thrombolysis
, vol.37
, pp. 464-468
-
-
Caliskan, A.1
Yavuz, C.2
Karahan, O.3
Yazici, S.4
Guclu, O.5
Demirtas, S.6
-
36
-
-
0038517977
-
Serum prolidase i activity and some bone metabolic markers in patients with breast cancer: In relation to menopausal status
-
Kir ZO, Oner P, Iyidogan YO, Turkmen S, Kocak H, Koser M et al. Serum prolidase I activity and some bone metabolic markers in patients with breast cancer: In relation to menopausal status. Clin Biochem 2003; 36: 289-294.
-
(2003)
Clin Biochem
, vol.36
, pp. 289-294
-
-
Kir, Z.O.1
Oner, P.2
Iyidogan, Y.O.3
Turkmen, S.4
Kocak, H.5
Koser, M.6
-
37
-
-
84862289057
-
Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer
-
Gecit I, Aslan M, Gunes M, Pirincci N, Esen R, Demir H et al. Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. J Cancer Res Clin Oncol 2012; 138: 739-743.
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, pp. 739-743
-
-
Gecit, I.1
Aslan, M.2
Gunes, M.3
Pirincci, N.4
Esen, R.5
Demir, H.6
-
38
-
-
73449125189
-
Serum prolidase activity and oxidative status in patients with stage i endometrial cancer
-
Arioz DT, Camuzcuoglu H, Toy H, Kurt S, Celik H, Aksoy N. Serum prolidase activity and oxidative status in patients with stage I endometrial cancer. Int J Gynecol Cancer 2009; 19: 1244-1247.
-
(2009)
Int J Gynecol Cancer
, vol.19
, pp. 1244-1247
-
-
Arioz, D.T.1
Camuzcuoglu, H.2
Toy, H.3
Kurt, S.4
Celik, H.5
Aksoy, N.6
-
39
-
-
84871905514
-
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism
-
Ding Y, Liu Z, Desai S, Zhao Y, Liu H, Pannell LK et al. Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism. Nature Commun 2012; 3: 1271.
-
(2012)
Nature Commun
, vol.3
, pp. 1271
-
-
Ding, Y.1
Liu, Z.2
Desai, S.3
Zhao, Y.4
Liu, H.5
Pannell, L.K.6
-
40
-
-
84864359086
-
Mechanism of chemical activation of Nrf2
-
Li Y, Paonessa JD, Zhang Y. Mechanism of chemical activation of Nrf2. PLoS One 2012; 7: e35122.
-
(2012)
PLoS One
, vol.7
-
-
Li, Y.1
Paonessa, J.D.2
Zhang, Y.3
|